Confinement Systems Research Articles

Bloch sphere representation for Rabi oscillation driven by Rashba field in the two-dimensional harmonic confinement system

Abstract We studied the dynamical properties of Rabi oscillations driven by an alternating Rashba field applied to a two-dimensional (2D) harmonic confinement system. We solve the time-dependent (TD) Schrödinger equation numerically and rewrite the resulting TD wavefunction onto the Bloch sphere (BS) using two BS parameters of the zenith (θB) and azimuthal (φB) angles, extracting the phase information φB as well as the mixing ratio θB between the two BS-pole states.

We employed a two-state rotating wave (TSRW) approach and studied the fundamental features of θB and φB over time. The TSRW approach reveals a triangular wave formation in θB. Moreover, at each apex of the triangular wave, the TD wavefunction passes through the BS pole, and the state is completely replaced by the opposite spin state. The TSRW approach also elucidates a linear change in φB. The slope of φB vs. time is equal to the difference between the dynamical terms, leading to a confinement potential in the harmonic system. The TSRW approach further demonstrates a jump in the phase difference by π when the wavefunction passes through the BS pole.

The alternating Rashba field causes multiple successive Rabi transitions in the 2D harmonic system. We then introduce the effective BS and transform these complicated transitions into an equivalent "single" Rabi one. Consequently, the effective BS parameters θB eff and φB eff exhibit mixing and phase difference between two spin states α and β, leading to a deep understanding of the TD features of multi-Rabi oscillations. Furthermore, the combination of the BS representation with the TSRW approach successfully reveals the dynamical properties of the Rabi oscillation, even beyond the TSRW approximation.

Effect of confinement system and recycled aggregates on axial compressive behaviors of CFST columns

The utilization of recycled aggregate concrete (RAC) has emerged as a pivotal technology for global environmental sustainability. Extending RAC’s application to Concrete-filled steel tube (CFST) columns offers an opportunity to strengthen RAC’s inherently weaker attributes. This research investigates the effects of recycled aggregates (RAs), basalt fiber (BF), and various confinement systems on the mechanical performance of CFSTs. A series of experiments were conducted on CFST columns under diverse confinement scenarios, incorporating varying proportions of basalt fiber and RAs. Additionally, numerical analysis was carried out to evaluate the influence of key design parameters on the load capacity of CFSTs, and theoretical discussion was conducted based on experimental results. The findings reveal that incorporating BF into concrete at an optimal dosage of 0.2 % significantly improves compressive, tensile, and flexural strengths across various RA replacement ratios, while the addition of BF results in minimal improvements in load capacity and fracture toughness for CFSTs. Replacing NAs with RAs generally reduces concrete strengths, with the severest reductions observed at higher RA replacement ratios. However, the degradation in the load capacity of CFSTs is less pronounced than the strength decrease observed in concrete. While a 40 % RA replacement in CFSTs has a minimal impact on the stress-strain curve, a 60 % RA replacement significantly alters the stress-strain relationship, leading to an average reduction of 26.3 % in fracture toughness and 13 % in load capacity. The confinement system plays a crucial role in the stress-strain relationship of CFSTs. Increasing the steel tube thickness from 2 mm to 4 mm substantially increases fracture toughness, and the introduction of GFRP wrapping further enhances both load capacity and ductility. The order of load capacity improvement based on confinement systems is as follows: combined confinement with a 4mm-thickness steel tube and GFRP wrapping, a 2mm-thickness steel tube with GFRP wrapping, a 4mm-thickness steel tube, and a 2mm-thickness steel tube. GFRP wrapping proves to be the most effective and economical method for enhancing load capacity compared to other strategies. It is suggested that the confinement stresses from the steel tube and GFRP reinforcement on the core concrete should be estimated independently, as combining them using a single confinement coefficient may not accurately reflect their individual contributions.

