Comprehensive Study Research Articles

A Review and Comprehensive Study on DC-DC Converters

Background: DC-DC converters are used in various applications based on their required voltage capabilities ranging from milli volts to thousands of volts. Methods: This review paper discusses various voltage boosting techniques, such as buck-boost, switched inductor, switched capacitors, isolated converters, etc., and provides a detailed evaluation of the literature and comparison of different DC-DC converters. Results: This study reports a number of storage elements included, such as inductors and capacitors as well as switches and diodes. Their features along with methodologies, merits, complexity, efficiency, and voltage gain have been tabulated. A comprehensive study, converter classification based on the characteristics, and a detailed analysis of isolated and non-isolated DC-DC converters have also been provided. Conclusion: As this study provides a comparison of each isolated and non-isolated converter's comprehensive gain, this research may help in future topology optimization for the choice of the ideal converter for applications. In addition, the examination of each isolated and non-isolated converter's comprehensive gain comparison has also been presented in this paper.

Tarsals from the Sima de los Huesos Middle Pleistocene site (Atapuerca, Burgos, Spain).

Here, we provide a complete, updated, and illustrated inventory, as well as a comprehensive study, of the tarsals (rearfoot) recovered from the Middle Pleistocene site of Sima de los Huesos (SH, Atapuerca, Spain) in comparison to other Homo comparative samples, both extant and fossil. The minimum number of individuals (MNI) estimated from the tarsals has been established as 15, which represents 51.7% of the 29 dental individuals identified within the SH sample. Within the SH hominin foot sample, an exclusive combination of primitive or plesiomorphic and derived or autapomorphic traits can be observed when compared with other Homo individuals/populations. Other characters are shared among SH hominins and Neandertals that might represent shared derived or autapomorphic traits for this evolutionary line, and most are likely related to robusticity (e.g., rectangular-like trochlea of the talus, broad calcanei, broad naviculars, and short lateral cuneiforms). Additionally, we observed some exclusive autapomorphic traits in the SH tarsal sample (e.g., narrow head of the talus and short intermediate cuneiforms). A few exclusive traits in SH tarsal remains are even more robust than in Neandertals (e.g., broad lateral malleolar facet in talus, more projected sustentaculum tali, and broad medial cuneiform). These traits could suggest a slightly higher level of gracilization in the tarsal bones of Neandertals compared to the SH sample that is also supported by other anatomical postcranial skeleton elements. Additionally, some paleobiological inferences are made in relation to body size (stature and body mass) and some associations are proposed within the SH sample. In conclusion, the morphology of the SH tarsi confirms an evolutionary relationship of sister groups between this population and Neandertals, probably representing a morphotype similar to the Neandertal ancestors.

Revisiting Recent Tissue Engineering Technologies in Alveolar Cleft Reconstruction.

Tissue engineering and regenerative medicine have received significant attention in treating degenerative disorders and presented unique opportunities for researchers. The latest research on tissue engineering and regenerative medicine to reconstruct the alveolar cleft has been reviewed in this study. Three approaches have been used to reconstruct alveolar cleft: Studies that used only stem cells or biomaterials and studies that reconstructed alveolar defects by tissue engineering using a combination of stem cells and biomaterials. Stem cells, biomaterials, and tissue-engineered constructs have shown promising results in the reconstruction of alveolar defects. However, some contrary issues, including stem cell durability and scaffold stability, were also observed. It seems that more prospective and comprehensive studies should be conducted to fully clarify the exact dimensions of the stem cells and tissue engineering reconstruction method in the therapy of alveolar cleft.

