Iodine Concentration Levels Research Articles

Bridging the Knowledge Gap: Discerning the Association between Adequately Iodized Salt Coverage and Household Knowledge, Attitudes and Practices in Madagascar

Background: Iodine deficiency disorders are one of Madagascar's public health issues regarding the low level of iodine concentration in the population as assessed in 2015. Since then, the national salt iodization program has been revitalized. Therefore, this study aimed to estimate the coverage of households' adequately iodized salt in Madagascar and assess their level of Knowledge, Attitudes, and Practices regarding iodized salt use and associated factors. Materials and Methods: A cross-sectional population-based study using a multistage random sampling was conducted in 2020 in 4410 households in Madagascar. After informed consent, a pre-tested questionnaire on iodized salt was administered to the households, followed by a table, or cooking salt sample collected for iodine content testing using the iodometric titration technique. In addition, bivariate and multivariate analyses were conducted at 95% confidence level to identify associated factors. Results: The study results estimated the coverage of adequately iodized salt (15-60 ppm) nationwide at 41.1% (CI95%: 39.7%-42.2%) with significant differences between provinces. In addition, 36.8% of women had a “good” knowledge, 45.0% “good” practice of iodized salt, and 24.4% had a “positive” attitude towards iodized salt. Finally, the study identified the following associated factors to adequately iodized salt: attitude or perception towards iodized salt, household size, residence, economic status, and education level. Conclusion: Household coverage of adequately iodized salt has improved since 2015 but remains below WHO recommendations. Thus, the Ministry of Health and its partners could reinforce nutrition education efforts on household attitudes toward iodized salt and other associated factors to maintain coverage progress. Keywords: Coverage, iodine deficiency disorders, iodized salt, supplementation.

Iodine concentration level, availability of adequately iodised salt and proper utilisation, and its influencing factors among households in Eastern Ethiopia: a community-based cross-sectional study

ObjectiveThe availability of iodine concentration in iodised salt at the household level does not guarantee the prevention of iodine deficiency disorders, but it can be significantly assured through proper utilisation....

Application of dual-source computed tomography in the diagnosis of thyroid cancer and evaluation of biological behaviors.

Thyroid cancer (TC) is an extremely prevailing malignant endocrine tumor. Therefore, effective diagnostic tools are necessary. This study explored the application value of dual-source computed tomography (DSCT) in TC diagnosis and biological behavior assessment. This study retrospectively selected 68 TC patients and another 74 benign patients with thyroid adenoma, nodular goiter, or adenomatous hyperplasia. All patients were confirmed by pathological examination and underwent DSCT examination. The iodine concentration (IC) obtained from plain computed tomography (CT) scanning and normalized iodine concentration (NIC) in the arterial phase and venous phase were recorded. The positive expression rates of estrogen receptor alpha (ERα), estrogen receptors beta (ERβ), and Ki67 in pathological tissues were determined by immunohistochemistry, and their correlation with IC in plain CT was assessed by Pearson correlation analysis, respectively. The diagnostic values of IC in plain CT and venous phase NIC in TC patients were evaluated using the receiver operating characteristic curve. Malignant patients had lower IC in plain DSCT scanning, venous phase NIC, and ERβ, and higher ERα and Ki67 than benign patients. IC level in plain DSCT scanning was inversely-correlated with ERα and Ki-67 positive expression rates, but positively-related to ERβ to different degrees. For the diagnosis of TC patients, the AUC of IC level in plain DSCT was 0.771, with a cut-off value of 1.250 (97.06% sensitivity and 41.89% specificity), and the AUC of venous phase NIC was 0.738, with a cut-off value of 0.825 (100% sensitivity and 43.24% specificity). The IC level obtained from DSCT scanning could assist in the differential diagnosis of malignant and benign thyroid nodules and evaluation of biological behaviors.

