Concomitant Effects Research Articles

COMPARATIVE EVALUATION OF PROTEIN AND NON-PROTEIN NITROGEN ON THE PERFORMANCE AND CARCASS CHARACTERISTICS OF RED SOKOTO BUCKS IN MUBI ADAMAWA STATE, NIGERIA

An experiment was conducted to evaluate the utilization of protein and non-protein nitrogen on the performance and carcass characteristics of Red Sokoto bucks (RSB) in Northern Nigeria. Twenty four (24) RSB approximately 5-6 months were used in a completely randomized design of four treatments replicated six times. Four different diets were formulated using two protein nitrogen (Cotton seed cake – CSC and ground nuts cake - GNC) and two non-protein nitrogen (Urea and Poultry litter - PL), mixed each with wheat offal (WO). The diets were designated as I (Urea/WO), II (PL/WO), III (CSC/WO) and IV (GNC/WO). Data were taken on growth performance and carcass characteristics. Data obtained were subjected to analysis of variance using SPSS 23.0 (2017) for windows. The results of growth performance showed that, daily supplement intake and total supplement intake were highly significantly (P<0.001), final live weight and total weight gain were significant (P<0.05) and daily weight gain was significantly (P<0.01) different among the treatments. However initial weight gains of the bucks and feed conversion ratio were not different among the dietary treatments. Result of carcass characteristics showed that, all the parameters measured were significantly (P<0.01 or P<0.001), except spleen which was not affected by the dietary treatments. It could be concluded that diet IV (CSC/WO) being the best diet in improving the growth of the bucks and with no concomitant effects on the carcass characteristics of the bucks be recommended for feeding goats at 189.61 g/day.

3D MR elastography at 0.55 T: Concomitant field effects and feasibility.

To demonstrate the feasibility of hepatic 3D MR elastography (MRE) at 0.55 T in healthy volunteers using Hadamard encoding and to study the effects of concomitant fields in the domain of MRE in general. Concomitant field effects in MRE are assessed using a Taylor series expansion and an encoding scheme is proposed to study the corresponding effects on 3D MRE at 0.55 T in numerical simulations and in phantom experiments. In addition, five healthy volunteers were enrolled and scanned at 60 Hz mechanical excitation with a Hadamard-encoded 3D MRE sequence at 0.55 T and were also scanned with a reference 3D MRE sequence at 3 T for comparison. The retrieved biomechanical parameters were the magnitude of the complex shear modulus (|G*|), the shear wave speed (Cs), and the loss modulus (G″). Comparison of apparent SNR between 3 T and 0.55 T was performed. Theoretical analysis, numerical simulations and phantom experiments demonstrated that the effects of concomitant fields in 3D MRE at 0.55 T are negligible. In the healthy volunteer experiments, the mean values of |G*|, Cs, and G″ in the liver were 2.1 ± 0.3 kPa, 1.5 ± 0.1 m/s, and 0.8 ± 0.1 kPa at 0.55 T, respectively, and 2.0 ± 0.2 kPa, 1.5 ± 0.1 m/s, and 0.9 ± 0.1 kPa at 3 T, respectively. Bland-Altman analysis demonstrated good agreement between the biomechanical parameters retrieved at 0.55 T and 3 T. A 2.1-fold relative apparent SNR decrease was observed in 3D MRE at 0.55 T in comparison with 3 T. Hepatic 3D MRE is feasible at 0.55 T, showing promising initial results in healthy volunteers.

Efficacy of acupuncture treatment for diarrhea-predominant irritable bowel syndrome with comorbid anxiety and depression: A meta-analysis and systematic review.

