Computer-aided Diagnosis Models Research Articles

Multitask Learning for Joint Diagnosis of Multiple Mental Disorders in Resting-State fMRI.

Facing the increasing worldwide prevalence of mental disorders, the symptom-based diagnostic criteria struggle to address the urgent public health concern due to the global shortfall in well-qualified professionals. Thanks to the recent advances in neuroimaging techniques, functional magnetic resonance imaging (fMRI) has surfaced as a new solution to characterize neuropathological biomarkers for detecting functional connectivity (FC) anomalies in mental disorders. However, the existing computer-aided diagnosis models for fMRI analysis suffer from unstable performance on large datasets. To address this issue, we propose an efficient multitask learning (MTL) framework for joint diagnosis of multiple mental disorders using resting-state fMRI data. A novel multiobjective evolutionary clustering algorithm is presented to group regions of interests (ROIs) into different clusters for FC pattern analysis. On the optimal clustering solution, the multicluster multigate mixture-of-expert model is used for the final classification by capturing the highly consistent feature patterns among related diagnostic tasks. Extensive simulation experiments demonstrate that the performance of the proposed framework is superior to that of the other state-of-the-art methods. Moreover, the potential for practical application of the framework is also validated in terms of limited computational resources, real-time analysis, and insufficient training data. The proposed model can identify the remarkable interpretative biomarkers associated with specific mental disorders for clinical interpretation analysis.

Enhancing cancer prediction in challenging screen-detected incident lung nodules using time-series deep learning

Lung cancer screening (LCS) using annual computed tomography (CT) scanning significantly reduces mortality by detecting cancerous lung nodules at an earlier stage. Deep learning algorithms can improve nodule malignancy risk stratification. However, they have typically been used to analyse single time point CT data when detecting malignant nodules on either baseline or incident CT LCS rounds. Deep learning algorithms have the greatest value in two aspects. These approaches have great potential in assessing nodule change across time-series CT scans where subtle changes may be challenging to identify using the human eye alone. Moreover, they could be targeted to detect nodules developing on incident screening rounds, where cancers are generally smaller and more challenging to detect confidently.Here, we show the performance of our Deep learning-based Computer-Aided Diagnosis model integrating Nodule and Lung imaging data with clinical Metadata Longitudinally (DeepCAD-NLM-L) for malignancy prediction. DeepCAD-NLM-L showed improved performance (AUC = 88%) against models utilizing single time-point data alone. DeepCAD-NLM-L also demonstrated comparable and complementary performance to radiologists when interpreting the most challenging nodules typically found in LCS programs. It also demonstrated similar performance to radiologists when assessed on out-of-distribution imaging dataset. The results emphasize the advantages of using time-series and multimodal analyses when interpreting malignancy risk in LCS.

HAMMF: Hierarchical attention-based multi-task and multi-modal fusion model for computer-aided diagnosis of Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive neurodegenerative condition, and early intervention can help slow its progression. However, integrating multi-dimensional information and deep convolutional networks increases the model parameters, affecting diagnosis accuracy and efficiency and hindering clinical diagnostic model deployment. Multi-modal neuroimaging can offer more precise diagnostic results, while multi-task modeling of classification and regression tasks can enhance the performance and stability of AD diagnosis. This study proposes a Hierarchical Attention-based Multi-task Multi-modal Fusion model (HAMMF) that leverages multi-modal neuroimaging data to concurrently learn AD classification tasks, cognitive score regression, and age regression tasks using attention-based techniques. Firstly, we preprocess MRI and PET image data to obtain two modal data, each containing distinct information. Next, we incorporate a novel Contextual Hierarchical Attention Module (CHAM) to aggregate multi-modal features. This module employs channel and spatial attention to extract fine-grained pathological features from unimodal image data across various dimensions. Using these attention mechanisms, the Transformer can effectively capture correlated features of multi-modal inputs. Lastly, we adopt multi-task learning in our model to investigate the influence of different variables on diagnosis, with a primary classification task and a secondary regression task for optimal multi-task prediction performance. Our experiments utilized MRI and PET images from 720 subjects in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. The results show that our proposed model achieves an overall accuracy of 93.15% for AD/NC recognition, and the visualization results demonstrate its strong pathological feature recognition performance.