Compressive behavior of concrete jacketed in basalt TRM shell: Experiments and predictions

Numerous studies have investigated the behavior of textile reinforced mortar (TRM)-confined concrete, yielding various stress-strain models predominantly derived from fiber-reinforced polymer (FRP)-confined concrete. Yet, these models frequently overlook the intricate constitutive behavior of TRM materials and inadequately capture how TRM delivers its confinement effects. This often leads to inaccurate representation of the true characteristics of the confinement system, particularly the crucial role of mortar. This paper focuses on the impact of variations in textile layers and mortar matrix strength on the stress-strain behavior of basalt TRM (BTRM)-confined concrete, aiming to enhance our understanding of the confinement mechanism. Additionally, the study critically evaluates the key components of an existing analysis-oriented stress-strain model for FRP-confined concrete and introduces a refined version that more precisely depicts the behavior of confined concrete. This refined model integrates an identified confinement mechanism to provide accurate predictions of BTRM-confined concrete behavior. Our results reveal that low-grade mortar significantly decreases the actual confinement stiffness of BTRM jackets, inducing a steeper decline in the stress-strain curve, while high-strength mortar slightly diminishes the hoop rupture strain. To address the challenges of quantifying the complex confinement effect-compounded by the variable stress state and constitutive behavior of TRM-a novel coefficient, termed km, is introduced to gauge the influence of mortar strength on the confinement stiffness within the confining pressure equation. Predictive outcomes, including stress-strain and axial-to-lateral strain curves, show close alignment with experimental data, particularly in the slope at the plateau stage. This research significantly advances the quantitative understanding of TRM confinement effects and proposes the potential for designing more ductile structures using these materials, which could lead to enhanced resilience against seismic events and other structural challenges.

Floquet engineering of interparticle correlations in electron-hole few-body system for strong radial confinement

We investigate the effects of off-resonant THz-frequency laser light coupling to bound few-body electron-hole system, i.e. the exciton and negatively charged trion confined in quantum wire. To solve this problem, we first conduct a unitary Hennerberger-Kramers transformation of the Hamiltonian and diagonalize its perturbative approximation to obtain the exciton and trion Floquet states. Within this framework, the light-matter coupling renormalizes an attractiveehinteraction, leaving the repulsiveeeunchanged, thus modifying corresponding two-particle correlation energies. Generally, the correlation energy ofehwould exceed theeeone for a semiconductor material with strongly localized heavy holes. However, as the former is weakened by increasing laser intensity, this relation can be reversed. Consequently, the trion may dissociate unconventionally, the hole gradually decouples from still strongly interacting electrons, and adequate energy and optical spectra changes accompany this process. The energy levels of the exciton and trion Floquet states are raised, while their optical brightness smoothly decreases for stronger laser intensities. We also show this process can be further modified by breaking the mirror symmetry of wire with a static electric field, and then the occurrence of the avoided crossings between the lowest energy levels of the trion depends on the laser intensity. These anticrossings shall be observed experimentally, confirming thus the usefulness of Floquet engineering for fast manipulations of the few-particle states in electron-hole systems on a subpicosecond time scale.

Large rupture strain cotton ropes hybridized with affordable fiberglass chopped strand mat sheets for enhanced compressive behavior of reinforced concrete columns

The hybrid confinement system combines various fiber types within a single matrix, allowing for the adjustment of volumetric ratios to optimize confinement performance. Synthetic FRPs are more expensive and have a higher carbon footprint due to significant CO2 emissions during production. In response, this study presents an innovative hybrid confinement approach using two natural materials: cotton ropes and FSMS (CFS) to improve concrete strength and ductility. Specimens, standardized at 300 mm height and 150 mm diameter with longitudinal steel bars and stirrups, were divided into two groups based on CFS configurations. The stress-strain response of CFS-confined concrete displayed distinctive behavior: an initial parabolic phase leading to peak compressive stress (ultimate strength), followed by a linearly degrading phase. Across all subgroups, CFS confinement significantly enhanced ultimate strength and corresponding compressive strains, with Subgroup 2A achieving the highest improvements of 246 % in ultimate strength and 1477 % in strain. Moreover, the ductility gain was reported as high as 20 for CFS-confined concrete. A non-proportional enhancement in the compressive behavior was observed with the increase in confinement ratio. Predictive models were developed for the idealized two-branch response of CFS-confined concrete, encompassing expressions based on nonlinear regression for ultimate strength, corresponding strain, ultimate strain, and elastic modulus. Two existing models were modified to trach each branch of the response. Integrating these two adjusted models closely replicated the experimental compressive curves.