Presently, a diverse range of Western medical interventions are accessible for the management of irritable bowel syndrome with diarrhea (IBS-D) concomitant with comorbid anxiety and depression. However, the concomitant adverse effects have also surfaced, exerting strain on healthcare resources and the socio-economic structure. In recent times, the benefits of acupuncture in the management of IBS-D with coexisting anxiety and depression have become progressively evident. Nevertheless, a paucity of evidence-based medicine exists to substantiate the utilization of acupuncture for the treatment of IBS-D with anxiety and depression. The objective of this study is to examine the effectiveness of acupuncture as an intervention for IBS-D with comorbid anxiety and depression. We searched 7 databases, including the Chinese Journal Full-text Database, Wanfang Academic Journals Full-text Database, VIP Chinese Scientific Journals Full-text Database, China Biomedical Literature Database, PubMed, Embase, and Cochrane Library, for randomized controlled trials (RCTs) related to acupuncture treatment for IBS with anxiety and depression, published from database inception to August 1, 2023. RevMan 5.4 and Stata 17.0 software were used for meta-analysis of relevant outcome measures. This study included a total of 16 RCTs, involving 1305 IBS-D patients (691 in the experimental group and 614 in the control group). The meta-analysis results showed that compared to oral medication, acupuncture therapy improved HAMD scores (MD = 0.88, 95% CI = [0.68, 1.07], P < .00001), HAMA scores (MD = 2.32, 95% CI = [1.70, 2.93], P < .00001), self-rating anxiety scale scores (MD = 11.67, 95% CI = [10.85, 12.49], P < .00001), SDS scores (MD = 9.84, 95% CI = [8.52, 11.16], P < .00001), IBS-SSS scores (MD = 37.48, 95% CI = [12.17, 62.78], P = .004), overall response rate (MD = 1.27, 95% CI = [1.20, 1.35], P < .00001), and relapse rate (MD = 0.27, 95% CI = [0.16, 0.47], P < .00001) in patients with IBS-D comorbid with anxiety and depression. Acupuncture treatment has a definite and beneficial effect on IBS-D patients with comorbid anxiety and depression.

Knockdown Proteomics Reveals USP7 as a Regulator of Cell-Cell Adhesion in Colorectal Cancer via AJUBA

Ubiquitin-specific protease 7 (USP7) is implicated in many cancers including colorectal cancer in which it regulates cellular pathways such as Wnt signalling and the P53-MDM2 pathway. With the discovery of small-molecule inhibitors, USP7 has also become a promising target for cancer therapy, and therefore systematically identifying USP7 deubiquitinase interaction partners and substrates has become an important goal. In this study, we selected a colorectal cancer cell model that is highly dependent on USP7 and in which USP7 knockdown significantly inhibited colorectal cancer cell viability, colony formation, and cell-cell adhesion. We then used inducible knockdown of USP7 followed by LC-MS/MS to quantify USP7 dependent proteins. We identified the Ajuba LIM domain protein as an interacting partner of USP7 through co-IP, its substantially reduced protein levels in response to USP7 knockdown, and its sensitivity to the specific USP7 inhibitor FT671. The Ajuba protein has been shown to have oncogenic functions in colorectal and other tumours, including regulation of cell-cell adhesion. We show that both knockdown of USP7 or Ajuba results in a substantial reduction of cell-cell adhesion, with concomitant effects on other proteins associated with adherens junctions. Our findings underlie the role of USP7 in colorectal cancer through its protein interaction networks and show that the Ajuba protein is a component of USP7 protein networks present in colorectal cancer.

Green path development: The agency of the City of Vaasa in establishing the battery industry

AbstractEmpirical studies on agency in green path development (GPD) have underexplored non‐firm actors' roles. Through a semi‐structured interview, this article provides insight into how the City of Vaasa exercises agency toward developing the battery industry and the concomitant effects. The findings reveal that the City of Vaasa provides place‐based leadership, for example, through a local‐based initiative, that is, the GigaVaasa, as a platform to increase participation and coordinate the actions of public and private actors. As an institutional entrepreneur, they govern the issuance of operating licenses to optimize their economic interest; as innovative entrepreneur, they strategically plan and coordinate infrastructure development to increase the region's attractiveness to external investors and talents. The City of Vaasa agency increases the chances for the region to participate in the global battery market and stimulate the region's economic development. Nonetheless, environmental sustainability concerns remain a profound unintended effect. Conceptually, the article introduces the agency cyclicality and synchronization model to enhance the understanding of the interplay and effect of agency in an emerging green industry's development trajectory.

