The construction and operation of commercial buildings in Nigeria pose significant challenges to sustainability, characterized by high resource consumption, energy inefficiency, and environmental degradation. This paper introduces the concept of biomimicry as a promising approach to address these challenges by drawing inspiration from nature's designs and processes (Benyus, 1997). It highlights the urgent need to transition towards environmentally conscious practices within the construction industry to mitigate the adverse impacts of commercial building activities on the environment. The study aims to explore and analyze biomimetic principles applicable to sustainable building design such as inspirations from termite mounds and rainforest canopies, evaluate their potential impact on commercial buildings in Nigeria, and propose practical applications tailored to the country's unique environmental, social, and economic contexts. The key findings of the study indicate that integrating biomimetic design principles into the construction and operation of commercial buildings in Nigeria can result in enhanced energy efficiency and a decreased environmental footprint. Biomimetic approaches inspired by natural systems, such as the temperature regulation of termite mounds (Billings, 2013), can inform the design of passive heating and cooling systems, leading to reduced energy consumption. Similarly, biomimetic designs can improve ventilation, water management, and insulation, minimizing the overall environmental impact of commercial buildings. The research provides actionable insights for architects, engineers, and policymakers, enabling them to design and construct commercial buildings that seamlessly integrate with the environment.