Hydromechanical Modulation of Enzymatic Kinetics Using Microfluidically Configurable Nanoconfinement Arrays.

Confinement of molecules occurs ubiquitously in nature and fundamentally affects their properties and reactions. Developing synthetic confinement systems capable of precise modulation of chemical reactions is critical to understanding the underlying mechanisms and to promoting numerous applications including biosensing. However, current nanoconfinement systems often require sophisticated fabrication and operation. Here we report a simplified nanoconfinement approach termed Configurable Hydromechanical Enzyme Modulation by Nanoconfinement Landscaping of Chemical Kinetics (CHEMNLOCK). This approach exploits a simple micropost device to generate an array of nanogaps with tunable geometries, enabling flexible spatial modulation of the kinetics of surface-bound enzymatic reactions and substantial enhancement of single-molecule reactions. We envision that the CHEMNLOCK concept could pave a new way for developing scalable and practical nanoconfinement systems with profound impacts on biosensing and clinical diagnostics.

A systematic review and meta-analysis of cow-level factors affecting milk urea nitrogen and urinary nitrogen output under pasture-based diets

With dairy cattle farming under pressure to lower its environmental footprint it is important to find effective on-farm proxies for evaluation and monitoring of management practices aimed at reducing the risk of nitrogen (N) losses and optimizing N use efficiency of dairy farm systems. Urinary N (UN) is regarded as the most potent source of N emissions. In contrast to confinement systems, there have been few studies from pasture-based systems associating on-farm animal and nutritional factors with UN output. Thus, the aims of this meta-analysis were to collate a database from pasture-based research to: (a) investigate the associations of management, dietary, and animal variables with MUN concentration, and daily UN output; (b) describe the MUN-UN association; and (c) assess whether animal, management, and dietary factors influence the relationship. We developed a data set consisting of 95 observations representing 919 lactating dairy cattle fed pasture-based diets, which was compiled from 32 unique research publications that reported both MUN and UN output. Multi-level, mixed meta-analysis regression techniques were used to analyze the data. Initially, all variables were assessed as the sole fixed effect in a 2-level random effects model, accounting for within publication heterogeneity. Meta-regression techniques were then used to assess the relationship of all variables with MUN and UN output, respectively, accounting for 3 sources of variability: the sampling error of the individual observation, within publication heterogeneity, and among publication heterogeneity. At the univariable level, despite more than 10 dietary, animal, or management variables being significantly associated with MUN, none explained a large amount of the MUN variation. The variables that explained the greatest amount of variation were dietary crude protein (CP) content and the nitrogen: metabolizable energy content ratio, which explained about 33% and 31% of the variation in MUN concentrations, respectively. Combining factors in multiple regressions improved the model fit, such that the variation within publications explained by dietary CP and N intake increased to 40.0% in the final multiple meta-regression model. For UN output, individual variables explained a greater proportion of variance reported among observations, compared with MUN, whereby diet CP content (pseudo R2 = 66.1%), N to metabolizable energy intake ratio (pseudo R2 = 64.0%), N intake (pseudo R2 = 58.3%), and MUN (pseudo R2 = 43.5%) explained the greatest amount of the total variation. Milk urea nitrogen, N intake and dry matter intake were associated with UN output in the final multiple meta-regression model. Substantial heterogeneity existed in both MUN and UN among publications, with among publication heterogeneity accounting for 73.4% of all the variation noted in MUN, and 88.6% of all the variation in UN output. As such, the meta-analyses could not predict MUN and UN to any great extent. It is recommended that a consistent approach to measuring and reporting MUN concentrations and UN output is carried out for all future research in pasture-based systems.

