Computer-aided Diagnostic Research Articles

Bag of Feature-Based Ensemble Subspace KNN Classifier in Muscle Ultrasound Diagnosis of Diabetic Peripheral Neuropathy

Muscle ultrasound quantification is a valuable complementary diagnostic tool for diabetic peripheral neuropathy (DPN), enhancing physicians’ diagnostic capabilities. Quantitative assessment is generally regarded as more reliable and sensitive than visual evaluation, which often necessitates specialized expertise. This work develops a computer-aided diagnostic (CAD) system based on muscle ultrasound that integrates the bag of features (BOF) and an ensemble subspace k-nearest neighbor (KNN) algorithm for DPN detection. The BOF creates a histogram of visual word occurrences to represent the muscle ultrasound images and trains an ensemble classifier through cross-validation, determining optimal parameters to improve classification accuracy for the ensemble diagnosis system. The dataset includes ultrasound images of six muscles from 53 subjects, consisting of 27 control and 26 patient cases. An empirical analysis was conducted for each binary classifier based on muscle type to select the best vocabulary tree properties or K values for BOF. The result indicates that ensemble subspace KNN classification, based on the bag of features, achieved an accuracy of 97.23%. CAD systems can effectively diagnose muscle pathology, thereby addressing limitations and identifying issues in individuals with diabetes. This research underscores muscle ultrasound as a promising diagnostic tool to aid physicians in making accurate diagnoses, streamlining workflow, and uncovering muscle-related complications in DPN patients.

Advancements in Hyperspectral Imaging and Computer-Aided Diagnostic Methods for the Enhanced Detection and Diagnosis of Head and Neck Cancer.

Background/Objectives: Head and neck cancer (HNC), predominantly squamous cell carcinoma (SCC), presents a significant global health burden. Conventional diagnostic approaches often face challenges in terms of achieving early detection and accurate diagnosis. This review examines recent advancements in hyperspectral imaging (HSI), integrated with computer-aided diagnostic (CAD) techniques, to enhance HNC detection and diagnosis. Methods: A systematic review of seven rigorously selected studies was performed. We focused on CAD algorithms, such as convolutional neural networks (CNNs), support vector machines (SVMs), and linear discriminant analysis (LDA). These are applicable to the hyperspectral imaging of HNC tissues. Results: The meta-analysis findings indicate that LDA surpasses other algorithms, achieving an accuracy of 92%, sensitivity of 91%, and specificity of 93%. CNNs exhibit moderate performance, with an accuracy of 82%, sensitivity of 77%, and specificity of 86%. SVMs demonstrate the lowest performance, with an accuracy of 76% and sensitivity of 48%, but maintain a high specificity level at 89%. Additionally, in vivo studies demonstrate superior performance when compared to ex vivo studies, reporting higher accuracy (81%), sensitivity (83%), and specificity (79%). Conclusion: Despite these promising findings, challenges persist, such as HSI's sensitivity to external conditions, the need for high-resolution and high-speed imaging, and the lack of comprehensive spectral databases. Future research should emphasize dimensionality reduction techniques, the integration of multiple machine learning models, and the development of extensive spectral libraries to enhance HSI's clinical utility in HNC diagnostics. This review underscores the transformative potential of HSI and CAD techniques in revolutionizing HNC diagnostics, facilitating more accurate and earlier detection, and improving patient outcomes.

Palette‐based colour normalization for histopathology images

AbstractWith the emergence of computer‐aided diagnostic (CAD) systems, the speed of histopathological image analysis and the accuracy of cancer detection have considerably improved. However, the appearance of histopathological slides can vary depending on the consistency of tissue thickness, stain concentrations, and equipment, thus affecting the judgment of CAD systems. This study proposes a palette‐based colour normalization method for histopathology images is proposed to solve the problem of colour differences between histopathology images. The method builds a graphical user interface based on an improved palette generation algorithm and colour transfer definitions, through which the user can complete the corresponding colour modification to achieve colour normalization. The evaluation of the metrics on histopathological images shows that our method is able to achieve higher image quality and better preservation of structural information of the source image compared with four other colour normalization algorithms. The peak signal‐to‐noise ratio values obtained by the proposed method on two publicly available datasets were 24.1914 and 21.3666, and the structural similarity index matrix values were 0.9871 and 0.9760. The proposed method provides new ideas for the development and design of CAD systems.

