Innovative Concept Research Articles

Earthquake Prediction and Alert System Using IoT Infrastructure and Cloud-Based Environmental Data Analysis

Earthquakes are one of the most life-threatening natural phenomena, and their prediction is of constant concern among scientists. The study proposes that abrupt weather parameter value fluctuations may influence the occurrence of shallow seismic events by focusing on developing an innovative concept that combines historical meteorological and seismic data collection to predict potential earthquakes. A machine learning (ML) model utilizing the ML.NET framework was designed and implemented. An analysis was undertaken to identify which modeling approach, value prediction, or data classification performs better in forecasting seismic events. The model was trained on a dataset of 8766 records corresponding to the period from 1 January 2001 to 5 October 2024. The achieved accuracy of the model was 95.65% for earthquake prediction based on weather conditions in the Vrancea region, Romania. The authors proposed a unique alerting algorithm and conducted a case study that evaluates multiple predictive models, varying parameters, and methods to identify the most effective model for seismic event prediction in specific meteorological conditions. The findings demonstrate the potential of combining Internet of Things (IoT)-based environmental monitoring with AI to improve earthquake prediction accuracy and preparedness. An IoT-based application was developed using C# with ASP.NET framework to enhance earthquake prediction and public warning capabilities, leveraging Azure cloud infrastructure. The authors also created a hardware prototype for real-time earthquake alerting, integrating the M5Stack platform with ESP32 and MPU-6050 sensors for validation. The testing phase and results describe the proposed methodology and various scenarios.

Visualisation Design Ideation with AI: A New Framework, Vocabulary, and Tool

This paper introduces an innovative framework for visualisation design ideation, which includes a collection of terms for creative visualisation design, the five-step process, and an implementation called VisAlchemy. Throughout the visualisation ideation process, individuals engage in exploring various concepts, brainstorming, sketching ideas, prototyping, and experimenting with different methods to visually represent data or information. Sometimes, designers feel incapable of sketching, and the ideation process can be quite lengthy. In such cases, generative AI can provide assistance. However, even with AI, it can be difficult to know which vocabulary to use and how to strategically approach the design process. Our strategy prompts imaginative and structured narratives for generative AI use, facilitating the generation and refinement of visualisation design ideas. We aim to inspire fresh and innovative ideas, encouraging creativity and exploring unconventional concepts. VisAlchemy is a five-step framework: a methodical approach to defining, exploring, and refining prompts to enhance the generative AI process. The framework blends design elements and aesthetics with context and application. In addition, we present a vocabulary set of 300 words, underpinned from a corpus of visualisation design and art papers, along with a demonstration tool called VisAlchemy. The interactive interface of the VisAlchemy tool allows users to adhere to the framework and generate innovative visualisation design concepts. It is built using the SDXL Turbo language model. Finally, we demonstrate its use through case studies and examples and show the transformative power of the framework to create inspired and exciting design ideas through refinement, re-ordering, weighting of words and word rephrasing.

Construction and Empirical Research of an Evaluation System for High-Quality Development of Small Towns in Guangxi Under the New Development Concept

The high-quality development of small towns in Guangxi is crucial for regional economic balance and sustainable development. This research conducts an in-depth exploration and systematic construction and validation analysis of the high-quality development of small towns in Guangxi. Guided by the new development concepts of innovation, coordination, green, openness, and sharing, a comprehensive evaluation system is established to assess the development levels of 70 small towns from 2005 to 2022. The research findings are as follows: 1. The analysis revealed significant growth in these dimensions over the study period, highlighting the unique characteristics of different types of small towns. 2. It was observed that small towns in southeastern Guangxi generally demonstrated higher development levels, while those in the northwestern regions exhibited considerable disparities, indicating regional imbalances. 3. The overall gap in the high-quality development level of small towns is gradually narrowing, but the difference is still relatively significant. 4. The findings underscore the advantages of the evaluation system developed, which effectively captures the multidimensional nature of high-quality development and serves as a robust framework for future research.

