Comprehensive Examination Research Articles

Exploring retinal vessel density alterations in prolactinoma patients: Insights from OCTA imaging.

To investigate microvascular changes in the macular and peripapillary area in prolactinoma patients by using optical coherence tomography angiography (OCTA). A retrospective study. This study included 40 patients with treatment-naive prolactinoma and 42 healthy controls. Participants underwent comprehensive ophthalmic examinations, visual field testing, and optical coherence tomography (OCT) assessments, including retinal nerve fiber layer (RNFL) thickness, macular, and peripapillary region OCTA by using the Topcon DRI OCT Triton Swept Source-OCT system. The OCTA results were evaluated between groups and then correlated with PRL levels. The differences in best-corrected visual acuities were statistically significant among the groups. The RNFL thickness in the superior and nasal quadrants was significantly lower in the prolactinoma group. The prolactinoma group showed significant reductions in macular vessel density (VD) across all layers than the control group, except in the deep retinal capillary plexus temporal quadrants. The radial peripapillary capillary (RPC) temporal VD in the prolactinoma group was significantly lower. In patients with optic neuropathy, correlations were observed between the RPC temporal and RNFL temporal sectors (r = 0.650, P = 0.03), and between the RPC inferior and RNFL inferior sectors (r = -0.612, P = 0.045). Between PRL levels and OCTA parameters, negative correlations were observed (RPC inferior: r = -0.452, P = 0.003; DCP superior: r = -0.379, P = 0.016). Our study revealed reduced VD in the macula and RPC temporal regions in patients with treatment-naive prolactinoma. OCTA holds significant importance in detecting potential retinopathies and vasculopathies. Future research should focus on examining pre- and post-treatment changes in treatment-naive patients without ON to better understand the impact of prolactinoma.

A Typology and Lead Isotope and Cultural Exchange Study on Bronze Knives from Shuangyuan Cemetery, Chengdu City, Southwest China

Background: Bronze knives, which have been excavated in large quantities and acquired hierarchical significance, are essential artifacts in Shu State in Southwest China. Building upon previous typological analyses of bronze knives, it is hypothesized that Shu culture may have imported foreign-style bronze knives. However, further demonstration of the provenance of metal materials, the typology of knives, and the cultural exchange necessitates a comprehensive examination through the lens of scientific analysis. The purpose of this study is to investigate the differences in the manufacturing processes and metal resources of Shu bronze knives with various cultural styles and whether bronze knives in the foreign styles were imported or locally imitated. Methods: In this study, the typology, portable X-ray fluorescence spectrometry and multi-collector inductively coupled plasma mass spectrometry were used to analyze twenty-four bronze knives unearthed from Shuangyuan cemetery, a cemetery of the Eastern Zhou Dynasty in Chengdu City, Sichuan Province, Southwest China. Results: The results of the study show that the knives of Shuangyuan Cemetery can be classified typologically into five types, encompassing both local and foreign styles. The predominant alloy composition of these knives is lead-tin bronze, characterized by a notably high tin content. Lead isotope ratios indicate that metal materials from the South China geochemical province and Yangtze geochemical province were mainly used to manufacture the bronze knives unearthed from the Shu state Conclusion: While the majority of foreign-style knives with ring-shaped heads were likely imported from neighboring regions like Chu state, distinctively styled type D and type E bronze knives appear to have been locally imitated by the Shu, showcasing a blend of external influences and indigenous innovation. The combination of typology and scientific analysis of the bronze knife may shed new light on the study of the Shu culture of the Eastern Zhou period.

Etiological spectrum of pancytopenia in adults based on hematological parameters and bone marrow studies

ABSTRACT Background This study aimed to investigate the demographic, clinical, and diagnostic aspects of adult pancytopenia while exploring its etiological spectrum through hematological parameters and bone marrow studies. Research design and methods This observational study involved 117 adult individuals ranging from 13 to 85 years who presented with pancytopenia. A comprehensive examination of demographic features, hematological parameters, clinical presentations, and physical findings, including liver and spleen characteristics, was conducted. Additionally, serological analyses for HBsAg and Anti HCV were performed. The diagnostic spectrum was determined through bone marrow studies. Results Pancytopenia manifested with varied clinical symptoms, with generalized weakness (72.65%), fever (64.1%), dyspnea (54.70%), bleeding (34.2%), and weight loss (25.6%) being prominent. Physical examination revealed a range of liver and spleen characteristics, with hepatomegaly observed in 32.48% and splenomegaly in 44.4% of cases. Serological findings indicated HBsAg positivity in 8.5% and Anti HCV positivity in 21.37% of cases. The diagnostic distribution encompassed diverse conditions, with aplastic anemia (17.1%), megaloblastic anemia (12.8%), and myelodysplastic syndromes (12.8%) being prevalent. Conclusions This study provides a comprehensive overview of the demographic, clinical, and diagnostic aspects of pancytopenia. The observed prevalence of different diagnoses underscores the necessity of a thorough evaluation, including bone marrow studies, for accurate diagnosis and appropriate management.

