Conical Teeth Research Articles

Improving Quality Of Life Through Prosthodontic Intervention In Ectodermal Dysplasia: A Case Report

Ectodermal dysplasia (ED) is a rare inherited disorder that affects ectodermal tissues such as hair, nails, teeth, and skin. Dental symptoms often include missing (anodontia) or reduced (hypodontia) primary and permanent teeth, conical teeth, and underdeveloped alveolar ridges. These orofacial issues frequently lead to psychosocial challenges, making the restoration of appearance and function particularly demanding. Hypohidrotic (anhidrotic) ED and hidrotic ED are the two most common syndromes in this group. The most prevalent form of ectodermal dysplasia is hypohidrotic ectodermal dysplasia (HED), which occurs in approximately one in every 100,000 infants. The primary symptoms of HED include hypohidrosis (reduced ability to sweat), hypotrichosis (sparse hair), and partial anodontia (missing teeth). Common facial features of ED include frontal bossing, sunken cheeks, saddle nose, thick everted lips. Treatment options for ED include removable, fixed, or implant-supported prostheses, either alone or in combination. This report describes the prosthetic rehabilitation of a patient with ED, focusing on improving both function and aesthetics

Reabilitação estética de dente conóide: relato de caso

As aesthetics advance in modern dentistry, people's expectations of their smiles become ever higher. Microdontia or conoid tooth, which refers to teeth smaller than normal, is one of the abnormalities that causes major aesthetic complaints due to its characteristics. Conoid teeth have a prevalence of 0.6 to 9.9%, with conical upper lateral teeth affecting approximately 55,000 people, with women being more susceptible than men. Many factors must be considered when restoring anterior teeth, depending on patient expectations and dental practice. The direct composite resin technique has stood out for providing aesthetic benefits, preserving tooth structure, being performed in a single consultation, being cheaper and not requiring any laboratory process. The objective of this study was to report a clinical case of aesthetic rehabilitation in a conoid tooth in the upper left lateral incisor with composite resin restoration using the direct technique. Clinical planning is essential for choosing the technique and restorative material to be used. Despite the various techniques proposed for the treatment of conoid lateral incisors, the aesthetic reanatomization with a direct veneer of composite resin, with diagnostic waxing, used in this study, was effective and inexpensive, allowing a minimally invasive treatment and possible posterior adjustments, enabling the restoration of self-esteem and the harmony of the patient's smile.

Design and Stress Analysis of Bevel Line Gears with Vertical Flank Suitable for Micro Machining

The line gear (LG) exhibits promising applications in micromachinery owing to its simple structure and minimal teeth count. This paper aims to advance the meshing theory of LG and introduce a conical LG tooth configuration specifically tailored for micro-machining that is capable of driving with high performance. Based on the meshing principle of LG, a conical line gear pair with vertical flank (VFLG) of the driving gear was designed. Subsequently, adhering to the curvature non-interference principle that no local interference occurs in the meshing process and the specified range of fitting error in one direction, the design parameters for LG were determined. A comparison of the contact stress between two sets of different contact line types revealed the distinct advantage of VFLG with parameters identical to those of traditional LG. The experimental results conclusively demonstrate a transmission ratio error of 0.004, affirming the feasibility of the design. The curvature non-interference design formula proposed in this paper refines the LG design theory, and the novel LG design method presented holds significant implications for subsequent micromachining.

Experimental study on the rock breaking effect of different tooth shapes of inserted teeth in a hobbing-cone hybrid PDC bit under complex stress environment

The hobbing-cone hybrid PDC bit has emerged with the increasing exploitation of deep oil and gas resources. As an important component of new bits, studying the mechanism of toothed fracturing of deep rocks is crucial for improving rock-breaking efficiency. In this paper, the spherical teeth and conical teeth were used to intrude sandstone under different confining pressures, and the brittleness index (BIm), specific energy (SE), and average fragment size (dm) were used to analyze the rock-breaking effect. The 3D contour scanner quantitatively analyzed the crushing pit area. Finally, the in-situ CT scanning and discrete element numerical simulation were used to summarize the crack propagation law. The results show that with the increase of confining pressure, the BIm of inserted teeth increases continuously, and the growth rate of conical teeth increases, while that of spherical teeth decreases. The SE and dm exhibit a symmetrical distribution with a confining pressure of 10MPa as the axis of symmetry. When the difference in principal stress is 5MPa, the SE is the lowest point, the rock-breaking efficiency is the highest, and the corresponding dm is at the highest point, but the curve trend is the opposite. When the stress difference is 5MPa, it is conducive to propagating surface cracks, thus forming a larger crushing area and the highest rock-breaking efficiency. Based on CT results, the dense particle core is formed near the inserted teeth, and that of the spherical teeth is located below. In contrast, that of the conical teeth is located on the side, which is also the reason for the difference in crack propagation between different tooth shapes.