USE OF ANIMAL FIBER-REINFORCEMENT IN CONSTRUCTION MATERIALS: A REVIEW

Although natural fibers (NFs), among which animal fibers (AFs) are found, have been used for millennia as reinforcement scheme of some construction materials (CMs), it is not until recent decades when scientific studies have been carried out to quantitively evaluate the impact of adding NFs into CMs, but with a special focus on vegetal fibers (VFs) over AFs. Nevertheless, there have been several studies addressing the use of AFs in different CMs and, therefore, the need of a systematic review study is evident. To contribute to this research gap, this paper presents a comprehensive review study addressing available scientific information of different types of AFs (e.g., sheep wool fibers (SWFs), chicken feathers fibers (CFFs), human hair fibers (HHFs), pig hair fibers (PHFs), silk fibers (SFs), and dog hair fibers (DHFs)) and also their use in four specific different CMs matrices (i.e., cementitious, gypsum, soil and polymer matrices). This comprehensive search was conducted in Web of Science and Science Direct, two of the largest and more prestigious scientific databases, using specific keyword and Boolean operators and the selection of the papers was based on the provision of enough quantitative information of the mixtures (e.g., specific characteristic and dosages of AFs and matrix used) as well as experimental findings. As a result of this study, organized, summarized and sufficient information is provided to support the positive use AF as reinforcement scheme to improve some physical/thermal/mechanical/damage/durability properties of CMs by taking advantage of the abundance of these resources worldwide. Moreover, the use of AFs provides environmental benefits care and cost reductions, which are global objectives within the construction sector. Finally, this review study found that there are still several research gaps in the use of particular AFs (e.g., DHFs) as well as combinations between the AFs CMs addressed in this study (e.g., effects of pig hair fibers in polymer matrices) and these gaps are recommended as future studies.

Media use and attitudes towards screens in children aged 36-72 months; a cross-sectional, descriptive study.

Introduction: The age at which children are introduced to media devices is becoming increasingly earlier. Studies regarding the media habits of young children have gained importance. The aim of the study was to describe the screen media habits (age of introduction media, time spend with screen, popular choices) of preschool children and to explore their relationship with household characteristics. Population and methods: Cross-sectional descriptive study; the parents of children aged 36-72 months who attended childcare centers in Kayseri, a central Anatolian city in Türkiye, completed a questionnaire on media habits of families and children. Results: There were 858 questionaires included. The proportion of children using screen media more than 2 h/day was 28%; 36% of children were introduced to media devices before the age of two. The most frequently used media tool was television (95%) and the program watched was cartoons for TV (86.7%). Children of highly educated parents had shorter TV, computer and smartphone screen time (p = 0.012, p = 0.007, p <0.01 for mother and p = 0.049, p = 0.032, p = 0.04 for father respectively). Introducing books in the first 6 months was associated with shorter daily screen time (p = 0.011, p = 0.009, p = 0.002 for TV, computer and smartphone ,respectively). Parent's time spent on TV was positively correlated with children's time spent on TV (p <0.05, r = 0.354). Conclusion: Parents' education levels, parents' screen time and introducing book in early age was related to children's media habits. Comprehensive studies are needed to explain this relationship more clearly.

Comprehensive Study on the Impacts of Gender Disparities Over Life and Work Balance in IT Sector in Bangalore

This study is focusing on, especially in the workforce of the information technology sectors, to look into the work and family life balance of the employees in the IT sectors, mainly in Bangalore City. The objective of this study is to learn the relation of gender and employees’ personal and professional life balance in the IT sector of Bangalore and how marital status affects work and personal life balance in the IT sector of Bangalore. The aim of this study is to identify how organizational support, policies, management, and leadership can help employees balance their personal and work lives in the organization. Work-life balance is to find time for family and family functions, neighbourhood participation, friends and relatives’ functions, enriching self-care, and personal and spiritual growth by attending sessions, other personal activities. Basically, it is to understand the need and how to adjust time and fulfil additional demands of the workplace. The method has been used with the collection of responses from different IT companies in Bangalore, and the chi square tool has been used for analysis.

Optimization and Effect of Substituents on the Transformation of 3-(Substituted acetoxy)azetidin-2-ones to Chiral 3-Hydroxyazetidin-2-ones, Molecular Docking and Enantiomeric Excess Determination

Abstract: The enantioselective synthesis of chiral cis-3-hydroxyazetidin-2-ones mediated by Porcine Pancreatic Lipase (PPL) via hydrolysis of cis-3-(chloro acetoxy) azetidin-2-ones in the presence of a phosphate buffer (0.1M, pH = 7.2) in acetonitrile at a temperature range of 25-35 °C was optimized. Under the optimized reaction conditions, the influence of various electron withdrawing/donating/neutral groups on ester functionality of cis-3-(substituted acetoxy)azetidin-2- ones towards hydrolysis was extensively studied, and the bromoacetoxy, propanyloxy, and formyloxy groups provided moderate to good yields of 90%, 91%, and 81%, respectively. Moreover, the chiral cis-3-hydroxyazetidin-2-ones underwent acetylation, and their enantiomeric excess was assessed using the 1H NMR technique, employing chiral shift reagents. To gain insights into the active sites of the biocatalyst, molecular docking studies of compounds 5(a-i) with pancreatic lipase (PDB ID: 1LBS) were carried out. Additionally, the proposed interaction of substituents with the biocatalyst established the absolute stereochemistry of the target chiral cis-3-hydroxyazetidin-2-ones using Seebach's model in comparison to Jone's models.