A novel stability-indicating chromatographic quantification of the antiparkinsonian drug safinamide in its pharmaceutical formulation employing HPTLC densitometry and ion-pair HPLC–DAD

Parkinson's disease (PD) emerges as a notable health concern among the elderly population. Safinamide mesylate (SAF) is a novel and emerging add-on therapy in PD treatment. The stability of innovative drug formulations and the development of appropriate stability-indicating methods are of great importance to modern pharmaceutical analysis. The current work has established novel comprehensive stability-indicating chromatographic approaches, HPTLC coupled with densitometric quantification and HPLC–DAD, for the selective assay of SAF in pharmaceutical formulation along with its synthetic precursor impurity; 4-hydroxy benzaldehyde (4-HBD) in presence of its stress induced degradation products. The stability of SAF was investigated under different stress conditions. It was found that SAF is likely to undergo acid, base hydrolysis, and oxidative degradation. Using mass spectrometry and infrared spectroscopy, the structures of the forced degradation products were confirmed and elucidated. The dissolution behavior of Parkimedine® Tablets was also monitored in the FDA suitable medium. Multiple assessment tools were used to evaluate the environmental sustainability of the proposed methods and the reported one. The greenness tools included Complex-GAPI and AGREE metrics. In addition, the innovative concepts of "blueness" and "whiteness" evaluation were incorporated through the newly introduced BAGI and RGB12 algorithms, respectively.

Integrating Artificial Intelligence into Service Innovation, Business Development, and Legal Compliance: Insights from the Hainan Free Trade Port Era

This research aims to inspect the application of Artificial Intelligence (AI) in product and service innovation from the perspective of the Hainan Free Trade Port (HFTP) and its relationship with corporate transformation, legal compliance, and regulatory oversight. Being critical to the fourth industrial revolution, digital business and international cooperation, technology propels enterprises across various industries to transition from traditional models to intelligent and service-oriented ones. It also elucidates the theoretical foundations of AI products, the digital economy, and service innovation. It can be used to analyzes the challenges enterprises face in the HFTP while implementing AI technology, including funding, technology, management, operations, corporate culture, and innovative concepts. Based on the proposed research methodology, three hypotheses can be formulated. Hypothesis 1 states that the HFTP could facilitate enterprise transformation by applying supportive policies. Hypothesis 2 state that domestic laws and international agreements are urgently needed due to the legal risks arising from artificial intelligence. Hypothesis 3 state that HFTP enterprises comply with these laws while systemically assuring, in theory, and practice, the legal risks of artificial intelligence and its implications for legal regulation, which is a significant aspect of research, addressing legal risks related to data privacy, security, and algorithmic bias with many strategies being proposed. This shows how AI technology can change businesses in the HFTP, demonstrating the application of AI technology in the transformation of enterprises in the HFTP and the various risks they may encounter, providing valuable references for other enterprises regarding the practical significance of AI product and service innovation in the HFTP, and emphasizing the importance of international cooperation and legal instruction.

3PM-guided innovation in treatments of severe alcohol-associated hepatitis utilizing fecal microbiota transplantation

