With the advancement of worldwide carbon neutralization, passive radiative cooling (PRC) has attracted tremendous interest in energy conservation by dissipating heat into the ultracold outer space without any electricity consumption. Despite some progress has been made in tailoring spectral properties for PRC, it still remains a crucial challenge in fabricating efficient and low-cost coolers for building energy saving. Herein, hierarchical cellulose-based aerogel coolers consisting of beads-on-string structural electrospun nanofibers are manufactured for all-day and all-region energy saving by combining radiative cooling and thermal insulation in one design. The hierarchically porous architectures and well-designed chemical compositions endow the aerogels with strong solar reflectance (∼0.974), high mid-infrared emittance (∼0.985), and ultra-low thermal conductivity (0.0285 W (m K)−1), achieving a sub-ambient cooling of ∼8.24 °C during the daytime and ∼7.41 °C during the nighttime. The aerogels also exhibit exceptional compressive resiliency, anti-aging, and self-cleaning properties, promising for durable cooling under harsh conditions. The building energy simulations show that about 23.1 kWh m−2 of the total energy consumption per year can be saved if the aerogel coolers are widely deployed as building envelopes in China. This work provides new perspectives for the development of advanced aerogel coolers for future energy saving applications.