Метагипермнезия: эффекты вознаграждения и типа задач (Изображение vs. Слово)

&lt;p&gt;People sometimes make predictions about life events. These often include monitoring and control processes. Metacognition, which is subfield of cognition, has these processes. Metacognition research includes memory, attention, and comprehension studies. Hypermnesia is one of the topics relating to memory, simply meaning level of recall with regard to a repeated task. Thus, metahypermnesia is thoughts and judgements about hypermnesia. The aim of the present study was to find out whether people would overestimate or underestimate their performance on a given hypermnesia task that used images and words. Additionally, the effect of monetary incentives on the image and word test were investigated. Thus, it was hypothesised that people would overestimate their performance compared to their actual performance in the tasks. 134 participants were recruited for the study. The results illustrated that participants&amp;rsquo; performance affected by monetary incentives and recall type. Importantly, giving incentives enhanced participants&amp;rsquo; performance on image test but not word test. Participants also overestimated their performance on both the image and word tests, regardless of whether they received monetary incentives. However, participants overestimated their performance when they were incentivized more than they were not.&lt;/p&gt;

A Study of Reading Comprehension and Receptive Vocabulary Retention Using the Electronic Glossing Sandwich Approach

Abstract The present research deals with the English as second language apprentices’ reading comprehension and receptive linguistic retention using the sandwich approach for the first language and making the way of communication simple by the use of electronic glossing in the education sector of Pakistan. The leading objectives of the article were to explore whether the learners who have approach to electronic glosses have better reading scores than the ones who have no access to electronic glosses in an ESL classroom and to investigate whether the learners who have access to electronic glosses have a higher vocabulary than the ones who have no access to electronic glosses in an ESL classroom. A quantitative research method was adopted to carry out this research. The data was collected from 40 students at a private school in Rawalpindi with different socio-economic backgrounds. The collected data was analyzed by three different analyses of variance (ANOVA) conducted to get the results of reading comprehension of the students followed by instant vocabulary test, and delayed vocabulary test. Moreover, four univariate analyses of the covariate (ANCOVAs) were introduced to examine the hypotheses using the Statistical Package for Social Science (SPSS-24) software. The results of present study demonstrated the benefits of the electronic glossing in ESL classroom. The use of electronic glossing should not be neglected while learning English as second language in the private education sector of Pakistan, where direct method is used for teaching English as second language.

Nomograms for predicting the overall and cancer-specific survival in patients with non-urothelial carcinoma of the bladder: A population-based study.

Non-urothelial carcinoma of the bladder (NUCB) is a relatively rare condition, with limited comprehensive studies conducted to date. This research aims to establish nomograms for forecasting overall survival (OS) and cancer-specific survival (CSS) in NUCB patients. It utilizes data of 2,522 patients from the Surveillance, Epidemiology, and End Results (SEER) database spanning from 2004 to 2015. The effectiveness of these nomograms was assessed using receiver operating characteristic (ROC) curves, calibration curves and decision curve analysis (DCA). Key independent predictors for OS included age, race, marital status, histological variants, grade, T stage, N stage, M stage, radical cystectomy and chemotherapy administration. For CSS, the predictors were similar, encompassing age, sex, marital status, histological variants, grade, T stage, N stage, M stage, radical cystectomy and chemotherapy. The nomograms showed strong predictive accuracy. In the training cohort, the area under the curve (AUC) values were 0.796 (OS) and 0.799 (CSS) at 1-year, 0.807 (OS) and 0.824 (CSS) at 3-year, and 0.807 (OS) and 0.827 (CSS) at 5-year intervals. In the validation cohort, AUC values were 0.798 (OS) and 0.798 (CSS) at 1-year, 0.810 (OS) and 0.826 (CSS) at 3-year, and 0.811 (OS) and 0.825 (CSS) at 5-year intervals, consistently around 0.8. Calibration curves indicated high congruence between predicted and actual probabilities of OS and CSS, while DCA demonstrated the models' substantial clinical utility. Overall, this study successfully developed and validated prognostic nomograms for NUCB, capable of accurately predicting OS and CSS at 1-, 3-, and 5-years, thereby offering valuable support in clinical decision-making and the design of clinical trials.