An investigation into augmentation and preprocessing for optimising X-ray classification in limited datasets: a case study on necrotising enterocolitis.

Obtaining large volumes of medical images, required for deep learning development, can be challenging in rare pathologies. Image augmentation and preprocessing offer viable solutions. This work explores the case of necrotising enterocolitis (NEC), a rare but life-threatening condition affecting premature neonates, with challenging radiological diagnosis. We investigate data augmentation and preprocessing techniques and propose two optimised pipelines for developing reliable computer-aided diagnosis models on a limited NEC dataset. We present a NEC dataset of 1090 Abdominal X-rays (AXRs) from 364 patients and investigate the effect of geometric augmentations, colour scheme augmentations and their combination for NEC classification based on the ResNet-50 backbone. We introduce two pipelines based on colour contrast and edge enhancement, to increase the visibility of subtle, difficult-to-identify, critical NEC findings on AXRs and achieve robust accuracy in a challenging three-class NEC classification task. Our results show that geometric augmentations improve performance, with Translation achieving +6.2%, while Flipping and Occlusion decrease performance. Colour augmentations, like Equalisation, yield modest improvements. The proposed Pr-1 and Pr-2 pipelines enhance model accuracy by +2.4% and +1.7%, respectively. Combining Pr-1/Pr-2 with geometric augmentation, we achieve a maximum performance increase of 7.1%, achieving robust NEC classification. Based on an extensive validation of preprocessing and augmentation techniques, our work showcases the previously unreported potential of image preprocessing in AXR classification tasks with limited datasets. Our findings can be extended to other medical tasks for designing reliable classifier models with limited X-ray datasets. Ultimately, we also provide a benchmark for automated NEC detection and classification from AXRs.

Computer-aided diagnostic system with automated deep learning method based on the AutoGluon framework improved the diagnostic accuracy of early esophageal cancer.

There have been studies on the application of computer-aided diagnosis (CAD) in the endoscopic diagnosis of early esophageal cancer (EEC), but there is still a significant gap from clinical application. We developed an endoscopic CAD system for EEC based on the AutoGluon framework, aiming to explore the feasibility of automatic deep learning (DL) in clinical application. The endoscopic pictures of normal esophagus, esophagitis, and EEC were collected from The First Affiliated Hospital of Soochow University (September 2015 to December 2021) and the Norwegian HyperKvasir database. All images of non-cancerous esophageal lesions and EEC in this study were pathologically examined. There were three tasks: task A was normal vs. lesion classification under non-magnifying endoscopy (n=932 vs. 1,092); task B was non-cancer lesion vs. EEC classification under non-magnifying endoscopy (n=594 vs. 429); and task C was non-cancer lesion vs. EEC classification under magnifying endoscopy (n=505 vs. 824). In all classification tasks, we took 100 pictures as the verification set, and the rest comprised as the training set. The CAD system was established based on the AutoGluon framework. Diagnostic performance of the model was compared with that of endoscopists grouped according to years of experience (senior >15 years; junior <5 years). Model evaluation indicators included accuracy, recall rate, precision, F1 value, interpretation time, and the area under the receiver operating characteristic (ROC) curve (AUC). In tasks A and B, the accuracies of medium-performance CAD and high-performance CAD were lower than those of junior doctors and senior doctors. In task C, the medium-performance and high-performance CAD accuracies were close to those of junior doctors and senior doctors. The high-performance CAD model outperformed the junior doctors in both task A (0.850 vs. 0.830) and task C (0.840 vs. 0.830) in sensitivity comparison, but there was still a large gap between high-performance CAD models and doctors in sensitivity comparison. In task A, with the aid of CAD pre-interpretation, the accuracy of junior and senior physicians were significantly improved (from 0.880 to 0.915 and from 0.920 to 0.945, respectively); the time spent on film reading was significantly shortened (junior: from 11.3 to 8.7 s; senior: from 6.7 to 5.5 s). In task C, with the aid of CAD pre-interpretation, the accuracy of junior and senior physicians were significantly improved (from 0.850 to 0.865 and from 0.915 to 0.935, respectively); the reading time was significantly shortened (junior: from 9.5 to 7.7 s; senior: from 5.6 to 3.0 s). The CAD system based on the AutoGluon framework can assist doctors to improve the diagnostic accuracy and reading time of EEC under endoscopy. This study reveals that automatic DL methods are promising in clinical application.