Simulation Research and Practical Application of Cutting Teeth for Drill Bits in Life-Support Holes

This study aims to achieve rapid drilling of life-support holes, regarding the optimization design of drill bits as the key, among which the simulation analysis of drill bit cutting teeth is an important technical means. Firstly, based on the rock mechanics test results in the study area combined with the corresponding logging information, the analysis and evaluation of the geological conditions in the study area were completed, a complete rock mechanics characteristic profile was established, and the drillability of the rock was calculated to be relatively good. Then, a numerical simulation of parallel cutting of rock with conical teeth was established by experimentally testing rock mechanics parameters and using the discrete element method (PFC2D). The simulation study of the drill bit cutting teeth was completed by parameter calibration, analysis of rock cutting morphology, analysis of the number of rock cutting cracks, and analysis of the specific work of rock cutting and breaking. It was determined that the optimal rock-entering angle of the drill bit cutting teeth in the Shouyang mining area is 14°. Finally, verified by field practice, the optimized drill bit has stable performance, strong cutting ability, and good wear resistance; the maximum instantaneous mechanical drilling speed reaches 58.14 m/h, and it shows a slightly worn state after continuously drilling 582 m in the stratum, meeting the requirements of one-trip drilling and hole formation for life-support holes. This research provides a scientific basis and practical techniques for the construction of life-support holes in the Shouyang mining area and under similar geological conditions. It can provide more effective emergency plans and rescue strategies for possible mine disasters in the future, which is crucial for improving the technical system of emergency rescue for mine accidents and enhancing the emergency rescue capability of surface drilling.

Restorative Management of Microdontia - A Case Report

“Conical tooth anomaly” is defined as those anomalies associated with volumes and shapes of the teeth, and as the malformation in which dental crowns are similar with cone and shape bluntly and in which mesiodistal crown size is smaller than cervical size. Although many treatment options are adopted for regaining the aesthetic structure and functions in such individuals, direct and indirect options are generally preferred. In this case report we have presented a patients presenting with “conical tooth anomaly” following the clinical and diagnosis of th is patient treated with direct composite resin.

Bioecology of Electric Fish (Actinopterygii: Gymnotiformes)

The poraquê has an elongated and cylindrical body, with just one anal fin, which extends across almost the entire abdomen it resembles the shape of an eel. Its head is flat and its mouth is equipped with a row of sharp, conical teeth. The color of this animal is always very dark, but the ventral part of the body is yellowish and they have poor vision. This group of fish is known for their ability to generate and detect electrical fields in the environment in which they occur, and these characteristics are used in communication, prey detection, defense, reproduction and even to help these animals move in the absence of light. This manuscript aims to describe the biology, ecology, morphology, geographic distribution, life cycle, habitat, and therapeutic use of electric fish (Chordata: Actinopterygii: Gymnotiformes). Concerned with establishing a public profile of quality research in the area, we sought to answer these questions based on a literature review in the main journals (national and international) classified by the Coordination for the Improvement of Higher Education Personnel (CAPES). Complement this analysis with other documents such as books, theses, dissertations, scientific journals, documents, and digital platforms.

Early ray‐finned herbivores: the dental system of Eurynotoidiidae (Actinopterygii; middle–late Permian, European Russia) and implications for palaeobiology and palaeoecology

