<i>Objective</i>: To investigate the effect of nursing program improvements on improving the utilization rate of gradient compression stockings in patients at high risk of deep vein thrombosis. <i>Methods</i>: To set up a special project improvement group, determine the topic of special project improvement, set 40 patients with postoperative Caprin score >5 before the implementation of special project improvement activities, i.e., from January to May 2022 in our hospital, as the control group, and 40 patients with postoperative Caprin score >5 after the implementation of special project improvement activities, i.e., from July to November 2022 in our hospital as the experimental group, and count the number of patients using gradient compression stockings to prevent deep vein thrombosis, and investigate the effect of using gradient compression stockings in improving the utilization rate of patients with high risk of deep vein thrombosis. The number of patients using gradient compression stockings to prevent deep vein thrombosis, the survey of patients' knowledge about deep vein thrombosis and satisfaction with care, and the comparison of the differences between the two groups before and after the project improvement. <i>Results</i>: The use rate of gradient compression stockings in the experimental group was 82.5% higher than that of gradient compression stockings in the control group, which was 15%, with statistically significant differences (p < 0.05); the experimental group's knowledge of DVT was higher than that of the control group, with statistically significant differences (p < 0.05); and the experimental group's satisfaction with nursing care increased from 91.73 points to 98.75 points, with statistically significant differences (p < 0.05). <i>Conclusion</i>: Project management can effectively increase the utilization rate of gradient compression stockings for high-risk patients with deep vein thrombosis and improve patients' knowledge of deep vein thrombosis and satisfaction with nursing care.