The Integration of Radiomics and Artificial Intelligence in Modern Medicine.

With profound effects on patient care, the role of artificial intelligence (AI) in radiomics has become a disruptive force in contemporary medicine. Radiomics, the quantitative feature extraction and analysis from medical images, offers useful imaging biomarkers that can reveal important information about the nature of diseases, how well patients respond to treatment and patient outcomes. The use of AI techniques in radiomics, such as machine learning and deep learning, has made it possible to create sophisticated computer-aided diagnostic systems, predictive models, and decision support tools. The many uses of AI in radiomics are examined in this review, encompassing its involvement of quantitative feature extraction from medical images, the machine learning, deep learning and computer-aided diagnostic (CAD) systems approaches in radiomics, and the effect of radiomics and AI on improving workflow automation and efficiency, optimize clinical trials and patient stratification. This review also covers the predictive modeling improvement by machine learning in radiomics, the multimodal integration and enhanced deep learning architectures, and the regulatory and clinical adoption considerations for radiomics-based CAD. Particular emphasis is given to the enormous potential for enhancing diagnosis precision, treatment personalization, and overall patient outcomes.

HcGAN: Harmonic conditional generative adversarial network for efficiently generating high-quality IHC images from H&E

Generating high quality histopathology images like immunohistochemistry (IHC) stained images is essential for precise diagnosis and the advancement of computer-aided diagnostic (CAD) systems. Producing IHC images in laboratory is quite expensive and time consuming. Recently, some attempts have been made based on artificial intelligence techniques (particularly, deep learning) to generate IHC images. Existing IHC stained image generation methods, still have a limited performance due to the complex structures and variations in cells shapes, potential nonspecific staining and variable antibody sensitivity. This paper proposes a novel technique known as harmonic conditional generative adversarial network (HcGAN) for generating high quality IHC-stained images. To generate the IHC images, the HcGAN model is fed with the widely available hematoxylin and eosin (H&E) images that contain cellular and morphological underlying structures of diverse cancer tissues. Such approach helps generate high quality IHC images mimicking the real ones that highlight the positive cells. The proposed HcGAN model is based generative adversarial learning with generator and discriminator networks. In HcGAN, harmonic convolution based on discrete cosine transform filter banks is employed in the generator and discriminator networks instead of the standard convolution in order to improve visual quality of the generated images and address the issue of overfitting. Our qualitative and quantitative results demonstrate that the proposed HcGAN achieved the highest performance over state-of-the-art methods using two publicly available datasets.

Automated analysis of digital medical images in cervical cancer screening: A systematic review.

Cervical cancer screening programs are poorly implemented in LMICs due to a shortage of specialists and expensive diagnostic infrastructure. To address the barriers of implementation researchers have been developing low-cost portable devices and automating image analysis for decision support.However, as the knowledge base is growing rapidly, progress on the implementation status of novel imaging devices and algorithms in cervical cancer screening has become unclear. The aim of this project was to provide a systematic review summarizing the full range of automated technology systems used in cervical cancer screening. A search on academic databases was conducted and the search results were screened by two independent reviewers. Study selection was based on eligibility in meeting the terms of inclusion and exclusion criteria which were outlined using a Population, Intervention, Comparator and Outcome framework. 17 studies reported algorithms developed with source images from mobile device, viz. Pocket Colposcope, MobileODT EVA Colpo, Smartphone Camera, Smartphone-based Endoscope System, Smartscope, mHRME, and PiHRME. While 56 studies reported algorithms with source images from conventional/commercial acquisition devices. Most interventions were in the feasibility stage of development, undergoing initial clinical validations. Researchers have proven superior prediction performance of computer aided diagnostics (CAD) in colposcopy (>80% accuracies) versus manual analysis (<70.0% accuracies). Furthermore, this review summarized evidence of the algorithms which are being created utilizing portable devices, to circumvent constraints prohibiting wider implementation in LMICs (such as expensive diagnostic infrastructure). However clinical validation of novel devices with CAD is not yet implemented adequately in LMICs.