Oral pre-treatment with Citronellol ameliorates Methotrexate-induced nephrotoxicity in Wistar rats via targeting oxidative stress and inflammation

Background Methotrexate (MTX) is a classical folic acid antagonist widely used in the treatment of malignant and non-malignant disorders. However, its clinical application is often restricted by concomitant adverse effects, including renal damage. Numerous studies have highlighted the role of oxidative stress and inflammation in mediating MTX-related nephrotoxicity. Therefore, the current study aimed to explore the possible renoprotective action of Citronellol (CT), a natural compound with prominent antioxidant and anti-inflammatory activities, against nephrotoxicity induced by MTX. Methods To fulfill our objective, 24 adult male Wistar rats were randomly allocated into four groups: control, MTX, 100 mg/kg CT plus MTX and 200 mg/kg CT plus MTX. At the end of the study, the experimental rats were anesthetized, blood samples were collected for biochemical assays, and the kidneys were surgically removed for biochemical and gene expression analyses, after which all rats were sacrificed by exsanguination. Results Compared to the MTX-treated group, our results revealed that pre-supplementation with 100 or 200 mg/kg CT remarkably ameliorated renal damage biomarkers, including serum urea, serum creatinine, and kidney injury molecule-1 (KIM-1). In addition, pre-treatment with 100 or 200 mg/kg CT enhanced the activity of the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx), diminished renal malondialdehyde (MDA) contents, and attenuated inflammation by suppressing renal nuclear factor kappa B (NF-κB) signaling and diminishing tumor necrosis factor-alpha (TNF-α) gene expression. Moreover, pre-treatment with 200 mg/kg CT markedly reduced interleukin-1 beta (IL-1β) gene expression. Conclusion Our findings demonstrate, for the first time, that CT can serve as a new promising agent for mitigating nephrotoxicity induced by MTX through its antioxidant and anti-inflammatory properties.

Multidimensional RF pulse design with consideration of concomitant field effects.

To develop a small-tip multidimensional RF pulse design procedure that incorporates linear time-invariant gradient imperfections and concomitant field effects. This could be particularly important for contemporary low-field MRI systems with high-performance gradients. We developed an extension of the small-tip excitation k-space formalism, where concomitant fields were approximated as a Bloch-Siegert shift in the rotating frame. This was evaluated using realistic simulations of 2D selective excitation at various field strengths (0.2T, 0.55T, 1.5T, 3T, and 7T) with single and parallel transmit. Simulated excitation profiles from the original and extended k-space formalisms were compared. Experimental validations were performed at 0.55T with a single-channel transmit. The extended formalism provides improved 2D excitation profiles in all scenarios simulated, compared against the original formalism. The proposed method corrects the concomitant field effects on 2D selective excitations for B0 > 0.2T when the magnitude of the B0 is far larger than that of nonrotating concomitant fields. Simulation and phantom experiments at 0.55T match well for both original and proposed methods, with the proposed method providing sharper and more accurate excitation profiles at off-isocenter distances up to 15 cm. The impact of the proposed method is greatest in scenarios where concomitant fields are substantial, such as low field strengths and off-isocenter. Concomitant fields can be modeled as a Bloch-Siegert shift in the rotating frame during multidimensional RF pulse design, resulting in improved excitation profiles with sharp edges. This is important to consider for off-isocenter excitations and imaging at low field strengths with strong gradients.

IMPACT OF HUMAN-RELEVANT DOSES OF ENDOCRINE DISRUPTING CHEMICAL AND DRUG MIXTURES ON TESTIS DEVELOPMENT AND FUNCTION.

