Comprehensive Benefits Research Articles

Perilla Seed Oil: A Review of Health Effects, Encapsulation Strategies and Applications in Food

Perilla (Perilla frutescens L.) is an annual herbaceous plant whose seed oil is rich in unsaturated fatty acids such as alpha-linolenic acid (ALA). This oil exhibits various health benefits, including antioxidant, anti-inflammatory, lipid-lowering, hypoglycemic, neuroprotective and immunomodulatory activities. In addition, incorporating perilla oil into a diet can effectively increase the abundance of beneficial bacteria in the gut microbiota. However, perilla oil is prone to oxidation, which reduces its nutritional value and lowers its bioavailability. To address these issues, encapsulation technologies such as emulsions, oleogels, liposomes and microcapsules have been employed, showing promising results. Nonetheless, further research is needed to fully elucidate the underlying mechanisms of perilla seed oil’s health effects, validate its benefits through large-scale human clinical trials and optimize encapsulation techniques. Future investigations should also explore the synergistic effects of combining perilla seed oil with other functional components and its role in modulating gut microbiota to achieve comprehensive health benefits.

Evaluation of comprehensive use benefits and analysis of influencing factors of China’s natural resources: based on a new spatial model

Evaluation of comprehensive use benefits and analysis of influencing factors of China’s natural resources: based on a new spatial model

Application of mathematical models on efficiency evaluation and intervention of medical institutions in China.

BACKGROUND: The efficiency of medical services directly impacts the economic burden of healthcare, making it crucial to analyze the input-output efficiency of various types of medical institutions. However, while hospitals had been extensively analyzed for their efficiency, other types of medical institutions had received limited attention in this regard. METHODS: In this study, we employed data envelopment analysis (DEA) methods based on time series and internal benchmarks to autonomously assess the efficiency of 18 distinct categories of healthcare facilities in China over the past decade. The verification was conducted through the utilization of the critical incident technique (CIT). Additionally, we utilized the Delphi process (AHP) method to evaluate suppliers of medical consumables, implemented a multi-population genetic algorithm for managing these consumethod and analytic hierarchymables efficiently, and applied stakeholder theory to manage medical personnel efficiency. RESULTS: Our findings indicated that medical institutions capable of providing clinical services exhibited higher levels of efficiency compared to those unable to do so. Multiple indicators suggested redundancy within these institutions. Notably, comprehensive benefit evaluation revealed that clinical laboratory had performed poorly over the past decade. We selected an inefficient medical institution for intervention in reagent management and the work efficiency of medical staff. After implementing the Delphi method and multi-population genetic algorithm for consumable replenishment, the reagent cost was reduced by 40%, 39% and 31% respectively in each of the three experimental groups, compared to the control group. By applying stakeholder theory and process reengineering methods, we were able to shorten quality control management time for medical staff in the experimental group by 41min per day, reduce clinical service time by 25min per day, and extend rest time by 70min per day, while the quality indicators were all meeting the targets. CONCLUSION: By employing various mathematical models as described above, we were able to reduce costs associated with medical consumables and enhance medical personnel work efficiency without compromising quality objectives.

Regulatory Threshold of Soil and Water Conservation Measures on Runoff and Sediment Processes in the Sanchuan River Basin

Research on the runoff and sediment reduction effects of soil and water conservation measures has always been a topic of interest, which is of great significance for carrying out sustainable strategies for soil and water conservation in the Yellow River Basin. This study aims to find the threshold years of soil and water conservation measures for reductions in runoff and sediment. Through the analysis of various soil and water conservation measures, runoff, sediment, and rainfall data in the Sanchuan River Basin from 1960 to 2019, we determined the threshold years of soil and water conservation measures on runoff and sediment processes using the Hydrology and Lagrange Multiplier method. The results are as follows: The trend in flood season rainfall and annual rainfall in the Sanchuan River Basin is consistent. The 1990s was a turning period in the annual rainfall and flood season rainfall of the Sanchuan River Basin. The 2000s was a turning period of the runoff in the Sanchuan River Basin, while the sediment entered a stable period after 2000. The best periods for reducing runoff and sediment were the initial treatment period (1967–1979) and the centralized treatment period (1980–1996). The runoff and sediment reduction effects of each soil and water conservation measure during the initial treatment period (1967–1979) were terrace (32.8%) > dam (30.1%) > grass (18.6%) > forest (18.5%), while their effects during the centralized treatment period (1980–1996) were grass (53.7%) > terrace (20.7%) > dam (14.6%) > forest (11.0%). The runoff and sediment reduction effects of various soil and water conservation measures during different treatment periods indicate that the runoff reduction effect reached its peak in 2003–2005, while the sediment reduction benefit reached its peak in 2013–2015. Based on the comprehensive benefits of runoff and sediment regulation, 2013–2015 are considered to be the threshold years for various soil and water conservation measures, with the measures covering respective average areas of 4.85 × 104, 17.80 × 104, 1.15 × 104, and 0.82 × 104 hm2. These research results will have a certain significance for the reasonable allocation of soil and water conservation measures and sustainable development in the Yellow River Basin.