Off‑label and unapproved pediatric drug utilization: A meta‑analysis.

Despite legislative enforcement on authorized drugs, off-label and unapproved pediatric drug use is prevalent. The present study aimed to assess the global prevalence of off-label and unlicensed prescriptions among hospitalized children via meta-analysis. A comprehensive examination of articles published between 1990 and 2023 from the PubMed, Scopus, Excerpta Medica Database, Web of Science and Google Scholar databases was conducted. Key word-based advanced searches were executed using the aforementioned databases. A total of 45 studies that reported the prescriptions of off-label and unlicensed drugs to pediatric patients were included. The global prevalence of off-label and unlicensed drug prescriptions to children in pediatrics or neonatal departments was 56%. Patient sample sizes varied from 40-13,426, with a range of 240-8,891 total prescriptions issued. Of the 45 studies examined, 22 studies originated from Europe, 13 from Asia, 3 from South America, 3 from Africa, and 2 each from North America and Australia. Africa had the highest prevalence rate at 66%, followed by Asia, South America, North America, Australia and Europe. The present meta-analysis demonstrated that the prevalence of off-label and unlicensed drug prescriptions given to pediatric patients was notably high and geographically diverse. Therefore, drug authorities should standardize pediatric prescription practices in future.

Small hepatitis B virus surface antigen (SHBs) induces dyslipidemia by suppressing apolipoprotein-AII expression through ER stress-mediated modulation of HNF4α and C/EBPγ.

Persistent infection with hepatitis B virus (HBV) often leads to disruptions in lipid metabolism. Apolipoprotein AII (apoAII) plays a crucial role in lipid metabolism and is implicated in various metabolic disorders. However, whether HBV could regulate apoAII and contribute to HBV-related dyslipidemia and the underlying mechanism remain unclear. This study revealed significant reductions in apoAII expression in HBV-expressing cell lines, the serum, and liver tissues of HBV-transgenic mice. The impact of HBV on apoAII is related to small hepatitis B virus surface antigen (SHBs). Overexpression of SHBs decreased apoAII levels in SHBs-expressing hepatoma cells, transgenic mice, and the serum of HBV-infected patients, whereas suppression of SHBs increased apoAII expression. Mechanistic investigations demonstrated that SHBs repressed the apoAII promoter activity through a HNF4α- and C/EBPγ-dependent manner; SHBs simultaneously upregulated C/EBPγ and downregulated HNF4α by inhibiting the PI3K/AKT signaling pathway through activating endoplasmic reticulum (ER) stress. Serum lipid profile assessments revealed notable decreases in high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglycerides (TG) in SHBs-transgenic mice compared to control mice. However, concurrent overexpression of apoAII in these mice effectively counteracted these reductions in lipid levels. In HBV patients, SHBs levels were negatively correlated with serum levels of HDL-C, LDL-C, TC, and TG, whereas apoAII levels positively correlated with lipid content. This study underscores that SHBs contributes to dyslipidemia by suppressing the PI3K/AKT pathway via inducing ER stress, leading to altered expression of HNF4α and C/EBPγ, and subsequently reducing apoAII expression.IMPORTANCEThe significance of this study lies in its comprehensive examination of how the hepatitis B virus (HBV), specifically through its small hepatitis B virus surface antigen (SHBs), impacts lipid metabolism-a key aspect often disrupted by chronic HBV infection. By elucidating the role of SHBs in regulating apolipoprotein AII (apoAII), a critical player in lipid processes and associated metabolic disorders, this research provides insights into the molecular pathways contributing to HBV-related dyslipidemia. Discovering that SHBs downregulates apoAII through mechanisms involving the repression of the apoAII promoter via HNF4α and C/EBPγ, and the modulation of the PI3K/AKT signaling pathway via endoplasmic reticulum (ER) stress, adds critical knowledge to HBV pathogenesis. The research also shows an inverse correlation between SHBs expression and key lipid markers in HBV-infected individuals, suggesting that apoAII overexpression could counteract the lipid-altering effects of SHBs, offering new avenues for understanding and managing the metabolic implications of HBV infection.