Pseudo-Data Based Self-Supervised Federated Learning for Classification of Histopathological Images.

Computer-aided diagnosis (CAD) can help pathologists improve diagnostic accuracy together with consistency and repeatability for cancers. However, the CAD models trained with the histopathological images only from a single center (hospital) generally suffer from the generalization problem due to the straining inconsistencies among different centers. In this work, we propose a pseudo-data based self-supervised federated learning (FL) framework, named SSL-FT-BT, to improve both the diagnostic accuracy and generalization of CAD models. Specifically, the pseudo histopathological images are generated from each center, which contain both inherent and specific properties corresponding to the real images in this center, but do not include the privacy information. These pseudo images are then shared in the central server for self-supervised learning (SSL) to pre-train the backbone of global mode. A multi-task SSL is then designed to effectively learn both the center-specific information and common inherent representation according to the data characteristics. Moreover, a novel Barlow Twins based FL (FL-BT) algorithm is proposed to improve the local training for the CAD models in each center by conducting model contrastive learning, which benefits the optimization of the global model in the FL procedure. The experimental results on four public histopathological image datasets indicate the effectiveness of the proposed SSL-FL-BT on both diagnostic accuracy and generalization.

Computer-aided diagnosis in real-time endoscopy for all stages of gastric carcinogenesis: Development and validation study.

Using endoscopic images, we have previously developed computer-aided diagnosis models to predict the histopathology of gastric neoplasms. However, no model that categorizes every stage of gastric carcinogenesis has been published. In this study, a deep-learning-based diagnosis model was developed and validated to automatically classify all stages of gastric carcinogenesis, including atrophy and intestinal metaplasia, in endoscopy images. A total of 18,701 endoscopic images were collected retrospectively and randomly divided into train, validation, and internal-test datasets in an 8:1:1 ratio. The primary outcome was lesion-classification accuracy in six categories: normal/atrophy/intestinal metaplasia/dysplasia/early /advanced gastric cancer. External-validation of performance in the established model used 1427 novel images from other institutions that were not used in training, validation, or internal-tests. The internal-test lesion-classification accuracy was 91.2% (95% confidence interval: 89.9%-92.5%). For performance validation, the established model achieved an accuracy of 82.3% (80.3%-84.3%). The external-test per-class receiver operating characteristic in the diagnosis of atrophy and intestinal metaplasia was 93.4±0% and 91.3±0%, respectively. The established model demonstrated high performance in the diagnosis of preneoplastic lesions (atrophy and intestinal metaplasia) as well as gastric neoplasms.

Accurate Liver Fibrosis Detection Through Hybrid MRMR-BiLSTM-CNN Architecture with Histogram Equalization and Optimization.

The early detection and accurate diagnosis of liver fibrosis, a progressive and potentially serious liver condition, are crucial for effective medical intervention. Invasive methods like biopsies for diagnosis can be risky and expensive. This research presents a novel computer-aided diagnosis model for liver fibrosis using a hybrid approach of minimum redundancy maximum relevance (MRMR) feature selection, bidirectional long short-term memory (BiLSTM), and convolutional neural networks (CNN). The proposed model involves multiple stages, including image acquisition, preprocessing, feature representation, fibrous tissue identification, and classification. Notably, histogram equalization is employed to enhance image quality by addressing variations in brightness levels. Performance evaluation encompasses a range of metrics such as accuracy, precision, sensitivity, specificity, F1 score, and error rate. Comparative analyses with established methods like DCNN, ANN-FLI, LungNet22, and SDAE-GAN underscore the efficacy of the proposed model. The innovative integration of hybrid MRMR-BiLSTM-CNN architecture and the horse herd optimization algorithm significantly enhances accuracy and F1 score, even with small datasets. The model tackles the complexities of hyperparameter optimization through the IHO algorithm and reduces training time by leveraging MRMR feature selection. In practical application, the proposed hybrid MRMR-BiLSTM-CNN method demonstrates remarkable performance with a 97.8% accuracy rate in identifying liver fibrosis images. It exhibits high precision, sensitivity, specificity, and minimal error rate, showcasing its potential for accurate and non-invasive diagnosis.

