Dear Editor: Myofibroma is an uncommon, benign myofibroblastic neoplasm of vascular origin, mostly occurring on the skin. It can also involve skeletal muscles, bones, or viscera, which can be fatal. As about 90% of myofibromas develop before the age of 2 years, it was previously termed infantile myofibroma. Adult-onset myofibroma is rare and is distinguishable from the infantile form. It is exclusively solitary and confined to the dermis and subcutis. However, a few cases of adult multiple myofibromas have been reported1,2. Herein, we report a rare and unusual case of adult multiple myofibromas occurring on a preexisting atrophic patch. A 62-year-old healthy woman presented with multiple firm subcutaneous nodules under a preexisting atrophic patch on the left thigh (Fig. 1). The patch was soft and heterogeneous, composed of atrophic and hypertrophic portions, and was >10 years old. During the last 3 years, multiple firm nodules developed under the patch. She had no history of trauma, burns, or treatment. Two incisional biopsies were performed on the nodule and the patch. Histopathological examination of the nodule showed well-circumscribed, biphasic tumors composed of intersecting fascicles of spindle cells and a vascular compartment resembling a hemangiopericytoma with polygonal cells (Fig. 2A~C). The tumor cells were positive for smooth muscle actin (SMA) staining and were negative for CD34, desmin, and S-100 staining (Fig. 2D, E), consistent with a myofibroma. Histopathological examination of the patch showed mild epidermal and dermal atrophy; however, these findings were not diagnostic. A small tumor suggestive of myofibroma was incidentally found in the dermis; this tumor was not clinically noticeable (Fig. 2F). She is currently being observed without excision, showing no remarkable change for 1 year. Fig. 1 Multiple firm subcutaneous nodules under the atrophic and telangiectatic soft patch on the left thigh. Fig. 2 Skin biopsy of the nodule showed well-circumscribed, biphasic tumors (A: H&E, ×12.5) composed of intersecting fascicles of spindle cells (B: H&E, ×200) and a vascular compartment with polygonal cells (C: H&E, ×200). ... Myofibromas are histologically well-circumscribed, biphasic- patterned tumors consisting of spindle and vascular portions; however, monophasic variants can occur. A myofibroma shows an arrangement of interlacing fascicles of spindle-shaped cells resembling myofibroblasts, and vascular foci resembling hemangiopericytoma with polygonal cells. Spindled cells express vimentin and SMA and are usually negative for desmin3. In our patient, the preexisting patch was clinically suspected to be smooth muscle hamartoma; however, the pathologic results were not diagnostic. The patch included a small myofibroma in the dermal layer, which implied that multiple myofibromas would continue to develop under the patch. Kim et al.4 previously reported a case of multiple myofibromas with congenital smooth muscle hamartoma on the thigh of a woman, which had very similar clinical manifestation as our case. The pericytes in vascular foci are considered to be the origin of spindle-shaped neoplastic cells that show myofibroblastic differentiation. However, the pericytes can also differentiate into other mesenchymal cells; their differentiation into smooth muscle cells was demonstrated in ultrastructural studies of hemangiopericytomas5. Therefore, smooth muscle hamartoma might develop from multipotent pericytes that later create myofibromas. Although the patch was not diagnosed in our case, we suggest the possibility that the preexisting patch and the myofibromas might have originated from the same parental cells before differentiation. Further investigations may help find their possible relation.