Abstract Rationale Severe alcohol-associated hepatitis (SAH) is the most critical, acute, inflammatory phenotype within the alcohol-associated liver disease (ALD) spectrum, characterized by high 30- and 90-day mortality. Since several decades, corticosteroids (CS) are the only approved pharmacotherapy offering highly limited survival benefits. Contextually, there is an evident demand for 3PM innovation in the area meeting patients’ needs and improving individual outcomes. Fecal microbiota transplantation (FMT) has emerged as one of the new potential therapeutic options. In this study, we aimed to address the crucial 3PM domains in order to assess (i) the impact of FMT on mortality in SAH patients beyond CS, (ii) to identify factors associated with the outcome to be improved (iii) the prediction of futility, (iv) prevention of suboptimal individual outcomes linked to increased mortality, and (v) personalized allocation of therapy. Methods We conducted a prospective study (NCT04758806) in adult patients with SAH who were non-responders (NR) to or non-eligible (NE) for CS between January 2018 and August 2022. The intervention consisted of five 100 ml of FMT, prepared from 30 g stool from an unrelated healthy donor and frozen at − 80 °C, administered daily to the upper gastrointestinal (GI) tract. We evaluated the impact of FMT on 30- and 90-day mortality which we compared to the control group selected by the propensity score matching and treated by the standard of care; the control group was derived from the RH7 registry of patients hospitalized at the liver unit (NCT04767945). We have also scrutinized the FMT outcome against established and potential prognostic factors for SAH — such as the model for end-stage liver disease (MELD), Maddrey Discriminant Function (MDF), acute-on-chronic liver failure (ACLF), Liver Frailty Index (LFI), hepatic venous-portal pressure gradient (HVPG) and Alcoholic Hepatitis Histologic Score (AHHS) — to see if the 3PM method assigns them a new dimension in predicting response to therapy, prevention of suboptimal individual outcomes, and personalized patient management. Results We enrolled 44 patients with SAH (NR or NE) on an intention-to-treat basis; we analyzed 33 patients per protocol for associated factors (after an additional 11 being excluded for receiving less than 5 doses of FMT), and 31 patients by propensity score matching for corresponding individual outcomes, respectively. The mean age was 49.6 years, 11 patients (33.3%) were females. The median MELD score was 29, and ACLF of any degree had 27 patients (81.8%). FMT improved 30-day mortality (p = 0.0204) and non-significantly improved 90-day mortality (p = 0.4386). Univariate analysis identified MELD ≥ 30, MDF ≥ 90, and ACLF grade > 1 as significant predictors of 30-day mortality, (p = 0.031; p = 0.014; p = 0.034). Survival was not associated with baseline LFI, HVPG, or AHHS. Conclusions and recommendations in the framework of 3PM In the most difficult-to-treat sub-cohort of patients with SAH (i.e., NR/NE), FMT improved 30-day mortality. Factors associated with benefit included MELD ≤ 30, MDF ≤ 90, and ACLF < 2. These results support the potential of gut microbiome as a therapeutic target in the context of 3PM research and vice versa — to use 3PM methodology as the expedient unifying template for microbiome research. The results allow for immediate impact on the innovative concepts of (i) personalized phenotyping and stratification of the disease for the clinical research and practice, (ii) multilevel predictive diagnosis related to personalized/precise treatment allocation including evidence-based (ii) prevention of futile and sub-optimally effective therapy, as well as (iii) targeted prevention of poor individual outcomes in patients with SAH. Moreover, our results add to the existing evidence with the potential to generate new research along the SAH’s pathogenetic pathways such as diverse individual susceptibility to alcohol toxicity, host-specific mitochondrial function and systemic inflammation, and the role of gut dysbiosis thereof.

Role of Technology Innovation in Economic Growth: A Bibliometric Analysis

Economic growth is a metric used to measure a country's development and advancement. Technological innovation is a driving force behind economic growth and helps to improve and modernize industrial techniques. Thus, this study aims to synthesize existing research on the impact of technology innovation on economic growth from 2010 to 2024 through bibliometric analysis. 414 documents were extracted from the Scopus database and then analyzed through the BiblioShiny software. This review provides insightful information on the background of technological innovation and its impact on economic growth and analyses data according to publication patterns, sources, documents, authors, nations, and keywords. The results indicate a rapid and remarkable growth (28.91%) in this field, suggesting that interest in this field has increased noticeably. China emerges as a leader in terms of research production, citations, and partnerships when national contributions are examined. China is also a keyword that is frequently used in related literature. Sharif A. and Liu J are the most influential authors in terms of citation and publication respectively. Jiangsu University is the top institution, and “Environment Science and Pollution Research” is the top source that has contributed the highest number of articles in this field. Various bibliometric studies have been carried out to explore the concept of technology innovation in different facets and contexts, but economic growth through the lens of technological innovation remains unexplored. Thus, this study advances our knowledge regarding the influential role of technology innovation in economic growth by using a bibliometric lens to examine the literature, identify knowledge gaps, indicate areas requiring more research, and highlight the potential for progress. These findings will have significant implications that can greatly benefit researchers, decision-makers, and professionals in crafting policies and focusing on infrastructure development to support technology innovation. This bibliometric study concludes with limitations and recommendations for further study.