A Comprehensive Study on Peppermint Oil and Cinnamon Oil as Nanoemulsion: Preparation, Stability, Cytotoxicity, Antimicrobial, Antifungal, and Antioxidant Activity.

Recent studies have shown that nanoemulsions prepared with essential oils have significant antimicrobial potential against multidrug-resistant pathogens due to increased chemical stability. Nanoemulsion also promotes controlled and sustained release, which increases their bioavailability and efficacy against multidrug-resistant bacteria. This study aimed to investigate the antimicrobial, antifungal, antioxidant, and cytotoxicity properties of cinnamon essential oil and peppermint essential oil as nanoemulsions compared to pure forms. For this purpose, analyses of the selected stable nanoemulsions were carried out. The droplet sizes and zeta potentials of peppermint essential oil nanoemulsions and cinnamon essential oil nanoemulsions were found to be 154.6±1.42 nm and -17.1±0.68 mV and 200.3±4.71 nm and -20.0±0.81 mV, respectively. Although the amount of essential oil used in nanoemulsions was 25% w/w, antioxidant and antimicrobial activities were found to be more effective compared to pure essential oils. In cytotoxicity studies on the 3T3 cell line, both essential oil nanoemulsions showed higher cell viability than pure essential oils. At the same time, cinnamon essential oil nanoemulsions exhibited a higher antioxidant property than peppermint essential oil nanoemulsions and showed superiority in the antimicrobial susceptibility test conducted against four bacteria and two fungi. Cell viability tests determined that cinnamon essential oil nanoemulsions showed considerably higher cell viability compared to pure cinnamon essential oil. These findings indicated that the prepared nanoemulsions in the current study might positively influence the dosing regimen and clinical outcomes of antibiotic therapy.

Comprehensive Study on Scoring and Grading Systems for Predicting the Severity of Knee Osteoarthritis.

Knee Osteoarthritis (KOA) is a degenerative joint ailment characterized by cartilage loss, which can be seen using imaging modalities and converted into imaging features. The older population is the most affected by knee OA, which affects 16% of people worldwide who are 15 years of age and older. Due to cartilage tissue degradation, primary knee OA develops in older people. In contrast, joint overuse or trauma in younger people can cause secondary knee OA. Early identification of knee OA, according to research, may be a successful management tactic for the condition. Scoring scales and grading systems are important tools for the management of knee osteoarthritis as they allow clinicians to measure the progression of the disease's severity and provide suggestions on suitable treatment at identified stages. The comprehensive study reviews various subjective and objective knee evaluation scoring systems that effectively score and grade the KOA based on where defects or changes in articular cartilage occur. Recent studies reveal that AI-based approaches, such as that of DenseNet, integrating the concept of deep learning for scoring and grading the KOA, outperform various state-of-the-art methods in order to predict the KOA at an early stage.

Cordyceps militaris: A Comprehensive Study on Laboratory Cultivation and Anticancer Potential in Dalton's Ascites Lymphoma Tumor Model.

