Polychlorinated Naphthalenes Concentrations Research Articles

Linking industrial emissions and dietary exposure to human burdens of polychlorinated naphthalenes

Relationships between toxic pollutant emissions during industrial processes and toxic pollutant dietary intakes and adverse health burdens have not yet been quantitatively clarified. Polychlorinated naphthalenes (PCNs) are typical industrial pollutants that are carcinogenic and of increasing concern. In this study, we established an interpretable machine learning model for quantifying the contributions of industrial emissions and dietary intakes of PCNs to health effects. We used the SHapley Additive exPlanations model to achieve individualized interpretability, enabling us to evaluate the specific contributions of individual feature values towards PCNs concentration levels. A strong relationship between PCN dietary intake and body burden was found using a robust large-scale PCN diet survey database for China containing the results of the analyses of 17,280 dietary samples and 4480 breast milk samples. Industrial emissions and dietary intake contributed 12 % and 52 %, respectively, of the PCN burden in breast milk. The model quantified the contributions of food consumption and industrial emissions to PCN exposure, which will be useful for performing accurate health risk assessments and developing reduction strategies of PCNs.

Polychlorinated naphthalenes in freshwater fish from Beijing markets: Species-specific differences, effects of cooking, and health risk assessment

Fish are an important source of human dietary exposure to polychlorinated naphthalenes (PCNs). The occurrence and sources of PCNs in different species of freshwater fish are unknown, and few studies have assessed human exposure risks to PCNs through freshwater fish. In this study, 140 freshwater fish samples from 10 species were collected from Beijing markets, China. The Σ75CNs concentration range in the fish was 20.7–1310 pg/g wet weight (ww). The highest median Σ75PCNs concentration (80.4 pg/g ww) was found in mandarin fish (Siniperca chuatsi), and the lowest (29.6 pg/g ww) in snakehead (Channa argus). Di- and tri-CNs were the dominant PCN homologues with contributions of 35.3 % and 30.8 %, respectively. Unintentionally produced PCNs from metal smelting might be the source of PCN contamination in freshwater fish. The cooking temperature and time did not significantly affect the PCN concentrations in fish or the PCN homologue profiles. The highest toxic equivalent (TEQ) value was observed in sturgeon (Acipenser sinensis), followed by mandarin fish. Hexa-CNs were the most abundant homologue for the PCN TEQs. A risk assessment indicated that the dietary exposure risks for local residents to PCNs through freshwater fish were low. However, the relatively high concentrations of PCNs in the samples deserve attention to avoid PCNs exposure risks for groups with high fish consumption rates. Furthermore, freshwater fish likely contain a mixture of contaminants including dioxin and furans which also display a similar mode of toxicity as the PCNs and could enhance the risk to fish consumers.

Target Analysis of Polychlorinated Naphthalenes and Nontarget Screening of Organic Chemicals in Bovine Milk, Infant Formula, and Adult Milk Powder by High-Resolution Mass Spectrometry.

Infant formula is intended as an effective substitute for breast milk but is the main source of polychlorinated naphthalenes (PCNs) to nonbreastfed infants. We performed target and nontarget analyses to determine PCNs and identify other organic contaminants in infant formula. The mean PCN concentrations in infant formula, milk powder, and bovine milk were 106.1, 88.8, and 78.2 μg kg-1 of dry weight, respectively. The PCN congener profiles indicated that thermal processes and raw materials were probably the main sources of PCNs in infant formula. A health risk assessment indicated that PCNs in infant formula do not pose health risks to infants. Using gas chromatography-Orbitrap mass spectrometry, 352, 372, and 161 organic chemicals were identified in the infant formula, milk powder, and bovine milk samples, respectively. Phthalate esters were detected in all four plastic-packed milk powder samples. The results indicated milk becomes more contaminated with organic chemicals during manufacturing, processing, and packaging.

