Strategic reservoir operation, a primary water management measures, plays a significant role in mitigating floods and droughts. Since the reservoir operation involves making complicated decisions on uncertain hydrological variables driven by climate variability, therefore, constructive tool for decision making like fuzzy logic is essential to optimize reservoir management and ensure water security. This study demonstrated fuzzy logic application to multiple reservoir operation in tropical region like Thailand. A Fuzzy Rule–Based Model (FRBM) exploiting FL approach was developed to control the upstream reservoir operation in the Upper Mun River Basin (UMRB) using the data from 2008 to 2021. Implementing FRBM for UMRB was conducted by identifying two key variables; available water storage and 7–day ahead predicted inflow, as fuzzy inputs. The fuzzy output of the system is the release fraction determined by three operational condition modules; flood, neutral, and drought. For flood module, fuzzy release is primarily determined by the predicted inflow. However, the determination of reservoir release for drought and neutral modules is influenced by the targeted water demand. The results of base case illustrate the capability of FRBM in increasing reservoir storages at the start of dry season by 123.56 MCM/yr in UMRB due to the new daily release schemes generated. This allows supplying water closer to the theoretical agricultural needs and gross irrigation water requirement potentially reducing the risk of water shortfall during consecutive dry years. Whereas, the maximum fuzzy release is constrained corresponding to safe channel capacity of tributaries and Upper Mun river, therefore, downstream flooding is accordingly prevented.