Cancer, a predominant cause of mortality, poses a formidable challenge in our pursuit of elevating life expectancy. Throughout history, individuals have sought natural remedies with minimal side effects as an appealing substitute for chemotherapeutic drugs. One such remedy is Cordyceps militaris, a renowned medicinal mushroom deeply entrenched in Asian ethnomedicine. Revered for its rejuvenating and curative attributes, it relied upon for ages. The mushroom's soaring demand outpaced natural availability, necessitating controlled laboratory cultivation as the core focus and exploring the potential of methanolic extracts from harvested Cordyceps militaris fruiting bodies against Dalton's Lymphoma Ascites (DLA) cells in vitro, with a specific emphasis on its anticancer traits. For cultivation, we employed a diverse range of rice substrates, among which bora rice showed promising growth of C. militaris fruiting bodies. To assess DLA cell cytotoxicity, several assays, including trypan blue exclusion assay, MTT assay, and LDH assay, were employed at different time points (24-96 h), which provided valuable insights on DLA cell viability and proliferation, shedding light on its therapeutic potential against cancer. Our studies unveiled that methanolic extract prompts apoptosis in DLA cells via AO/EB dual staining, manifesting consistent apoptosis indicators such as membrane blebbing, chromatin condensation, nuclei fragmentation, and cellular shrinkage at 48-96 h of treatment. Furthermore, these striking repercussions of apoptosis were comprehended by an in silico approach having molecular docking simulation against antiapoptotic proteins like BCL-2, BCL-XL, MCL-1, BFL-1 & HSP100. Methanolic C. militaris extracts exhibited cytotoxicity and apoptotic alterations in DLA cells.

TESS photometry and CAOS spectroscopy of six eclipsing binaries with Am components

In this paper, we present the results of a comprehensive study of six eclipsing binaries whose components are confirmed or suspected Am stars. By combining long-term, high-resolution Catania Astrophysical Observatory Spectropolarimeter (CAOS) spectroscopy and TESS photometry, we have been able to accurately obtain the orbital parameters of each system as well as the atmospheric parameters of its components. We performed an in-depth chemical analysis and provided chemical abundances of C, O, Na, Mg, Si, Ca, Sc, Ti, Cr, Mn, Fe, Ni, Zn, Sr, Y, Zr, and Ba. From the solution of the light and radial curves, we have determined the masses, radii, and temperatures with a good degree of accuracy. We observe apsidal motion in the eccentric system HD 216429, in which the Rossiter-McLaughlin effect is also noted. We inferred the age of our targets by fitting isochrones on the HR diagram and find that both components in each system are properly described with the same isochrone, which reinforces our results. Furthermore, dynamical and evolutionary masses, independently obtained, show an excellent agreement. According to the out-of-eclipse variability shown in their TESS light curves and their position on the Hertzsprung-Russell diagram, we claim that the stars HD 42954 (as δ Sct type) and HD 151604 (γ Dor) have a pulsating nature. Based on the chemical analysis, we corroborate that four of the systems studied here are formed by Am stars, while in the remaining ones (HD 126031 and HD 216429) only the primary component exhibits a peculiar composition. Additionally, the age distribution found in Am stars supports their suitability as age tracers in stellar populations.

Sida cordifolia L.: Ethnobotany, Phytochemistry, Phytonanotechnology, and Commercial Application.

After a period of prolonged indifference, where synthetic drugs were preferred, interest in the biological aspects and bioactive ingredients of plants accountable for therapeutic potential has been explored eminently. Sida cordifolia L. is a perennial herb that has been widely utilized in Indian (Ayurveda, Unani, and Siddha), American, and Chinese folk medicine and herbalism practice for curing a wide range of ailments in human beings. The goal of this review is to elucidate indigenous knowledge parallelly with the pharmacotherapeutics potential of Sida cordifolia L. against various diseases. It is also intended to display pertinent information related to nanoparticle profiling. In the current comprehensive study, web-based searches were performed by using several databases, such as Google Scholar, PubMed, ResearchGate, Science Direct, and Scopus, to figure out relevant research work and data published in academic journals from 1930 to July, 2023 using single or combination of keywords listed herewith. More than 50 chemical constituents, including quinazoline and phenethylamine alkaloids, flavones, flavonol, phytosterol, fatty acids, etc., were reported to be found in different parts of healthy plants. Apart from traditional claims and pharmacological aspects, several marketed herbal formulations and granted patents were also described. Several in-vitro and in-vivo studies validated the usage of S. cordifolia as antiinflammatory, antibacterial, antifungal, antiprotozoal, anthelmintic, anticancer, antiulcer, cardioprotective, hypoglycemic, etc. agent. Few patents are also related to S. cordifolia, and more research work needs to be carried out for its potential granted to use as an antiviral agent and other new drug discovery molecules.