AbstractEurynotoidiformes are a little‐known group of actinopterygian fishes from the Permian of European Russia, characterized by the possession of multicuspid marginal teeth arranged in a single row. Morphologically, the teeth resemble those of Recent Cichlidae, Acanthuridae, Siganidae or Serrasalmidae, suggesting similar trophic adaptations related to herbivory. Tooth histology is similar to the majority of basal actinopterygians (composed of dentine, acrodin and collar enamel). Teeth are ankylosed in their attachment, and labial pleurodont in implantation, strengthening the tooth. The multicuspid tooth crowns derive from conical teeth of predatory or omnivorous ancestors, analogous to the evolution of multicuspid teeth in cichlid fishes. Tooth replacement in eurynotoidiforms is most comparable to an alternating pattern, with a possible simultaneous, unilateral replacement occurring in the whole jaw, similar to characiform fishes. Replacement teeth were formed extraosseously. Teeth of the inner dental arcade were conical. Based on comparisons with the teeth of extant actinopterygians specialized for herbivory, along with functional morphological analysis and consideration of wear patterns, we hypothesize that eurynotoidiforms represent the oldest known actinopterygians specialized for herbivory. Several strategies of herbivory in Recent actinopterygians were already realized by eurynotoidiforms as early as the Late Palaeozoic (middle and late Permian): grazing/cutting filamentous algae (Lapkosubia spp., Isadia suchonensis), browsing/biting off macrophyte fragments (Isadia aristoviensis), scraping/harvesting periphyton from hard substrates (Isadia opokiensis, I. arefievi). However, notable morphological differences in the jaws (elongate) and tooth arrangement (homodont along the jaw, functional teeth separated) suggest that this Permian experiment in herbivory followed different pathways compared to extant taxa.

Replacement tooth in mesosaurs and new data on dental microanatomy and microstructure.

The Permian mesosaurs are well known for being the earliest amniotes to exhibit adaptations for living in a marine environment (Irati-Whitehill Sea). In addition to their set of skeletal features associated with aquatic dwelling life, their dentition includes important characteristics related to feeding in this habitat, which is described in this work, based on the analysis of mesosaur specimens from the Lower Permian Irati Formation of Brazil. Mesosaurs have several slender, conical teeth bordered by enamel apicobasal ridges, a feature predominantly found in aquatic amniotes. Internally, the dentine walls are formed by the arrangement of layers of orthodentine and globular dentine. To prevent tooth loss, the basal area is equipped with plicidentine, a particular type of orthodentine, allied with cementum, alveolar bone trabeculae, and periodontal space that reinforces anchorage and provides some flexibility. The teeth are replaced in a labio-vertical path, and the dentition replaces alternately. This feature is regarded as plesiomorphic, and it ensures the oral cavity is supplied with enough teeth. However, these features do not the assessment of whether mesosaurs teeth were capable of piercing prey with resistant tegument. Instead, we interpret this adaptation as a mechanism for catching prey, at least in adults, and we endorse a possible ontogenetic dietary shift from small to large forms.

Structural Design and Analysis of Large-Diameter D30 Conical Polycrystal Diamond Compact (PDC) Teeth under Engineering Rotary Mining Conditions.

In the realm of engineering rotary excavation, the rigid and brittle nature of the Polycrystal Diamond Compact (PDC) layer poses challenges to the impact resistance of conical teeth. This hinders their widespread adoption and utilization. In this paper, the Abaqus simulation is used. By optimizing the parameters of the radius of the cone top arc, we analyzed the changing law of the parameters of large-diameter D30 series conical PDC teeth, such as the equivalent force, impact force, and energy absorption of the conical teeth during the impact process, and optimized the best structure of the conical PDC teeth. After being subjected to a high temperature and high pressure, we synthesized the specimen for impact testing and analyzed the PDC layer crack extension and fracture failure. The findings reveal the emergence of a stress ring below the compacted area of the conical tooth. As the radius of the cone top arc increases, so does the area of the stress ring. When R ≥ 10 mm, the maximum stress change is minimal, and at R = 10 mm, the stress change in its top unit is relatively smooth. Optimal impact resistance is achieved, withstanding a total impact work value of 7500 J. Extrusion cracks appear in the combined layer part of PDC layers I and II, but the crack source is easy to produce in the combined layer of PDC layer II and the alloy matrix and extends to both sides, and the right side extends to the surface of the conical tooth in a "dragon-claw". The failure morphology of the conical teeth includes ring shedding at the top of the PDC layer, the lateral spalling of the PDC layer, and the overall cracking of the conical teeth. Through this study, we aim to promote the popularization and application of large-diameter conical PDC teeth in the field of engineering rotary excavation.

