Concept Of Chinese Medicine Research Articles

The Clinical Progress of the Combined Treatment of Lung and Intestine on Immune Response

Lung-intestinal homoeopathy is a comprehensive therapeutic strategy that combines traditional theories of traditional Chinese medicine and modern medical concepts. We review the clinical progress of lung-gut homoeopathy on immune function. aiming to positively affect the immune function of patients with lung diseases. By regulating the intestinal microbiota, influencing intestinal mucosal immunity, and modulating immune mediators, some clinical treatments has been proved to be effective. In addition, lung-intestinal homoeopathy can improve the immune function of patients with lung diseases by regulating the expression of immunity and immune mediators in the intestinal mucosa and influencing the play of immune response. Although lung-intestinal homoeopathy has made some progress in the regulation of immune function, further clinical studies are needed to verify its efficacy and safety.

Resveratrol regulates Thoc5 to improve maternal immune activation-induced autism-like behaviors in adult mouse offspring

Maternal infection during pregnancy is an important cause of autism spectrum disorder (ASD) in offspring, and inflammatory infiltration caused by maternal immune activation (MIA) can cause neurodevelopmental disorders in the fetus. Medicine food homologous (MFH) refers to a traditional Chinese medicine (TCM) concept, which effectively combines food functions and medicinal effects. However, no previous study has screened, predicted, and validated the potential targets of MFH herbs for treating ASD. Therefore, in this study, we used comprehensive bioinformatics methods to screen and analyze MFH herbs and drug targets on a large scale, and identified resveratrol and Thoc5 as the best small molecular ingredient and drug target, respectively, for the treatment of MIA-induced ASD. Additionally, the results of in vitro experiments revealed that resveratrol increased the expression of Thoc5 and effectively inhibited lipopolysaccharide-induced inflammatory factor production by BV2 cells. Moreover, in vivo, resveratrol increased the expression of Thoc5 and effectively inhibited placental and fetal brain inflammation in MIA pregnancy mice, and improved ASD-like behaviors in offspring.

Bioinformatics database and production layout visual analysis platform of medicinal plants:a case study of Dao-di medicinal materials in Sichuan province

In the new stage of trans-omics and trans-subjects for medicinal plants, it is an urgent need to integrate big data, provide interactive applications, and form a unified and multi-level research system and big data platform. Dao-di medicinal material, as an important source of medicinal plants, is a unique quality concept and comprehensive standard of tranditional Chinese medicine(TCM). Several databases have been developed in China and abroad, such as the Encyclopedia of Traditional Chinese Medicine(ETCM) and the Global Pharmacopoeia Genome Database(GPGD). Yet, most databases do not provide multi-dimensional data, including geographic data, phenotype data, compound data, and genetic data. Sichuan, known as the hometown of TCM therapies and the treasure trove of TCM, is the most representative region of medicinal plant diversity in China. According to the latest data of the fourth national survey of TCM resources, there are more than 8 000 TCM and 86 Dao-di medicinal materials in Sichuan province. Based on resource census data and relevant achievements, this study constructed the bioinformatics database of medicinal plants and the visual analysis platform of production layout by taking the Dao-di medicinal materials in Sichuan province as an example, covering geographic data, phenotype data, compound data, and genetic data. It effectively integrates multi-dimensional data of Dao-di medicinal materials and provides different levels of data interaction applications. The platform is the first large-scale multi-dimensional database and visual platform of Dao-di medicinal materials in Sichuan province, which serves as an essential resource for germplasm resources identification, decomposition of biosynthetic pathways, molecular breeding of varieties and provides medicinal plant resource information and data support for development and utilization of medicinal plants in China and abroad.

Common mechanisms of Wumei pills in treating ulcerative colitis and type 2 diabetes: Exploring an integrative approach through network pharmacology.

Wumei pills (WMP), a classical Chinese herbal formula, have shown efficacy in the treatment of ulcerative colitis (UC) and type 2 diabetes (T2DM). However, the underlying mechanisms by which WMP simultaneously targets these distinct diseases remain unclear. In this study, a network pharmacology approach was employed to unravel the potential molecular mechanisms of WMP in UC and T2DM treatment. This analysis provides a bioinformatics foundation for the traditional Chinese medicine concept of "treating different diseases with the same treatment." WMP was found to contain 65 active components, including flavonoids, sterols, and alkaloids, that act on 228 shared targets for UC and T2DM. Network analysis identified 5 core compounds (Quercetin, Kaempferol, beta-Sitosterol, Isocorypalmine, Stigmasterol) and 8 core proteins (AKT1, ESR1, TP53, IL6, JUN, MYC, TNF, EGFR) that play pivotal roles in the treatment of UC and T2DM by WMP. WMP exerts its therapeutic effects by modulating signaling pathways, including the NF-κB pathway, PI3K-Akt pathway, and p53 pathway. Molecular docking results indicate a strong binding affinity between core compounds and core genes. This study bridges the understanding of 2 diseases using network pharmacology and provides insights into shared therapeutic mechanisms, opening doors for further research in modern Chinese herbal formulations.