Polychlorinated naphthalene concentrations and temporal trends in serum from the general Chinese adult population and effects of polychlorinated naphthalenes on thyroid function

Polychlorinated naphthalenes (PCNs) have stopped being produced and used but have been detected in human serum around the world. Investigating temporal trends in PCN concentrations in human serum will improve our understanding of human exposure to PCNs and the risks posed. We determined the PCN concentrations in serum collected from 32 adults in five consecutive years (2012–2016). The total PCN concentrations in the serum samples were 0.00–5443 pg/g lipid weight. We found no significant decreases in the total PCN concentrations in human serum and even found that the concentrations of some PCN congeners (e.g., CN20) increased over time. We found differences in the PCN concentrations in serum from males and females, the CN75 concentration being significantly higher in serum from females than males, meaning CN75 poses more serious risks to females than males. We found, using molecular docking techniques, that CN75 interferes with thyroid hormone transport in vivo and that CN20 affects thyroid hormone binding to receptors. These two effects are synergistic and can cause hypothyroidism-like symptoms.

Polychlorinated naphthalenes in milk-based infant and toddler formula sold on the Chinese market

Polychlorinated naphthalenes (PCNs) are dioxin-like compounds that have been reported to be present in a wide variety of foodstuffs. Milk-based infant and toddler formula sometimes plays an important role in the diet of young children and could potentially cause adverse effects if contaminated with PCNs. This study investigated the concentrations of PCNs in commercial milk-based formula produced in different countries and sold on the Chinese market for three age groups: 0–6, 6–12 and 12–36 months. The total concentrations of PCNs in 72 samples from different countries of formula based on cow milk ranged from 7.8 to 30.3 pg/g whole weight (ww). Although the PCN concentrations in formula produced in Asia, Europe and South Pacific varied, all had comparable toxic equivalent (TEQ) values. Tri-CNs were the predominant PCN homologue in all samples. No significant differences in the concentrations of PCNs were found between samples of formula for each of the three age groups. The mean TEQ for PCNs in goat milk formula samples (0.0031 pg TEQ/g ww) was higher than the value for cow milk formula (0.0009 pg TEQ/g ww) produced in China, and the proportion of higher chlorinated PCNs in goat milk formula was also higher. Based on dry weight, the mean concentration of PCNs in the raw cow milk (119 pg/g dry weight (dw)) used to produce infant and toddler formula was higher than that in the actual formula (24.2 pg/g dw), and the PCN profiles also varied between the raw milk and formula. A risk assessment indicated that, in China, consuming formula poses a lower risk to infants and toddlers from based on exposure to PCNs compared with consuming breast milk.

Spatial and temporal trends of polychlorinated naphthalenes in the Arctic atmosphere at Ny-Ålesund and London Island, Svalbard

Polychlorinated naphthalenes (PCNs) are ubiquitous atmospheric pollutants that can even be found in the most remote region of the Arctic. However, temporal trend analysis and reports on mono- to octa-CN in the Arctic air are still scarce. In the present study, 8 years of atmospheric monitoring data of PCNs on Svalbard was investigated using XAD-2 resin passive air samplers (PASs) from 2011–2019. The concentrations of ∑75 PCNs in the Arctic air ranged from 4.56 to 85.2 pg/m3, with a mean of 23.5 pg/m3. The mono-CNs and di-CNs were the dominant homologue groups accounting for 80 % of the total concentrations. The most abundant congeners were PCN-1, PCN-2, PCN-24/14, PCN-5/7, and PCN-3, respectively. A declining time trend of PCN concentration was observed from 2013 to 2019. The reduction in PCN concentrations is likely due to declining global emissions and banned production. However, no significant spatial difference was observed among the sampling sites. The total PCN toxic equivalency (TEQ) concentrations in the Arctic atmosphere ranged from 0.043 to 1.93 fg TEQ/m3 (mean 0.41 fg TEQ/m3). The fraction of combustion-related congeners to ∑PCNs (tri- to octa-CN) analysis results indicated that the sources of PCNs in the Arctic air were contributed mainly from reemissions of historical Halowax mixtures and combustion-related sources. To the best of our knowledge, this is the first research to report all 75 PCN congeners and homologue groups in Arctic air. Therefore, this study provides data on recent temporal trend analysis as well as all the 75 PCN congeners in the Arctic atmosphere.