Leukemia detection and classification using computer-aided diagnosis system with falcon optimization algorithm and deep learning

Leukemia is a type of blood tumour that occurs because of abnormal enhancement in WBCs (white blood cells) in the bone marrow of the human body. Blood-forming tissue cancer influences the lymphatic and bone marrow system. The early diagnosis and detection of leukaemia, i.e., the accurate difference of malignant leukocytes with little expense at the beginning of the disease, is a primary challenge in the disease analysis field. Despite the higher occurrence of leukemia, there is a lack of flow cytometry tools, and the procedures accessible at medical diagnostics centres are time-consuming. Distinct researchers have implemented computer-aided diagnostic (CAD) and machine learning (ML) methods for laboratory image analysis, aiming to manage the restrictions of late leukemia analysis. This study proposes a new Falcon optimization algorithm with deep convolutional neural network for Leukemia detection and classification (FOADCNN-LDC) technique. The main objective of the FOADCNN-LDC technique is to classify and recognize leukemia. The FOADCNN-LDC technique utilizes a median filtering (MF) based noise removal process to eradicate the image noise. Besides, the FOADCNN-LDC technique employs the ShuffleNetv2 model for the feature extraction process. Moreover, the detection and classification of the leukemia process are performed by utilizing the convolutional denoising autoencoder (CDAE) model. The FOA is implemented to select the hyperparameter of the CDAE model. The simulation process of the FOADCNN-LDC approach is performed on a benchmark medical dataset. The investigational analysis of the FOADCNN-LDC approach highlighted a superior accuracy value of 99.62% over existing techniques.

Machine Learning Approaches for Automated Diagnosis of Cardiovascular Diseases: A Review of Electrocardiogram Data Applications.

Cardiovascular diseases (CVDs) have been identified as the leading cause of mortality worldwide. Electrocardiogram (ECG) is a fundamental diagnostic tool used for the diagnosis and detection of these diseases. The new technological tools can help enhance the effectiveness of ECGs. Machine learning (ML) is widely acknowledged as a highly effective approach in the realm of computer-aided diagnostics. This article presents a review of the effectiveness of ML algorithms and deep-learning algorithms in diagnosing, identifying, and classifying CVDs using ECG data. The review identified relevant studies published in the 5 major databases: PubMed, Web of Science (WoS), Scopus, Springer, and IEEE Xplore; between 2021 and 2023, a total of 30 were chosen for the comprehensive quantitative and qualitative. The study demonstrated that different datasets are available online with data related to CVDs. The various ML techniques are employed for the purpose of classification. Based on our investigation, it has been observed that deep learning-based neural network algorithms, such as convolutional neural networks and deep neural networks, have demonstrated superior performance in the detection of entire record data. Furthermore, deep learning showcases its efficacy even when confronted with a scarcity of data. ML approaches utilizing ECG data exhibit a notable proficiency in the realm of diagnosis, hence holding the potential to mitigate the occurrence of disease-related consequences at advanced stages.

Skin cancer classification leveraging multi-directional compact convolutional neural network ensembles and gabor wavelets

Skin cancer (SC) is an important medical condition that necessitates prompt identification to ensure timely treatment. Although visual evaluation by dermatologists is considered the most reliable method, its efficacy is subjective and laborious. Deep learning-based computer-aided diagnostic (CAD) platforms have become valuable tools for supporting dermatologists. Nevertheless, current CAD tools frequently depend on Convolutional Neural Networks (CNNs) with huge amounts of deep layers and hyperparameters, single CNN model methodologies, large feature space, and exclusively utilise spatial image information, which restricts their effectiveness. This study presents SCaLiNG, an innovative CAD tool specifically developed to address and surpass these constraints. SCaLiNG leverages a collection of three compact CNNs and Gabor Wavelets (GW) to acquire a comprehensive feature vector consisting of spatial–textural–frequency attributes. SCaLiNG gathers a wide range of image details by breaking down these photos into multiple directional sub-bands using GW, and then learning several CNNs using those sub-bands and the original picture. SCaLiNG also combines attributes taken from various CNNs trained with the actual images and subbands derived from GW. This fusion process correspondingly improves diagnostic accuracy due to the thorough representation of attributes. Furthermore, SCaLiNG applies a feature selection approach which further enhances the model’s performance by choosing the most distinguishing features. Experimental findings indicate that SCaLiNG maintains a classification accuracy of 0.9170 in categorising SC subcategories, surpassing conventional single-CNN models. The outstanding performance of SCaLiNG underlines its ability to aid dermatologists in swiftly and precisely recognising and classifying SC, thereby enhancing patient outcomes.