We Need to Talk about the Penis

Abstract: What does epistemic decolonization mean for contemporary rethinking of the body, gender/sexuality, and knowledge in feminist and queer scholarship? Through a close reading of Chinese medicine's classical text Huang Di Nei Jing ( Yellow Emperor's Inner Canon ), this essay proposes a "body-of-orifices" in which the penis like the vagina and the anus is but another orifice among other more visible bodily openings. In feminist and queer theorization, the penis has been almost only accounted for as something else, as the metaphoric pen, the psychoanalytic phallus, as anything other than the organ itself. Meanwhile, in pornographic, cinematic, and other visual representations, the Asian man's member(ship) is largely denied, nowhere to be seen. This invisibility mirrors the overrepresentation of white male philosophers in much of queer theory's theoretical foundation. Engaging closely with feminist and queer re-readings of Freudian and Lacanian psychoanalysis while delving deeply into the philosophical and cosmological concepts of Chinese medicine, the essay also argues that the body-of-orifices entails a different heuristic model for a less hegemonic practice of knowing based on cultivation of passivity and receptiveness, which is very different from the colonial/modern model of knowledge-acquisition as mastery, penetration, and possession.

Event I. The development of oriental medicine in Russia in the XVIII-XIX centuries. The role of scientists of the Imperial Medico-Surgical (Military Medical) Academy

The article presents the history of nascence traditional oriental medicine in Russia during XVIII–XIX centuries. The first information about oriental medicine was brought to Russia in the XVIII century by doctors, who visited Mongolia and China as members of embassy expeditions. The first decades of the XVIII century can be considered as beginning of a systematic study oriental treatment methods. It was possible thanks to the many years efforts of the employees of the Russian ecclesiastical mission in Beijing. This organization from 1715 to 1864 years served religious, diplomatic and scientific functions. An invaluable contribution to the study of Chinese medicine was made by the leaders of the mission. Major role belongs to Nikita Yakovlevich Bichurin (father Iakinf), archimandrite of the IX mission. He was fluent in Chinese, studied the primary sources of medical literature, translated significant treatises into Russian, and taught Chinese to the mission staff. The head of the X mission, Pavel Ivanovich Kamensky, compiled a Chinese-Russian medical dictionary, reorganized the mission, and insisted on the need to introduce the position of a doctor among the staff. Starting from 1821, doctors O.P. Voitsekhovsky, P.E. Kirillov, A.A. Tatarinov, S.I. Bazilevsky and P.A. Kornievsky, graduates of the Imperial Medical and Surgical (Military Medical) Academy worked as physician of the X–XIV missions. Doctors continued to study the theoretical concepts of Chinese medicine, philosophical and cultural traditions that underlie healthcare. In addition to medical work, in accordance with the instructions of the Medical Council at the Ministry of Foreign Affairs, they explored epidemiology, healthcare organization and the process of training doctors in China, analyzed Eastern approaches in the diagnosis and treatment of diseases, pharmacopoeia, used of herbal remedies, methods of prevention and health maintenance. The scientific approach, knowledge of the Chinese language, and a long stay in the country allowed them to lay the foundations of Oriental medicine in Russian, acquaint medical community with the methods of treatment and prevention of diseases adopted in China, introduce acupuncture, moxa, the use of new types of herbal remedies, enrich the collections of medicinal plants.

Differentiation and Treatment of Chronic Renal Failure Based on the Theory of "Peace and Balance"

Chronic renal failure is slow, the course of disease is long, and it is difficult to heal. At present, modern medicine is faced with many difficulties in treatment, and it is difficult to break through. The Chinese medicine treats the symptoms according to the whole concept and has obtained good curative effect. Although the pathogenesis of the disease is complicated, in the whole process of onset, deficiency in origin and excess in superficiality is still the most critical. It is often caused by deficiency of spleen and kidney, disorder of liver ascending and lung descending, combined with phlegm-dampness and stasis toxin, and the disturbance of internal and external wind. Consequently. It is necessary to treat multiple viscera at the same time, and treat both manifestation and root cause of disease. The theory of "Peace and Balance" fully interprets the overall concept of Chinese medicine, we advocate "aim for peace" and Incorporate "balance" throughout the entire treatment,to reach the balance of yin and yang. Therefore, this article will discuss the treatment based on syndrome differentiation of Chronic renal failure by the theory of "Peace and Balance".