Distributions of polychlorinated naphthalenes in beef from China and associated health risks

Polychlorinated naphthalenes (PCNs) are toxic and can accumulate through the food chain. PCNs have been detected in different categories of foods. Intake of animal-derived foods is an important pathway for human exposure to PCNs. However, information on PCNs in meat from farmed animals is scarce. In this study, PCNs were assessed in beef sourced from local markets in Beijing and six provinces in China. The mean PCN concentrations in beef samples from the seven regions varied from 41.2 to 88.7 pg/g wet weight (ww). The homologue profiles of PCNs in the specimens were similar, with tri- and di-CNs being dominant. The mean concentration of PCNs in the flank (74.7 pg/g ww) was higher than that in the round (58.2 pg/g ww) or shank (53.6 pg/g ww), likely because the former contained a higher proportion of lipids than the latter. Significantly different PCN distributions in beef and dairy cow milk were identified using machine learning. The toxic equivalencies (TEQs) of PCNs in all beef samples ranged from 0.0003 to 0.022 pg TEQ/g ww. PCNs contributed to approximately 4.6% of the total TEQ values of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, polychlorinated biphenyls, and PCNs in the beef. Health risks related to the intake of PCNs through beef consumption by the average person living in China were minimal.

PCNs, PCBs, and PCDD/Fs in Soil around a Cement Kiln Co-Processing Municipal Wastes in Northwestern China: Levels, Distribution, and Potential Human Health Risks.

To evaluate the impact of the first cement kiln co-processing municipal wastes in northwest China on the surrounding environment, the concentrations of polychlorinated naphthalenes (PCNs), polychlorinated biphenyls (PCBs), and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) were determined in 17 soil samples collected around the plant. The concentration ranges of PCNs, PCBs, and PCDD/Fs were 132–1288, 10.8–59.5, and 2.50–5.95 pg/g, and the ranges of toxic equivalents (TEQ) were 1.98–20.8, 2.36–48.0, and 73.2–418 fg/g, respectively. The concentrations of PCNs, PCBs, and PCDD/Fs in this study were generally lower than those in soil around municipal waste incinerators and industrial parks in other areas. An exponential function equation was applied for the relationship between the concentration of the target compounds and the distance from the cement kiln stack, the results showed that PCN and PCB concentrations declined with the increasing of distance from the stack. Furthermore, it was found that the effect of the cement kiln on surrounding soil contaminations with PCNs and PCBs was stronger than that of PCDD/Fs by comparing the PCN, PCB, and PCDD/F homologue profiles in the fly ash sample from the plant and soil samples at different distances. The total carcinogenic risks (CR) of PCNs, PCBs, and PCDD/Fs for children and adults in soil were 1.65 × 10−8–8.93 × 10−8 and 1.70 × 10−8–9.16 × 10−8, respectively, which was less than the risk threshold (CR = 1 × 10−6), and there was no health risk.

Spatial and temporal trends in polychlorinated naphthalenes in sediment from Ulsan and Onsan Bays of Korea: Potential sources and ecotoxicological concerns.

Few studies have been conducted on spatial and temporal trends in polychlorinated naphthalenes (PCNs) in coastal environments. Here, we describe 18 PCN congeners found in surface and dated sediment samples collected from highly industrialized bays of Korea. Measurable levels of PCN congeners were detected in all sediment samples, suggesting concurrent and historical contamination. The highest PCN concentrations were observed in sediment from rivers, streams, and the inner portions of the bays, which are surrounded by industrial complexes and commercial harbors. CNs 73, 66/67, and 52 were dominant in surface and dated sediment samples. Congener patterns and diagnostic ratios revealed that PCN contamination is originated from combustion processes and the use of polychlorinated biphenyl (PCB) technical mixtures. PCN concentrations in dated sediment increased from the 1980s to the mid-2000s and then decreased to 2015. Although the toxic equivalent (TEQ) levels of PCNs in our study did not exceed sediment quality guidelines proposed by international authorities, the cumulative risks from the TEQ concentrations of polychlorinated dibenzo-p-dioxins, furans, PCBs, and PCNs can be expected for benthic organisms.