Exposure to endocrine-disrupting chemicals (EDCs) and pharmaceuticals during development has been linked to reproductive dysfunction, reduced semen quality, and infertility. Research indicates that EDC mixtures, which are common in the modern environment, can pose significant risks that may not be fully assessed by studying individual compound toxicity, especially at environmentally relevant doses or concentrations. Understanding the contribution of chemical mixtures to male reproductive toxicity is crucial, given the increasing reliance on pharmaceuticals and pervasiveness of anthropogenic pollution. Recent studies on EDC effects have expanded to a more diverse range of microplastics, pesticides, antimicrobials, phytoestrogens, and pharmaceuticals such as analgesics, which can collectively impact testicular function and fertility. Adverse outcomes observed across studies include reproductive tract malformations, decreased sperm count and motility, lowered testosterone, delayed-onset puberty, and possible causal effects such as oxidative stress and altered gene expression. Still, limited data exists on combinations of environmental pollutants and pharmaceuticals with ED potential at human-relevant doses. This review of the recent literature aims to synthesize the toxicological impact of low dose chemical mixtures on male reproductive health. Overall, humans are exposed to EDCs and drugs through various ways, necessitating an understanding of their concomitant effects on male reproductive health.

Effect of α-tocopherol on the oil absorption of French fries based on physicochemical characteristics of frying oil and the morphology of French fries

With the development of oil processing technology, the retention rate of lipid concomitants in oil has increased. The effect of lipid concomitants on the physicochemical characteristics of oil has garnered significant interest; however, the effect of the lipid concomitant α-tocopherol on the physicochemical properties of rice bran oil (RBO) and the oil absorbency of French fries during frying is unclear. Thus, the influence of α-tocopherol on total polar compounds, diacylglycerols content, and viscosity of frying oil as well as oil content and distribution, moisture content, micromorphology, and quality of French fries is studied. The results revealed that RBO with 0%–0.1% α-tocopherol dose-dependently decreased the total polar compounds, diacylglycerols content, and the viscosity of RBO. This primarily affected the adsorption of surface and structural oils in the French fries. Additionally, RBO with 0%–0.1% α-tocopherol decreased the porous structure of the French fries. Compared with other α-tocopherol levels, RBO supplemented with 0.1% α-tocopherol demonstrated a better effect on reducing the oil absorption in French fries. Moreover, α-tocopherol had a minimal effect on French fry quality. Consequently, incorporating α-tocopherol (0.1%) into frying oil because of its inhibitory effect on the oil absorption of French fries is recommended.

Tensile and Elastocaloric Properties of Natural/Devulcanized Waste Rubber Blends.

The need for eco-friendly cooling materials and material recycling are two urgent challenges to address. In this paper, the role of the ground tyre rubber treatment (cryo-grinding and devulcanization) is investigated on the tensile and elastocaloric properties of Natural rubber (NR)/ ground tyre rubber (GTR). The GTR particles that are sieved (<63µm) and devulcanized by microwave irradiation (1 min at 800Watts) exhibit a low network chain density (0.53 × 10-4mol.cm-3) resulting from crosslinks breakage and rubber chains scission, as supported by FTIR showing a decrease of S─S, C─S, and C─C bonds. The NR/GTR blends show a high elastocaloric effect as compared to the pristine NR, which can be ascribed to the high content of carbon black in the GTR (52wt.%) and also the high level of devulcanization of the GTR. NR/GTR blends reach a heating of +8°C and a cooling of >-6°C, resulting in a material's coefficient of performance COPmat = 2.8-3 compared to 2.6 for the pristine NR. The concomitant effect of cryogrinding and microwave devulcanization is proposed as a way to improve the tensile and elastocaloric properties of natural rubber/waste rubber blends for their possible integration into elastocaloric devices for heating/cooling applications.

Dysphagia Prevalence in Brazil, UK, China, and Indonesia and Dysphagic Patient Preferences.

Dysphagia is common, but there is limited information about its prevalence and patient preferences regarding dosage forms (oral solids, liquids, topical, etc.) in Brazil, China, the United Kingdom (UK), and Indonesia. We conducted an online survey of 1000 adults from each country, without any required disease, to estimate the prevalence of dysphagia in these four nations and the dosage form preferences among UK patients. A total of 36.9%, 40.5%, 54.9%, and 64.5% from the UK, Indonesia, Brazil, and China, respectively, had an Eating Assessment Tool (EAT-10) score of ≥3 (indicative of dysphagia). Only 2% of UK respondents and 5% of Brazilian respondents reported a formal diagnosis of dysphagia. Indonesian (74%) and Chinese respondents (77%) were more likely than Brazilian (52%) and UK respondents (45%) to report that their swallowing problems affected their ability to adhere to medication instructions. Liquids were the oral medication formulation most preferred by those who reported difficulty swallowing. To conclude, substantial populations have difficulty swallowing, which can translate into an access issue for medical treatment. The availability of people's preferred dosage forms may help alleviate the adherence issues associated with difficulty swallowing and the concomitant effects on health outcomes.