The prevalence and impact of changes in the severity of secondary TR during hospitalization in acute heart failure

Abstract Background Secondary tricuspid regurgitation (TR) is a prevalent entity in patients hospitalized for acute heart failure (AHF), and concomitant moderate or severe TR at admission has been demonstrated to be associated with a poor prognosis. However, no study has described the trajectories of the severity of secondary TR during admission, and the prognostic implications of changes in the severity of secondary TR. Purpose This study aimed to investigate the dynamism of secondary TR observed during hospitalization due to worsening heart failure, and its prognostic impact in patients with AHF. Methods A post-hoc analysis of 1,061 consecutive patients hospitalized with AHF was performed, enrolled in the prospective, multicenter Registry Focused on Very Early Presentation and Treatment in Emergency Department of Acute Heart Failure (REALITY-AHF). Patients included in the study underwent a comprehensive echocardiographic examination within 24 hours of admission and again prior to discharge. Patients were divided into four groups based on the TR severity at admission and discharge: none to mild TR at both admission and discharge (no/no group), moderate to severe TR at admission but improved to none to mild TR at discharge (resolution group), none to mild TR at admission but moderate to severe TR at discharge (worsening group), and moderate to severe TR at both admission and discharge (persistent group). The primary endpoint was the composite of 1-year all-cause mortality and HF re-hospitalization after discharge. Results The no/no, resolution, worsening, and persistent groups included 479 (45%), 275 (26%), 85 (8%), and 222 patients (21%), respectively. The no/no group and the resolution group had significantly lower tricuspid regurgitant pressure gradients prior to discharge compared to the worsening and persistent groups (P<0.001). Also, right ventricular dysfunction evaluated at discharge, defined by tricuspid annular plane systolic excursion <17 mm, was more prevalent in the worsening (65.7%) and persistent groups (66.4%) compared to the no/no (43.7%) and resolution (53.2%) groups (P<0.001). Compared to the no/no group, the worsening and persistent groups, but not the resolution group, were associated with a higher incidence of the primary endpoint (Log-rank: P<0.001). This association remained significant in an adjusted Cox regression analysis, with the worsening group (hazard ratio: 1.48, 95% confidence interval [CI]: 1.01–2.20) and persistent group (hazard ratio: 1.35, 95% CI: 1.01–1.83) independently associated with the primary endpoint, but not the resolution group (hazard ratio: 1.10, 95% CI: 0.81–1.49). Conclusions In patients hospitalized for AHF, the severity of secondary TR is dynamic, and changes in the severity of TR are significantly associated with prognosis. Our study results underscore the importance of repetitive evaluation of TR in hospitalized patients with AHF.

Prognostic significance of right ventricular dysfunction in patients with TTR amyloidosis

Abstract Background Transthyretin amyloidosis (ATTR) is increasingly recognized as a cause of heart failure (HF) that now benefits from effective treatment. While the role of right ventricular (RV) systolic dysfunction has been widely accepted as an independent predictor of poor prognosis in HF patients, its implications in ATTR remain poorly understood. Right ventricular free wall strain (FWS) over pulmonary arterial systolic pressure (PAsP) has been recently proposed as an accurate and sensitive tool to evaluate RV function and its coupling to the afterload. Purpose Our study sought to analyze whether indexing FWS to PASP should integrate the set of fundamental data we have to assess the prognosis of ATTR patients. Methods 191 consecutive patients diagnosed with ATTR were enrolled. A comprehensive echocardiographic examination was part of the systematic evaluation. The primary outcome was a composite of cardiovascular mortality and hospitalization caused by heart failure worsening. Results After a median follow-up of 24 months, among patients with ATTR [median age 82 (77, 85), 89.5% male], the primary composite outcome occured in 26%. Cardiovascular mortality rate was 7.3% and the hospital event rate was 18.8%. Tricuspid annular plane systolic excursion (TAPSE), FWS, TAPSE/PAsP and PAsP were univariately significant risk factors for adverse outcome. In multivariate Cox regression analysis, after adjustment of confounding factors, FWS/PASP emerged as an independent predictor of the composite endpoint of cardiac death and rehospitalization (HR 1.61, 95% CI 1.07-2.42, p=0.021). Based on receiver-operating characteristic analysis, the optimal FWS/PASP cut-off value for event prediction was 42.5% (area under the curve = 0.749, p = 0.001). Conclusion Right ventricular function assessed with speckle-tracking echocardiography is an independent prognostic marker for cardiac mortality and heart failure hospitalization in patients with ATTR. FWS/PAsP should be integrated into regular clinical practice for a better evaluation and follow-up of ATTR patients.