Processing of Real World Data in Traditional Chinese Medicine

Traditional Chinese medicine (TCM) is a unique traditional medicine in China and has been passed down to the present day with its unique theoretical basis and treatment model. The introduction of the concept of evidence-based medicine into traditional Chinese medicine and the scientific evaluation of its clinical efficacy are essential for the better development and transmission of TCM. Randomised controlled trials have always been the "gold standard" of clinical trial evidence due to their strict inclusion and exclusion criteria and strict control of the data collection process, but the specificity of the TCM treatment model, the holistic, ambiguous, diverse and complex nature of the data, and the concomitant events in the research process make it difficult to conduct randomized ontrolled trials in TCM. Real World Study (RWS), which is conducted in actual clinical settings with broad inclusion and exclusion criteria to obtain treatment effects and long-term clinical outcomes as endpoints, can be used for long-term evaluation of treatment measures based on patients' preference. Real world studies allow for the long-term evaluation of treatment measures based on patients' preference, and are able to evaluate the overall effects, adapting to the holistic concept of Chinese medicine and the characteristics of evidence-based treatment. This paper summaries the data characteristics and data processing methods of real world studies in TCM, with a view to providing a reference for real world studies in TCM.

DYNAMICS OF ELEMENTSOFNATIONAL CONSCIOUSNES ONTHE EXAMPLEOF ALCHEMICAL ASPECTS IN TAOISM

The article examines the influence of alchemical aspects in Taoist medicine on the national consciousness of China during its historical development and in the modern context. The main focus of the article is directed towards exploring the stages of evolution of alchemical concepts in Chinese medicine, investigating moments of significant qualitative changes and transformations of key research objects, as well as studying the vectors of development of medical culture in China as a whole. In the early stages of alchemical practice in China, alchemists based their teachings on philosophical foundations, which manifested in the rapid development of alchemical medicine. The result was new medicines, treatment methods, and tools. Discussions unfolded, and institutions created were associated with alchemical medical practice. The intersection of external and internal alchemy in practices such as Taoist massage and psychotherapy, where religious and magical elements correlate with physical procedures, is noted. For this stage, it is important to define the specificity of Taoism, which became the environment where medical culture in China actively developed through alchemy. A particular emphasis is placed on the interaction of alchemical aspects with political power, specifically the support and utilization of Taoist medical ideas by the Communist Party. It is noted that this contributed to the survival and popularization of Taoist medicine in China, and Taoist concepts found their reflection in the ideology of communism, allowing them not only to survive but also to firmly establish themselves in the mass consciousness of the Chinese citizens. In contemporary society, the medical culture of China is closely linked to everyday life. In particular, the general attitude towards health, expressed in preventive measures and the use of traditional medicine, is emphasized. Taoist concepts, such as the connection of emotions with health, continue to play a key role in the culture of treatment and health maintenance among the population. In conclusion, the article reveals the multifaceted contribution of alchemical aspects of Taoist medicine to the formation of China's national consciousness, their evolution throughout history, and their significant role in the modern medical landscape of China.

Aquaporins: A new target for traditional Chinese medicine in the treatment of digestive system diseases.

Aquaporins (AQPs) are a family of transmembrane proteins expressed in various organ systems. Many studies have shown that the abnormal expression of AQPs is associated with gastrointestinal, skin, liver, kidneys, edema, cancer, and other diseases. The majority of AQPs are expressed in the digestive system and have important implications for the physiopathology of the gastrointestinal tract as well as other tissues and organs. AQP regulators can prevent and treat most gastrointestinal-related diseases, such as colorectal cancer, gastric ulcer, and gastric cancer. Although recent studies have proposed clinically relevant AQP-targeted therapies, such as the development of AQP inhibitors, clinical trials are still lacking and there are many difficulties. Traditional Chinese medicine (TCM) has been used in China for thousands of years to prevent, treat and diagnose diseases, and is under the guidance of Chinese medicine (CM) theory. Herein, we review the latest research on the regulation of AQPs by TCMs and their active components, including Rhei Radix et Rhizoma, Atractylodis macrocephalae Rhizoma, Salviae miltiorrhizae Radix et Rhizoma, Poria, Astragali radix, and another 26 TCMs, as well as active components, which include the active components include anthraquinones, saponins, polysaccharides, and flavonoid glycosides. Through our review and discussion of numerous studies, we attempt to explore the regulatory effects of TCMs and their active components on AQP expression in the corresponding parts of the body in terms of the Triple Energizer concept in Chinese medicine defined as "upper energizer, middle energizer, and lower energizer,"so as to offer unique opportunities for the development of AQP-related therapeutic drugs for digestive system diseases.

