Concept Of Therapeutic Window Research Articles

A New Tumor-Immunotherapy Regimen based on Impulsive Control Strategy

Autologous tumor infiltrating lymphocyte (TIL) therapy refers to a kind of immunotherapy in which the tumor-resident lymphocytes are harvested, cultured, and then transferred into the patient. In spite of some well-known TILs expansion recommendations, there is a lack of well-established TILs injection protocol. This paper addresses the challenge using a feedback-based control strategy. Utilizing Lyapunov technique, a novel dose calculation method is proposed which considers TILs pharmacokinetics. Then, to determine the timing of TILs administration, the concept of therapeutic window in pharmacy is exploited. The resultant therapy protocol is both practical and implementable while it ensures tumor remission. Comparing with previous studies, the proposed method takes the discontinuity of TILs delivery process into consideration. Computational results suggest the following therapy protocol which is in accordance with experimental observations: A few high dose TILs injections are required. Then, there is a longtime drug free interval.

Ischemic brain protection

Despite advances in the understanding of the pathophysiology of cerebral ischemia, no single brain resuscitation therapy has yet been shown to be clinically superior to brain-oriented intensive care. Basic concepts in cardiopulmonary-cerebral resuscitation (CPCR) are discussed, as are two specific phases of CPCR, cerebral preservation and cerebral resuscitation. Cerebral preservation is initiated during cardiac arrest (ie, prior to restoration of spontaneous circulation [ROSC]) and includes use of artificial perfusion techniques and drugs to produce cerebral perfusion during this phase. Cerebral resuscitation is brain-oriented therapy initiated after ROSC. Pharmacologic agents currently under study for cerebral resuscitation include the barbiturates, calcium antagonists, and iron chelators. With respect to defining efficacy of the pharmacologic agents, the concept of therapeutic window is important. Although no agent has been proven clinically, several appear to be promising.

A comparative study of subcutaneously administered terbutaline and epinephrine in the treatment of acute bronchial asthma

Despite advances in the understanding of the pathophysiology of cerebral ischemia, no single brain resuscitation therapy has yet been shown to be clinically superior to brain-oriented intensive care. Basic concepts in cardiopulmonary-cerebral resuscitation (CPCR) are discussed, as are two specific phases of CPCR, cerebral preservation and cerebral resuscitation. Cerebral preservation is initiated during cardiac arrest (ie, prior to restoration of spontaneous circulation [ROSC]) and includes use of artificial perfusion techniques and drugs to produce cerebral perfusion during this phase. Cerebral resuscitation is brain-oriented therapy initiated after ROSC. Pharmacologic agents currently under study for cerebral resuscitation include the barbiturates, calcium antagonists, and iron chelators. With respect to defining efficacy of the pharmacologic agents, the concept of therapeutic window is important. Although no agent has been proven clinically, several appear to be promising.