Occurrence of polychlorinated naphthalenes in dairy cow farms in proximity to an iron smelting plant in China: A preliminary study

Animal derived foods are the primary pathway for human exposure to polychlorinated naphthalenes (PCNs), and various foodstuffs have been reported to contain PCNs. However, information on how PCN emission sources affect surrounding animal farms is scarce. The present study determined PCN levels in cow's milk, excrement, feed, plant and soil samples collected from four dairy farms situated within 10 km of an iron smelting plant in China. PCN concentrations in the milk samples from all four farms were in the range from 470 to 797 pg/g lipid weight while the PCN concentrations in the other specimens decreased in the order: plant > soil > excrement > feed. Higher PCN concentrations appeared in silage than in other feedstuffs, and the relationships between PCNs in milk, excrement and feed were closer than those in plant and soil. Human exposure risk to PCNs by consuming milk from this region was relatively higher than in less polluted areas.

Pilot study on the effect of secondary copper smelters on polychlorinated naphthalene contamination in surrounding agricultural areas

Polychlorinated naphthalenes (PCNs) are dioxin-like persistent organic pollutants that are primarily produced unintentionally during industrial thermal processes. These compounds are harmful to the environment and human health. This study investigated the occurrences of all 75 PCN congeners in agricultural areas near secondary copper smelters in China. The PCN concentrations in aquatic foods, eggs, crops, sediments and soils within 10 km of these smelters were higher than those in samples collected 20–30 km away from such facilities. In contrast, the PCN concentrations in compound animal feed samples collected at different distances from the secondary copper smelters were comparable to one another. Similar PCN homologue patterns were found in crop, egg, feed and soil samples collected at different distances from the smelters but the homologue profiles of PCNs in aquatic food and sediment samples collected from different distances varied. Lower chlorinated naphthalenes were the predominant homologues in most samples. The contamination of farm animals and crops with PCNs might result from the emission of these compounds from such sources into the surrounding environment. However, the health risks associated with human exposure to PCNs through food consumption are low for both distances (<10 km and 20–30 km) from secondary copper smelters.

Polychlorinated naphthalenes (PCNs) in soils and plants from Svalbard, Arctic: Levels, distribution, and potential sources

As persistent organic pollutants (POPs) newly banned by the Stockholm Convention, polychlorinated naphthalenes (PCNs) have been widely detected in various environmental matrices. To date, however, the occurrence of PCNs in soils and plants in the Arctic environment has not been reported. In the current study, the concentrations and distribution of PCNs in Arctic soils and plants from Svalbard were analyzed. Total PCN concentrations ranged from 5.3 to 2550 pg/g dry weight (dw) in soils and 77 to 870 pg/g dw in plants. The higher levels of PCNs near the research stations and Longyearbyen town highlighted the significant influence of local anthropogenic emission sources. The composition of PCNs in Arctic soils and plants was dominated by lower chlorinated homologues, especially mono- to trichlorinated naphthalenes, which accounted for over 80 % of total PCNs in the soil and plant samples. The correlation analysis indicated the potential influences of total organic carbon (TOC) content on PCN concentrations in the soil, and octanol-air partition coefficients (KOA) or octanol-water partition coefficients (KOW) on PCN accumulation from soils to plants. To the best of our knowledge, this is the first study to report on the concentration and distribution of PCNs in Arctic soils and plants.

Contamination and sources of polychlorinated naphthalenes in the surface sediments of Chaobai River, China

In aquatic systems, sediment is both a sink for persistent organic pollutants (POPs) and a potential source of POPs release. Consequently, it is important to understand the pollution characteristics and sources of polychlorinated naphthalenes (PCNs) as POPs of Stockholm Convention in sediment for control of the ecological risk. Atmospheric deposition is a potential source of PCNs in sediment. However, there is no clear report on the contribution of atmospheric deposition to PCNs in sediments. In this study, the Chaobai River in China was selected because it is an important drinking water source that is not affected by wastewater discharge. Surface sediments from the river were analyzed for 75 PCN congeners by using high resolution gas chromatography combined with high resolution mass spectrometry. The total PCNs concentration ranged from 54 to 2266 (mean: 402) pg/g. The toxic equivalent quantity of 19 PCNs in surface sediments was 9.69 × 10−2, and CN73, CN66/CN67, and CN63 had the largest contributions to this value. Dichlorinated and trichlorinated naphthalenes were the dominant homologs. The PCN data from the sediment samples in this study were combined with data for PCNs in ambient air from a literature, which has a good match with this study in both temporal and spatial scales. The contribution of atmospheric deposition to PCNs in the surface sediment was evaluated by comparing congener characteristics and correlation analysis. Our study indicated atmospheric transportation and deposition are important pathways for transport of PCNs into surface sediments.