"Six-step strategy" for effective compounds in Chinese medicinal prescriptions based on in vitro-in vivo integration and its application in research on component-based Chinese medicine

The discovery and identification of effective components are pivotal in the research on Chinese medicinal prescriptions. Given two basic conditions for effective components in Chinese medicinal prescriptions, i.e., active structure and a certain level of drug exposure in the body(including the intestine), a "six-step strategy" for the effective compounds in Chinese medicinal prescriptions based on in vitro-in vivo integration(SSS for short) has been proposed and established, as well as the key technologies. SSS contains qualitative and quantitative analyses of components in five steps, including those in Chinese medicinal extract, intestinal contents, portal vein blood, liver, and peripheral blood. The components(prototype components and metabolites) with a certain exposure level(including in the intestine) and those with large differences between in vitro content and in vivo exposure or in exposure among various parts in the body are selected as the minority prioritized candidates. The sixth step is to screen the pharmacological activity of candidate components specifically extracted from Chinese medicinal materials or artificially synthesized. SSS can significantly narrow the screening range, enhance the hit rate, and speed up the identification of effective components specifically targeting indications. Based on the effective components identified by the SSS, the "upstream" can be linked(mechanism research based on the effective components with clear structures) and the "downstream" can be combined(development of innovative component-based Chinese medicine with definite pharmacodynamic composition). In this study, the concept of component-based Chinese medicine and specific applications of SSS in the development of component-based Chinese medicine are also introduced.

Application of Chinese Herbal Plants in Rehabilitation Landscape Design

Urban public landscape development up to now, gradually formed diversified development system, to meet the needs of different conditions on landscape, therefore, the landscape is also with the passage of time, again and again of the shift, in recent years, the rapid development of modern industrial science and technology lead to a variety of problems have been neglected, accumulate over a long period to today's situation, aiming at this situation, we put forward using the rehabilitation landscape concept of Chinese herbal medicine and western union, from the aspects of landscape in the sustainable development of the improvement plan, realize the development of modern society and traditional culture on Chinese herbal medicine feedback.

β -Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency-A Randomized, Placebo-Controlled, and Double-Blinded Trial.

To test the hypothesis that β -glucan enhances protective qi (PQi), an important Chinese medicine (CM) concept which stipulates that a protective force circulates throughout the body surface and works as the first line of defense against "external pernicious influences". A total of 138 participants with PQi deficiency (PQD) were randomized to receive β -glucan (200 mg daily) or placebo for 12 weeks. Participants' PQi status was assessed every 2 weeks via conventional diagnosis and a standardized protocol from which a PQD severity and risk score was derived. Indices of participants' immune and general health status were also monitored, including upper respiratory tract infection (URTI), saliva secretory IgA (sIgA), and self-reported measures of physical and mental health (PROMIS). PQi status was not significantly different between the β -glucan and placebo treatment groups at baseline but improved significantly in the β -glucan (vs. placebo) group in a time-dependent manner. The intergroup differences [95% confidence interval (CI)] in severity score (scale: 1-5), risk score (scale: 0-1), and proportion of PQD participants (%) at finish line was 0.49 (0.35-0.62), 0.48 (0.35-0.61), and 0.36 (0.25-0.47), respectively. Additionally, β -glucan improved URTI symptom (scale: 1-9) and PROMIS physical (scale: 16.2-67.7) and mental (scale: 21.2-67.6) scores by a magnitude (95% CI) of 1.0 (0.21-1.86), 5.7 (2.33-9.07), and 3.0 (20.37-6.37), respectively, over placebo. β -glucan ameliorates PQi in PQD individuals. By using stringent evidence-based methodologies, our study demonstrated that Western medicine-derived remedies, such as β -glucan, can be employed to advance CM therapeutics. (ClinicalTrial.Gov registry: NCT03782974).