Development and Testing of a Helicon Plasma Thruster Based on a Magnetically Enhanced Inductively Coupled Plasma Reactor Operating in a Multi-Mode Regime

A disruptive Electric Propulsion system is proposed for next-generation Low-Earth-Orbit (LEO) small satellite constellations, utilizing an RF-powered Helicon Plasma Thruster (HPT). This system is built around a Magnetically Enhanced Inductively Coupled Plasma (MEICP) reactor, which enables acceleration of quasi-neutral plasma through a magnetic nozzle. The MEICP reactor features an innovative design with a multi-dipole magnetic confinement system, generated by neodymium iron boron (NdFeB) permanent magnets, combined with an azimuthally asymmetric half-wavelength right (HWRH) antenna and a variable-section ionization chamber. The plasma reactor is followed by a solenoid-free magnetic nozzle (MN), which facilitates the formation of an ambipolar potential drop, enabling the conversion of electron thermal energy into ion beam energy. This study explores the impact of an inhomogeneous magnetic field on the heating mechanism of the HPT and highlights its multi-mode operation within a pulsed power range of 200 to 500 W of RF. The discharge state, characterized by high-energy electron-excited ions and low-energy excited neutral particles in the plasma plume, was analyzed using optical emission spectroscopy (OES). The experimental testing campaign, conducted under pulsed power excitation, reveals that, as RF input power increases, the MEICP reactor transitions from inductive (H-mode) to wave coupling (W-mode) discharge modes. Spectrograms, electron temperature, and plasma density measurements were obtained for the Helicon Plasma Thruster within its operational envelope. Based on OES data, the ideal specific impulse was estimated to exceed 1000 s, highlighting the significant potential of this technology for future LEO/VLEO space missions.

Dynamic simulation of ITER cryo-distribution system using Aspen HYSYS

The ITER cryogenic system consists of the Liquid Helium (LHe) plant, the Cryo-Distribution (CD) system, and the cryo-lines. The Auxiliary Cold Boxes (ACBs) dedicated to cooling the superconducting (SC) magnet system and the Cryoplant Termination Cold Box (CTCB) of the ITER CD system are in the factory acceptance phase. The internal components of ACBs, e.g., cryogenic valves, a cold compressor (CCp), heat exchangers, and a cold circulator (CCr), have been sized and assembled, ensuring their functionality. The interdependency of the functional parameters of one component over the others needs to be assessed, as their integrated performance under the dynamic heat load deposition from the SC magnets may impact the overall operation of the ITER cryogenic system. The ACBs are equipped with two helium baths having ∼ 1200 kg of He inventory and situated inside the Tokamak building. These baths act as a thermal buffer for the LHe plant, situated in the cryoplant building, allowing it to operate at a quasi-steady state despite heat load variation from the applications. Such a large helium inventory can challenge the secondary confinement system of ITER due to helium ingress accidental events and thus needs to be optimized. The integrated system-level simulation is therefore necessary for the safe and reliable operation of the cryogenic system under such demanding requirements. The present study summarizes the results obtained for ACBs dedicated to the magnet system, including CTCB for the enhanced ITER operation modes, and confirms the integrated performance of the system. The results show that the LHe baths inside the ACBs can be used as a thermal buffer with the proposed limit of initial filling and by keeping a constant opening of the respective J-T valves upstream of the LHe baths. The study outcome and the proposed recommendations would be beneficial to mitigate the pulsed heat load to the LHe plant while minimizing the helium inventory.

An integral assessment of the impact of diet and manure management on whole-farm greenhouse gas and nitrogen emissions in dairy cattle production systems using process-based models

