Smart home is a building, network, communication, automation, set management, and service, as one of the efficient, comfortable, safe, and environmental protection of the living environment, and can provide personalized living space according to the needs of different users. Due to the advantages of wireless sensor network (WSN), such as strong expansion ability, strong communication ability, and strong self-organization ability, the smart home system based on WSN has become the main development direction in the field of smart home. This paper analyzes the different functions and features of wireless sensor network routing protocol and use scope, aiming at the application layer, using the MQ queue enhance server concurrent processing capacity and system scalability and design based on application layer gateway and terminal node “data matching list,” which are introduced in the design of smart home system based on geographic information location energy-efficient routing protocols. The solution of routing void problem is improved by using information feedback mechanism and alternate nodes. Simulation results show that this method can improve the energy saving of energy-efficient routing protocol. Finally, the intelligent home system experiment platform was built to verify the overall function of the system, and the communication function of the WiFi network and ZigBee network was tested. Based on the analysis of the interference between ZigBee and WiFi network, frequency agility algorithm is used to solve the problem of the same frequency interference, so as to ensure the performance of the system to meet the needs of the smart home system.