Reference intervals of thyroidstimulating hormone in pregnant women living in the central regions of the Russian Federation

Pregnancy is a condition with important structural and physiological changes in the thyroid gland. In this regard, experts of thyroid associations have recommended developing specific reference intervals taking into account the natural and socio-geographical characteristics of the region under study. To conduct an epidemiological analysis and evaluate TSH reference intervals in pregnant women living in the central regions of the Russian Federation with mild iodine deficiency. We have conducted the observational multicenter cross-sectional study included 2008 healthy pregnant women at different trimesters of pregnancy, from three regions of the Russian Federation (Moscow, Ivanovo and Smolensk). We assessed the level of thyroid-stimulating hormone, antibodies to thyroid peroxidase, antibodies to serum thyroglobulin, the level of iodine concentration in the morning portion of urine (cerium arsenic method) and we have conducted a questionnaire (date birth and gestational age). Women with elevated titers of anti-TPO and/or anti-TG antibodies were excluded from the study (245 women). As a result, we assessed high and medium levels of TSH and its overestimation with iodine sufficiency in pregnant women. The results are presented using the calculation of 2.5 and 97.5 percentiles. We confirmed the presence of iodine deficiency in the study areas. The median concentration of iodine in the urine was: in Moscow 106 μg/l, in Ivanovo 119 μg/l, in Smolensk 134 μg/l. Pregnant women were divided into 2 groups according to iodine adequacy. In the group with optimal iodine supply, the level of TSH was 0,006-3,36 in the 1st trimester, 0,20-3,74 in the 2nd trimester, and 0,33-3,68 mIU/L in the 3rd trimester. In the group with mild iodine deficiency - in the 1st trimester it was 0,11-3,00, in the 2nd trimester 0,22-3,78, in the 3rd trimester 0,07-3,04 mIU/l. Statistical analysis of the data revealed that when comparing the level of TSH by trimester, depending on the place of residence, no statistical difference was found (p = 0,239). We obtained that the level of TSH in healthy pregnant women living in the central regions of the Russian Federation does not exceed 3.8 mIU/l in all trimesters.

Spatial-Temporal Analysis of Factors Influencing the Median Urine Iodine Concentration of 8-10-year-old Children in Xinjiang, China 25 Years after Implementation of the Salt Iodization Policy.

The iodine status of children has improved and stabilized since China implemented salt iodization measures 25years ago, but routine monitoring of iodine cannot reflect regional factors that influence the iodine level in children. Therefore, we conducted a regional spatial-temporal analysis of children's median urinary iodine concentration (MUIC) and searched for possible factors that might affect children's iodine levels by mining monitoring data. We analyzed data from Xinjiang collected as part of the "Iodine Deficiency Disease National Monitoring Program" from 2017 to 2020. The study population consisted of 76,268 children who participated in the study. We used global autocorrelation analysis to determine whether the MUIC of children was spatially clustered, local autocorrelation analysis to identify specific clustering areas, local cold and hot spot analysis to verify the reliability of the local autocorrelation results, and a spatial lag model to identify factors affecting the children's MUIC. The MUIC values were 217.70, 227.00, 230.67, and 230.67µg/L in 2017, 2018, 2019, and 2020, respectively. Global autocorrelation analysis showed that the MUIC of all children in the study was significantly related to region (Z scores all > 1.96, P values all < 0.05) from 2017 to 2020. Partial auto-correlation analysis showed that counties with clusters of high values were mostly concentrated in the southwestern region of Xinjiang, whereas counties with clusters of low values were located in the northern part of Xinjiang. Partial cold spot and hot spot analysis showed the same trend, and there are more overlapping districts and counties in 4years. Three-dimensional trend analysis indicated that children from the western part of Xinjiang had high levels of urinary iodine. According to spatial lag model, urine iodine concentration level is positively correlated with thyroid volume, average salary, and urbanization rate classification. The MUIC of 8-10-year-old children in Xinjiang was spatially clustered and related to geographic region. Our results show that spatial analysis of survey data combined with geographic technology and public health data can accurately identify areas with abnormal iodine concentrations in children. Additionally, understanding the factors that influence iodine levels in the human population is conducive to improving monitoring methods.

Iodine concentration level of iodized dietary salt and its associated factors: a systematic review and meta-analysis.