Feed management decisions are crucial in mitigating greenhouse gas (GHG) and nitrogen (N) emissions from ruminant farming systems. However, assessing the downstream impact of diet on emissions in dairy production systems is complex, due to the multifunctional relationships between a variety of distinct but interconnected sources such as animals, housing, manure storage, and soil. Therefore, there is a need for an integral assessment of the direct and indirect GHG and N emissions that considers the underlying processes of carbon (C), N and their drivers within the system. Here we show the relevance of using a cascade of process-based (PB) models, such as Dutch Tier 3 and (Manure)-DNDC (Denitrification-Decomposition) models, for capturing the downstream influence of diet on whole-farm emissions in two contrasting case study dairy farms: a confinement system in Germany and a pasture-based system in New Zealand. Considerable variation was found in emissions on a per hectare and per head basis, and across different farm components and categories of animals. Moreover, the confinement system had a farm C emission of 1.01 kg CO2-eq kg−1 fat and protein corrected milk (FPCM), and a farm N emission of 0.0300 kg N kg−1 FPCM. In contrast, the pasture-based system had a lower farm C and N emission averaging 0.82 kg CO2-eq kg−1 FPCM and 0.006 kg N kg−1 FPCM, respectively over the 4-year period. The results demonstrate how inputs and outputs could be made compatible and exchangeable across the PB models for quantifying dietary effects on whole-farm GHG and N emissions.

Strain-driven magnetic transition of intercalated pressure-stabilized cobalt and cobalt oxide nanoparticles in linked graphene oxide nanoscale reactors

The study of the evolution and metamorphosis of nanoparticles under high pressure and in nanoscale confinement is a rapidly developing field that promises a diverse range of fundamental research and application opportunities. Here, we demonstrate how a linked and strained graphene oxide (GO)-based confinement system, functioning as a nanoscale reactor at high pressures, allows the evolution of the magnetic properties of an in situ generated composite cobalt (Co) nanoparticle system and further enables the retention of such properties when the pressure of the system is returned to ambient. We posit that this phenomenon is due to an ‘induced pressure’ created by strain, on the flexible planes of the 2D GO system, created by the intercalated Co-based nanoparticles. For graphene/GO this strain is characterized by shifts in the Raman “G-band”. Specifically, the studied system comprises in situ generated Co-containing nanoparticles confined between linked GO layers upon pressurization between 0 and 25 GPa. After quenching to ambient pressure, each of these samples exhibited innate ferromagnetic behaviors, demonstrating that our confinement system can be used to ‘lock in’ phase changes created by the application of transient high pressure. Importantly, while the unpressurized sample exhibited antiferromagnetic Co3O4 nanoparticles of ∼4 nm size, the samples pressurized to 10 GPa and 25 GPa, presented ferromagnetic order on the shell of an antiferromagnetic core of Co3O4 and CoO.

Economic viability and production of cattle in confinement under high-grain and conventional diets

Brazilian beef cattle farming stands out for its large-scale production, playing a vital role in national and international trade. Despite this, there is a need for improvement in productivity and profitability. The extensive model, despite territorial demand, exhibits low use of technologies and problematic management. Intensive livestock farming minimizes these issues, offering greater production efficiency by reducing the age at which cattle are finished and optimizing the use of space on the property. The choice of diet in confinement systems aims to enhance the cost/benefit ratio. This research aims to compare the performance of Nelore cattle subjected to different diets during the finishing phase in confinement, considering intake, productivity, carcass characteristics, and economic viability. For the experiment, 20 Nellore cattle were used, divided into two groups of 10 animals, where one received the treatment of feed + forage, and the other a high-grain diet. For the variables of average daily gain (ADG), total weight gain (TWG), and feed-lot time, there was no effect (P < 0.05) from the treatments. However, an effect (P < 0.05) on carcass yield between diets was observed, directly impacting the economic viability of beef cattle production, as the abattoir pays per kilogram (cwt) of carcass.