Structural Chinese medicine: new research field on pharmacodynamic substance basis of traditional Chinese medicine

The research on the pharmacodynamic substance basis of traditional Chinese medicine(TCM) is a key scientific issue for the inheritance and development of TCM. At present, a large number of remarkable achievements have been made in the field of chemical components in Chinese medicine, however, another important aspect, namely the physical structure and mode of action of the multi-component assembly of TCM, has not been clearly understood and deeply studied. From the bottleneck of restricting material ba-sic research, we objectively analyzed the common cause of the existing problems. Based on the new discoveries and advances of active substances from TCM emerging in recent years, we extracted and summarized the concept of structural Chinese medicine, elaborated the basic ideas, main features and research modes, hoping to provide theoretical and practical references for the study on the pharmacodynamic substance basis and other research fields of TCM.

Thoughts on post-marketing evaluation of classical Chinese patent medicines based on clinical value

Classical Chinese patent medicines(CPMs) are a kind of modern preparation developed from the experience of compatibility and application about ancient prescriptions. Its rich history of human use and reliable clinical efficacy imply the unique theoretical essence and precious value of traditional Chinese medicine(TCM). With the development of evidence-based medicine and the improvement of medical policy, it is particularly urgent to evaluate the clinical values of post-marketing classical CPMs. In this paper, some problems on the clinical value evaluation of CPMs would be described, and it is considered that the simplified evaluation procedures can lead to the lack of evidence for evaluating clinical value of CPMs, causing the difficulty in evaluating the quality of CPM, lack of R&D motivation of enterprises, low content of science and technology, and poor international development. Based on this background, it points out that the clinical value evaluation is the core of the post-marketing evaluation of the classical CPMs, and the eva-luation should be based on the direction of literature research and the latest practice. We should adhere to the research mode of combination disease with syndrome, and select the appropriate type of trials, with clinical efficacy, health economic benefits and safety eva-luation as the main content of the studies, in order to refine the indications and standardize the clinical positioning. Clinical value eva-luation is the basis and main content of post-marketing comprehensive researches on classic and famous CPMs to clarify their clinical value, obtain the conditions for continued marketingand standardize their clinical application, so as to optimize the evidence and quality service of classic and famous CPMs and inherit the core value concept of Chinese medicine.

Acupuncture for Hypertension Using Traditional Chinese Medicine Concepts.

Hypertension affects 25% of the adult population worldwide. Biomedical treatment involves various blockers and is associated with side-effects. Acupuncture was one of the earliest methods of treatment for "hard pulse disease" (now called hypertension); it is effective and is associated with no untoward effects. Various studies showing the effectiveness of acupuncture for addressing hypertension are presented, along with an illustrative case. Acupuncture is effective for reducing blood pressure. This modality can be used as a stand-alone therapy or along with antihypertensive medications-in which case the dosages of the medications can be reduced significantly-and this helps to reduce the side-effects of medications.

Translation and Study of the “Tendon Transformation Classic” (Yi Jin Jing)

The article includes the first complete and annotated translation of the “Tendon Transformation Classic”, the fundamental treatise in the tradition of spiritual-somatic practice specific for China. Both by its language and contents, the Yi Jin Jing which connects medicine, spiritual self-cultivation and martial art occupies a unique place in the history of Chinese civilization, hence its interpretation encounters some special difficulties. Until now complete translation and systematic study of this scripture has not appeared in Western literature. The author analyzes the historical and cultural background of this unusual text and various legends related to it. Translation is accompanied by textual notes. The most salient feature of the “Tendon Transformation Classic” is the idea of the natural and hence innate unity of spiritual and physical dimensions of human individual. Interestingly, the proofs for this thesis were ascribed to the legendary founder of the Chan school in Chinese Buddhism Bodhidharma (in Chinese Damo). The main link between psychic and biological plans of human existence according to the authors of the Yi Jin Jing is fascia (mo). A special attention is paid to the meaning of this original concept in Chinese medicine and somatic psychology as well as its relation to the idea of nurturing “life energy” (qi) and organic unity of “inner” and “outer” strength etc. The article reveals this scripture’s importance for the evolution of the bio-spiritual practice in China and contradictions inherent in it.