The History and Current Status of Platelet-Rich Plasma Therapy in Dermatology.

Since the 1800s, platelet-rich plasma (PRP) has been used as a treatment for a wide range of medical conditions with a concomitant effect of tending to reduce the need for some invasive procedures. The aim of this narrative review was to concisely document the history and current usage of PRP specifically in the field of dermatology. Four databases (PubMed, Google Scholar, CINAHL, and Web of Science) were searched for primary articles written in English that evaluated human subjects and focused on PRP use in dermatology. Initial search terms included "platelet rich plasma,""alopecia,""androgenic alopecia,""dermatology,""PDGF,""aging,""skin rejuvenation,""diabetic ulcers,""venous leg ulcers," "acne,""acne scars,""scars,""hyperpigmentation,""melasma,""hypopigmentation,""vitiligo,"and "PRP."After review, articles were excluded if they were commentaries, editorials, animal studies, review articles, or were unrelated to dermatology. The bibliography of retrieved articles was also searched for relevant articles.The present review results describe the function of PRP from its first usage for thrombocytopenia to its usage for melasma. In this time frame, its use in dermatology has gone through many evolutions from using its healing factors for treating wounds to using it as the treatment for wrinkles, hair loss, scars, ulcers, and skin pigmentation disorders. Its anti-inflammatory and growth factors have been shown to initiate a healing cascade that promotes the growth and regeneration of tissues. It is hoped that this review will help educate patients and physicians about the efficacy of PRP therapy and thereby help avoid unnecessary invasive procedures for certain conditions.

Acute exposure to electronic cigarette components alters mRNA expression of pre-osteoblasts.

The use of traditional nicotine delivery products such as tobacco has long been linked to detrimental health effects. However, little work to date has focused on the emerging market of aerosolized nicotine delivery known as electronic nicotine delivery systems (ENDS) or electronic cigarettes, and their potential for new effects on human health. Challenges studying these devices include heterogeneity in the formulation of the common components of most available ENDS, including nicotine and a carrier (commonly composed of propylene glycol and vegetable glycerin, or PG/VG). In the present study, we report on experiments interrogating the effects of major identified components in e-cigarettes. Specifically, the potential concomitant effects of nicotine and common carrier ingredients in commercial "vape" products are explored invitro to inform the potential health effects on the craniofacial skeleton through novel vectors as compared to traditional tobacco products. MC3T3-E1 murine pre-osteoblast cells were cultured invitro with clinically relevant liquid concentrations of nicotine, propylene glycol (PG), vegetable glycerin (VG), Nicotine+PG/VG, and the vape liquid of a commercial product (Juul). Cells were treated acutely for 24 h and RNA-Seq was utilized to determine segregating alteration in mRNA signaling. Influential gene targets identified with sparse partial least squares discriminant analysis (sPLS-DA) implemented in mixOmics were assessed using the PANTHER Classification system for molecular functions, biological processes, cellular components, and pathways of effect. Additional endpoint functional analyses were used to confirm cell cycle changes. The initial excitatory concentration (EC50) studied defined a target concentration of carrier PG/VG liquid that altered the cell cycle of the calvarial cells. Initial sPLS-DA analysis demonstrated the segregation of nicotine and non-nicotine exposures utilized in our invitro modeling. Pathway analysis suggests a strong influence of nicotine exposures on cellular processes including metabolic processes and response to stimuli including autophagic flux. Further interrogation of the individual treatment conditions demonstrated segregation by treatment modality (Control, Nicotine, Carrier (PG+VG), Nicotine+PG/VG) along three dimensions best characterized by: latent variable 1 (PLSDA-1) showing strong segregation based on nicotine influence on cellular processes associated with cellular adhesion to collagen, osteoblast differentiation, and calcium binding and metabolism; latent variable 2 (PLSDA-2) showing strong segregation of influence based on PG+VG and Control influence on cell migration, survival, and cycle regulation; and latent variable 3 (PLSDA-3) showing strong segregation based on Nicotine and Control exposure influence on cell activity and growth and developmental processes. Further, gene co-expression network analysis implicates targets of the major pathway genes associated with bone growth and development, particularly craniofacial (FGF, Notch, TGFβ, WNT) and analysis of active subnetwork pathways found these additionally overrepresented in the Juul exposure relative to Nicotine+PG/VG. Finally, experimentation confirmed alterations in cell count, and increased evidence of cell stress (markers of autophagy), but no alteration in apoptosis. These data suggest concomitant treatment with Nicotine+PG/VG drives alterations in pre-osteoblast cell cycle signaling, specifically transcriptomic targets related to cell cycle and potentially cell stress. Although we suspected cell stress and well as cytotoxic effects of Nicotine+PG/VG, no great influence on apoptotic factors was observed. Further RNA-Seq analysis allowed for the direct interrogation of molecular targets of major pathways involved in bone and craniofacial development, each demonstrating segregation (altered signaling) due to e-cigarette-type exposure. These data have implications directed toward ENDS formulation as synergistic effects of Nicotine+PG/VG are evidenced here. Thus, future research will continue to interrogate how varied formulation of Nicotine+PG/VG affects overall cell functions in multiple vital systems.