BackgroundIodine deficiency disorder (IDD) is a major public health problem in Ethiopia. The availability of adequate iodized dietary salt at the household level is immensely important. Hence, this review aimed to estimate the pooled prevalence of adequate iodine concentration level of iodized dietary salt at the household level and its associated factors in Ethiopia.MethodsWe searched the literature using electronic databases (PubMed/Medline, Google Scholar, Science Direct, and Embase) and gray literature from January 9, 2022, to February 25, 2022. The rapid test kit was used to measure the adequacy of iodine level of dietary salt. The quality of studies was assessed using Joanna Briggs Institute critical appraisal tool. Heterogeneity between studies was checked using I2 test statistics and publication bias was checked using funnel plot and Egger’s statistical test at a 5% significance level. A random-effects model was employed to estimate the pooled prevalence of the outcome variable and its determinants in Ethiopia.ResultsThe search identified 149 studies of which 18 studies were included with a total of 10,556 participants. The pooled prevalence of adequate iodine levels of iodized salt in Ethiopia was 44.37% (95% CI: 35.85-52.88). Women who had formal education (adjusted odds ratio (AOR) = 1.99 (95% CI: 1.47–2.48)), good knowledge of women (AOR = 2.14, 95% CI: 1.36–3.36), packed iodized salt (AOR = 3.85 (95% CI: 1.88–7.87)) and storage of iodized salt at home for less than 2 months (AOR = 2.66 (95% CI: 2.11–3.35) were the significant factors.ConclusionThis review suggests that the pooled prevalence of adequate iodine levels was low. Our finding highlights the need for considering the educational status, knowledge, and duration of salt storage to enhance the prevalence of adequate levels of iodized salt at the national level.

Wrangle with hypertension: lowered salt intake may not compromise iodine status among tribes of Central India.

The most important risk factor of cardiovascular disease is hypertension and high salt intake contributes to high blood pressure. However, to prevent iodine deficiency disorders, the iodisation of salt is a proven strategy. So, on one hand, we suggest people reduced salt consumption but on the other hand, we also fear an increase in the prevalence of iodine deficiency disorders. In the present study, we investigated the possibility of salt intake at WHO recommended levels resulting in higher or lower iodine status in India by assessing the urinary iodine status and its relation with blood pressure. It was a cross-sectional study. It was a community-based study. We collected 24-hour urine samples for estimation of iodine concentrations in urine from 411 adult hypertensives in the Mandla district of central India. Urinary iodine was estimated using Thermo ORION make ion-selective electrodes. The median urinary iodine excretion was 162·6 mcg/l. Interestingly 371 (90·26 %) subjects were observed with > 200 mcg/l urinary iodine concentration level indicating iodine sufficiency. Individuals with high urine Na significantly had high blood pressure as compared with individuals with low urinary Na excretion (P < 0·01). There is a higher probability of high urine iodine levels among individuals with higher urine Na levels. The study revealed that 90 % of the population were excreting excessive iodine in urine, which is more than adequate iodine uptake. This excess uptake enables a scope for reduction in salt intake to control hypertension.

Salt Iodization and Urinary Iodine Concentration Levels among Primary School Children in Mt. Elgon Sub-County, Kenya

Aims: Iodine plays a key role in thyroid hormone production and functioning. Inadequate iodine intake results in iodine deficiency (ID) which impairs the normal functioning of the thyroid. The deficiency is responsible for damage to brain development, growth retardation, cretinism, and thyroid dysfunction. Millions of people have been condemned to a life of few prospects and continued underdevelopment due to ID. The study was conducted to assess iodine status among primary school children in the Mt. Elgon region and the impact of salt iodization on this status.&#x0D; Study Design: A school-based cross-sectional descriptive study to assess iodine status among primary school children was employed in the study.&#x0D; Study Area and Duration: The study was carried out in Kenya, Bungoma County, Mount Elgon Sub-County. The study period was between 27th November 2018 and 26th November 2019.&#x0D; Methodology: Healthy primary school children aged 6 to 12 years who met the inclusion criteria were included in the study. Spot urine samples were collected in schools, while water samples were collected from different water sources. Salt was collected from households (HH) and at distribution outlets. The Sandell Kolthoff reaction was used to analyse urine and water samples while salt was analysed using iodometric titration.&#x0D; Results: The median urinary iodine concentration (UIC) was 200.7 µg/l. Out of which 0.55% were severely deficient, 5.25% moderately deficient, 18.23% with a mild deficiency, 25.69% had adequate iodine levels, 22.38% had more than adequate, and 27.90% had excess iodine levels. Household and salt samples from different distribution outlets that conformed to set standards of iodization were 49.4% and 63.64%, respectively. Iodine was not detected in all the water samples collected.&#x0D; Conclusion: The study population was found to have adequate iodine based on the median UIC of 200.7 µg/l. However, there was a coexistence of both deficiency and excessive UIC and salt iodization within the population. No iodine was detected in the water samples in the region.

