Objective To explore the effect of early comprehensive rehabilitation and hyperbaric oxygen therapy on the swallowing dysfunction of brain stroke patients. Methods A total of 117 brain stroke patients with swallowing dysfunction were divided into observation (n = 59) and control (n = 58) groups, observation group was given additional nursing besides routine nursing, including psychological intervention, early comprehensive rehabilitation and hyperbaric oxygen therapy. The swallowing function was measured by drinking water test. Results The effective rate of observation and control groups were 89. 8% and 60.3% respectively, and there was significantly different between the two groups (χ2 = 13. 64, P <0. 01) . Conclusions Psychological intervention, early comprehensive rehabilitation and hyperbaric oxygen therapy can improve the swallowing function of brain stroke patients, and promote early recovery of patients. Key words: Brain stroke; Swallowing dysfunction; Psychological intervention; Rehabilitation; Hyperbaric oxygen