Stress concentration factors (SCFs) for welded tubular joints can be decreased by filling the chord with concrete leading to a longer fatigue life. However, there are currently no design formula available in guidelines to predict the SCF of concrete-filled circular hollow section (CFCHS) K-joints, thus limiting their applicability in bridge design. To address this gap, finite element models for CFCHS K-joints were developed and compared against test results to ensure their accuracy. Then, a comprehensive parametric study was conducted to establish relationships between maximum SCFs and four variables: brace-to-chord diameter ratio (β), chord diameter-to-thickness ratio (2γ), brace-to-chord thickness ratio (τ), and the angle between braces and chord (θ). A total of 480 FE models were examined under three loading conditions including brace and chord loading: balanced axial force, chord axial force, and chord bending. Design equations to predict the maximum SCF for CFCHS K-joints were established by multiple regression analyses of the numerical results. A comparison of maximum SCFs between circular hollow section (CHS) and CFCHS K-joints was made, and it was concluded that average reductions of 42% and 33% in maximum SCFs in CFCHS K-joints at the locations of the chord and brace were found compared to CHS joints for balanced axial force, respectively. Finally, a case study illustrating how to use the proposed equations for fatigue safety verification was presented.