Early ontogenetic development of Cynodon gibbus (Characiformes: Cynodontidae) in the Amazon River basin

Abstract Knowledge regarding the early life history of neotropical fish, although incipient, is crucial for the accurate identification of larvae collected from the natural environment. Such details are important for defining spawning, drift, and nursery areas as well as the reproductive periods of species. Herein, the larval development of Cynodon gibbus was described using morphological, meristic, and morphometric characteristics. Specimens were collected from open water limnetic zones and under macrophyte stands in the Amazon basin from 2010 to 2023. Forty-eight larvae with standard lengths ranging from 5.73 to 21.57 mm were studied. The larvae have a long to very long body, small eyes, and a small head, which progresses to a moderate size in the preflexion stage. Furthermore, the larvae had ample mouths with numerous conical teeth, an oval-triangular swim bladder, overlapping dorsal and anal fins, and the tip of the pectoral fin not reaching the swim bladder. Pigmentation pattern comprised two punctate pigments above the fontanelle, the rectum, and at the lower and upper ends of the caudal peduncle. Various body parts exhibited predominant allometric relationships, reflecting differential developmental rates among them in response to fundamental ecological requirements for survival. The C. gibbus larvae can be identified by a combination of the position of dorsal, anal and pectoral fins, pigmentation pattern, swim bladder shape, and the total number of myomeres (51 to 53).

Developmental process of the modern house shrew's molars: implications for the evolution of the tribosphenic molar in Mesozoic mammals.

Phylogenetically, the tribosphenic molars-prototypes of multi-cusped cheek teeth in marsupial and placental mammals-are derived from the single-cusped conical teeth of reptiles through the addition of cusps. Ontogenetically, mammalian molars are formed through the interface between the dental epithelium and mesenchyme (future enamel-dentin junction), becoming geometrically complex by adding epithelial signaling centers, called enamel knots, which determine future cusp positions. To reevaluate cusp homologies in Mesozoic mammals from an ontogenetic perspective, this study tracked molar development in a living placental mammal species, the house shrew (Suncus murinus), whose molars are morphologically the least derived from tribosphenic prototypes. The development of shrew molars proceeded as if it replayed the evolutionary process of tribosphenic molars. The first formed enamel knots gave rise to the evolutionarily oldest cusps-upper paracone and lower protoconid. The order of formation of other enamel knots and their location in development seemed to trace the order of cusp appearance in evolution. The parallel relationship between ontogeny and phylogeny of mammalian molars, if any, suggests that a change in the timing between developmental events rather than a change in the morphogenetic mechanism itself, should have been a major causal factor for the evolutionary transformation of tooth morphology.

Design and experiment of a double-sided staggered conical teeth traveling wave ultrasonic motor

This paper proposed a double-sided staggered conical teeth traveling wave rotating ultrasonic motor based on in-plane bending mode, which reduces the difficulty of rotor preload application and improves the output characteristics of in-plane bending mode traveling wave rotating ultrasonic motor. The motor has four sets of drive teeth alternately distributed on both the inner and outer sides of the vibrator, with the drive teeth gap dedicated to accommodate the piezoelectric ceramic piece, and the staggered drive teeth on both sides of the vibrator are used to drive the rotor rotation. The motor operates in two in-plane third-order bending modes with the same frequency and orthogonal to each other, and is excited by four sets of piezoelectric ceramic disks spaced 90 degrees apart from the inner and outer sides. After the prototype was completed, its vibration characteristics and output performance were experimentally tested, and the actual effects of the three excitation schemes were compared. The experimental results show that the motor can provide a maximum output torque of 1.82 N·mm and a maximum no-load speed of 96.4 rpm when the excitation voltage is 300 V and the excitation frequency is 20.60 kHz.

SPINOSAURS AS PHYTOSAUR MIMICS: A CASE OF CONVERGENT EVOLUTION BETWEEN TWO EXTINCT ARCHOSAURIFORM CLADES

Spinosaurids are a highly morphologically specialized clade of large tetanuran theropod dinosaurs, characterized by their proportionally long, narrow snouts and conical teeth with fluted surfaces. The unusual morphology of spinosaurids has been usually compared with modern crocodilians, but distinct differences between them have been reported as well. Here, numerous craniodental characters that are shared by spinosaurids and large, robust phytosaurs often termed as “brachyrostral” forms are reviewed. Phytosaurs are a clade of carnivorous archosauriforms that resemble crocodilians in overall morphology, and as such a similar lifestyle has been inferred for them as well. Although based on preliminary observations, the shared craniodental characters of spinosaurids and “brachyrostral” phytosaurs, including those not shared with crocodilians, raise the possibility that at least some aspects of the lifestyle of these extinct archosauriform clades were more similar to each other rather than to that of crocodilians.

Two new species of the bathyal holothurian genus Pannychia (Elasipodida, Laetmogonidae) from Japanese waters.