Новелла Пу Сун-лина «Беседы зрачков»

The article covers the plot and translation peculiarities of the short-story by Pu Songling (蒲松齡, 1640–1715) “Pupils’ Talk”. The connection between Pu Songling’s ideas and tradition of Chinese popular medicine and Taoist concepts of soles and spirits of a human body is thoroughly analyzed; along with that the tradition of the story’s interpretation in Russian is also studied. The issue of special spirits inhabiting all organs and anatomical areas of a human has been thoroughly worked out in both parts of “Huang Di’s Inner Classic” as well as in “Huang ting Classic” and was a part of a common knowledge in traditional Chinese routine. Special medical treatises known as “Suishu” gave their own recipes of traditional medication combined with exorcism, and Pu Songling happened to be an author of such a treatise in two parts. Thus one has to admit that Pu Songling must be quite well acquainted with the tradition of Chinese folksy medicine based on the stated integrity of human physical organization with controlling spirits of each and every body-part. Therefore with the undeniable influence of Ming fiction on “Pupils’ Talk” one can’t help acknowledging that the descriptive means of expression as well as the chief idea of the story are authentic and independent. Taoist ideas about human anatomy and physiology can be met not only in this story, but in other pieces of the “Strange Tales from a Chinese Studio” (Liao Zhai zhi yi). Artistic peculiarities of the text as well as fundamentals of the translation are divisively demonstrated. A new variant of translation of the whole text is provided.

Proof-of-Concept and Feasibility Study to Evaluate the Effect of β-Glucan on Protective Qi Deficiency in Adults.

To preliminarily explore the potential effect of β-glucan on Chinese medicine (CM) concept protective qi deficiency (PQD), and the methodology for future definitive studies. To have a standardized assessment of PQD, a list of 13 potentially PQD-relevant parameters were firstly created, each with defined quantitative or categorial scales. Using the data from 37 participants with (21 cases) or without (16 cases) PQD, multivariate logistic modeling was conducted to create a preliminary diagnostic PQD risk score. Subsequently, 21 participants diagnosed with PQD were treated with β-glucan in a dose of 200 mg/day for 8 weeks. Data were collected for trial acceptability measures (rate of recruitment, withdrawal, and compliance), and the participants were assessed for PQD status at baseline and every 2 weeks thereafter. The preliminary logistic model consisted of 3 parameters (low voice and apathy, aversion to wind and cold, and Cun pulse). The resulting risk score demonstrated a degree of PQD-predicting accuracy that, as evaluated by statistical (discrimination and classification) methods, was higher than those obtained from any of the individual candidate parameters. The 21 PQD participants treated with β-glucan demonstrated good receptibility and a time-dependent improvement in PQD status as evidenced by the decrease of PQD participant to 9.5% at the end of study. This study demonstrated the effect of proof-of-concept of β-glucan on improving PQD and the proof-of-concept of a multivariate-model-derived diagnostic PQD risk score. It also indicated feasibility for future definitive studies. Studies like this embody an innovative approach that uses therapies derived from the mainstream biomedicine to enrich therapeutics guided by CM principle. (Trial registration No. NCT03829228).

Treating Different Diseases With the Same Method-A Traditional Chinese Medicine Concept Analyzed for Its Biological Basis.

IntroductionThe fundamental theory of traditional Chinese medicine (TCM) implies that when different diseases have the same pathogen, the syndromes of these individual diseases will be the same. “Treating different diseases with the same method” is a TCM principle suggesting that when different diseases have similar pathological changes during different stages of their development, the same method of treatment can be applied. Our study aims to analyze the concept “treating different diseases with the same method” from a molecular perspective, in order to clarify its biological basis and to objectively standardize future TCM syndrome research.ObjectiveThe TCM syndromes Qi deficiency and blood stasis have similar pathogenesis in relation to coronary heart disease (CHD) and stroke. We aim to use big data technology and complex network theory to mine the genes specifically relevant to these TCM syndromes. This study aims to explore the correlation between the biological indicators of CHD and stroke from a scientific perspective.MethodsMining the relevant neuroendocrine-immune (NEI) genes by means of gene entity recognition, complex network construction, network integration, and decomposition to categorize relevant syndrome terms and establish a digital dictionary of gene specifically related to individual diseases. We analyzed the biological basis of “treating different diseases with the same method” from a molecular level using the TCMIP v2.0 platform in order to categorize the TCM syndromes most relevant to CHD and stroke.ResultsWe found 46 genes were involved in the TCM syndromes of Qi deficiency and blood stasis of CHD and stroke. The same genes and their molecular mechanism also appeared to be in close relation to inflammatory response, apoptosis, and proliferation.ConclusionBy using information extraction and complex network technology, we discovered the biological indicators of the TCM syndromes Qi deficiency and blood stasis of CHD and stroke. In the era of big data, our results can provide a new method for the researchers of TCM syndrome differentiation, as well as an effective and specific methodology for standardization of TCM.