Exploring the barriers to digital twin adoption in the Nigerian construction industry: a structural equation modelling approach

Purpose The adoption of emerging technologies is critical to enhance construction industry performance. Previous studies have shown that the Nigerian construction industry (NCI) is slow to adopt digital technologies and faces performance issues. As a result, this study aims to investigate and model the barriers to adopting digital twin (DT) technology in the NCI with the view to provide stakeholders with adequate information on the multifaceted nature of DT barriers and provide strategies to improve DT adoption. Design/methodology/approach The study adopts a qualitative and quantitative approach to achieve the overall aim of the study. The qualitative approach included a scoping review used to identify barriers to DT adoption from the literature. A five-point Likert scale questionnaire was administered to 246 construction professionals in the NCI. This was followed by critical analysis using mean ranking and standard deviation, Kruskal–Wallis, factor analysis and partial least squares structural equation modelling (PLS-SEM). Findings The exploratory factor analysis revealed four categories of barriers to DT adoption in the NCI: “technological and investment”, “data management and government”, “project and human resources” and “digital transformation”. The PLS-SEM results revealed the causal relationships of four barriers categories and their concomitant effects on DT adoption in the NCI. The top three barrier categories that require critical attention in order of significance are: technological and investment (ß = 0.655), data management and government (ß = 0.313) and project and human resources (ß = 0.194). Digital transformation (ß = −0.046) has the least significance. Overall, all the barriers’ categories were accepted at a significance level of p &lt; 0.05. Practical implications The practical implications include guiding policymakers and practitioners in making informed decisions to address the identified barriers to DT adoption in the NCI. The findings may also be applicable to other developing countries in Africa and beyond. By implementing effective policies and stakeholder guidelines, the NCI can advance technologically and enhance its competitiveness to execute advanced construction projects. Originality/value This research contributes to the construction industry by shedding light on the barriers to DT adoption and their intricate interconnections within the NCI context. It is also the first study in NCI context to present the level of DT awareness and explore the concomitant effects of the barriers.

Academic librarians’ Twitter practices and the production of knowledge infrastructures in higher education