Concentration and risk assessment of PCNs in green tea in different locations in China

Polychlorinated naphthalenes (PCNs) were added to the Stockholm Convention list of persistent organic pollutants in 2015. PCNs are mainly unintentionally produced during industrial processes nowadays, and can be widely found in environmental media and foodstuffs. Dietary intake is the primary pathway for human exposure to PCNs. PCNs in different categories of foodstuffs have been reported. However, little information on PCN concentrations in green tea, a popular beverage worldwide is available. In this study, all 75 PCN congener concentrations and distributions in green tea samples (n = 102) from 11 regions in China were determined, and risk assessment of human exposure to PCNs through tea consumption was conducted. The PCN concentrations in all the green tea samples were 3.62–175 pg/g dry weight (mean 36.1 pg/g dry weight). Similar PCN homolog and congener profiles were found in green tea samples from different areas. The dominant PCN homologs in all of the green tea samples were di-CNs, tetra-CNs, and tri-CNs. No direct relationships were found between PCN emission sources and PCN concentrations in the green tea samples. The brewing technique could affect the PCN concentrations and homolog profiles in tea leaves. PCNs in green tea from China were found to pose little risk to humans.

Determination of polychlorinated naphthalenes in ambient air by isotope dilution gas chromatography-triple quadrupole mass spectrometry

环境空气中的多氯萘(PCNs)一般为痕量水平(pg/m3),要实现其准确定量必然对分析方法的提取、净化和仪器分析提出较高要求。研究通过考察提取溶剂种类、净化流程和色谱-质谱参数,建立了加速溶剂萃取(ASE)-多层硅胶复合中性氧化铝柱的净化方法,并利用同位素稀释气相色谱-三重四极杆质谱(GC-MS/MS)对环境空气中的多氯萘进行测定。同时,通过在采样、提取和进样分析前分别添加同位素内标,开展质量控制和保证。结果表明,在2~100 ng/mL范围内3~8氯萘的平均相对响应因子(RRF)的相对标准偏差(RSD)均小于16%。PCNs同类物的方法检出限为1~3 pg/m3(以样品体积为288 m3计算)。采用基质加标法评价了方法对环境空气样品中PCNs测定的精密度和准确度,低、中、高加标水平下3 ~8氯萘的平均加标回收率分别为89.0%~119.4%、98.6%~122.5%和93.7%~124.5%,测定结果的平均相对标准偏差分别为1.9%~7.0%、1.6%~6.6%和1.0%~4.8%。整个分析过程中,采样内标和提取内标的平均回收率分别为136.2%~146.0%和42.4%~78.1%, RSD分别为5.6%~7.5%和2.7%~17.5%,满足痕量分析的要求且平行性较好。方法的灵敏度和准确度高,精密度良好,适用于环境空气中3~8氯萘的准确定量测定,可在一定程度上缓解多氯萘监测对高分辨气相色谱-高分辨质谱的依赖,为实现多氯萘的国际履约提供方法支持。

Occurrence and source analysis of polychlorinated naphthalenes in raw cow milk

The potential contamination of food items with polychlorinated naphthalenes (PCNs) has attracted increasing attention because of their toxicity, persistence and bioaccumulative characteristics. Humans are exposed to PCNs primarily through consuming animal-derived foodstuffs. However, the pathways by which PCNs can enter the food supplying chain are poorly understood. In this study, Σ75PCNs were determined in raw cow milk (n = 82) collected from three different regions that varied in the intensity of PCNs emission sources in North China, using high-resolution gas chromatography/high-resolution mass spectrometry method. Higher PCN concentrations (214–2050 pg/g lw) were found in raw cow milk from dairy cow farms located in the region with relatively higher intensity of emission sources. Less chlorinated congeners were dominant in all raw cow milk samples. PCNs in cow milk might result from industrial fly ash emissions that contaminate animal feed through atmospheric deposition. Risks posed to humans through consuming PCNs in cow milk were low.

