In our previous study, Molecular Dynamics (MD) simulated water flow with no dissolved gas in nanometer slit pores of the hydrophobic talc surfaces revealed a slip length of about 0.5 nm, which is close to the size of “water exclusion zone” but much less than experimental slip length. Atomic Force Microscopy (AFM) imaging confirmed the presence of pancake shape nanobubbles at the hydrophobic talc (001) surface (size from tens to hundreds of nanometers). The effect of CO2 on water slip flow in talc nanopores is reported to reveal the importance of dissolved gas for confined fluid flow. MD simulated 7 nm CO2 nanobubbles were found to attach and spread at the talc (001) surface, consistent with the AFM observation. Simulated CO2 saturated water flow in the slit pores of talc (001) surfaces predicted the generation of CO2 nanobubbles at the end of the slit pore, due to the stabilization of a CO2 film at the talc (001) surfaces and a water barrier at the edge surfaces of talc. A “critical thickness” of about 1.5 nm was found for CO2 nanobubbles to be stabilized at the end of the talc (001) surface. With 1.5 nm CO2 nanobubbles at the talc (001) surface of a 6 nm slit pore, a water slip length of 1.8 nm was determined. The nanometer slit pore simulations with dissolved CO2 in water revealed an increased slip length. It is expected that an increased slip length value would be found with an increased CO2 film thickness.