Rationale. The steady increase in the number of patients with type 2 diabetes mellitus in large industrial cities necessitates the study of the immune response to this disease. The goal is to study the cytokine profile of residents of a large industrial city (using the example of Chelyabinsk) depending on the presence of type 2 diabetes. Methods. The cross-sectional study included 61 people, including 39 people with type 2 diabetes and 22 clinically healthy volunteers. The concentrations of 11 cytokines in blood serum were assessed using the multiplex assessment method: GM-CSF, IFNγ, IL-2, IL-4, IL-5, IL-8, IL-12 (p70), IL-13, IL-17A, MIP- 1β, TNFα (pg/ml). Results. Determination of the concentration of cytokines in the blood serum of patients with type 2 diabetes in Chelyabinsk revealed a number of features consisting in the predominance of pro-inflammatory cytokines and chemokines (IFN-γ, TNF-α, IL-8, MIP-1β, IL-12p70, IL-17A) and a shift in the Th1/Th2 balance towards a pro-inflammatory Th1 phenotype. When conducting a correlation analysis of a group of patients with type 2 diabetes, no statistically significant relationships were identified between the concentration of proinflammatory cytokines and glucose-lowering therapy. Conclusion. The results obtained confirm the presence of inflammation in type 2 diabetes in the population of Chelyabinsk and are not corrected by the glucose-lowering therapy received.