Patient perspectives on health care models in cardiac surgery: a qualitative evaluation

BackgroundThe implementation of ERAS represents a promising solution to improve treatment efficiency and facilitate patient involvement. This innovative care model aims to optimize recovery processes following surgeries by adopting a holistic, interprofessional approach. At our hospital, ERAS was implemented in minimally invasive heart valve surgery, offering two distinct ERAS models. Additionally, there is also the standard of care without ERAS. The objective of the study is to gain insight into patient satisfaction and perceived differences across these various care models.MethodsPatients were interviewed using semi-structured interviews approximately two to three months after undergoing surgery. The data were analysed using qualitative content analysis in accordance with the methodology proposed by Kuckartz. Four main categories were established: Preoperative care, postoperative care and communication, patient participation and involvement, and rehabilitation and post-clinical course.ResultsComprehensive preoperative education and seamless communication throughout the perioperative care journey were identified as fundamental to patient satisfaction and optimal care processes. Patients in the ERAS + model reported higher overall satisfaction with their care compared to patients in the standard of care and ERAS groups.ConclusionPreoperative education establishes the foundation for patients’ subsequent behaviours and expectations regarding their treatment. Physical activity, nutrition, and mental health are significant aspects. The active involvement and participation of patients and their families in the treatment process facilitated superior postoperative care, intensive physiotherapy, mental support, and faster recovery. A functional flow of information throughout the entire care process is vital. Moreover, having a dedicated point of contact had a beneficial impact on patients´ well-being. The integration of innovative ERAS concepts, which encompass interprofessional preoperative patient education and psychosomatic support, represents a promising approach from a patient perspective, offering benefits to a broad spectrum of cardiac surgical patients.

An active and durable perovskite electrode with reversibly phase transition-induced exsolution for protonic ceramic cells

Protonic ceramic cells (PCCs) possess great application potential, attributed to their cleanliness and high energy conversion efficiency. However, designing active air electrodes with both high stability is challenging. Herein, we report a nanospinel-modified perovskite oxide, Nd0.5Ba0.5Mn0.7Co0.15Ni0.15O3−δ-(CoxNiy)3O4 (CNO@NBMCN), obtained by a reversibly phase transition-induced exsolution process, as a highly active and durable air electrode for PCCs. Phase-field simulations reveal the intrinsic mechanism of nanoparticles strongly pinning to the substrate in a high-temperature oxidizing environment. The CNO@NBMCN electrode exhibits remarkable low area specific resistance (0.38 Ω cm2 at 600 °C) and exceptional stability (degradation rate 0.01 % h−1). It is confirmed by soft X-ray absorption spectroscopy that the construction of the heterostructure leads to more distortion in Mn–O octahedra and weaker metal–oxygen bonds, thereby contributing to the formation of oxygen vacancies. And the exceptionally high durability supported by both fast ion surface exchange and charge transfer at triple-phase boundaries. A single cell with the CNO@NBMCN air electrode achieves outstanding performances in the fuel cell (peak power density of 1.28 W cm−2) and electrolysis modes (current density of −2.14 A cm−2 at 1.3 V), recorded at 700 °C. This work inspires innovative design concepts for robust heterogeneous electrocatalysts.

3.M. Skills building seminar: Culture, Arts and Mental Health

Abstract Improving mental health is a challenge, not only for the health sector, so research into innovative ways to improve mental health in the community is necessary. The WHO Regional Office for Europe together with its expert group on the cultural contexts of health and well-being promote a culturally grounded approach to enrich policies related to health and well-being. The cultural contexts of health and well-being argues that incorporating cultural issues into policy-making is critical to the development of adaptive, equitable and sustainable health care systems, and to making general improvements in many areas of population health and well-being. Population health and well-being are influenced by actions external to health care systems, also. By health-in-all-policies approach it is given an understanding of how policies in non-health domains can foster or constrain a culture and art for health. Social prescribing and art-for -health activities are important tool for improvenment mental health. This skils building seminar will discuss some good practice and examples, and also cooperation with experts from cultural sector in the mental health field. Key messages • The innovative concept of cooperation between Culture and Health institutions brought positive experiences and impressions to all participants who used ‘culture on prescription’. • The integration of arts into healthcare and community settings offers a holistic approach to promoting health and fostering well-being.

Addressing Stigma-Related Health Disparities for Autistic Individuals Through Cultural Competemility: Insights from Research and Lived Experience.

Autistic individuals experience disproportionate stigma across the life course in interpersonal, healthcare, and educational contexts. These experiences contribute to negative health and healthcare outcomes for this population. This paper seeks to describe autistic individuals' experiences of stigma and marginalization; discuss frameworks such as Campinha-Bacote's innovative concept of cultural competemility and its relevance to autistic populations; offer recommendations to healthcare providers based on this framework; and apply theory to practice in a case study. Autistic individuals increasingly understand autism as an important aspect of their identity. There are, however, few culturally informed healthcare efforts that reflect this understanding. As a result, efforts to address stigma-related health disparities for this population have limited effectiveness. In this manuscript, we highlight opportunities within clinical encounters, medical training, healthcare offices and systems, and research to provide higher quality culturally informed care to autistic populations and address stigma-related health disparities.