Classification of AO/OTA 31A/B femur fractures in X-ray images using YOLOv8 and advanced data augmentation techniques

Femur fractures are a significant worldwide public health concern that affects patients as well as their families because of their high frequency, morbidity, and mortality. When employing computer-aided diagnostic (CAD) technologies, promising results have been shown in the efficiency and accuracy of fracture classification, particularly with the growing use of Deep Learning (DL) approaches. Nevertheless, the complexity is further increased by the need to collect enough input data to train these algorithms and the challenge of interpreting the findings. By improving on the results of the most recent deep learning-based Arbeitsgemeinschaft für Osteosynthesefragen and Orthopaedic Trauma Association (AO/OTA) system classification of femur fractures, this study intends to support physicians in making correct and timely decisions regarding patient care. A state-of-the-art architecture, YOLOv8, was used and refined while paying close attention to the interpretability of the model. Furthermore, data augmentation techniques were involved during preprocessing, increasing the dataset samples through image processing alterations. The fine-tuned YOLOv8 model achieved remarkable results, with 0.9 accuracy, 0.85 precision, 0.85 recall, and 0.85 F1-score, computed by averaging the values among all the individual classes for each metric. This study shows the proposed architecture's effectiveness in enhancing the AO/OTA system's classification of femur fractures, assisting physicians in making prompt and accurate diagnoses.

Deep learning-based computerized diagnosis of lung cancer

The Deep-Learning (DL) technique is capturing increasingly flexible in the sector of processing medical images. Rapid and precise lung cancer detection requirements a standardized computer-aided diagnostic (CAD) architecture. For a quick and reliable detection of lung cancer, a standardized CAD framework is required. High-risk patients are advised by the National Lung Screening Trial to undertake standard screenings with low-dose CT to support the early detection of cancer and decrease the consequence of lung cancer death. In this paper, a lung CT scan and probabilistic bilateral convolutional neural networks (PB-CNN)-based automated diagnosis system for lung cancer are developed. The PB-CNN models were trained using sample cases from the LUNA16 dataset. We used existing techniques, such as Decision Trees (DT), Artificial Neural Networks (ANN) and K-Nearest Neighbors (KNN) to detect lung cancer. We employed accuracy, precision, recall, and f-measure in our experimental investigation. The proposed PB-CNN is automatically detecting lung cancer, yielding an acceptable performance.

Advancements in Computer-Aided Diagnosis of Celiac Disease: A Systematic Review.

Celiac disease, a chronic autoimmune condition, manifests in those genetically prone to it through damage to the small intestine upon gluten consumption. This condition is estimated to affect approximately one in every hundred individuals worldwide, though it often goes undiagnosed. The early and accurate diagnosis of celiac disease (CD) is critical to preventing severe health complications, with computer-aided diagnostic approaches showing significant promise. However, there is a shortage of review literature that encapsulates the field's current state and offers a perspective on future advancements. Therefore, this review critically assesses the literature on the role of imaging techniques, biomarker analysis, and computer models in improving CD diagnosis. We highlight the diagnostic strengths of advanced imaging and the non-invasive appeal of biomarker analyses, while also addressing ongoing challenges in standardization and integration into clinical practice. Our analysis stresses the importance of computer-aided diagnostics in fast-tracking the diagnosis of CD, highlighting the necessity for ongoing research to refine these approaches for effective implementation in clinical settings. Future research in the field will focus on standardizing CAD protocols for broader clinical use and exploring the integration of genetic and protein data to enhance early detection and personalize treatment strategies. These advancements promise significant improvements in patient outcomes and broader implications for managing autoimmune diseases.

