Concentration Of GnPs Research Articles

In vitro and in vivo efficacy of zinc oxide green nanoparticles against multidrug-resistant Salmonella Typhi.

Antibiotic resistance is an increasing threat, requiring novel therapeutic solutions. Metal nanoparticles e.g., zinc oxide nanoparticles (ZnO NPs) exhibited the potential against many bacterial pathogens. Strains of Salmonella enterica serovar Typhi resistant to ceftriaxone were reported first from Pakistan in 2016. Since then, S. Typhi is a pathogen of concern globally owing to its rapidly emerging resistance potential against many last resort antibiotics. In the present study, in vitro and in vivo antimicrobial activity of ZnO NPs against multidrug resistant (MDR) and extensively drug resistant (XDR) Salmonella Typhi strains from Pakistan was evaluated. Zinc oxide green nanoparticles (ZnO GNPs), synthesized from Aloe vera, were characterized by SEM, XRD, UV-vis and Raman spectroscopy. In vitro antibacterial activity of two different concentrations of ZnO GNPs (7 and 15%) was checked using agar well diffusion method. Further, broth microdilution and time kill assays were performed using the ZnO GNPs. In vivo assays were conducted in BALB/c mice sepsis models. In all the three methods, agar well diffusion assay broth microdilution and time kill assay, different zinc oxide dihydrate precursor concentrations had shown the antibacterial activity. The minimum inhibitory concentration (MIC) of ZnO GNPs nanoparticles against MDR and XDR S. Typhi strains was found as 16 to 64µg/ml. In vivo experiment has shown a significant decrease in CFU/ml in the mice treated with ZnO GNPs as compared to the control group. Our findings have revealed that ZnO GNPs have significant antibacterial activity against MDR and XDR S. Typhi, both in vitro and in vivo.

Influence of curing time on some properties of GNPs/PDMS nanocomposites

Graphene nanoplatelets/polydimethylsiloxane (GNPs/PDMS) nanocomposites foils are obtained by dispersing nanoplatelets of graphene (GNPs) into polydimethylsiloxane (PDMS) at a given GNPs concentration but at different curing times to study the effects of curing time on some their bulk and surface properties. Their appearance and morphology have been examined by optical and scanning electron microscopies, their wettability and roughness by the sessile drop method and profilometry, their bonds by µRaman and ATR-FTIR spectroscopies, their dielectric response by dielectric spectroscopy. In particular, optical and SEM images and roughness measurements indicate a roughened and hydrophobic surface at the shortest curing time that becomes less roughened, more uniform and less hydrophobic as curing time increases. ATR-FTIR and µRaman spectra reveal the absence of chemical interaction between GNPs and PDMS. The behavior of the PDMS real and imaginary parts of dielectric permittivity without and with GNPs and at increasing curing times seems to define the obtained GNPs/PDMS nanocomposites as low-loss materials. The obtained results show that the curing time significantly affects the filler distribution in the PDMS matrix and consequently the properties of the final nanocomposites.

Enhancing Power Generation in Triboelectric Nanogenerators via Integration of Graphene Nanoplatelets and Polyvinyl Alcohol

Triboelectric nanogenerators (TENGs) provide promising power supply solutions by transforming mechanical energy into electrical energy. However, enhancing electrical performance of TENGs is essential for their widespread practical applications and commercialization. In this study, we fabricated TENGs in vertical contact‐separation mode using a tribopositive material—polyvinyl alcohol (PVA) slime—which is biocompatible, flexible, and wearable, decorated with graphene nanoplatelets (GnPs), and paired with tribonegative silicone. We analyzed the correlation between the electrical performance of the TENGs and the inherent triboelectric properties of the constituent material, including the evaluation of surface roughness, the measurement of the contact potential difference (CPD), and the material’s dielectric constant. The incorporation of GnPs increased the dielectric constant of the composite material and its electron‐donating tendency, thus, increasing the contact potential difference. The GnPs concentration of 1 wt% was identified as the optimal value, resulting in a 42% increase in power density. The 1 wt% GnPs@PVA&Silicone TENG exhibited an open‐circuit voltage of 718 V and a peak power density of 15.3 W/m2. This study sheds light on enhancing the energy harvesting efficiency of TENGs through the utilization of biocompatible tribopositive and tribonegative materials.