This short paper describes the use of infrastructural theory to interrogate data gathered for an ongoing study on the Twitter practices of academic librarians at one research-intensive university in the United Kingdom. In tandem with wider changes in networked technologies and ways of producing scholarship, academic librarians’ roles have shifted increasingly to knowledge production, particularly in the area of research support. A related shift has been academic librarians’ adoption of social media, particularly Twitter, to disseminate information and encourage community and collaboration. The few existing studies of librarians’ Twitter practices, however, frame such activity as service promotion, overlooking the relationship between technology and professional practice entwined and concomitant social effects in the university. The theoretical framework devised for this study was woven from research in anthropology and Science and Technology Studies about the nature of infrastructure. Instead of viewing infrastructure as separate and monolithic substrates supporting the circulation of goods and information, such theory posits infrastructure as relational and contingent, constituted of political decisions and having broad and co[1]constitutive social effects on knowledge, subjectivities and agencies (Jensen &amp; Morita, 2017). The study’s theoretical framework particularly draws on the notion of knowledge infrastructures defined as “networks of people, artifacts, and institutions that generate, share, and maintain specific knowledge about the human and natural worlds” (Edwards, 2010). The framework therefore emphasises the invisible labour of infrastructure — often dubbed infrastructuring — and related socio-political practices of design and maintenance that embody promises for the future (Larkin, 2018). In this picture, infrastructure is fragile and contingent, shaped by its installed base, and remarkably complicated, unfixed and open to contestation. Based on preliminary findings, the study argues that academic librarians' Twitter practices constitute knowledge infrastructures in higher education. Using an infrastructural framework helped foreground the material conditions of librarians’ knowledge production in terms of entanglements of technology and professional values, shifts in professional subjectivities and performative effects within the university. A tentative implication for studies of technology and learning is that, by insisting that infrastructure and social activity are intertwined, learners and teachers are not framed in opposition to infrastructure and are thus better able to contest totalising narratives surrounding infrastructural learning technologies such as VLEs or MOOCs. In this picture, therefore, infrastructure is not simplistically background bulwark or sinister force. Appreciating the invisible labour involved in creating and sustaining infrastructure is therefore important for understanding contemporary learning contexts.

Intrinsic negative magnetoresistance from the chiral anomaly of multifold fermions

The chiral anomaly - a hallmark of chiral spin-1/2 Weyl fermions - is an imbalance between left- and right-moving particles that underpins phenomena such as particle decay and negative longitudinal magnetoresistance in Weyl semimetals. The discovery that chiral crystals can host higher-spin generalizations of Weyl quasiparticles without high-energy counterparts, known as multifold fermions, raises the fundamental question of whether the chiral anomaly is a more general phenomenon. Answering this question requires materials with chiral quasiparticles within a sizable energy window around the Fermi level that are unaffected by extrinsic effects such as current jetting. Here, we report the chiral anomaly of multifold fermions in CoSi, which features multifold bands within ~0.85 eV of the Fermi level. By excluding current jetting through the squeezing test, we measure an intrinsic, longitudinal negative magnetoresistance. We develop a semiclassical theory to show that the negative magnetoresistance originates in the chiral anomaly, despite a sizable and detrimental orbital magnetic moment contribution. A concomitant non-linear Hall effect supports the multifold-fermion origin of the magnetotransport. Our work confirms the chiral anomaly of higher-spin generalizations of Weyl fermions, currently inaccessible outside solid-state platforms.

Marine heatwaves in a shifting Southern Ocean induce dynamical changes in primary production

Marine heatwaves are discrete, albeit prolonged, episodes of extreme ocean temperatures that are significantly impacting marine ecosystems worldwide. However, there is limited research solely focusing on marine heatwaves and their concomitant effects on ecosystem dynamics in the Southern Ocean, known to play a major role in the Earth’s climate system. Here we use daily high-resolution satellite-derived and modelled data from 1982 to 2021 to characterise general spatiotemporal patterns of marine heatwaves in the Southern Ocean, assess their physical drivers and explore their interconnections with marine biogeochemistry. We find that increasing climate change-related marine heatwave activity, primarily explained by sea-air heat fluxes and vertical diffusion anomalies, enhances net primary production through stabilization of the water column. We empirically reveal causal nonlinear relationships between ocean extremes and primary productivity, especially in the southernmost subantarctic areas where the concurrent sea ice decrease also plays a key role. Furthermore, our study shows zonally asymmetric responses of primary producers to changing physical conditions north of the Antarctic polar front. These results provide key insights into the role of marine heatwaves promoting carbon assimilation (and uptake) in the Southern Ocean through the biological carbon pump, which is crucial for constraining the oceanic carbon cycle under climate change.