Comparison of Low Dose Performance of Photon-Counting and Energy Integrating CT

The purpose of this study was to investigate the potential of photon-counting CT (PCCT) to improve quantitative image quality for low dose imaging compared to energy-integrating detector CT (EID CT). An investigational scanner (Siemens, Germany) with PCCT and EID CT subsystems was used to compare image quality performance at four dose levels: 1.7, 2, 4, 6 mGy CTDIvol, all at or below current dose values used for conventional abdominal CT. A CT quality control phantom with a homogeneous section for noise measurements and a section with cylindrical inserts of air (-910 HU), polystyrene (50 HU), acrylic (205 HU), and Teflon (1000 HU) was imaged and characterized in terms of noise, resolution, contrast-to-noise ratio (CNR), and detectability index. A second phantom with a 30 cm diameter was also imaged containing iodine solutions ranging from 0.125 to 8 mg I/mL. CNR of the iodine vials was computed as a function of CT dose and iodine concentration. With resolution unaffected by dose in both PCCT and EID CT, PCCT images exhibited 22.1-24.0% improvement in noise across dose levels evaluated. This noise improvement translated into a 29-41% improvement in CNR and 20-36% improvement in detectability index. For iodine contrast, PCCT images had a higher CNR for all combinations of iodine contrast and dose evaluated. For the conditions studied, PCCT exhibited superior image quality compared to EID CT. For iodine detection, PCCT offered a notable advantage with improved CNR at all doses and iodine concentration levels.

Qualitative Determination of Urinary Iodine Concentration and Related Intelligence Quotient among High School Young Teenagers

Nutritional Essential Balance is a common trend in life. Iodine is not produced in the body and it is vital in maintaining good health, therefore it is needed to be consumed regularly. Essential iodine supplies are found in the ocean's bounty such as, sea salt, and fish. On land, iodine levels in the soil are great and are sufficiently maintained by plants such as cereals, vegetables. Several of the body functions rely upon iodine, including energy production, mental development, thyroid hormones production, reproductive glands support, and maintenance of the strong lymphatic system as well as cell growth regulation. Small amounts of iodine are found in the blood, nerves, and other organs of the body, but most of the body's iodine is present in the thyroid, breasts, ovaries, uterus, and prostate glands. The study was aimed to determine and evaluate the level of iodine concentration in the urine of school-age children, and its correlation to their intelligence quotient (IQ). The Titrimetric method was used in iodine urine concentration analysis. Urine (5 ml) was measured from a universal bottle and transferred to a beaker and 20 ml of water was added. After preparing the test mixture, it was titrated with 0.001M sodium thiosulphate using a burette, and at the endpoint colorless solution was obtained, this done for all the samples. From the results, the median urinary iodine levels were 117.7µg/L which is within the adequate iodine intake range (100-199 µg/L). This suggests that iodine was not deficient in any form amongst the school children. There may also be no risk of mental impairment and goiter development among these children if iodine concentration in urine is a risk factor. Therefore, checking the iodine nutrition of a population is vital and a good marker in the assessment of iodine deficiency-related disorders.