Graphene nanoplatelets/Li-Mg-Sm spinel ferrite nanocomposites with improved dielectric and magnetic properties

This study aims to present Li0.2Mg0.6Sm0.03Fe2.17O4/Graphene nanoplatelets [LMSF/GNPs] composites prepared via SGAC route. X-ray diffraction study vindicated the pure spinel matrix and found that crystallite size (D) showed decreasing behavior with the substitution of GNPs in the LMSF lattice. Raman analysis was employed to study the molecular vibrational bands and, also verified the spinel structure along with the presence of GNPs. The dielectric constant was exponentially decreased up to 100 kHz frequency and then obtained constant behavior. However, the minimum dielectric tangent loss was also reduced with increasing frequency. The magnetic properties showed that saturation magnetization was reduced from 89.74 to 49.96 emu/g by an increasing GNPs concentration and the microwave operating frequency revealed a similar trend as saturation magnetization. Hence, based on LMSF/GNPs composites dielectric and magnetic behavior, LMSF/GNP composites are promising materials in applications related to high frequency and recording and storing media devices.

New discovery on the role of graphene nanoplates in enhancing the structural and electrical properties of carbon nanofibers

In this study, carbon nanofibers (CNFs) were successfully manufactured from special polyacrylonitrile (SPAN) copolymer/graphene nanoplates (GNPs) via an electrospinning process after that stabilization and carbonization approaches. The carbonization stage for stabilized SPAN/GNPs nanofibers was applied by heating the samples to 900 °C under an N2 inert atmosphere. The relationship of the GNPs concentration with morphological and structural properties of SPAN/GNPs composite nanofibers has been examined. The fineness and crystallinity of composite nanofiber increase with increasing concentration of GNPs from 0 to 4 wt%. With increasing the GNPs concentration in the SPAN/GNPs solutions from 0 to 4 wt%, the average diameter of nanofibers decreased from 480 ± 78 nm to 174 ± 18 nm. All CNFs samples synthesized at 900 °C have acceptable morphological, structural, and electrical properties. Moreover, the microstructure of the SCNFs can be controlled with GNPs concentration in composite nanofibers. The electrical conductivity of CNFs attained from neat nanofibers is 0.25 × 10+4 S/m, which is increased to 1.37 × 10+4 S/m with 4 wt% GNPs. Therefore, the unique 2D structure of GNPs is very suitable for the development of low-cost and conductive CNFs with low temperatures of carbonization.

Optical properties and zeta potential of polyvinyl pyrrolidone capped gold nanoparticles dispersed nematic liquid crystal mixture E7

The effect of dispersion of polyvinyl pyrrolidone (PVP) capped gold nanoparticles in nematic mixture E7 on the optical properties (absorbance and photoluminescence, fluorescence life time and Raman imaging) and zeta potential is studied. The gold nanoparticles of 0.25, 0.5 and 1.0 wt% concentrations are dispersed into E7. It has been found that the absorbance and photoluminescence intensity of dispersed systems are increased and depend on the GNPs concentration. These increase correspond to the coupling between the radiation field (electromagnetic waves of the light source) and the GNPs low-energy phonons and constructive coupling of emissions between the E7 and GNPs, respectively. The change in the fluorescence lifetime of pristine and GNPs dispersed E7 systems has confirmed the energy transfer between E7 and GNPs molecules. The study of Raman spectrum shows the variations in the intensity of the Raman peaks with different orientations. Due to dispersion of GNPs in E7 the values of zeta potential are increased. This ensures the good stability of the dispersed systems. The conductivity of dispersed system has increased drastically. In conclusion, the dispersion of GNPs in host nematic mixture E7 has influenced significantly its properties, thereby making the dispersed material more promising for the potential applications.

Tailoring Multifunctional and Lightweight Hierarchical Hybrid Graphene Nanoplatelet and Glass Fiber Composites

In this work, hybrid polypropylene (PP)-based composites reinforced with graphene nanoplatelets (GnPs) and glass fiber (GF) were fabricated by injection molding to elucidate how the hybrid approach can produce synergistic effects capable of achieving properties and functionalities not possible in biphasic composites. Synergism between the reinforcements translated to improved mechanical performance, which was attributed to the chemically and/or electrostatically assembled hierarchical structure that facilitates load transfer at the interface while simultaneously tailoring the crystalline microstructure of the matrix by inducing transcrystallization and β-crystal formation. It was demonstrated that there exists an optimal concentration of 0.5 wt % GnP, producing the greatest mechanical properties and synergistic effect, corresponding to the highest degree of crystallinity (∼6% greater than Neat PP) and peak formation of β-crystals within the PP matrix. The greatest synergistic effect was found to be ∼52 and ∼39% for the specific tensile strength and flexural strength, respectively. The same optimal concentration of GnPs was found to produce the highest synergistic effect for thermal conductivity of ∼68% due to the volume exclusion effect induced by the GFs combined with the higher crystallinity of the microstructure, promoting the formation of thermally conductive pathways. Ultimately, the mechanisms contributing to the synergistic effect presented in this work can be used to maximize the performance of hybrid composite systems, giving them the potential to be tailored for a variety of high-performance industrial applications to meet the rising demands for ultra-strong, thermally conductive, and lightweight materials.