Left atrial reservoir strain measured by three-dimensional echocardiography is associated with major adverse cardiovascular events in the general population

Abstract Background Left atrial (LA) strain measured by three-dimensional (3D) echocardiography (3DE) is a novel way of evaluating LA function. The prognostic value of LA strain by 3DE in incident heart failure (HF) and cardiovascular (CV) death has not previously been documented. Purpose We south to investigate whether 3D LA strain measures were associated with incident heart failure (HF) and cardiovascular (CV) death in a population at low risk of CV events. Methods A total of 1,934 participants from a prospective longitudinal cohort study of the general population underwent a comprehensive transthoracic echocardiographic examination including 3DE where LA reservoir strain (LASr), conduit strain (LAScd) and contraction strain (LASct) were quantified. All participants were at sinus-rhythm during 3DE. The endpoint was a composite of HF and CV death. Cox proportional hazards regression was applied. Multivariable adjustments were made for the ARIC-HF risk score (age, gender, heart rate, systolic blood pressure, antihypertensive medication, diabetes, ischemic heart disease, smoking, and body mass index) and left atrial volume index. Results Mean age was 54±17 years, 43% were male. During a median follow-up time of 4.8 years (interquartile range 4.3-5.4 years), 89 participants (4.6%) either developed HF or died of a CV cause. In univariable analysis, LASr and LAScd, but not LASct were significantly associated with the outcome, but after multivariable adjustment only LASr remained significantly associated with outcome (HR 1.04 (95% CI: 1.01-1.08), p=0.016, per 1% decrease) while LAScd and LASct did not. LASr provided incremental prognostic information beyond the ARIC-HF risk score (continuous NRI 0.21±0.11, p=0.027). Compared to participants with a LASr in the 1st tertile (LASr>32%) Participants with an LASr in the in the 3rd tertile (LASr<26.5%) had an almost 7-fold increased risk of HF or CV-death (HR 6.93 (95% CI 3.29-14.58; p=0.001)(Figure). Conclusion LA reservoir strain assessed by 3DE was independently associated with incident HF and CV death, which was not the case for LA conduit and contraction strain. In addition, LA reservoir strain added incremental value beyond clinical risk scores.

Beyond Numbers: Investigating the Impact of COVID-19 on Suicide Rates in Austria

Abstract During the COVID-19 pandemic, individuals’ mental health faced substantial challenges. This study aims to provide a comprehensive examination of the pandemic’s impact on suicide rates in Austria, with a particular focus on variations by gender, region, and age. The study employs a regression discontinuity in time design and an interrupted time series analysis, utilising monthly death records from January 2015 to December 2021. To account for seasonal variations and potential underreporting of suicides, harmonic Fourier terms are incorporated into the analysis, and both suicides with intended self-harm and self-harm with undetermined intent are included. While existing research offers valuable insights into the impact of the pandemic on suicidal behaviour, it does not yet allow for specific conclusions to be drawn for Austria. In contrast to the methods typically employed in previous research on other countries, this approach enables a comprehensive examination of the temporal effects surrounding the implementation and lifting of pandemic-related measures. The study reveals a significant negative trend in Austria’s suicide rates before the start of the pandemic and more suicides than expected after its onset. In particular, the number of suicides among men aged 64-85 and women in the age groups 0-19, 20-34, and 65-84 was significantly higher than expected. Conversely, the data indicated a positive impact among women aged 35-64. This study contributes to understanding the impact of the pandemic on suicide rates in Austria. It demonstrates that, even within the same country, the impact can differ by gender, age, and region, thereby supporting the need for subgroup analysis. It also highlights that potential underreporting of suicides may result in an underestimation of the impact of the pandemic on suicides in previously conducted studies. Understanding these nuances is crucial for suicide prevention and informing policy decisions to improve health system resilience. Key messages • The study found higher than expected suicide rates in Austria during the COVID-19 pandemic, especially among men aged 64-85 and women aged 0-19, 20-34, and 65-84. • The underreporting of suicides may result in an underestimation of the impact of COVID-19 on suicides in previously conducted studies.