Sea cucumbers are one of the most common large animals in the deep-sea benthic communities, and those of the genus Pannychia are particularly abundant in the bathyal North Pacific Ocean. In Japanese waters, three species of Pannychia have been reported, mainly from the northern and eastern parts of the country. Here, we describe two new species from the western part of Japan. These two new species were placed in Pannychia by the presence of dorsal papillae on the ventrolateral radii and the presence of large wheel ossicles with rim teeth. They are distinguished from all other nominal species of Pannychia on the basis of the morphological characteristics of their body wheel ossicles. Pannychia nagasakimaruae sp. nov. has a unique ossicle composition in its dorsal and ventral body walls: four forms of wheel ossicles. Pannychia rinkaimaruae sp. nov. differs from other congeners in its small wheel ossicles in the dorsal and ventral body walls, which have conical rim teeth. We barcoded partial COI gene sequences from holotypes and paratypes of two new Japanese species. Our molecular phylogenetic analysis showed that these two new morphologically recognized Japanese species form distinct clades separated from other Pacific Pannychia species, so that the two new Japanese species were also supported by genetic results. In addition, we describe and visualize the poorly calcified calcareous rings of the two new species using X-ray μCT system, a useful method for observing such structures, which are important structures in holothurian anatomy.

The dental system of †Kazanichthys viatkensis (Actinopterygii, Acrolepididae) from the middle Permian of European Russia: palaeobiological and palaeoecological inferences

AbstractAmong ray‐finned fishes (Actinopterygii), the crushing, durophagous feeding strategy first evolved in the early Carboniferous period, with the †Eurynotiformes possessing dentitions with single layers of partially to fully fused blunt teeth. In the †‘Platysomidae’ (Permian), a new form of crushing dentition evolved (phyllodonty), in which multiple layers of superimposed crushing teeth developed intraosseously, within the jaw. The phyllodont durophagous dentition is also recovered from later‐occurring taxa originating mainly in the Mesozoic, such as the †Bobastraniiformes, the neopterygians †Pycnodontiformes and Ginglymodi, and in the teleost group †Phyllodonta. By comparison, †Kazanichthys viatkensis, an actinopterygian from the middle Permian of European Russia, is characterized by a third, putatively durophagous dentition, with anterior conical teeth and closely packed molariform teeth on the buccal dental plates (a potential similarity with eurynotiforms). Whereas the conical teeth are similar to those of basal actinopterygians, the molariform teeth superficially resemble teeth of some teleosts (Characiformes, Tetraodontiformes), but are unique among known fossil and living Actinopterygii in being crowned by anastomosing, sharp apical ridges. Teeth are ankylosed to the jaw and acrodont in implantation. There is neither evidence of plicidentine, nor cavities corresponding to intraosseous crypts. Most replacement teeth formed extraosseously, differing from the phyllodont dentition, but similar to several more phylogenetically basal actinopterygians. The dental system morphologically resembles recent Sparidae (Teleostei; Perciformes), possibly indicating a similar trophic adaptation. Based on these comparisons and patterns of wear, we propose that †K. viatkensis was a generalist durophagous feeder, with the ability to switch prey types with its unique and complex dentition.

Feeding-Related Skull Structures of Climbing Perch Anabas testudineus (Anabantidae)

The feeding-related skull structures are described and occluding elements of the upper and lower regions of the buccopharyngeal cavity are analyzed in climbing perch. At each side of the neurocranium, the transverse process of the parasphenoid with four or five large conical teeth oppose the hypobranchial 3, and the medial teeth of the parasphenoid oppose the medial joints between paired hypobranchials 3 and ceratobranchials 4. As in the majority of other advanced Teleostei, the pharyngeal bite is carried out by the lower pharyngeal jaw (fused ceratobranchials 5) and upper pharyngeal jaws (left and right plates of pharyngobranchials 3–4). The latter jaws are articulated with paired pharyngeal processes of the basioccipital. At both sides of the skull, the strong elongated Baudelot’s ligament joins the basioccipital and supracleithrum. The hypothesis on the occurrence of the unique lower pharyngeal jaw–parasphenoid bite in climbing perch is rejected.

