The empirical interpretation of cone penetration test (CPT) cone factors ( N k ) can be subject to considerable variability for clays derived from weathered mudstones, leading to significant deviations in the estimation of undrained shear strength ( S u ). This paper presents a comparison of triaxial and CPT data from a site investigation in clays derived from weathered mudstones in central England. Corrected cone factors ( N kt,UU ) were derived from a one-to-one comparison of 94 pairs of unconsolidated, undrained triaxial and CPT data from equivalent depths. The performance of the cone factors was evaluated using a training set (75 pairs) and a test set (19 pairs). A parametric study was used to explore the variability of N kt,UU , quantified using the coefficient of variation (COV Nkt,UU ), for varied separation distance thresholds ( D s ) between individual triaxial and CPT data. The absolute deviation between the laboratory shear strength ( S u(Lab) ) and that predicted from CPT profiles (S u(CPT) ) was not sensitive to N kt,UU values in the range 25 < N kt,UU < 31. The parametric study showed that D s could be increased from 50 to 250 m, to include more data pairs for estimates of N kt,UU , without substantially increasing COV Nkt,UU .