Data Security in Cloud Environment by Using Hybrid Encryption Technique: A Comprehensive Study on Enhancing Confidentiality and Reliability

Data Security in Cloud Environment by Using Hybrid Encryption Technique: A Comprehensive Study on Enhancing Confidentiality and Reliability

A Survey of Cutting-edge Multimodal Sentiment Analysis

The rapid growth of the internet has reached the fourth generation, i.e., web 4.0, which supports Sentiment Analysis (SA) in many applications such as social media, marketing, risk management, healthcare, businesses, websites, data mining, e-learning, psychology, and many more. Sentiment analysis is a powerful tool for governments, businesses, and researchers to analyse users’ emotions and mental states in order to generate opinions and reviews about products, services, and daily activities. In the past years, several SA techniques based on Machine Learning (ML), Deep Learning (DL), and other soft computing approaches were proposed. However, growing data size, subjectivity, and diversity pose a significant challenge to enhancing the efficiency of existing techniques and incorporating current development trends, such as Multimodal Sentiment Analysis (MSA) and fusion techniques. With the aim of assisting the enthusiastic researcher to navigating the current trend, this article presents a comprehensive study of various literature to handle different aspects of SA, including current trends and techniques across multiple domains. In order to clarify the future prospects of MSA, this article also highlights open issues and research directions that lead to a number of unresolved challenges.

Реформирование пенсионной системы для плательщиков налога на профессиональный доход: региональная платформа

The difficulties that arose after the entry into force of the Federal Law “On conducting an experiment to estab-lish a special tax regime “Tax on professional income”” dated November 27, 2018 No. 422-FZ require a com-prehensive study and modification of the legislative framework. Many citizens who pay tax on professional in-come do not make contributions to the pension insurance system, which is one of the reasons for the high sub-sidy dependence of the Social Fund of Russia on the federal budget. According to the authors, it is necessary to develop a way to attract citizens to participate in the pension insurance program. The article considers an ex-ample of a possible solution to this issue: the introduction of tax deduction for taxpayers of tax on professional income in part of the tax paid, and assesses its impact on the regional budgets of the constituent entities of the Russian Federation.

Adaptive solar power generation forecasting using enhanced neural network with weather modulation

Solar power generation forecasting plays a vital role in optimizing grid management and stability, particularly in renewable energy-integrated power systems. This research paper presents a comprehensive study on solar power generation forecasting, evaluating traditional and advanced machine learning methods, including ARIMA, Exponential Smoothing, Support Vector Regression, Random Forest, Gradient Boosting, and Physics-based Models. Moreover, we propose an innovative Enhanced Artificial Neural Network (ANN) model, which incorporates Weather Modulation and Leveraging Prior Forecasts to enhance prediction accuracy. The proposed model is evaluated using real-world solar power generation data, and the results demonstrate its superior performance compared to traditional methods and other machine learning approaches. The Enhanced ANN model achieves an impressive Root Mean Square Error (RMSE) of 0.116 and a Mean Absolute Percentage Error (MAPE) of 36.26%. The integration of Weather Modulation allows the model to adapt to changing weather conditions, ensuring reliable forecasts even during adverse scenarios. Leveraging Prior Forecasts enables the model to capture short-term trends, reducing forecasting errors arising from abrupt weather changes. The proposed Enhanced ANN model showcases its potential as a promising tool for precise and reliable solar power generation forecasting, contributing to the efficient integration of solar energy into the power grid and advancing sustainable energy practices.

Reducing shallow foundation rotation due to reverse faulting using predefined shear planes

Permanent ground displacement due to faulting during strong earthquakes threatens the stability of civil structures. To protect surface foundations from faulting, several mitigation techniques have been developed. Owing to the limitations of earlier mitigation strategies for unidentified reverse faulting conditions, this research presents a novel mitigation system, including the installation of sliders beneath the wings of a V-shaped concrete element, to reduce footing rotation. To evaluate the effectiveness of the suggested mitigation strategy, concrete strength tests, a physical centrifuge test and a comprehensive numerical study for different fault locations and dip angles were conducted for the first time. Results demonstrated that the placement of the sliders beneath the V-shaped wings had a significant effect on dissipating the fault dislocation. Compared to the previous mitigation techniques, the proposed system decreased the foundation rotation from a high value (11°) to a low value (3·2°) for the worst-case scenarios. Furthermore, the friction coefficients among sliders and concrete, the concrete wing inclination angle, length and thickness were critical parameters to design the optimum proposed system. In contrast, soil layer thickness and relative density did not significantly affect the footing rotation.