A Heterozygous Nonsense Variant of NFKBIA Leading to Gain-of-Function

The NFKBIA gene encodes the protein IκBα, an important regulatory protein that interacts with nuclear factor kappa B family of transcription factors required for innate and adaptive immune responses and normal ectodermal development. Heterozygous nonsense and missense variants of the NFKBIA gene have been reported in a total of 19 individuals with autosomal dominant ectodermal dysplasia with immunodeficiency (EDA-ID) since 2003. Here, we report a patient with a novel de novo heterozygous nonsense variant in the N-terminal of NFKBIA. This patient initially presented to Immunology due to an abnormal presentation of IgA nephropathy (IgAN) with solely kappa staining and a notable history of recurrent AOM, PNA and viral infections including septic shock, diffuse watershed ischemic injury and new seizure onset due to influenza A. Immunologic assessment revealed lymphocytosis of T- and B-cells, particularly CD4+ and CD8+ memory, and CD27-IgD+ cells. In contrast, class-switched, non-class-switched memory B-cells, CD21lo, and plasmablasts were low. A distinct B-cell population expressing less CD19 with negative surface IgD, IgG, and IgM was also observed. Roughly 50% of these cells had IgM expression without surface IgD and were CD24 and CD27 negative, CD21 lo, and CD28 mid. Functionally, T-cells had poor response and proliferation to PHA as well as soluble anti-CD3, anti-CD3+anti-CD28, and anti-CD3+IL-2. Vaccine response was diminished, particularly to polysaccharides. Furthermore, TLR function of PBMCs were assessed revealing decreased cytokine response to soluble ligand exposure. Physical exam findings consistent with EDA-ID included several absent and conical teeth, xerosis, and sparse hair with a history notable for heat intolerance. In line with prior reports of patients with early truncating variants in NFKBIA, the infectious manifestations in these patients have been mild, particularly in comparison to those with missense variants that affect serine 32. In this patient, HSCT was not undertaken, but rather IgG replacement therapy was initiated resulting in absence of any further serious infections. Additionally, glucocorticoid therapy was initiated for IgAN with subsequent sustained remission. With an increase in published data, this may help broaden our scope of what phenotypical presentation can be expected, which may help increase the rate of diagnosis and early identification.

A human ITPR3 variant causes a dominant negative attenuation of calcium responses with immunodeficiency and growth delay confirmed in a mouse model

The inositol 1,4,5 triphosphate receptors (ITPRs) regulate intracellular calcium stores following diverse receptor-ligand interactions. Three iso-forms, ITPR1, ITPR2 and IPTR3 form homo- or hetero- tetramers in the ER that regulate calcium levels. Mutations in ITPR3 cause Charcot Marie Tooth disease. Two unrelated children who presented with immunodeficiency have the same de novo ITPR3 mutation. The ITPR3 variant (c.7570C>T) results in a single amino acid substitution (p.Arg2524Cys) within the calcium pore that is predicted to disrupt calcium release. Patient 1 is a 5 year old African-American female who had abnormal newborn screens for SCID. She has T cell deficiency, a predominance of memory T cells, and depressed B cells. Mitogen responses were low. She is small in stature, has conical deciduous teeth, anhidrosis, gait abnormalities and bilateral vocal fold paralysis. Nerve conduction studies (NCS) demonstrated sensorimotor polyneuropathy most prominent in lower extremities. Patient 2 is a 12 year old boy born to parents of Pakistani descent with a very similar clinical presentation as Patient 1.The ITPR3 mutation was genocopied in mice using CRISPR/Cas technologies. The Itpr3Wt/R2524C mice are significantly smaller than littermate controls with severe B cell immunodeficiency, reduced peripheral T cell numbers and impaired antigen-receptor induced calcium responses. The full details of the immune cell defects as well as eccrine and peripheral neuronal cell functions will be presented. Importantly, the data indicate that the single allelic Itpr3 mutation acts as a dominant negative, suggesting that the targeting of this gene will enable the two related Itpr family members to improve immune, neuronal and endocrine functions in the patients.

Oral manifestations in child patient with Ellis-van Creveld syndrome: case report

Ellis–van Creveld syndrome is an autosomal recessive disorder characterized by a tetrad of disproportionate dwarfism, ectodermal dysplasia, postaxial polydactyly, and congenital heart malformations. In this article, we hereby present a case of a 6-year-old Brazilian boy with Ellis–van Creveld syndrome who presented with a remarkable number of classical oral and dental features and uncommon findings such as taurodontism. Clinical examination revealed multiple enamel hypoplasia, absent vestibular sulcus, alveolar serrations in the maxilla anterior region, missing teeth, conical teeth, lower canine rotation, bilateral posterior crossbite, dental caries, and a nodule. Radiographically were observed teeth agenesis, taurodontism of deciduous and permanent molars, and delayed tooth eruption. Clinical and radiographic findings may be present from birth and the pediatric dentist has a fundamental role in the early diagnosis of Ellis–van Creveld syndrome, as well as oral problems prevention, rehabilitation, and aesthetic interventions.