Discrimination and Quantification of Soil Nanoparticles by Dual-Analyte Single Particle ICP-QMS.

This study presents the new application of dual-analyte single particle inductively coupled plasma quadrupole mass spectrometry (spICP-QMS) to the discrimination and quantification of two typical soil nanoparticles (kaolinite and goethite nanoparticles, abbr. KNPs and GNPs) in three samples (SA, SB, and SC) with three detection events (Al unpaired event, Fe unpaired event, and paired event). SA was mainly composed of KNPs with a concentration of 28 443 ± 817 particle mL-1 and a mean particle size of 140.7 ± 0.2 nm. SB was mainly composed of GNPs with a concentration of 39 283 ± 702 particle mL-1 and a mean particle size of 141.8 ± 2.9. In SC, the concentrations of KNPs and GNPs were 22 4541 ± 1401 and 70 604 ± 1623 particle mL-1, respectively, and the mean particle sizes of KNPs and GNPs were 140.7 ± 0.2 and 60.2 ± 0.3 nm, respectively. The accuracy of dual-analyte spICP-QMS was determined by spiking experiments, comparing these results with the measurements of other techniques, analyzing the samples in different SA and SB proportions and in different SC concentrations. Our results demonstrated that the dual-analyte spICP-QMS is a promising approach to distinguishing different kinds of natural NPs in soils.

Use of ultrasonic dual-mode mixing for graphene infusion to make hybrid GFRPs: Study on mechanical performance

Optimized process parameters of a top–down approach via the ultrasonic dual-mode mixing process are adopted to disperse and exfoliate graphene nanoplatelets uniformly in the epoxy resin and fabricate hybrid GFRP laminates. The in-plane tensile and out-of-plane flexural behavior of the hybrid GFRPs made with different concentration of GNPs have been investigated. The test results show that ∼39.47% and ∼40.87% enhancement in tensile strength and flexural strength has been attained for the hybrid GFRPs made with 1 wt% of GNPs. In addition, the enhancement of ∼117% in absorbed failure energy and ∼28.56% in work of fracture is also achieved. Mori Tanaka Method has been used to calculate the modulus of the GNP-epoxy composite system, and these results are used further to predict the modulus of the hybrid GFRPs. The theoretical moduli so obtained are used to compare the experimental modulus of the hybrid GFRPs as a function of GNP concentration. Fractography examination of the fractured hybrid GFRPs reveals it reduced interlaminar delamination, which is governed by the effective load transferability of GNP-infused epoxy network.

Evaluation of fracture toughness in graphene-based cementitious nanocomposites via electrical impedance

The present work investigates experimentally the improvement of fracture toughness and electrical conductivity in the hardened cementitious matrix after the addition of graphene nanoplatelets (GnPs), at four different concentrations varying between 0.05 wt% and 0.4 wt% per cement. The experimental investigation is conducted through flexural and electrical impedance spectroscopy (EIS) tests on prismatic specimens. The study is oriented towards establishing a correlation between the electrical response of the nanocomposites under alternate current and the exhibited fracture toughness values (KIc). The flexural test results show that the incorporation of the GnPs in the matrix can increase the average KIc values and can decrease the average resistivity (ρ) when compared with the reference matrix. The maximum increase in KIc (+ 29 %), and the decrease in ρ (- 68 %) were found in the mixture with the lowest amount (0.05 wt%) of GnPs. Moreover, the comparison of the ρ values and the KIc values, as a function of the GnPs concentration, reveals a reverse relation between the two parameters (KIc and ρ). The functional correlation between these parameters was also confirmed by linear regression analysis, resulting from the experimental data fitting. The analysis provides evidence that EIS can be used as a non-destructive tool to assess the fracture toughness of cementitious nanocomposites.

Synthesis, Optimization, and Characterization of Ecofriendly Production of Gold Nanoparticles Using Lemon Peel Extract.

