To satisfy the design strength of manufactured sand concrete (MSC) in practical engineering applications, a plethora of geotechnical tests are frequently conducted. An effective approach is imperative to reduce the consumption of labor and resources during these tests. The objective of this paper is to introduce an interpretable machine learning (ML) method to evaluate the compressive strength (CS) of MSC. Firstly, a dataset was established by compiling experimental results from 208 literatures. 3382 data points were selected from the dataset for algorithm training. Recursive Feature Elimination with Cross-Validation (RFECV) was employed to select input parameters. Four algorithms with 12 selected input variables and 1 output variable were constructed to predict CS of MSC using Random Forest (RF), Gradient Boosting Decision Trees (GBDT), eXtreme Gradient Boosting algorithm (XGBoost), and Categorical Boosting (CatBoost). The results show that XGBoost has the highest accuracy and generalization ability (R2=0.934, MAE=3.44, RMSE=5.16, MAPE=0.07). To enhance model transparency, SHapley Additive exPlanations (SHAP) was adopted to explain the underlying predictive mechanisms of ML models. Analyses show that, 1) the cement content, curing time, and water content were the main feature parameters influencing the CS of MSC, 2) the cement content, curing time, and water content have a linear increase, logarithmic increase, and exponential decrease with the CS of MSC, respectively. Partial Dependence Plots (PDP) and Individual Conditional Expectation (ICE) plots were used to further analyze the impacts of these significant influencing factors on the CS of MSC. Additionally, the Local Interpretable Model-Agnostic Explanations (LIME) method was employed to investigate thresholds for various material dosages in MSC containing 5–10 % stone powder. Two typical scenarios were selected for analysis, yielding recommended dosage ranges for concrete of two distinct strengths. Finally, a graphical user interface (GUI) for the CS of MSC has been designed, which might be of great use to material engineers. This provides reference and guidance for concrete engineering practice.