A comprehensive survey on the present scenario and future production potentials of small-scale turkey farming in Bangladesh

Turkey (Meleagris gallopavo) is one of the potential species of specialized fowls, quite popular in western countries, has recently been introduced in Bangladesh, and gained considerable attention from small-scale poultry farmers. The purpose of this study was to assess the current scenario, production systems and potentialities of turkey farming in Bangladesh. Data were collected using a pre-tested questionnaire from 100 turkey farmers residing in rural areas in different districts of Bangladesh. The problems and prospects of turkey rearing in the selected areas were quantified and assessed. No illiterate farmers were involved in turkey farming and 97% of the farmers have small household with 3.67 members per family. Most of the farmers (60%) were medium income size with income range BDT 250001 to 400000 year. Most of the farmers (57%) reared turkey for meat purpose whereas the average turkey population per household was 43.20 birds. About 24% of farmers reared turkey in confinement system, and 76% of farmers reared in semi-intensive management system and 68% of farmers had no related training on turkey farming. All farmers use ready broiler/layer feed due to the unavailability of turkey feed that was bought from local market. Grazing was practiced to supply vegetative plants as diet for turkeys. Most of the farmers (86%) vaccinate turkey regularly, and among them 96% complained about vaccine unavailability. Average mortality was recorded at around 6.2%. All the farmers follow a natural breeding system for reproduction. The farmers mentioned that turkey farming is decreasing day by day due to unskilled farmers, lack of turkey ready feed, unavailability of vaccines and lack of marketing facilities. Collectively, it can be inferred that the introduction of ready-made turkey feed, ensuring vaccination, providing financial and technical assistance and offering training to small-scale turkey farmers are the pivotal factors in boosting small-scale turkey farming in Bangladesh. This, in turn, may have the potential to increase household income and generate employment opportunities for youth, rural women, and small-scale marginal farmers. Bangladesh Journal of Animal Science 53 (2): 40-54, 2024

Preservation of Christian dignity and identity in the oppressive context of the communist confinement regime. Young Nicolae Rădulescu’s carceral periplus

The present paper examines the modifications that occur to human beings amidst the deplorable conditions of Romania’s communist confinement system, using Nicolae Rădulescu’s story as a case study. After being imprisoned, the individual endured a horrifying system that elevated horror and treason to new heights. His stigma as a political and counter-revolutionary prisoner naturally drew dramatic consequences, both inside and outside of prison. From the Security people’s point of view, he was a pariah, a peripsema mundi who only needed to be forced in order to satisfy the demands of the new Soviet man. The uniqueness and, respectively, the originality of our research approach are supported by the consultation of primary resources, the main source of information being the Archive document, the tabs in the file from the Informative Fund drawn up in the name of our subject, ensuring the originality of this approach. At the same time, in order to eliminate the danger of slipping into the logic of the former Security, we used the data obtained from the memorial literature and specialized works that dealt with the issue of the concentration space under communist totalitarianism, in general, and of our subject, in particular. Simultaneously, we employed the information gleaned from the memorial literature and specialised works that addressed the problem of the concentration space under communist totalitarianism, in general, and of our subject, in particular, in order to eliminate the risk of falling back on the logic of the previous State Security. Furthermore, of the 16 individuals that the Security’s goals and mindset brought together in the famous Burning Altar group in 1958, Nicolae Rădulescu is the only one who remains alive today to respond to inquiries concerning the oppression of the communist concentration system against them. The main argument of the paper is that we need to examine the structural mechanisms that shaped the Romanian Gulag in accordance with the demands of the political police’s ideology in order to comprehend the scope of the struggle waged by those who fought to preserve their religious identity and dignity in the communist prisons.

A mixture of free and microencapsulated essential oils combined with turmeric and tannin in the diet of cattle in the growing and finishing phase: A new tool to enhance productivity