This study examines the importance of utilizing green synthesis using lemon peel for gold nanoparticles over other chemicals since it is environmentally friendly, available, and cheap. Several parameters were optimized to ensure the extraction of the GNPs concentration of lemon peels using HAuCl4 and lemon peel extract having a ratio of 2 : 1. For the optimum result, the ratio used was 2 : 1. The gold nanoparticles fabrication happened in 10 minutes. The initial observation was the color change of the solution. The UV-visibility spectroscopic studies are performed to confirm the result. The experiments are done concurrently to ensure the solution is mixed on the proper ratio. The GNP is also characterized by the different techniques in their sizes and electronic transmission microscopy, essential in extracting gold nanoparticles. Other elements of the composition are removed by the EDAX methods, the FTIR method, and the TEM methods, all of which reveal the real reason behind the required extraction capacity. Most gold nanoparticles show a maximum absorption rate at the peak of 535 to 579 nm. The result obtained from the TEM and the SEM analysis revealed that the grain size is analogized to the average size of 6.67 nm. With a simple synthesis of the price, some processes show that the medically available nanoparticles are necessary. The used method in this paper to fabricate GNPs is cheap, easy, fast, and sustainable and it can be done with ease in any laboratory.

Effect of GNPs Concentration on the Pool Boiling Performance of R-134a on Cu-GNPs Nanocomposite Coatings Prepared by a Two-Step Electrodeposition Method

Effect of GNPs Concentration on the Pool Boiling Performance of R-134a on Cu-GNPs Nanocomposite Coatings Prepared by a Two-Step Electrodeposition Method

Preparation and Properties of SBR Composites Containing Graphene Nanoplatelets Modified with Pyridinium Derivative.

The goal of this work was to study the effect of graphene nanoplatelets (GnPs) modified with ionic liquid (IL) on properties of styrene–butadiene rubber (SBR) composites. GnPs were decorated with IL or were modified in bulk directly during rubber mix preparation. The ionic liquid used was 1-butyl-4-methylpyridinium tetrafluoroborate (BMPFB). The textural properties were studied to confirm surface modification of GnPs with BMPFB. In these investigations, the impact of the concentration of GnPs and the effect of the method of GnPs’ modification with IL on elastomers properties are described. Some thermal measurements (e.g., differential scanning calorimetry and thermogravimetry) were conducted to characterize the thermal stability or the vulcanization process of the investigated samples. Complementary experimental techniques were used to investigate the properties of the obtained elastomers, specifically tensile testing, and electrical and barrier property measurements. The deposition of IL on the GnPs’ surface positively influenced the mechanical and barrier properties of elastomers. However, samples containing graphene nanoplatelets modified from solution were characterized by less electrical conductivity. SEM analysis was additionally performed to investigate GnPs’ dispersion within SBR composites.

Graphene nanoplatelet modified basalt/epoxy multi-scale composites with improved tribological performance

The wear performance of non-toxic and respiratory non-hazardous natural fiber reinforced epoxy composites has steadily become an important design parameter due to their increasing applications in self‐lubricating and sliding components in contact with metal counterparts. Epoxy matrix has weak wear resistance, and reinforcing the matrix with nano-sized particles has been shown to improve the tribological performance of the resulting multi-scale composites. For this, the epoxy matrix was reinforced with various concentrations of GNPs, and the BF/EP composites were fabricated via the vacuum bagging method, subsequently. The tensile strength and modulus were enhanced up to 42.5 and 74.5% compared to the bare BF/EP laminates, respectively. Moreover, the ball-on-disk wear tests revealed that GNP reinforcement was reasonably effective in reducing the coefficient of friction (23%) in contact areas. As a result, GNP reinforced BF/EP composites exhibited 60% higher wear resistance. In addition to well-known solid lubricant characteristics of GNPs, thermal camera recordings were identified that the improved thermal conductivity in all directions was also responsible for the enhanced tribological performance. The microscopic studies identified the related micro-scale mechanisms responsible for the improved tribological performance of the multi-scale composites. We proposed a unique wear mechanism to represent the tribological behavior of the GNP reinforced BF/EP composites based on electron microscopy and thermal camera recordings.