Comparison of machine learning models on breast cancer risk prediction challenge

Breast cancer is a malignant tumor that poses a serious risk to women's life and wellbeing. To make matters worse, this cancer is less symptomatic in its early stages. It is not easily diagnosed through traditional means. The topic of this essay is to investigate machine learning for the determination of breast cancer.. The methods based on machine learning are as followed: automated nuclear section segmentation model, BCRecommender System, DNNs, and computer-aided diagnosis model (CADM). The methods studied are all based on the BreCaHad dataset and use a comparative metric.To measure the performance of each model, the accuracy, F1-score, specificity, and precision are used. The result shows that the approaches based on machine learning work well in diagnosing breast carcinoma, with high accuracy. Most of them have a percentage over 90% in accuracy and some of them are even higher than 95%. However, some of the models work poorly, such as layer 1 of BCRecommender with 61.06% accuracy and EfficientNetB0 with 72.96%. With every aspect taken into consideration, computer-aided diagnosis (CADM: Using combined features of HOG, WPD, ResNet as well as PCA + SVM) has the greatest advantage in diagnosing BC.

PMP-SVM: A Hybrid Approach for effective Cancer Diagnosis using Feature Selection and Optimization

Cancer disease is becoming a prominent factor in increasing the death ration over the world due to the late diagnosis. Machine Learning (ML) is playing a vital role in providing computer aided diagnosis models for early diagnosis of cancer. For the diagnosis process the microarray data has its own place. Microarray data contain the genetic information of a patient with a large number of dimensions such as genes with a small sample such as patient details. If the microarray is directly taken without reducing the dimension as the input to any ML model for classification, then Small Sample Size is the resulting issue. So, size of the microarray data needs to be reduces by using either of dimensionality reduction technique or the feature selection technique to increase the model’s performance. In this work, proposed a hybrid model using Principal Component Analysis (PCA), Maximum Relevance Minimum Redundancy (MRMR), Particle Swarm Optimization (PSO) and Support Vector Machine (SVM) for cancer diagnosis. PCA and MRMR is used for feature selection and PSO is applied to get the optimized feature set. Finally, SVM is applied as the classification model. The proposed model is evaluated against multiple cancer microarray datasets to measure the performance in terms of accuracy, precision, recall, and F1 score. Result shows that proposed model performs better than existing state of art model.

Diagnosis of Alzheimer’s Disease Based on Accelerated Mirror Descent Optimization and a Three-Dimensional Aggregated Residual Network

Alzheimer’s disease (AD), a neuropsychiatric disorder, continually arises in the elderly. To date, no targeted medications have been developed for AD. Early and fast diagnosis of AD plays a pivotal role in identifying potential AD patients, enabling timely medical interventions, and mitigating disease progression. Computer-aided diagnosis (CAD) becomes possible with the burgeoning of deep learning. However, the existing CAD models for processing 3D Alzheimer’s disease images usually have the problems of slow convergence, disappearance of gradient, and falling into local optimum. This makes the training of 3D diagnosis models need a lot of time, and the accuracy is often poor. In this paper, a novel 3D aggregated residual network with accelerated mirror descent optimization is proposed for diagnosing AD. First, a novel unbiased subgradient accelerated mirror descent (SAMD) optimization algorithm is proposed to speed up diagnosis network training. By optimizing the nonlinear projection process, our proposed algorithm can avoid the occurrence of the local optimum in the non-Euclidean distance metric. The most notable aspect is that, to the best of our knowledge, this is the pioneering attempt to optimize the AD diagnosis training process by improving the optimization algorithm. Then, we provide a rigorous proof of the SAMD’s convergence, and the convergence of SAMD is better than any existing gradient descent algorithms. Finally, we use our proposed SAMD algorithm to train our proposed 3D aggregated residual network architecture (ARCNN). We employed the ADNI dataset to train ARCNN diagnostic models separately for the AD vs. NC task and the sMCI vs. pMCI task, followed by testing to evaluate the disease diagnostic outcomes. The results reveal that the accuracy can be improved in diagnosing AD, and the training speed can be accelerated. Our proposed method achieves 95.4% accuracy in AD diagnosis and 79.9% accuracy in MCI diagnosis; the best results contrasted with several state-of-the-art diagnosis methods. In addition, our proposed SAMD algorithm can save about 19% of the convergence time on average in the AD diagnosis model compared with the gradient descent algorithms, which is very momentous in clinic.

