The two structural systems named “functional integration structural systems” and “functional separation structural systems” were proposed based on the design concept of energy dissipation. To study the seismic performance of reinforced concrete (RC) frame-shear wall dual structural systems in which shear walls are used for “functional integration” and “functional separation”, quasi-static tests of two single-story and two-span RC frame-shear wall specimens with a scale of 1:3 were carried out, and numerical simulation analysis of two five-story frame-shear wall dual structures based on the conditional mean spectrum-incremental dynamic analysis (CMS-IDA) method was carried out. The shear walls bearing lateral load and a small part of the vertical load are named functional separation structure. When the shear walls bearing both lateral load and vertical load are named as functional integration structure, the seismic performance was investigated in terms of crack initiation and damage, hysteresis performance, stiffness degradation, energy dissipation capacity, ductility of the specimens, and seismic collapse resistance of the whole structure. The studies showed that when the load-bearing function and lateral resistance function of the shear walls were separated, the structure had better ductility, energy dissipation capacity, damage development process, and seismic collapse resistance.