Developing Bluetooth phonocardiogram for detecting heart murmurs using hybrid MFCC and LSTM

Cardiovascular disease is a leading global cause of mortality. Most stethoscopes still necessitate the use of tubing, which entails direct physical contact between the healthcare provider and patient. The stethoscope can serve as a means of transmission if it is utilized on individuals who have been diagnosed with airborne and droplet-borne infectious illnesses. A prototype was created to capture heart sounds using a Phonocardiography (PCG) device over website-based Bluetooth connectivity. This approach offers the benefits of being cost-effective, facilitating computer-aided diagnostics, and being wearable. In addition, the primary significance of this study resides in the identification of heart sound irregularities caused by cardio dynamic abnormalities of the heart valves, known as murmurs. The heart sound categorization process utilizes a machine learning model that involves extracting 25 Mel frequency cepstral coefficients (MFCC) as features. The model employs a hybrid approach combining convolutional neural network and long short-term memory (CNN-LSTM) techniques. The research findings indicate that the suggested model achieves an average accuracy rate of 95.9% over five distinct categories, i.e., normal, atrial stenosis, mitral regurgitation, mitral stenosis, and mitral valves prolapse. Further study can be conducted on hardware development by incorporating an infrared sensor at the fingertip of the stethoscope.

Machine Learning and Artificial Intelligence in Thyroid Cancer Screening and Diagnosis: A Comprehensive Systematic Review

This systematic review explores the role of artificial intelligence (AI) and machine learning (ML) technologies in the diagnosis and treatment of thyroid cancers (TC), focusing on enhancing precision, risk assessment, and tailored care. By analyzing ten studies, the review highlights how AI and ML technologies, such as deep learning (DL) and computer-aided diagnostics (CAD), improve the accuracy of ultrasound imaging, risk stratification, and the detection of high-risk nodules. Despite advancements, challenges persist in transitioning to personalized care, including uneven prognostication and diagnostic uncertainty. The review evaluates the effectiveness of AI and ML compared to conventional methods, their ability to address diverse tumor characteristics, and their strengths and limitations in prognosis prediction. Findings suggest AI's potential in improving precision and risk assessment, but limitations such as inconsistent approaches and biases highlight the need for larger datasets and standardized procedures. Moreover, the review underscores the importance of interpretability and transparency in AI models and calls for further research to validate findings in clinical settings. Despite limitations and challenges, AI's transformative potential in TC management is evident, underscoring the need for ongoing investigation and integration into clinical practice.

Applied artificial intelligence in dentistry: emerging data modalities and modeling approaches.

Artificial intelligence (AI) is increasingly applied across all disciplines of medicine, including dentistry. Oral health research is experiencing a rapidly increasing use of machine learning (ML), the branch of AI that identifies inherent patterns in data similarly to how humans learn. In contemporary clinical dentistry, ML supports computer-aided diagnostics, risk stratification, individual risk prediction, and decision support to ultimately improve clinical oral health care efficiency, outcomes, and reduce disparities. Further, ML is progressively used in dental and oral health research, from basic and translational science to clinical investigations. With an ML perspective, this review provides a comprehensive overview of how dental medicine leverages AI for diagnostic, prognostic, and generative tasks. The spectrum of available data modalities in dentistry and their compatibility with various methods of applied AI are presented. Finally, current challenges and limitations as well as future possibilities and considerations for AI application in dental medicine are summarized.

Multiple semantic X-ray medical image retrieval using efficient feature vector extracted by FPN.

Content-based medical image retrieval (CBMIR) has become an important part of computer-aided diagnostics (CAD) systems. The complex medical semantic information inherent in medical images is the most difficult part to improve the accuracy of image retrieval. Highly expressive feature vectors play a crucial role in the search process. In this paper, we propose an effective deep convolutional neural network (CNN) model to extract concise feature vectors for multiple semantic X-ray medical image retrieval. We build a feature pyramid based CNN model with ResNet50V2 backbone to extract multi-level semantic information. And we use the well-known public multiple semantic annotated X-ray medical image data set IRMA to train and test the proposed model. Our method achieves an IRMA error of 32.2, which is the best score compared to the existing literature on this dataset. The proposed CNN model can effectively extract multi-level semantic information from X-ray medical images. The concise feature vectors can improve the retrieval accuracy of multi-semantic and unevenly distributed X-ray medical images.