Choquet integral based deep learning model for COVID-19 diagnosis using eXplainable AI for NG-IoT models

The COVID-19 outbreak has caused a global threat to the world healthcare system. The virus has mutated into different variants and mutations which spread more rapidly, are more deadly and have the lesser effect of vaccines. The number of cases is way more than the number of cases doctors can handle. Widely used methods of RT-PCR are tedious and time-consuming, Instant methods like antigen are very less effective and give incorrect results. Hence Artificial Intelligence (AI)-based Computer-aided Diagnosis (CAD) methods that help doctors in the correct and efficient diagnosis are the need of the hour. In this study, we propose a Deep Learning based XAI model for aiding clinical interpretation on Chest X-ray (CXR) images. The XAI diagnostic model can be integrated into NG-IoT devices using CAD models by provide accurate explainable diagnostics. We used deep-learning models with integrated Choquet integral as an aggregation function for more precise classification. Integrating it with the XAI model Grad CAM ++ increased its explainability. In our proposed work we used four different deep learning models ResNet-50, Inception V3, Densenet-121 and DCNN with integrated Choquet Integral function which increased the accuracy by 2% for Densenet-121 and DCNN and 1% for ResNet-50 and Inception V3. Using Grad CAM++ on the images increases the acceptance by medical professionals by clearly depicting how the models took the decision. We can depict that our proposed model Densenet 121 integrated with ChI outperformed all the other methods.

An Interpretable Three-Dimensional Artificial Intelligence Model for Computer-Aided Diagnosis of Lung Nodules in Computed Tomography Images.

Lung cancer is typically classified into small-cell carcinoma and non-small-cell carcinoma. Non-small-cell carcinoma accounts for approximately 85% of all lung cancers. Low-dose chest computed tomography (CT) can quickly and non-invasively diagnose lung cancer. In the era of deep learning, an artificial intelligence (AI) computer-aided diagnosis system can be developed for the automatic recognition of CT images of patients, creating a new form of intelligent medical service. For many years, lung cancer has been the leading cause of cancer-related deaths in Taiwan, with smoking and air pollution increasing the likelihood of developing the disease. The incidence of lung adenocarcinoma in never-smoking women has also increased significantly in recent years, resulting in an important public health problem. Early detection of lung cancer and prompt treatment can help reduce the mortality rate of patients with lung cancer. In this study, an improved 3D interpretable hierarchical semantic convolutional neural network named HSNet was developed and validated for the automatic diagnosis of lung cancer based on a collection of lung nodule images. The interpretable AI model proposed in this study, with different training strategies and adjustment of model parameters, such as cyclic learning rate and random weight averaging, demonstrated better diagnostic performance than the previous literature, with results of a four-fold cross-validation procedure showing calcification: 0.9873 ± 0.006, margin: 0.9207 ± 0.009, subtlety: 0.9026 ± 0.014, texture: 0.9685 ± 0.006, sphericity: 0.8652 ± 0.021, and malignancy: 0.9685 ± 0.006.