Biofortification of green bean (Phaseolus vulgaris L.) and lettuce (Lactuca sativa L.) with iodine in a plant-calcareous sandy soil system irrigated with water containing KI

Uptake and translocation of iodine by green bean (Phaseolus vulgaris L.) and lettuce (Lactuca sativa L.) were investigated in a calcareous sandy soil-plant system. These plants were cultivated in calcareous sandy soil in presence of irrigation water with the iodine concentrations of 0.10, 0.25 and 0.50 mg/L. The growth of these plants was stimulated at the two lower iodine concentrations of 0.10 and 0.25 mg/L, but hampered at 0.50 mg/L. In lettuce the highest iodine dosage resulted in smaller leaf surface and higher number of leaves, nearly with the same biomass production. In the edible parts of green bean and lettuce plants irrigated with 0.25 mg/L iodine containing water, the iodine concentration levels amounted to 0.6 and 5.2 mg/kg dry weight (DW), respectively. In lettuce, the uptake and translocation of selected essential elements (P, Mg, Mn, Fe, Cu, Zn, B) were also stimulated (20-260%) by iodine treatment; however, in fresh bean pods this phenomenon was negligible. Considering the iodine level and moisture content of the fresh lettuce leaves and fresh bean pods, the consumption of 100 g fresh vegetable covers about 66%, 3% of the recommended dietary allowance (150 μg).

A study to assess the prevalence of iodine deficiency disorders in Betul district, Madhya Pradesh, India

Background: Iodine deficiency disorders (IDD) constitute the single largest cause of preventable neurological damage worldwide. Majority of consequences of IDD are invisible and irreversible but at the same time these are preventable. The study was conducted to assess the prevalence of goiter in school children aged 6-12 years, to estimate the urinary iodine excretion and to assess the level of iodine concentration in salt samples obtained from households of selected school children.Methods: Population proportionate to size sampling. Sample size was 90 primary school-going children of age 6-12 years in each selected village, total 2700 from 30 villages/wards in Betul district, Madhya Pradesh, India.Results: The prevalence of goiter among the 6-12 years children was found to be 32.06%. Females had higher prevalence compared to males. Of the 540 salt samples, 370 (68.4%) had iodine concentration ≥15 ppm at household level.Conclusions: IDD is a mild public health problem in Betul district.

Iodine levels in brands of salt on the markets of Accra, Ghana.

The analysis sought to verify the presence or otherwise and the concentration levels of iodine in the claimed iodated salts on the Ghanaian market. Eleven (11) most patronized brands of salts, including both local and foreign brands and the raw-pellet salt (crystallized directly from sea water), were obtained from popular shops and markets in Accra. These were analysed both qualitatively and quantitatively by titrimetry, involving the iodate-iodide reaction in acid medium that generates molecular iodine (IO3 - + I-+ 6H+ → I2 + 3H2O). The iodine content (in ppm) at retail, recorded for the samples are as follows: Sample A (25.4), B (51.8), C (52.9), D (45.5), E (25.4), F (75.1), G (28.6), H (0), I (13.7), J (34.9) and K (16.9). No iodine was observed in the raw-pellet salt (sample H) crystallized directly from sea water, in contrast to the long-held belief that it contains natural iodine. Furthermore, all samples analyzed did not meet the concentration levels indicated on their labels and did not meet the Ghana Standard Authority's standard. Only samples B and C were close to the Ghana Standard Authority's specification. The Ghana Standard Authority's standard of 100ppm at production and 50ppm at retail may be too high or, probably, the salt iodination companies are not adhering to the rules. The authors therefore recommend that the regulatory authorities (The Food and Drugs Authority and The Ghana Standard Authority) regularize their regulatory activities and educate the public appropriately. The study was self-funded by the researchers/authors.

Iodine status of pregnant women and children age 6 to 12 years feeding from the same food basket in Mopani district, Limpopo province, South Africa