Elucidating the fate of nanoparticles among key cell components of the tumor microenvironment for promoting cancer nanotechnology

Successful integration of nanotechnology into the current paradigm of cancer therapy requires proper understanding of the interface between nanoparticles (NPs) and cancer cells, as well as other key components within the tumor microenvironment (TME), such as normal fibroblasts (FBs) and cancer-associated FBs (CAFs). So far, much focus has been on cancer cells, but FBs and CAFs also play a critical role: FBs suppress the tumor growth while CAFs promote it. It is not yet known how NPs interact with FBs and CAFs compared to cancer cells. Hence, our goal was to elucidate the extent of NP uptake, retention, and toxicity in cancer cells, FBs, and CAFs to further understand the fate of NPs in a real tumor-like environment. The outcome of this would guide designing of NP-based delivery systems to fully exploit the TME for a better therapeutic outcome. We used gold nanoparticles as our model NP system due to their numerous applications in cancer therapy, including radiotherapy and chemotherapy. A cervical cancer cell line, HeLa, and a triple-negative breast cancer cell line, MDA-MB-231 were chosen as cancer cell lines. For this study, a clinically feasible 0.2 nM concentration of GNPs was employed. According to our results, the cancer cells and CAFs had over 25- and 10-fold higher NP uptake per unit cell volume compared to FBs, respectively. Further, the cancer cells and CAFs had over 30% higher NP retention compared to FBs. There was no observed significant toxicity due to GNPs in all the cell lines studied. Higher uptake and retention of NPs in cancer cells and CAFs vs FBs is very important in promoting NP-based applications in cancer therapy. Our results show potential in modulating uptake and retention of GNPs among key components of TME, in an effort to develop NP-based strategies to suppress the tumor growth. An ideal NP-based platform would eradicate tumor cells, protect FBs, and deactivate CAFs. Therefore, this study lays a road map to exploit the TME for the advancement of “smart” nanomedicines that would constitute the next generation of cancer therapeutics.

Effect of graphene nanoplatelets concentration on optical, dielectric and electrical properties of poly(2-ethyl-2-oxazoline)–polyvinylpyrrolidone–graphene nanocomposites

The polymer nanocomposites with good optical, dielectric and electrical properties have taken faithfulness in research due to their distinguishing benefits in electronic applications. Hence, in the present investigation, poly(2-ethyl-2-oxazoline)–polyvinylpyrrolidone–graphene nanoplatelets (PEOX–PVP–GNPs) nanocomposites were synthesized and their properties were evaluated. Field emission scanning electron microscopy micrograph images showed a uniform dispersion of GNPs within the PEOX–PVP binary matrix. X-ray diffraction analysis illustrated the increase of crystallinity of nanocomposites with increasing weight percentage of GNPs. Fourier-transform infrared spectroscopy confirmed intermolecular interaction between the PEOX–PVP matrix and the GNPs. PEOX–PVP–graphene nanocomposite shows decrease in the optical energy band gap and increase in Urbach energy with increasing GNPs concentration. PEOX–PVP–10 wt% graphene nanocomposite has the lowest band gap (= 1.2 eV) and highest Urbach energy (= 7.43 eV). Dielectric constant, dielectric loss and tangent loss of nanocomposites decrease with increasing frequency of the applied electric field. On the other hand, the AC electrical conductivity of nanocomposites is independent of frequency, at lower frequencies, and increases with increasing frequency, at higher frequencies. PEOX–PVP–10 wt% graphene nanocomposite has the higher dielectric constant (= 16), low dielectric loss (= 0.09) and low AC conductivity (= 8.47 × 10−9 S/cm) at 1 kHz. This nanocomposite having good dielectric, electrical and optical properties may find use in electronic and optoelectronic applications due to its enhanced properties.

Study of transport and elastic properties of YBCO superconductor by inclusion of GnPs

The variation in superconducting and elastic parameters of YBa2Cu3O7-δ (YBCO) superconductor due to addition of Graphene nanoplatelets (GnPs) was examined. All the composite samples (1-x) YBCO + x GnPs (x = 0.1, 0.3, 0.5, 0.7 and 0.9%) were synthesized by conventional solid state reaction route. The structural and morphological characterizations of composite samples were investigated through the X-ray diffraction and FESEM analysis respectively. An improvement of superconducting transition temperature (TC) was observed with an increasing wt.% of GnPs concentration. Similarly, the critical current density (JC) was found to be increased and optimum value is found to be 892.48 A/cm2 for 0.7 wt.% GnPs added to the sample at 77 K. This may be attributed to the enhancement of superconducting volume fraction and reduction of porosity of the material under the addition of GnPs. Furthermore, to investigate the elastic parameters of the samples Vickers microhardness and Ultrasonic pulse-echo technique were utilized.