Improved medical image inpainting using automatic multi-task learning driven deep learning approach

Distorted medical images can drastically reduce diagnosis accuracy using computer-aided diagnostic (CAD) systems. The objective of medical image classification is to improve diagnostic imaging precision and restore regions degraded by image inpainting. Deep Learning (DL) methods like Generative Adversarial Networks (GANs) are being used to solve these medical image inpainting issues. Recently, various improved GAN models were proposed for improved image inpainting, but challenges like computational inefficiency, unreliable restoration quality, and lack of correct analysis of discriminator block. To overcome these problems, a novel GAN model is proposed with modified Generator and Discriminator blocks for improved medical image inpainting. To improve image inpainting quality with minimum computational complexity, the Multi-Task Learning (MTL)-based generator block is designed. The MTL encoder is connected with three decoders for three tasks edge detection, organ boundary generation, and image completion. The MTL-based encoder and decoders are modified with an optimum number of layers and regularization functions to improve the outcomes. The output of the generator block is input into the discriminator block, where we designed the relevant feedback strategy to decrease generator loss by automatically changing the weights on wrong classifications. The simulation results revealed the efficiency of the proposed medical image inpainting approach and discriminator block performances over the state-of-the-art. Due to the modified MTL-based generator and discriminator block in the proposed approach, the PSNR is improved by 14.31 %, SSIM is improved by 8.56%, UQI is improved by 9.45%, and MSE is reduced by 22.78% using the proposed model compared to the state-of-the-arts.

P-322 Development of a CD138-based histopathological scoring system to diagnose chronic endometritis

Abstract Study question Does a standardized histopathological classification system lead to a robust interobserver agreement to diagnose chronic endometritis (CE) and can an accurate computation algorithm be developed? Summary answer The proposed scoring system has a particularly good to excellent interobserver agreement among pathologists. A machine-learning algorithm outperformed pathologists in the clinically most relevant 2-tier-system. What is known already Plasma cell (PC) presence in the stromal endometrium has been proposed as a marker for CE, yet no standardized classification system that considers the amount or distribution of PCs exists. Also, interobserver agreement has been insufficiently reported in the previous publications on the topic. Without a robust histopathological score, the potential clinical impact of CE on ART treatment outcomes cannot be investigated. This issue is strongly reflected in the heterogeneity of the current diagnostic and therapeutic approaches, specifically for patients experiencing repeated implantation failure (RIF) or recurrent pregnancy loss (RPL). Study design, size, duration A 5-tier classification system based on CD138-positive PCs (Roche B-A38/automated Ventana system) was established: class0 (no PCs), classIPC (isolated PCs), class1 (³1 cluster of 5-19 PCs/0.25mm2), class2 (³1 cluster of 20-49 PCs/0.25mm2), class3 (³1 cluster of 50 or more PCs/0.25mm2). A test set of 78 endometrial biopsies (collected over two years) was selected by a certified pathologist who sorted &amp;gt;1000 biopsies to ensure the full spectrum of PC counts/distribution was accounted for. Participants/materials, setting, methods The 3DHistech-platform digitized the slides (pixel size 0.2738x0.2738mm) and a scoring session was set up in the Pathomation software suite. Six pathologists scored independently after training. Overall agreement was expressed by Fleiss’ Kappa values. Pairwise interobserver agreement was calculated using Cohen’s Kappa statistics. A supervised machine-learning algorithm was developed in QuPath(V0.4.2) and considered a seventh observer in the interobserver agreement calculations. Main results and the role of chance The CD138-based semiquantitative scoring system showed particularly good to excellent interobserver agreement among all observers. Overall agreement values were 0.722 for the 5-tier system and 0.858 for the 2-tier system (0+IPC versus 1 + 2+3, which was considered the clinically most relevant classification, i.e. CE absent versus diagnosed). Pairwise interobserver agreement was 0.871-0.951. Intra-class correlations varied from 0.727 to 0.839 in the 5-tier system and 0.893 to 0.965 in the 2-tier system. All findings were statistically significant (p &amp;lt; 0.001). The supervised machine-learning algorithm was able to compete with human pathologist observers and outperformed them in the 2-tier system. The proposed classification system provides a framework for assessing the presence and severity of endometrial PC infiltration and can guide further research. Limitations, reasons for caution Inconsistent staining intensity, non-specific epithelial staining and background interference are common problems that might limit interlaboratory use of the algorithm. Furthermore, the algorithm has not yet been associated to patient/clinical parameters. Accurate analysis of an endometrial biopsy might still be insufficient to provide a formal diagnosis of CE. Wider implications of the findings To unravel the association between PCs in endometrial biopsies (as a proxy for the diagnosis of CE) and the reproductive outcomes following ART, a standardized methodology is of crucial importance for future studies. Higher accuracy, efficieny and automation are advantages when using computer-aided diagnostics for CE. Trial registration number BUN 143202042810