Polychlorinated Naphthalene Concentrations in Green Tea from Different Locations in China and Assessment of the Risks Posed

Polychlorinated Naphthalene Concentrations in Green Tea from Different Locations in China and Assessment of the Risks Posed

Polychlorinated Naphthalene Concentrations in Green Tea from Different Locations in China and Assessment of the Risks Posed

Polychlorinated Naphthalene Concentrations in Green Tea from Different Locations in China and Assessment of the Risks Posed

Polychlorinated naphthalenes in farmed Chinese mitten crabs in China: Concentration, distribution and source analysis

Polychlorinated naphthalenes (PCNs) are both highly toxic and bioaccumulative environmental contaminates. Dietary intake is the primary pathway for human exposure to PCNs, and PCN concentrations in aquatic foodstuffs are relatively high. Chinese mitten crab (Eriocheir sinensis) is one kind of popular aquatic foodstuffs in Asian countries. Farmed crabs could exposure to PCNs both through feed and environment. However, information on the occurrence of PCNs in farmed crabs is scarce. The present study investigated 75 PCN congeners in farmed Chinese mitten crabs, crab compound feed and sediments collected from Anhui Province and Shanghai in China. The total PCN concentrations in farmed Chinese mitten crabs from Anhui Province and Shanghai were 11.2–42.2 and 5.46–43.8 pg/g wet weight (ww), respectively. The PCN homologue profiles in crabs from both areas were similar, and both were dominated by di-CNs and penta-CNs. In contrast, lower chlorinated PCNs (di-CNs, tri-CNs and tetra-CNs) were the most common homologues in specimens of crab compound feed and sediment samples, indicating that selective bioaccumulation and metabolism of PCNs might occur in farmed crabs. No regional differences were found in the PCN congener profiles of farmed crabs, feed and sediment samples taken from Anhui Province and Shanghai. An assessment found no significant health risk associated with Chinese exposure to PCNs through farmed Chinese mitten crab consumption.

Distribution of Polychlorinated Naphthalenes in Sediment From Industrialized Coastal Waters of Korea With the Optimized Cleanup and GC-MS/MS Methods

Limited studies have been conducted on polychlorinated naphthalenes (PCNs) in the coastal environment worldwide. In this study, analytical methods were optimized for 18 PCN congeners in sediment using a multi-layer silica gel column and a gas chromatograph coupled to tandem mass spectrometry (GC-MS/MS). The optimized analytical methods of PCNs were employed for sediment samples from heavily industrialized bays of Korea to assess the occurrence, contamination, potential sources, and ecotoxicological concerns. PCNs were detected in all sediment samples, indicating ubiquitous contamination in industrialized coastal regions of Korea. Total concentrations and toxic equivalents (TEQs) of PCNs ranged from 0.99 to 21,500 (mean: 568) pg/g dry weight and from 1.72 × 10–5 to 18.8 (mean: 0.52) pg TEQ/g dry weight, respectively, which were within the ranges reported by other studies. A clear decreasing gradient was observed for the sedimentary PCNs from inner to outer parts of the bays, streams, and rivers. This result indicates that industrial activities are primary sources of PCNs. The highest PCN concentrations were observed in sediment close to non-ferrous and petrochemical industries, indicating potential sources. CNs 73 and 52 were predominant congeners of PCNs in all sediment samples. Diagnostic ratios and non-parametric multidimensional scaling analysis showed that the potential primary sources of PCNs are thermal-related emissions and the use of PCB technical mixtures. Although a few sediment samples exceeded the sediment quality guidelines of TEQs, the cumulative risks by dioxin-like contaminants may be caused for almost all coastal zones surveyed. This is the first report on PCNs in sediment from Korean coastal waters.