Enhanced growth of benthic microalgae by tablet from liquid dairy cattle manure-based anaerobic digestate

An effective strategy for utilizing anaerobic digestates is required to promote biomass power generation. We developed an anaerobic digestate tablet using liquid dairy cattle manure derived from a small mesophilic anaerobic digester installed on a dairy farm. Anaerobic digestate tablets are intended for use in the fertilization of oligotrophic coastal seas to promote primary production. The purpose of this study was to evaluate (1) the dissolution behavior of nutrients from anaerobic digestate tablets and (2) the effect of the application of anaerobic digestate tablets on the growth of benthic microalgae using a culture experiment. Batch experiments were conducted to investigate the dissolution behavior of the nutrients. Cumulative amounts of dissolved inorganic nitrogen and phosphate in the anaerobic digestate tablet ranged from 110 to 28.9 μg g−1 after 28 days. The dissolved inorganic nitrogen in the anaerobic digestate tablet was mainly ammonium nitrogen and accounted for 92.4–96.9%, which is advantageous for the growth of microalgae. The growth curve of the benthic microalga Nitzchia longissima was monitored using f/2 medium added to the anaerobic digestate tablet. The growth of Nitzchia longissima was two orders of magnitude greater than that of the positive control. The enhanced growth of Nitzchia longissima by the anaerobic digestate tablet was considered a concomitant effect of moderate dissolution of ammonium nitrogen and high affinity for benthic microalgae. In conclusion, the anaerobic digestate tablets prepared in this study have the advantage of supplying nitrogen to benthic microalgae. This study proposes a new method for utilizing anaerobic digestates.

The increasing water stress projected for China could shift the agriculture and manufacturing industry geographically

The sustainable development of China has been challenged by the misalignment of water demand and supply across regions under varying climate change scenarios. Here we develop a water stress prediction index using a fuzzy decision-making approach, which analyzes spatiotemporal variations of water stress and concomitant effects on the populace within China. Our results indicate that water stress will increase from 2020 to 2099 under both low and high emission scenarios, primarily due to decreased water supplies like surface runoff and snow water content. Seasonal analysis reveals that annual fluctuations in water stress are mainly driven by changes in spring and autumn. Water stress is projected to be considerably lower in southeastern provinces compared to northwestern ones, where, on average, over 20% of the Chinese population could be severely impacted. These changes in water stress could lead to the north-to-south migration of the agriculture sector, manufacturing sector, and human population.

Concomitant Effects of Metformin and Vitamin C on Indomethacin-Induced Gastric Ulcer in Rats: Biochemical and Histopathological Approach.

Gastric ulcer is one of the most common and serious conditions in the gastrointestinal tract. One of the main causes of gastric ulcers is using of non-steroidal anti-inflammatory drugs (NSAIDs) which have limited their use in clinical practice. Several studies have revealed that metformin and Vitamin C (Vit C) exhibit protective effects against gastric mucosal damage in different animal models. However, no studies indicate their combination's effect on gastric ulcer models. Therefore, this study aims to investigate the protective effects of metformin and Vit C combination on indomethacin-induced gastric ulcers. In total, thirty rats were divided into six groups, including the control group, rats received indomethacin (50 mg/kg, i.p.), rats received indomethacin and pretreated with ranitidine (100 mg/kg), metformin (100 mg/kg, i.p.), Vit C (100 mg/kg), or metformin combined with Vit C. Four hours after indomethacin administration, rats were euthanized, and gastric tissues were removed for macroscopic, histopathologic, and biochemical examinations. All therapeutics used in this study were found to alleviate gastric mucosal injury caused by indomethacin, as observed in histopathologic and macroscopic evaluations. Both Vit C and metformin were observed to significantly decrease lipid peroxidation and enhance the activity of anti-oxidative enzymes, SOD, GPx, and catalase. However, a more significant effectiveness was observed in catalase and GPx activities when Vit C was co-administered with metformin. In conclusion, the present study revealed that metformin and Vit C combination therapy could potentially treat gastric ulcers associated with indomethacin.