Computer-aided Diagnosis System For Early Detection Research Articles

Novel MRI-Based CAD System for Early Detection of Thyroid Cancer Using Multi-Input CNN.

Early detection of thyroid nodules can greatly contribute to the prediction of cancer burdening and the steering of personalized management. We propose a novel multimodal MRI-based computer-aided diagnosis (CAD) system that differentiates malignant from benign thyroid nodules. The proposed CAD is based on a novel convolutional neural network (CNN)-based texture learning architecture. The main contribution of our system is three-fold. Firstly, our system is the first of its kind to combine T2-weighted MRI and apparent diffusion coefficient (ADC) maps using a CNN to model thyroid cancer. Secondly, it learns independent texture features for each input, giving it more advanced capabilities to simultaneously extract complex texture patterns from both modalities. Finally, the proposed system uses multiple channels for each input to combine multiple scans collected into the deep learning process using different values of the configurable diffusion gradient coefficient. Accordingly, the proposed system would enable the learning of more advanced radiomics with an additional advantage of visualizing the texture patterns after learning. We evaluated the proposed system using data collected from a cohort of 49 patients with pathologically proven thyroid nodules. The accuracy of the proposed system has also been compared against recent CNN models as well as multiple machine learning (ML) frameworks that use hand-crafted features. Our system achieved the highest performance among all compared methods with a diagnostic accuracy of 0.87, specificity of 0.97, and sensitivity of 0.69. The results suggest that texture features extracted using deep learning can contribute to the protocols of cancer diagnosis and treatment and can lead to the advancement of precision medicine.

Medical image segmentation based on fuzzy 2-partition Kapur entropy using fast recursive algorithm

Segmentation is a foremost part of computer-aided diagnosis (CAD) and medical image analysis. This paper provides an automatic threshold selection approach for the segmentation of medical images based on fuzzy 2-partition using Kapur entropy. The fuzzy 2-partition Kapur entropy approach converts the image into fuzzy 2-partition by applying two parameterised fuzzy membership functions. The optimal threshold is attained by searching for an ideal combination of the parameter for the fuzzy membership functions so that the fuzzy 2-partition Kapur entropy is maximised. The complexity of searching the optimal combination of parameters is reduced by integrating the concept of fast recursive algorithm and Kapur entropy. The proposed approach performance is measured using several medical images and it is found that results are considerable encouraging. The proposed approach could be put up as a component of a CAD system for early detection of diseases like cancer.

A Computer Aided Diagnosis System for Lung Cancer Detection \Using Support Vector Machine

Problem statement: Computer Tomography (CT) has been considered as the most sensitive imaging technique for early detection of lung cancer. Approach: On the other hand, there is a requirement for automated methodology to make use of large amount of data obtained CT images. Computer Aided Diagnosis (CAD) can be used efficiently for early detection of Lung Cancer. Results: The usage of existing CAD system for early detection of lung cancer with the help of CT images has been unsatisfactory because of its low sensitivity and False Positive Rates (FPR). This study presents a CAD system which can automatically detect the lung cancer nodules with reduction in false positive rates. In this study, different image processing techniques are applied initially in order to obtain the lung region from the CT scan chest images. Then the segmentation is carried with the help of Fuzzy Possibility C Mean (FPCM) clustering algorithm. Conclusion/Recommendations: Finally for automatic detection of cancer nodules, Support Vector Machine (SVM) is used which helps in better classification of cancer nodules. The experimentation is conducted for the proposed technique by 1000 CT images collected from the reputed hospital.

SVM-based CAD system for early detection of the Alzheimer's disease using kernel PCA and LDA

Single-photon emission tomography (SPECT) imaging has been widely used to guide clinicians in the early Alzheimer's disease (AD) diagnosis challenge. However, AD detection still relies on subjective steps carried out by clinicians, which entail in some way subjectivity to the final diagnosis. In this work, kernel principal component analysis (PCA) and linear discriminant analysis (LDA) are applied on functional images as dimension reduction and feature extraction techniques, which are subsequently used to train a supervised support vector machine (SVM) classifier. The complete methodology provides a kernel-based computer-aided diagnosis (CAD) system capable to distinguish AD from normal subjects with 92.31% accuracy rate for a SPECT database consisting of 91 patients. The proposed methodology outperforms voxels-as-features (VAF) that was considered as baseline approach, which yields 80.22% for the same SPECT database.