INNOVATIONS IN HUMAN RESOURCE MANAGEMENT IN THE PUBLIC SECTOR OF UKRAINE

The article examines the characteristics of innovations in human resource management within Ukraine’s public sector. It defines the concept of innovation in human resource management as the introduction of new ideas, methods, technologies, and processes aimed at enhancing the efficiency and effectiveness of managing human resources. The importance of studying this topic is highlighted, particularly in light of the need for the public sector and government bodies to adapt to the demands of wartime and the socio-political crisis, as well as the necessity to develop a strategy for advancing the public sector through the implementation of various international agreements. The main objective of the study is to analyze the specific features of introducing innovations in the human resource management system of Ukraine’s public sector. This includes identifying successful practices for implementing electronic systems, key areas for the digitalization of public administration, and promising research directions. The study demonstrates that several organizational, technological, and social variables influence the interactions between employees, management, and other stakeholders. For instance, technological innovations enable the automation of HR processes (e.g., talent management systems, HR analytics, electronic document management platforms) and the use of online tools for employee training and development (e-learning, webinars). Organizational innovations promote the adoption of new management models. The study highlights several priority areas for further development: strategic communications in public policy, shaping the corporate culture of government agencies, defining their mission, strategic goals, values, and vision; fostering innovative leadership; developing horizontal connections within organizations through innovation; and ensuring principles such as fairness, transparency, openness, and equal access through the digital transformation of public administration.

Evaluating the relationship between knowledge management and green innovation: a systematic literature review

Purpose Managing knowledge is relevant for the innovativeness of an organization. The innovation of the organization currently aligns with the environment and applies green innovation concepts. Knowledge management (KM) is a key to fostering green innovation and to saving the environment from unnecessary pollution. In line with this, this study aims to evaluate the relationship between KM and green innovation in the literature from 2000 to 2023 synthesize and suggest future directions. Design/methodology/approach This study used the preferred reporting items for systematic review and meta-analysis technique to identify eligible articles. The papers were identified from the Web of Science core collection and ScienceDirect databases. The results were presented using tables, graphs and the co-occurrence of citations was analyzed using VOSviewer software. Findings From the review, the authors were assured that there is a strong relationship between KM practices and green innovation in different organizations. Some papers were supported by different theories. From the total of 48 papers, 16 have not mentioned the theories applied in their studies. The geographical distribution of the papers is asymmetrical. Asian and European scholars published more papers. The papers distribution across publishers also varies. For instance, Elsevier and Emerald Group Publishing Ltd. published 29 papers and the remaining papers were published in BMC, Springer, Frontiers Media Sa, IEEE-Inst Electrical Electronics Engineers Inc., MDPI, Routledge Journals and Taylor & Francis Ltd. Major themes were identified and future research directions were forwarded. Research limitations/implications The limitation of this review is the authors generated the papers from two databases (WoS and ScienceDirect). This paper does not consider other databases (Scopus, dimensions, etc.) papers. This can be considered as a limitation of this review. Originality/value The review is original by integrating PARISMA and bibliometric analysis method (VOS Viewer). The paper tried to explore the role of KM on green innovation.

CO2 thermal network prototype: Identifying control parameters for optimal operation in transcritical mode

An innovative concept has been developed and patented recently called CO2 Thermal Network (CO2TN) to improve the performance of heating and cooling systems in buildings. It is a decentralized system circulating two-phase CO2 at 20 ± 5 °C inside a building, instead of water, as a heat carrier fluid (HCF) in a single pipe. Heat pumps connected to this pipe provide heating and cooling inside a building using CO2 at their source side. Thus, the heat pumps operate with enhanced and consistent performance. The pipe also facilitates heat recovery between the connected units. Additionally, leveraging the latent heat of two-phase CO2, the CO2TN operates with a reduced mass flow rate in the loop, requiring a lower circulation energy consumption than conventional hydronic systems.This study introduces the concept and the first prototype of a CO2TN system. Then, the paper experimentally investigates the influential parameters that control the system’s operation and optimize its performance in transcritical mode. The results showcase that a CO2TN’s performance depends on its gas cooler (GC) temperature and pressure, the number of working heat pumps, and their mode of operation. An optimal GC outlet temperature exists for each GC pressure, which can improve system performance by up to 30%. Moreover, the GC pressure depends on the temperature range of the thermal energy sources used to balance the CO2TN. Additionally, the system shows significant performance improvement—up to 63%—when multiple heat pumps operate simultaneously in different modes.