Hybrid-supervised bidirectional transfer networks for computer-aided diagnosis

Medical imaging techniques have been widely used for diagnosis of various diseases. However, the imaging-based diagnosis generally depends on the clinical skill of radiologists. Computer-aided diagnosis (CAD) can help radiologists improve diagnostic accuracy as well as the consistency and reproducibility. Although convolutional neural network (CNN) has shown its feasibility and effectiveness in CAD, it generally suffers from the problem of small sample size when training CAD models. Nowadays, self-supervised learning (SSL) has shown its effectiveness in the field of medical image analysis, especially when there are only limited training samples. However, the backbone of downstream task sometimes cannot be well pre-trained in the conventional SSL framework due to the limitation of the pretext task and fine-tuning mechanism. In this work, an improved SSL framework, named Hybrid-supervised Bidirectional Transfer Networks (HBTN), is proposed to improve the performance of CAD models. Specifically, a novel Gray-Scale Image Mapping (GSIM) task is developed, which still takes the widely used image restoration task in SSL as the pretext task, but further embeds the class label information into it to improve discriminative feature learning of its corresponding network model. The proposed HBTN then integrates two different network architectures, i.e. the image restoration network for the pretext task and the classification network for the downstream task, into a unified hybrid-supervised learning (HSL) framework. It jointly trains both networks and collaboratively transfers the knowledge between each other. Consequently, the performance of downstream network is thus improved. The proposed HBTN is evaluated on two medical image datasets for CAD tasks. The experimental results indicate that HBTN outperforms the conventional SSL algorithms for CAD with limited training samples.

Peripheral Blood Smear Analysis Using Automated Computer-Aided Diagnosis System to Identify Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a cancer of the myeloid line of cells caused due to the rapid increase of abnormal cells that later interfere with healthy cells. One of the main reasons for the increase in mortality is the cost of the devices used for the determination and late diagnosis. The most effective treatment option can be provided by accurate medical diagnosis. Automated segmentation of blood smear images plays a crucial role in the identification of the AML. This article proposes a new computer-aided diagnosis model to segment the blood smear images and identifies the stage of AML. The methodology presented in this work consists of various stages: Image acquisition, image segmentation, feature extraction/selection, and classification. The model is trained using 800 blood smear images collected from Kasturba Medical College Manipal, and 200 images collected from the dataset of microscopic peripheral blood cell images for the development of automatic recognition systems. The model is tested on 500 images. A novel algorithm is designed to accurately segment the blood smear images to identify AML and its stages. The segmentation algorithm addresses critical issues in blast cell detection, including identifying the blast cell and extracting the cytoplasm of the cell without involving manual intervention. It can identify the multiple lobes and the nucleated red blood cells (NRBCs), separate the overlapped erythrocytes from white blood cells (WBCs), and discover the presence of Auer rods and granules. The feature selection is performed using the InfoGainAttributeEval and the ranker search method. This article compares the performance of the various machine learning algorithms exploited for the classification of different types of cells and hence determines AML. The model successfully differentiated between NRBC and WBC with an accuracy of 99.81&#x0025;. The model obtained a classification accuracy of 99.48 &#x0025;. It achieved a prediction accuracy of 99.2&#x0025; while predicting the unknown stage of AML. The algorithm&#x2019;s efficiency proves that it can be used by pathologists to form a prognosis.

Deep Learning-Based Computer-Aided Diagnosis Model for the Identification and Classification of Mammography Images

Deep Learning-Based Computer-Aided Diagnosis Model for the Identification and Classification of Mammography Images

A multi-class deep learning model for early lung cancer and chronic kidney disease detection using computed tomography images.

Lung cancer is a fatal disease caused by an abnormal proliferation of cells in the lungs. Similarly, chronic kidney disorders affect people worldwide and can lead to renal failure and impaired kidney function. Cyst development, kidney stones, and tumors are frequent diseases impairing kidney function. Since these conditions are generally asymptomatic, early, and accurate identification of lung cancer and renal conditions is necessary to prevent serious complications. Artificial Intelligence plays a vital role in the early detection of lethal diseases. In this paper, we proposed a modified Xception deep neural network-based computer-aided diagnosis model, consisting of transfer learning based image net weights of Xception model and a fine-tuned network for automatic lung and kidney computed tomography multi-class image classification. The proposed model obtained 99.39% accuracy, 99.33% precision, 98% recall, and 98.67% F1-score for lung cancer multi-class classification. Whereas, it attained 100% accuracy, F1 score, recall and precision for kidney disease multi-class classification. Also, the proposed modified Xception model outperformed the original Xception model and the existing methods. Hence, it can serve as a support tool to the radiologists and nephrologists for early detection of lung cancer and chronic kidney disease, respectively.