Organizational barrier to herpes zoster vaccination uptake in Europe: a systematic review

Abstract Background The Herpes Zoster virus represents a significant public health threat for unvaccinated frail individuals and older adults, aged 50 or older. Globally, 95% of elderly and frail individuals are susceptible to develop Herpes Zoster as already being exposed to Varicella Zoster Virus. Organizational and logistical barriers, such as cost management, vaccine storage requirements, supply limitation, logistic difficulties, absence of a streamlined collection system, and healthcare system deficiencies might reduce vaccination uptake. Methods A systematic review was conducted to identify studies published in the last 10 years, and focused on logistic and organizational barriers for Herpes Zoster vaccination uptake among frail and participants aged 50+ in Europe. Prisma guidelines were followed, and AXIS tool was used to evaluate the risk of bias. Results After a thorough analysis, 4 studies were selected from a total of 863 for detailed review. The analysis revealed several barriers to vaccination uptake, including challenges involving healthcare professionals, participant-related obstacles concerning perceptions and knowledge, accessibility issues, structural deficiencies, and social dynamics. A significant barrier identified is the perception among participants that general practitioners either do not support the vaccination or that participants themselves underestimate the risk of developing Herpes Zoster. Additionally, current communication strategies have proven inadequate, indicating a need for more effective and updated approaches to increase public awareness. These factors contribute to hesitancy regarding vaccination. Conclusions This study provides a comprehensive examination of the organizational and logistical barriers to the Herpes Zoster vaccination uptake. Tailored interventions are essential to overcome these barriers. Successfully addressing these challenges might enhance vaccination rate and reduce the public health burden associated with Herpes Zoster. Key messages • Several logistic and organizational barriers reduce the Herpes Zoster vaccination uptake. • Further literature is required to understand how to overcome those barriers, and increase vaccination uptake.

A Novel Natural Language Processing Model Transfer Strategy Tailored for Deep Learning Platforms

As artificial intelligence technology continues to evolve, numerous advancements enable smoother communication and collaboration between humans and computers. Natural language processing (NLP), as a key direction in the field of computer and artificial intelligence, has been attracting much attention. It focuses on the language used by people in daily life, devoting itself to improving the ability of language generation and understanding, thus making communication between people and computers more fluent and natural, effectively breaking through the problem of human-computer interaction. With the advancement of deep learning technology, the migration of NLP models onto deep learning platforms has emerged as a key trend. Model transfer, a crucial aspect of deep learning, holds significant value in enhancing the performance and efficiency of NLP models. This paper begins by outlining the fundamentals of deep learning platforms and NLP model transfer, followed by a comprehensive examination of current research progress and challenges in this field. Subsequently, we introduce a novel NLP model transfer strategy tailored for deep learning platforms and validate its effectiveness through rigorous experiments. In conclusion, the paper highlights our noteworthy advancements, pointing toward promising future developments.

Exploring non-smokers’ attitudes toward e-smoking: results from the Minerva Project Europe

Abstract Background In the shifting paradigm of tobacco use, the attitudes of non-smokers toward e-cigarettes are crucial for public health planning, as in the literature it has been suggested that non-smokers who use e-cigarettes could be more prone to switch to tobacco. This multi-center study investigates the interplay between traditional smoking and the potential benefits of transitioning to e-smoking, through a comprehensive examination of smoking behaviors, dietary, and lifestyle practices. Methods MINERVA (My changINg lifEstyles, our Research, and eVeryone’s heAlth) is an ongoing prospective international cohort study aimed at investigating the association between smoking habits and dietary and lifestyle habits among the study participants. The secondary objective pertains to the assessment of subjects’ willingness to try e-cigarettes. We implemented an univariable logistic regression analysis on a dataset comprising 2367 nonsmokers to identify factors influencing their willingness to smoke e-cigarettes. Results Employment significantly predicted willingness, with employed non-smokers showing a higher likelihood to consider e-smoking (OR 2.5, p = 0.002). Household dynamics, specifically the presence of children, also affected the decision, indicating a protective effect against adopting e-smoking (OR 1.26, p < 0.001). Lifestyle choices, particularly fitness and dietary habits, played a discernible role. Surprisingly, age inversely correlated with the willingness to try e-smoking, as younger non-smokers were more likely to consider it (OR 0.97 per year increase, p < 0.001), suggesting that this openness could increase their risk of future tobacco use, which carries important public health consequences. Conclusions The study’s outcomes underscore the impact of socio-economic and lifestyle factors on non-smokers’ openness to e-cigarettes. These insights are pivotal for devising culturally competent educational campaigns and regulatory policies. Key messages • In the shifting paradigm of tobacco use, the attitudes of non-smokers toward e-cigarettes are crucial for public health planning. • By thoroughly analyzing smoking habits, diet, and lifestyle choices, the Minerva Project research aims to shed light on the complex dynamics between health behaviors and smoking.