The study was conducted to evaluate whether adding a blend containing free and microencapsulated essential oils, combined with turmeric and tannin, can replace monensin as a performance improver, positively influencing animal health and meat quality. Fourteen male cattle with an average initial body weight of 253 kg and ten females with an average initial body weight of 239 kg were included in the experiment in a confinement system. The animals were divided into four independent groups: Males (M-PHYTO, inclusion of the phytogenic mixture; M-MONEN, inclusion of monensin); Females (F-PHYTO, inclusion of phytogenic; F-MONEN, inclusion of monensin). The diets were formulated for an average daily gain of 1.5 kg, with food provided twice daily. Data and biological samples were collected on days 33, 100, and 153. M-PHYTO and F-PHYTO showed greater average daily gain and body weight, with a tendency to consume more dry matter and feed efficiency. However, the apparent digestibility of nutrients was higher in animals in the MONEN group than those in the PHYTO group, regardless of sex. The total number of leukocytes in cattle in the M-PHYTO and F-PHYTO groups was higher due to the higher lymphocyte count in the blood of these animals. The activity of gamma-glutamyltransferase and aspartate aminotransferase in animals that consumed the phytogenic mixture was lower compared to animals that consumed monensin. TBARS levels were lower in the serum and meat of cattle in the M-PHYTO and F-PHYTO groups, as were the total thiol concentration and glutathione S-transferase activity in the blood and meat of these animals. Bacterial activity was greater in the rumen fluid of cattle that consumed the phytogenic, as demonstrated by the methylene blue reduction test. The total production of short-chain fatty acids and acetic acid showed an interaction between treatment and days for both sex classes and an effect of treatment for females, with a higher concentration in the rumen in the M-PHYTO and F-PHYTO groups. Propionic acid affected treatment and the treatment x day interaction for males and females, with the M-PHYTO and F-PHYTO groups showing higher concentrations. There was an interaction between treatment and day in the acetate/propionate ratio, being lower in M-PHYTO and F-PHYTO cattle. Treatment between ruminal microbiota groups had no effect. The rib eye area had more significant gains when consumed phytogenic by males and females. The subcutaneous and sirloin fat thickness was greater in F-PHYTO animals than in the control group; however, in males, the result was the opposite. The sum of polyunsaturated fatty acids in meat was higher in M-PHYTO compared to M-MONEN and lower in F-PHYTO meat compared to F-MONEN. These results indicate that the phytogenic mixture is a potential performance improver in the diet of growing and finishing cattle, regardless of sex, but meat characteristics differ between males and females.

Microbial β-Glucuronidase Hydrogel Beads Activate Chemotherapeutic Prodrug.

Bacteria-assisted chemotherapeutics have been highlighted as an alternative or supplementary approach to treating cancer. However, dynamic cancer-microbe studies at the in vitro level have remained a challenge to show the impact and effectiveness of microbial therapeutics due to the lack of relevant coculture models. Here, we demonstrate a hydrogel-based compartmentalized system for prodrug activation of a natural ingredient of licorice root, glycyrrhizin, by microbial β-glucuronidase (GUS). Hydrogel containment with Lactococcus lactis provides a favorable niche to encode GUS enzymes with excellent permeability and can serve as an independent ecosystem in the transformation of pro-apoptotic materials. Based on the confinement system of GUS expressing microbes, we quantitatively evaluated chemotherapeutic effects enhanced by microbial GUS enzyme in two dynamic coculture models in vitro (i.e., 2D monolayered cancer cells and 3D tumor spheroids). Our findings support the processes of prodrug conversion mediated by bacterial GUS enzyme which can enhance the therapeutic efficacy of a chemotherapy drug under dynamic coculture conditions. We expect our in vitro coculture platforms can be used for the evaluation of pharmacological properties and biological activity of xenobiotics as well as the potential impact of microbes on cancer therapeutics.

Cross-sectional shape effect of stay-in-place formwork column on axial compressive behaviour

Experimental and numerical studies on the behavior of composite columns with prefabricated self-compacting mortar (SCM) stay-in-place (SIP) formwork and post-cast normal-strength core concrete were presented.The axial compression of twenty-eight reinforcement concrete (RC) composite columns having square or circular cross-section shapes, with formwork thicknesses of 10 mm or 15 mm, and confined with one or two layers of Carbon Fibre Reinforced Polymer (CFRP (, were tested. A finite element (FE) model was generated to simulate the stress–strain relationship, and failure mode of the column using ABAQUS software. The results show that square cross-section-shaped columns exhibited lower axial load and displacement capacities than their counterparts of equivalent circular cross-section-shaped columns. This behavior maintained consistent regardless of the use of the SCM-SIP formworks or the wrapping with CFRP fabrics. Among the various confinement systems compared in this study, the efficiency of the CFRP was the greatest. Good bonding with no peeling failure was observed between SCM-SIP formwork and core concrete, indicating the good integrity of the composite columns. Consistency between the FE model and experimental results was observed for both cross-section shapes, indicating the precise and plausible characteristics of the model to sensibly estimate the stress-strain behaviors.

