The aim of this prospective longitudinal study of 62 consecutively treated Class II malocclusions was to determine whether bite-jumping causes temporomandibular disorders (TMD). The function of the temporomandibular joint (TMJ) was assessed anamnestically, clinically, and by means of magnetic resonance images (MRIs) taken before (T1), after (T2), and 1 year after (T3) Herbst treatment. Average treatment time with the Herbst appliance was 7.2 months. In all subjects, Herbst treatment resulted in a Class I or overcorrected Class I dental arch relationship. Thereafter, treatment was continued with a multibracket appliance. The condyle was positioned significantly forward during treatment but returned to its original position after removal of the Herbst appliance. A temporary capsulitis of the inferior stratum of the posterior attachment was induced during treatment. Over the entire observation period from before treatment to 1 year after treatment, bite-jumping with the Herbst appliance: (1) did not result in any muscular TMD; (2) reduced the prevalence of capsulitis and structural condylar bony changes; (3) did not induce disc displacement in subjects with a physiologic pretreatment disc position; (4) resulted in a stable repositioning of the disc in subjects with a pretreatment partial disc displacement with reduction; and (5) could not recapture the disc in subjects with a pretreatment total disc displacement with or without reduction. A pretreatment total disc displacement with or without reduction did not, however, seem to be a contraindication for Herbst treatment. In conclusion, bite-jumping using the Herbst appliance does not have a deleterious effect on TMJ function and does not induce TMD on a short-term basis.