The substantial thermal energy of two-phase NaCl-H2O hydrothermal fluids makes them a significant target for utilizing deep-sea energy. A fundamental understanding of the thermal performance of two-phase NaCl-H2O hydrothermal fluids during condensation is crucial for heat energy harnessing. It aims to obtain the flow and condensation heat transfer characteristics of two-phase NaCl-H2O fluids during the heat transfer process outside a spiral coil structure in this paper. The properties of the NaCl-H2O binary systems were adopted instead of pure water, and the salt transport equation was considered to reflect the impact of salinity change on heat transfer, making the simulation more representative of natural venting fluids. The results indicated a significant tangential velocity when the fluids externally swept the spiral coil. Secondly, the heat transfer area can be divided into the “normal region” and the “island region,” of which convection and condensation contribute to the heat transfer mechanisms. The “island region” formation was attributed to both vapor condensation and the spoiler effect caused by the spiral structure. Moreover, the heat flux increased with decreasing salinity in the “island region,” and a weak interaction was observed between heat flux and salinity in the “normal region.” Finally, the spiral structure's heat transfer performance was superior to the straight structure's. This investigation may provide a basis for designing and optimizing the heat transfer equipment for deep-sea hydrothermal extraction.