Bridging the Clinical-Computational Transparency Gap in Digital Pathology.

Computational pathology combines clinical pathology with computational analysis, aiming to enhance diagnostic capabilities and improve clinical productivity. However, communication barriers between pathologists and developers often hinder the full realization of this potential. To propose a standardized framework that improves mutual understanding of clinical objectives and computational methodologies. The goal is to enhance the development and application of computer-aided diagnostic (CAD) tools. The article suggests pivotal roles for pathologists and computer scientists in the CAD development process. It calls for increased understanding of computational terminologies, processes, and limitations among pathologists. Similarly, it argues that computer scientists should better comprehend the true use cases of the developed algorithms to avoid clinically meaningless metrics. CAD tools improve pathology practice significantly. Some tools have even received US Food and Drug Administration approval. However, improved understanding of machine learning models among pathologists is essential to prevent misuse and misinterpretation. There is also a need for a more accurate representation of the algorithms' performance compared to that of pathologists. A comprehensive understanding of computational and clinical paradigms is crucial for overcoming the translational gap in computational pathology. This mutual comprehension will improve patient care through more accurate and efficient disease diagnosis.

Artificial intelligence-driven computer aided diagnosis system provides similar diagnosis value compared with doctors’ evaluation in lung cancer screening

ObjectiveTo evaluate the consistency between doctors and artificial intelligence (AI) software in analysing and diagnosing pulmonary nodules, and assess whether the characteristics of pulmonary nodules derived from the two methods are consistent for the interpretation of carcinomatous nodules.Materials and MethodsThis retrospective study analysed participants aged 40–74 in the local area from 2011 to 2013. Pulmonary nodules were examined radiologically using a low-dose chest CT scan, evaluated by an expert panel of doctors in radiology, oncology, and thoracic departments, as well as a computer-aided diagnostic(CAD) system based on the three-dimensional(3D) convolutional neural network (CNN) with DenseNet architecture(InferRead CT Lung, IRCL). Consistency tests were employed to assess the uniformity of the radiological characteristics of the pulmonary nodules. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic accuracy. Logistic regression analysis is utilized to determine whether the two methods yield the same predictive factors for cancerous nodules.ResultsA total of 570 subjects were included in this retrospective study. The AI software demonstrated high consistency with the panel's evaluation in determining the position and diameter of the pulmonary nodules (kappa = 0.883, concordance correlation coefficient (CCC) = 0.809, p = 0.000). The comparison of the solid nodules' attenuation characteristics also showed acceptable consistency (kappa = 0.503). In patients diagnosed with lung cancer, the area under the curve (AUC) for the panel and AI were 0.873 (95%CI: 0.829–0.909) and 0.921 (95%CI: 0.884–0.949), respectively. However, there was no significant difference (p = 0.0950). The maximum diameter, solid nodules, subsolid nodules were the crucial factors for interpreting carcinomatous nodules in the analysis of expert panel and IRCL pulmonary nodule characteristics.ConclusionAI software can assist doctors in diagnosing nodules and is consistent with doctors' evaluations and diagnosis of pulmonary nodules.