This study investigates the impact of different space utilization on energy use intensity, heating load, cooling load, and thermal comfort of occupants using a combination of empirical data gathering and simulation-based studies. The increasing worldwide preoccupation with energy consumption and environmental sustainability has led to increased attention on optimizing interior spaces to mitigate total energy demand. The considered case study for conducting this research was the Norwegian living lab namely Zero Emission Building (ZEB) Flexible Lab in Trondheim, Norway. In this study, 10 different scenarios of occupancy schedules based on flexible arrangements from standard workweeks to extensive remote work configurations were designed and analyzed using IDA ICE 5.0. The findings demonstrate significant reductions in energy use across scenarios with increased teleworking and compressed work weeks. The remote scenario achieved the most significant decrease in Energy Use Intensity (EUI), with a reduction of 46 % compared to the base case. Similarly, the implementation of flexible hours and remote working in scenarios resulted in a reduction of electric heating demand by up to 23 %, underscoring the potential of occupancy-based strategies in enhancing building energy efficiency. However, uncomfortable hours increased by 59 % in the 2-day remote working scenario compared to the base case, demonstrating the need to consider climate conditions when implementing remote work. The research offers valuable insights into the complex connections between flexible arrangements and energy efficiency, considering many elements such as occupancy schedule and use dynamics. This article offers a comprehensive analysis that may give architects, building managers, and policymakers valuable insights. This study contributes to the developing sustainable architecture by emphasizing the impact of dynamic occupancy on the energy performance of office buildings.