Semi-Supervised Multi-View Fusion for Identifying CAP and COVID-19 With Unlabeled CT Images

Recently, under the condition of reducing nucleic acid testing for COVID-19 in large population, the computer-aided diagnosis with the chest computed tomography (CT) image has become increasingly important in differential diagnosis of community-acquired pneumonia (CAP) and COVID-19. In practice, there usually exist a mass of unlabeled CT images, especially in regions without adequate medical resources, and the existing diagnosis methods cannot take advantage of the useful information among them. Therefore, it is practical and urgent need to develop a computer-aided diagnosis model that can effectively exploit both labeled and unlabeled samples. To this end, in this paper, we propose a semi-supervised multi-view fusion method for the diagnosis of COVID-19. It explores both the discriminative features from labeled samples and the structure information from unlabeled samples and fuses multi-view features extracted from CT images, including image feature, statistical feature, and lesions specific feature, for improving the diagnostic performance. Specifically, in the proposed model, we utilize semi-supervised learning technique with pairwise constraint regularization to learn the model with both labeled samples and unlabeled samples. Simultaneously, we employ low-rank multi-view constraint to capture latent complementary information among different features from CT images. Experimental results show that the proposed method outperforms the state-of-the-art methods in differential diagnosis of CAP vs. COVID-19.

Transfer learning approach for pediatric pneumonia diagnosis using channel attention deep CNN architectures

Chest X-ray is the most commonly adopted non-invasive and painless diagnostic test for pediatric pneumonia. However, the low radiation levels for diagnosis make accurate detection challenging, and this initiates the need for an unerring computer-aided diagnosis model. Our work proposes stacking ensemble learning on features extracted from channel attention deep CNN architectures. The features extracted from the channel attention-based ResNet50V2, ResNet101V2, ResNet152V2, Xception, and DenseNet169 are individually passed through Kernel PCA for dimensionality reduction and concatenated. A stacking classifier with Support Vector Classifier, Logistic Regression, K-Nearest Neighbour, Nu-SVC, and XGBClassifier is employed for the final- Normal and Pneumonia classification. The stacking classifier achieves an accuracy of 96.15%, precision of 97.91%, recall of 95.90%, F1 score of 96.89%, and an AUC score of 96.24% on the publicly available pediatric pneumonia dataset. We expect this model to help the real-time diagnosis of pediatric pneumonia significantly.

Ultrasonography-based radiomics and computer-aided diagnosis in thyroid nodule management: performance comparison and clinical strategy optimization.

To compare ultrasonography (US) feature-based radiomics and computer-aided diagnosis (CAD) models for predicting malignancy in thyroid nodules, and to evaluate their utility for thyroid nodule management. This prospective study included 262 thyroid nodules obtained between January 2022 and June 2022. All nodules previously underwent standardized US image acquisition, and the nature of the nodules was confirmed by the pathological results. The CAD model exploited two vertical US images of the thyroid nodule to differentiate the lesions. The least absolute shrinkage and operator algorithm (LASSO) was applied to choose radiomics features with excellent predictive properties for building a radiomics model. Ultimately, the area under the receiver operating characteristic curve (AUC) and calibration curves were assessed to compare diagnostic performance between the models. DeLong's test was used to analyze the difference between groups. Both models were used to revise the American College of Radiology Thyroid Imaging Reporting and Data Systems (ACR TI-RADS) to provide biopsy recommendations, and their performance was compared with the original recommendations. Of the 262 thyroid nodules, 157 were malignant, and the remaining 105 were benign. The diagnostic performance of radiomics, CAD, and ACR TI-RADS models had an AUC of 0.915 (95% confidence interval (CI): 0.881-0.947), 0.814 (95% CI: 0.766-0.863), and 0.849 (95% CI: 0.804-0.894), respectively. DeLong's test showed a statistically significant between the AUC values of models (p < 0.05). Calibration curves showed good agreement in each model. When both models were applied to revise the ACR TI-RADS, our recommendations significantly improved the performance. The revised recommendations based on radiomics and CAD showed an increased sensitivity, accuracy, positive predictive value, and negative predictive value, and decreased unnecessary fine-needle aspiration rates. Furthermore, the radiomics model's improvement scale was more pronounced (33.3-16.7% vs. 33.3-9.7%). The radiomics strategy and CAD system showed good diagnostic performance for discriminating thyroid nodules and could be used to optimize the ACR TI-RADS recommendation, which successfully reduces unnecessary biopsies, especially in the radiomics model.