A Case of A Middle-Aged Woman with Cor Triatriatum Dexter and Sick Sinus Syndrome: Comprehensive Cardiovascular Evaluation

This case study discusses a 51-year-old woman with a complex cardiovascular condition, cor triatriatum dexter, complicated by sick sinus syndrome. The patient presented with a history of bradycardia, dizziness, and amaurosis, and was admitted to the emergency department due to numbness in her right limb. Diagnostic examinations, including computed tomography (CT) and cardiac color-ultrasound screening, revealed cor triatriatum dexter along with an enlarged left atrium and ventricle. Additional findings included the absence of the inferior vena cava and polysplenic syndrome. Based on these results, double-chamber pacemaker surgery was recommended, supported by cardiac and thoracic-abdominal CT angiography and three-dimensional vascular reconstruction. This case underscores the importance of comprehensive examinations in identifying associated cardiovascular abnormalities.

Recognizing objects in complex scenes: A Recent Systematic Review

This systematic review provides a comprehensive examination of recent advancements in object recognition within complex scenes, focusing on addressing challenges such as clutter, occlusion, and diverse environmental conditions. Leveraging the PRISMA framework, the study meticulously analysed a diverse range of literature from esteemed sources, employing advanced search methods on Scopus and WoS databases to identify and analyse primary research studies (n = 25). The review encompasses three key themes: Theme 1 concentrates on Image Noise Identification and Removal Techniques, while Theme 2 delves into Image Classification and Recognition under Noise. Additionally, Theme 3 explores Innovative Models and Approaches for Noise-Robust Image Analysis. Despite the progress achieved, contemporary recognition systems struggle with real-world complexities such as varied scales, lighting variations, and different viewpoints. The synthesis of findings emphasizes the necessity for innovative strategies that capitalize on contextual cues and harness the potential of deep learning to enhance precision in object recognition within intricate visual environments. The insights gleaned from this synthesis are poised to guide future research directions, informing the development of more resilient algorithms capable of navigating challenges and catalysing advancements in the field of object recognition.

Optimal class of memory type imputation methods for time-based surveys using EWMA statistics

Time-based surveys often experience missing data due to several reasons, like non-response or data collection limitations. Imputation methods play an essential role in incorporating these missing values to secure the accuracy and reliability of the survey outcomes. This manuscript proposes some optimal class of memory type imputation methods for imputing missing data in time-based surveys by utilizing exponentially weighted moving average (EWMA) statistics. The insights into the optimal conditions for incorporating our proposed methods are provided. A comprehensive examination of the proposed method utilizing simulated and real-life datasets is conducted. Comparative analyses against the existing imputation methods exhibit the superior performance of our methods, particularly in the scenarios characterized by developing trends and dynamic response patterns. The outcomes highlight the effectiveness of utilizing EWMA statistics into memory type imputation methods, displaying their flexibility to changing survey dynamics.

A Review of Tiktok Livestreaming Commerce

In recent years, live-streaming commerce has witnessed remarkable global growth, catalyzed in part by the COVID-19 pandemic. TikTok, originally a video-sharing app, has undergone rapid expansion and now offers livestreaming capabilities. This review aims to explore how TikTok livestreaming is reshaping the marketing landscape. The objective is to uncover the advantages of TikTok livestreaming for various stakeholders, shedding light on its potential implications for marketers, customers, and content creators. A comprehensive examination of existing literature was conducted, analyzing studies, reports, and academic papers. The analysis focused on the multifaceted benefits of TikTok live streaming for marketers, customers, and content creators. It also considered practical implications for businesses utilizing this platform. TikTok livestreaming fosters real-time engagement between marketers and customers, leading to enhanced trust and more effective product demonstrations. It appeals to younger demographics, offering a valuable marketing avenue. For customers, it facilitates interactive, informative, and emotionally engaging shopping experiences. Content creators can leverage TikTok live streaming to monetize their content and deepen connections with their audience, enhancing brand exposure. In conclusion, TikTok livestreaming is reshaping e-commerce by facilitating immersive, interactive, and trust-building experiences for marketers, customers, and content creators. Marketers should focus on quality interaction, product presentation, and partnering with suitable content creators. Collaborations with influencers should consider credibility and alignment with brand values. Leveraging TikTok's livestreaming capabilities offers the potential to cultivate customer loyalty and retention, transforming conventional marketing paradigms in the process