'The god of criminals is their belly': diet, prisoner health, and prison medical officers in mid-nineteenth-century English and Irish prisons.

Existing scholarship on prison diets has emphasised the role of food and its restriction as a key aspect of the deterrent system of prison discipline introduced in the 1860s. Here we suggest that a strong emphasis was placed on dietary regulation after the establishment of the reformist, but also 'testing', separate system of confinement in the mid-nineteenth century. While the impact of diet on the physical health of prisoners was a major concern, we argue that the psychological impact of food was also stressed, and some prison administrators and doctors argued that diet had an important protective function in preserving inmates' mental wellbeing. Drawing on a wide range of prison archives and official reports, this article explores the crucial role of prison medical officers in England and Ireland in implementing prison dietaries. It highlights the importance and high level of individual adaptations to dietary scales laid down centrally, as a means of utilising diet as a tool of discipline or as an intervention to improve prisoners' health. It examines the forays of some prison doctors into dietary experiments, as they investigated the impact of different dietaries or made more quotidian adjustments to food intake, based on local conditions and food supplies. The article concludes that, despite central policies geared to establishing uniformity and interest in new scientific discourses on nutrition, a wide range of practices were pursued in individual prisons, mostly shaped by practical rather than scientific factors, with many prison medical officers asserting their autonomy in making dietary adjustments.

Critical Assessment of Novel Developments in HPGR Technology Using DEM.

Advances in high-pressure grinding roll (HGPR) technology since its first commercial application in the cement industry include new roll wear protection techniques and new confinement systems. The latter contribute to reductions in the edge effects in an attempt to reach a more homogenous product size along the rolls. Additional advances in this technology have been made in recent years, while modeling and simulation tools are also reaching maturity and can now be used to subject such novel developments to detailed scrutiny. This work applies a hybrid approach combining advanced simulations using the discrete element method, the particle replacement model and multibody dynamics to a phenomenological population balance model to critically assess two recent advances in HPGR technology: spring-loaded cheek plates and the offset roller press. Force and torque controllers, included in the EDEM 2022.1 software, were used to describe the responses of the geometries in contact with the granular material processed. Simulations showed that while the former successfully reduced the lateral bypass of the material by as much as 65% when cheek plates became severely worn, the latter demonstrated lower throughput and higher potential wear but an ability to generate a finer product than the traditional design.

Surface Heating Calculation of Composite Material Under the Influence of an Electron Beam on the Surface

Introduction. Modern plasma magnetic confinement systems use tungsten as a material in contact with plasma. Under the influence of high-density plasma irradiation, tungsten undergoes cracking, intense erosion, and macro-particle emission. High-temperature ceramics are considered a promising material for protective coating of plasma components, as they are resistant to thermal loads. One possible solution could be a boron carbide coating, which has a high melting temperature.Materials and Methods. The impact of an electron beam on samples of rolled tungsten and boron carbide and tungsten composite was studied in experiments on the BETA setup. The heat from the beam propagates into the samples, with the maximum temperature reached at the center and decreasing towards the edges. The modeling area represents a cross-section of the samples, optimal for a task with a cylindrical coordinate system. The numerical implementation is based on the correction scheme and the marching method.Results. A new model of heating the boron carbide and tungsten composite sample under the influence of surface heating by an electron beam is presented. The model is based on solving the heat conduction equation in an axially symmetric setup with constant values of specific heat capacity, density, and thermal conductivity of metals.Discussion and Conclusions. An analysis of the model of heating the composite material under the influence of surface heating by an electron beam at constant values of density, thermal conductivity, and specific heat capacity has been conducted. The modeling results are in demand for analyzing experimental results and planning experiments at the Beam of Electrons for Materials Test Applications (BETA) facility, created at the Budker Institute of Nuclear Physics SB RAS.