Objectives: The aim of the study was to assess the iodine status of pregnant women and children age 6 to 12 years feeding from the same food basket in Mopani District.Design: A cross-sectional study was conducted.Setting: The setting was primary health care clinics and households from five municipalities of Mopani District in Limpopo province.Subjects: A total of 565 conveniently selected pregnant women and 116 children aged 6 to 12 years were recruited, of which 116 were mother–child pairs.Methods: The demographic information, iodine nutrition knowledge and salt consumption patterns were obtained using a validated questionnaire. Spot urine, household drinking water and salt samples were collected and analysed for iodine using standard procedures. A professional nurse, using filter paper to determine thyroid stimulating hormone (TSH) levels, collected spot finger-stick blood samples from pregnant women.Results: The findings showed that only 52.5% of household salt had an iodine concentration level of more than and equal to 15 ppm. The median iodine concentration of household drinking water was 46.2 μg/l (interquartile range [IQR] 10.8–73.4 μg/l). The TSH levels of the majority of pregnant women were normal and the maternal overall median urinary iodine concentration (UIC) was 164 μg/l (IQR 92–291 μg/l), indicating maternal iodine sufficiency. However, median UIC in the first and third trimesters was below 150 μg/l, indicating iodine insufficiency. The UIC level of children in the study was 386 μg/l (IQR 200–525 μg/l), signifying iodine excess.Conclusion: Iodine status of pregnant women in this study was sufficient, with UIC for children excessively high, more than two times higher than the iodine status of pregnant women. The reasons for the excessive UIC in school-age children need to be elucidated.

SU‐F‐I‐41: Calibration‐Free Material Decomposition for Dual‐Energy CT

Purpose:To eliminate tedious phantom calibration or manually region of interest (ROI) selection as required in dual‐energy CT material decomposition, we establish a new projection‐domain material decomposition framework with incorporation of energy spectrum.Methods:Similar to the case of dual‐energy CT, the integral of the basis material image in our model is expressed as a linear combination of basis functions, which are the polynomials of high‐ and low‐energy raw projection data. To yield the unknown coefficients of the linear combination, the proposed algorithm minimizes the quadratic error between the high‐ and low‐energy raw projection data and the projection calculated using material images. We evaluate the algorithm with an iodine concentration numerical phantom at different dose and iodine concentration levels. The x‐ray energy spectra of the high and low energy are estimated using an indirect transmission method. The derived monochromatic images are compared with the high‐ and low‐energy CT images to demonstrate beam hardening artifacts reduction. Quantitative results were measured and compared to the true values.Results:The differences between the true density value used for simulation and that were obtained from the monochromatic images, are 1.8%, 1.3%, 2.3%, and 2.9% for the dose levels from standard dose to 1/8 dose, and are 0.4%, 0.7%, 1.5%, and 1.8% for the four iodine concentration levels from 6 mg/mL to 24 mg/mL. For all of the cases, beam hardening artifacts, especially streaks shown between dense inserts, are almost completely removed in the monochromatic images.Conclusion:The proposed algorithm provides an effective way to yield material images and artifacts‐free monochromatic images at different dose levels without the need for phantom calibration or ROI selection. Furthermore, the approach also yields accurate results when the concentration of the iodine concentrate insert is very low, suggesting the algorithm is robust with respect to the low‐contrast scenario.

Prevalence of iodine deficiency disorders among 6 to 12 years school children of Ramanagara district, Karnataka, India

Background: Iodine is an essential micronutrient with an RDA of 100-150 μg for normal human growth and mental development. Iodine deficiency disorders (IDD) constitute the single largest cause of preventable brain damage worldwide. Majority of consequences of IDD are invisible and irreversible but at the same time these are preventable. The study was conducted to assess the prevalence of goiter in school children aged 6-12 years and to assess the level of iodine concentration in salt samples obtained from households of selected school children. Methods: Population proportionate to size sampling. Sample size: 90 primary school-going children of age 6-12 years in each selected village, total 2700 from 30 villages in Ramanagara district, Karnataka, India. Results: The prevalence of goiter among the 6 - 12 years children was found to be 8.6%. Females had higher prevalence compared to males in all the age groups but the difference was not statistically significant (0.437). Of the 540 salt samples, 518(95.3%) had iodine concentration ≥15 ppm at household level. Conclusions: IDD is a mild public health problem in Ramanagara district. There is a need of periodic surveys to assess the change in magnitude of the IDD with respect to impact of iodized salt (IS) intervention.

The Rise and Fall of Universal Salt Iodization in Vietnam: Lessons Learned for Designing Sustainable Food Fortification Programs With a Public Health Impact.