Analysing the Impact of Socioeconomic Factors on Mental Health Differences in Chinese Society: Integrating Cultural, Psychological and Technological Perspectives.

Mental health (MH) differences remain an issue in contemporary Chinese society, with various factors influencing individuals' well-being. This study investigates the complex connection between results related to psychological wellness and social issues, integrating cultural, psychological and technological perspectives. Through a quantitative research methodology, data were collected from 1000 individuals using a questionnaire survey and analysed using SPSS software. The study's findings shed light on the impact of socioeconomic status (SES) on MH stigma, help-seeking behaviour and overall well-being. The findings identify that lower SES was associated with heightened levels of MH stigma and decreased the search for assistance actions. Cultural beliefs emphasising MH stigma and societal expectations were identified as mediators in the connection involve SES and MH outcomes. Digital technology use emerged as a moderator, indicating that higher levels of technology utilisation were linked to reduced disparities in accessing MH resources. The novelty of this study lies in its comprehensive examination of the multifaceted factors influencing MH disparities within Chinese society. Additionally, psychological factors such as resilience and social support were observed to mitigate the negative lower SES's effect on MH consequences. The interaction between SES and cultural factors was found to predict MH outcomes, with lower SES exacerbating the effects of MH stigma and cultural barriers.

A Review of Comprehensive Guidelines for Computational Fluid Dynamics (CFD) Validation in Solar Chimney Power Plants: Methodology and Manzanares Prototype Case Study

This review provides a comprehensive examination of CFD modeling procedures for SCPP, with an emphasis on the detailed methodologies and a case study of the Manzanares prototype in Spain. The introduction delineates the historical context and physical modeling principles of solar chimneys, while highlighting their potential in industrial applications. The governing equations are meticulously discussed, covering assumptions in both 2D and 3D CFD modeling, the continuity and momentum equations, and the selection and accuracy of turbulence models, particularly the k-ε equations. The review also delves into heat transfer modeling, encompassing the energy equation and radiation modeling. Analytical evaluations of turbine pressure drop ratios and performance metrics for power generation efficiency are critically analyzed. The establishment of boundary conditions in solar chimney applications, including sky temperature assessments and distinctions between 2D and 3D boundary conditions, is extensively explored. Mesh generation techniques for both 2D and 3D CFD models are presented, supported by case studies. Parametric studies and experimental investigations are scrutinized to elucidate their impact on the performance of solar chimneys. The temperature–entropy diagram for an idealized Brayton cycle is introduced as a conceptual framework for efficiency analysis. Validation of the CFD codes, both 2D and 3D, against experimental data is performed to ensure model accuracy. The review further examines energy balance approaches in modeling solar chimneys, presenting state-of-the-art CFD results and discussing their implications in both 2D and 3D contexts. The synthesis of these findings culminates in a comprehensive conclusion, offering insights into the future directions and potential advancements in the CFD modeling of solar chimneys. This work aims to serve as a definitive reference for researchers and practitioners in the field, providing a robust foundation for the development and optimization of SCPP technology.

Gen Z’s enduring commitment to fitness apps: a comprehensive examination

Gen Z’s enduring commitment to fitness apps: a comprehensive examination

Integration Approaches in Forensic Portrait Examination

The article reviews some actual issues of the theory and practice of the production of forensic portrait examinations: the tight deadlines of the preliminary investigation, the increased time expenditures to produce forensic video examination, the need for an integrated approach to the training of forensic portrait experts. The author proposes to revise some approaches to the training of forensic experts in the field of forensic portrait examinations. Along with the possibility of a comprehensive forensic examination, taking into consideration current needs of practice, more attention needs to be paid to software application for processing photo and video images processing in order to improve visual perception of the information displayed and to study montage marks and their detectability. All this will contribute to the evolvement of a portrait examiner as a specialist of double competence.