ABSTRACT High-rise buildings have become a significant solution to address the challenges posed by the rapid growth of urban populations and space limitations in cities. Efficient planning and design of these buildings, aiming to achieve more productivity, can be realized through ensuring space efficiency. This research compares architectural and structural design criteria affecting space efficiency in high-rises based on their functions, aiming to assess the degree of correlation among these criteria, space efficiency, and their interrelations. Currently, no studies examine the differences or similarities in space efficiency of high-rise buildings based on their functions. Additionally, selecting buildings from the same region as samples is a unique aspect of this study. Employing a case study method, the analysis encompasses 42 high-rises in Türkiye, ranging from 100 m to 300 m, and utilizes correlation analysis methods to examine the data. The comprehensive review of space efficiency in high-rises, based on their functions, yielded the following results: (i) Space efficiency ranged from 82.7% to 65.2% in high-rise case studies with different functions, with an average of 73.2%. (ii) A significant majority (83%) of the buildings followed orthogonal designs. (iii) Central core floor planning emerged as the preferred approach. (iv) Increasing elevator density reduced space efficiency. (v) Office buildings favored reinforced concrete frame systems, while residential buildings commonly used reinforced concrete shear wall systems. (vi) As building height increased, elevator and core areas expanded. These findings provide guidance for future high-rise building design and planning.