In 2005, more than 90% of Vietnamese households were using adequately iodized salt, and urinary iodine concentration among women of reproductive age was in the optimal range. However, household coverage declined thereafter to 45% in 2011, and urinary iodine concentration levels indicated inadequate iodine intake. To review the strengths and weaknesses of the Vietnamese universal salt iodization program from its inception to the current day and to discuss why achievements made by 2005 were not sustained. Qualitative review of program documents and semistructured interviews with national stakeholders. National legislation for mandatory salt iodization was revoked in 2005, and the political importance of the program was downgraded with consequential effects on budget, staff, and authority. The Vietnamese salt iodization program, as it was initially designed and implemented, was unsustainable, as salt iodization was not practiced as an industry norm but as a government-funded activity. An effective and sustainable salt iodization program needs to be reestablished for the long-term elimination of iodine deficiency, building upon lessons learned from the past and programs in neighboring countries. The new program will need to include mandatory legislation, including salt for food processing; industry responsibility for the cost of fortificant; government commitment for enforcement through routine food control systems and monitoring of iodine status through existing health/nutrition assessments; and intersectoral collaboration and management of the program. Many of the lessons would apply equally to universal salt iodization programs in other countries and indeed to food fortification programs in general.

Iodine Nutritional Status among Adolescent Girls in Uttarakhand, India.

Uttarakhand (UK) state is a known endemic region for Iodine deficiency. To assess iodine nutritional status among adolescent girls in districts: Udham Singh Nagar (USN), Nainital (N) and Pauri (P) of UK state. In each district, 30 clusters (schools) were identified by using population proportionate to size cluster sampling. In each school, 60 girls (12-18 years) attending the schools were included. Total of 5430 girls from USN (1823), N (1811) and P (1796) were studied. Clinical examination of thyroid of each girl was conducted. From each cluster, spot urine and salt samples were collected. Total goiter rate was found to be 6.8% (USN), 8.2% (N) and 5.6% (P). Median urinary iodine concentration levels were 250 μg/l (USN), 200 μg/l (N) and 183 μg/l (P). Findings of the study documented that adolescent girls had adequate iodine nutritional status in the three districts of UK.

Marginal Iodine Status and High Rate of Subclinical Hypothyroidism in Washington DC Women Planning Conception

Subclinical hypothyroidism during pregnancy has been associated with adverse maternal and fetal outcomes. A subset of pregnant women in the United States have been shown to have mild iodine deficiency. No study has evaluated the thyroid and iodine status of women who are planning to become pregnant in the near future. Thyroid function tests, thyroid antibodies, and urine iodine levels were evaluated in women presenting for preconception screening and counseling. A thyrotropin (TSH) level above 3.0 mIU/L was considered abnormal. One hundred and forty one women enrolled in the study. The median TSH level was 1.70 mIU/L (range 0.43-5.3 mIU/L). Sixteen women (11%) had a TSH above the upper limit of normal (>3.0 mIU/L). Eleven women (8%) were positive for TPO-Ab and 21 women (15%) for TgAb. Twenty-three women (16%) were positive for at least one thyroid antibody (TPOAb and/or TgAb). Median serum TSH concentrations were higher in women with detectable antithyroid antibodies than in women who were antibody negative (2.2 mIU/L vs. 1.7 mIU/L; p=0.005). The median urinary iodine concentration was 100.5 μg (range 19-843 μg/L). The present cohort exhibited the lowest median urinary iodine concentration levels to date reported in the United States for women in their childbearing years. One out of every nine women (11%) had thyroid function tests consistent with subclinical hypothyroidism.

Trace elements in bovine milk from different regions in Norway

Dairy milk samples from 37 milk tours in 15 areas of Norway were collected during indoor feeding or on pasture in 2008 and analyzed with respect to 6 major elements (Ca, P, K, S, Na, Mg) and 28 trace elements (As, Ba, Be, Bi, Cd, Ce, Co, Cr, Cs, Cu, Dy, Fe, I, La, Li, Mn, Mo, Nd, Pb, Rb, Sb, Se, Sm, Sr, V, Y, Yb and Zn). Surprisingly, the least-square means of major and trace elements in milk did not vary much from one region to another. The concentration levels of iodine, copper, manganese and lithium in milk from the northern region were higher compared with milk from other regions. Milk from the south was enriched with respect to selenium, yttrium, cerium and bismuth, while milk from the western region was enriched with respect to rubidium.