Marketing-Driven Supply Chain Innovation: A Framework for FMCG SME Sustainability

In an increasingly competitive and sustainability-conscious market, small and medium-sized enterprises (SMEs) in the Fast-Moving Consumer Goods (FMCG) sector face unique challenges in achieving long-term sustainability. This review explores the concept of marketing-driven supply chain innovation as a strategic framework for enhancing SME sustainability. By integrating consumer-centric marketing strategies with supply chain operations, SMEs can align their product offerings, sourcing practices, and logistics with growing consumer demand for environmentally and socially responsible products. The framework outlined in this study includes key components such as sustainable product design, green logistics, ethical sourcing, and the incorporation of circular economy principles. Additionally, technology-driven innovation, such as data analytics and digital platforms, is emphasized as a tool to improve supply chain transparency, reduce waste, and optimize resource utilization. Through these collaborative efforts, SMEs can foster stronger consumer trust, enhance brand loyalty, and build a competitive edge in the market. Despite the potential benefits, the review also discusses the challenges SMEs may face, including limited financial resources, resistance to organizational change, and balancing profitability with sustainability goals. However, by leveraging green financing options, cross-sector partnerships, and phased implementation strategies, SMEs can overcome these barriers. Ultimately, the integration of marketing-driven supply chain innovation is positioned as a critical path for FMCG SMEs to achieve long-term sustainability, profitability, and market competitiveness in an evolving global economy. Keywords: Marketing-Driven, Supply Chain, FMCG SME, Review.

Best supportive care for patients with primary progressive multiple sclerosis (PPMS) in Germany prior to ocrelizumab treatment: Final results from the RETRO PPMS study.

Best supportive care (BSC) measures are an essential component for the management of primary progressive multiple sclerosis (PPMS). RETRO PPMS (ML39631) is the first study to systematically analyze the therapeutic journey and standard of BSC of patients with PPMS in Germany. This multicenter, non-interventional study retrospectively analyzed patient charts. Methods: Data were recorded up until the first infusion of ocrelizumab (July 2018 to October 2021). Medical history, disease status, disease activity and treatments were assessed from 12 months before PPMS diagnosis until study start. Acute interventions, BSC parameters and rehabilitation measures from the past 27 months were assessed. The core analysis population (N = 462) had a mean age (range) of 57.4 (27-85) years and mean disease duration of 13.7 (0.3-55.2) years. The most frequently reported symptoms were muscle spasticity, bladder disorder, ataxia, gait disturbance and fatigue. The most commonly used treatment was physical/occupational therapy (66.5% of patients); 47.2% received off-label treatment with corticosteroids/disease-modifying therapies. BSC measures for many symptoms were strikingly rare - especially for fatigue and cognitive impairment. This analysis uncovers severe BSC deficits for many debilitating PPMS symptoms. There is still a large unmet need for innovative multidisciplinary care concepts and improvements in neurological primary and secondary care.

Solar Passive House Conceptand Thermal System Design

This aricle puts forward a concept of family home enclosed in a greenhouse. Inspired by Naturhus and Earthship ideas, it leverages thermofluid technologies inspired by nuclear power passive cooling systems. The solar gain of the greenhouse allows for enhanced heating fuel efficiency in winter, while a system of solar-drive heat exchangers dissipates excess heat in summer. This general living qualities of such innovative housing concepts are discussed, followed by an outline of the computational challenges that need to be overcome by experiment-driven modelling, aiming for the demonstrator that successfully controls summer daily temperature peaks.