Facilitating supercritical CO2 assisted exfoliation of graphene nanoplatelets with the polymer matrix

The currently mass-produced graphene materials are typically graphene nanoplatelets (GnPs) with multiple-layer structures the properties of which are not comparable to those of mono-layer or few-layer graphene. In this work, high concentrations of commercial GnPs (15 wt% with potential to be higher) were effectively exfoliated in polypropylene (PP)/GnP nanocomposites using supercritical CO2 (sc-CO2) in a foaming process. It was shown that the exfoliation of GnPs was increased with an increased expansion ratio in the foaming window of PP/GnP (159–163 °C). However, a high degree of GnP exfoliation can be maintained at elevated temperatures (e.g., 200 °C) with minimized expansion ratios (<1.3), indicating gas expansion inside GnPs is the main mechanism for graphene delamination during foaming. The electrical conductivity of the solid PP/15 wt%-GnP was increased by almost 5 orders of magnitude after sc-CO2 treatment. The foaming pressure was shown to have a critical influence on GnP exfoliation, and the pressure threshold to delaminate graphene layers was significantly reduced in the presence of PP matrix, as compared to GnP powder. The results were attributed to PP chain penetration into GnP under sc-CO2, and the prevention of rapid loss of intercalating CO2 by the PP molecules surrounding the GnPs during the pressure release step. This study opens up a new potential avenue for developing highly exfoliated and versatile polymer/graphene solid nanocomposites using supercritical fluid treatment.

Optical Properties of Liquid Crystalline Alkoxy Benzoic Acids with Dispersed Citrate-Capped Gold Nanoparticles

Abstract Citrate-capped gold nanoparticles (Gnps) have multiple applications in all optical devices and influence the properties of birefringence in liquid crystalline (LC) molecules. In the present paper, systematic studies have been carried out on LC compounds p-n-undecyloxy benzoic acid (11oba) and p-n-dodecyloxy benzoic acid (12oba) with dispersed citrate-capped Gnps in different low molar concentrations. The phase transition temperatures of the LC nanocomposites obtained from polarizing thermal microscopy (POM), differential scanning calorimetry (DSC) and modified spectrometry are found to be reduced with the increase in concentration of dispersed citrate-capped Gnps. The information was obtained from textural data utilizing the simple technique gradient measurement of standard deviation (GMSD) using the MATLAB tool, which is analogous to DSC. Further, the existence of citrate-capped Gnps in 11oba and 12oba was determined by spectroscopic techniques like ultraviolet-visible spectrometry and scanning electron microscopy. The birefringence measurements were carried out at different wavelengths (460, 500, 570 and 635 nm) using a wedge-shaped cell with a modified spectrometer. The birefringence (δ n) increases with increase in weight concentration of citrate-capped Gnps in the nematic thermal range. Further, the order parameter S values obtained from the Kuczynski internal field model, the Vuks model, the Haller extrapolation model and the effective geometry parameter methods are in good agreement. It is found that the order parameter S increases with increase in dispersion of concentration of citrate-capped Gnps. This is due to strong Van der Waal’s interaction between the LC molecules and citrate-capped Gnps, which increases the alignment of the LC molecules.

Assessment of Enhanced Thermal Effect Due to Gold Nanoparticles during MR-Guided High-Intensity Focused Ultrasound (HIFU) Procedures Using a Mouse-Tumor Model.

An in vivo study was conducted using a mouse tumor model, to assess the utility of using gold nanoparticles (gNPs) during HIFU procedures to locally enhance heating at low powers. Tumors were grown using melanoma tumor cells (B16/F10) subcutaneously on the right flanks of mice (C57Bl/6J). Physiologically relevant concentrations (0 and 0.125%) of gNPs were directly injected into the tumors. Sonications at acoustic powers of 10 and 30 W were performed for a duration of 16 s inside a magnetic-resonance system. Temperature increases and lesion volumes were calculated and compared for procedures with and without gNPs. Histopathology study was conducted using a cleaved caspase 3 antibody and hematoxylin and eosin staining after removing the tumors from the mice. For an acoustic power of 30 W, end-of-sonication temperature increases of 25.4 ± 3.8 °C (0% gNP) and 42.2 ± 4.6 °C (0.125% gNP) were measured. Using cleaved caspase 3 antibody, it was observed that more than 1% of nuclei are affected in the case of 0.125% and 30 W but only 0.01% of nuclei are affected in the 0% case. For 30 W and a gNP concentration of 0.125%, a lesion volume of 0.33 ± 0.22 mm3 was obtained, while no lesion was observed without gNP's.