Bio-Based Innovation and the Global Patent System: Exploring the WIPO Treaty on Intellectual Property, Genetic Resources and Associated Traditional Knowledge

Abstract This opinion critically examines the 2024 WIPO Treaty on Intellectual Property, Genetic Resources and Associated Traditional Knowledge, a new instrument addressing the use of genetic resources (GR), and traditional knowledge associated with GR (ATK) in the global patent system. Given the Treaty’s position at the intersection of intellectual property and environmental law, this article discusses its history and negotiation in the first part, including the Treaty’s links to the Convention on Biological Diversity (CBD) and the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS). It then discusses the concept of bio-based innovation and its role in the bioeconomy. Following this, the article assesses the Treaty’s contents, including its context and objectives, scope, the Patent Disclosure Requirement (PDR), sanctions and remedies for non-compliance with the PDR, information systems on GR and ATK, and its relationship with other international instruments. The article highlights the extensive diplomatic negotiations that shaped the final text and considers potential amendments that could be made during the Treaty’s review process. The Treaty is intended to improve the global patent system’s effectiveness, transparency, and quality concerning GR and ATK and to prevent Offices from granting patents erroneously. Its provisions present new challenges and complexities for stakeholders, and its long-term success will depend on ongoing international collaboration and engagement, both within and outside the Treaty’s framework, and ensuring equitable benefit-sharing from the use of GR and ATK as part of a global sustainable bioeconomy.

Frugal innovation and entrepreneurial university: a case study of African first development university in Africa

The concept of frugal innovation has gained significant traction in low middle-income countries due to its potential to contribute to sustainable development goals (SDGs). This study examines the role of universities in promoting frugal innovation and their capacity to drive socio-economic development through entrepreneurial initiatives. The objective is to explore how universities can serve as both entrepreneurial and development-focused institutions and to develop a conceptual framework to guide their efforts. The study utilizes an exploratory single case study methodology, focusing on the American University of Nigeria (AUN), a leading institution in Nigeria known for its development and entrepreneurship programs. Drawing on data from the AUN THE global impact ranking 2024, the results of the study indicate that the ability of a university to effectively manage technology and skills transfer in frugal innovations is influenced by six university capabilities, and the generation of frugal innovations is moderated by policy and innovation ecosystems involving government agencies, regulatory bodies, and policymakers. This study contributes to the existing body of knowledge by initiating a discussion on how development and entrepreneurship can support frugal innovation, and offers practical insights to inspire other universities to develop their own models for societal and economic impact. The study underscores the necessity of integrating “development” into the vision of universities, particularly in low middle-income and developing economies, and emphasizes the significance of universities embracing both entrepreneurial and development-focused roles. The findings highlight the potential of universities in advancing sustainable development goals, particularly in low middle-income and developing economies, as they work towards meeting the global SDGs by 2030.

To What Extent Can Digital Health Technologies Comply With the Principles of Responsible Innovation? Practice-and Policy-Oriented Research Insights Regarding an Organisational and Systemic Issue

Background: Digital health technologies (DHTs) have expanded exponentially since the COVID-19 crisis and have prompted questions about their impact across all levels of health systems. Because health organisations and systems play a central role in the success or failure of the transition to more equitable and sustainable societies, the concept of Responsible Innovation in Health (RIH), focused on aligning the processes and outcomes of innovation with societal values, is gaining interest in research, policy, and practice. This study aims to explore enablers and constraints to the development, procurement and/or utilisation of responsible DHTs in health organisations. Methods: Semi-structured interviews were conducted with 29 stakeholders concerned with the development, procurement, and/or utilisation of DHTs in a large Canadian academic health centre. Data were thematically analysed through a mixed deductive-inductive process using the RIH framework. Results: Our findings highlight that the consideration of RIH principles in the development, procurement, and/or utilisation of DHTs depends mainly on organisational and systemic factors and conditions, namely: (1) the presence of an organisational culture that promotes RIH in its innovation-related practices and processes; (2) availability of material and financial resources as well as expertise in certain fields (eg, environmental sustainability); (3) the evolution of health technology assessment (HTA) practices to include other dimensions beyond effectiveness, safety, and costs; (4) the scope of the regulatory and legal frameworks that govern the approval and use of DHTs; and (5) the role of the market (eg, venture capital) in the design of federal and provincial innovation policies. Conclusion: This study provides insights on practice, policy, and political issues that health organisations may face in the development, procurement, and/or utilisation of responsible DHTs. It can help scholars, practitioners, decision-makers, and industry to create the conditions for a better integration of RIH principles into health organisations and systems.