Analyze the Cultural Efficacy of the Ancient Shipwreck Hailao Porcelain in the New Era from the Perspective of Culture

The presence of Hailao porcelain in the world is widespread, with historical, economic, practical, artistic, and other functional attributes, so its comprehensive benefits cannot be underestimated. The development of modern science and technology, and the reasonable and effective development of Hailao porcelain in different times, are conducive to the development of China’s cultural construction. Because Hailao porcelain is different from the traditional ancient porcelain (handed down and unearthed), it is a new cultural research field. This marine wealth has great economic, cultural, and historical value, and plays an important role in the cultural construction and social development of the country in the new period. The cultural efficacy covered by the ancient shipwreck Hailao porcelain includes the functions of inheritance, cognition, education, communication, and so on, which is conducive to the current cultural development. People can use the new perspective and new concept of cultural and creative thinking to make these cultural relics “alive”, give play to the new cultural value, promote the economy of cultural relics and works of art, serve the spiritual and cultural life, and strengthen the cultural exchanges and cooperation between China and other countries in the world.

Hierarchical Game Theory-Based Optimal Power Management for Both Seaports and Ships

Unlike land-based power systems, a seaport microgrid is not only equipped with extensive electrification but also connected with ships, which turns maritime power management into a comprehensive transportation-power coordination problem. To fully exploit the potential of shipboard power systems for energy efficiency improvement of seaports, a hierarchical Stackelberg game-based framework is developed in this paper to achieve efficient power management for both seaports and ships. In this framework, the seaport microgrid serves as a leader to manage the local sources and determine the price for ships to maximize revenue, considering the influence of both the power side and transportation side. On the other hand, the ships act as followers to decide the charging and service strategies for an optimal trade-off between the benefits from onboard battery charging and the ship service cost. The proposed game is solved as a bilevel optimization problem via mathematical programming with the equilibrium constraints method. The proposed algorithm's efficiency is evaluated through numerical simulations. The simulation results demonstrate that the proposed power management method can simultaneously increase the economic profits of seaports and improve the service of ships at berth. Compared to traditional energy management methods, the comprehensive benefits can be increased by approximately 36%.

Multi-objective cooperation search algorithm based on decomposition for complex engineering optimization problems

This study introduces a novel multi-objective cooperation search algorithm based on decomposition (MOCSA/D) to address multi-objective competitive challenges in engineering problem. Inspired by the optimization strategy of single-objective Cooperation Search Algorithm (CSA) and the decomposition framework of MOEA/D, MOCSA/D algorithm randomly generates initial solutions in the optimization space, and then repeatedly executes four search strategies until the end of iteration: Cooperative updating strategy gathers high-quality information to update solutions with balanced distribution. Reflective adjustment strategy expands the exploration range of the population, enabling the acquisition of solutions with strong optimization capabilities. Internal competition strategy selects superior individuals with better performance for subsequent optimization. Density updating strategy improves the competitiveness of optimized individuals within the population, fostering a more diverse solution set. Three numerical experiments (including DTLZ, WFG unconstrained test problems, ZXH_CF constrained test problems and RWMOP real-world multi-objective optimization problems) are tested to further comprehensively evaluate the dominant performance of MOCSA/D. The test results in different problem scenarios show that compared with the existing excellent evolutionary algorithms, MOCSA/D can always obtain a better, stable and uniform distribution of non-dominated solutions, and has higher solving efficiency and optimization quality under different performance evaluation metrics with the increasing difficulty of solving problems. Finally, the proposed algorithm is applied to the multi-objective reservoir engineering optimization problem to verify the feasibility of the decision scheme and the comprehensive benefit optimization of MOCSA/D. Overall, MOCSA/D can simplify the problem optimization difficulty based on decomposition mechanism, and improve the global optimization of population, path diversity and individual competition through different search strategies, which provides an advantageous tool for addressing multi-objective competitive challenges.

Impact of SMOFlipid on Clinical Outcomes in Neonates Receiving Parenteral Nutrition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Aims/Background Neonatal morbidity, including various diseases such as sepsis, cholestasis, and bronchopulmonary dysplasia (BPD), is a significant concern, especially in preterm infants. Selecting the appropriate lipid emulsion in parenteral nutrition (PN) is essential to improve clinical outcomes. This analysis aimed to assess the impact of a novel composite lipid emulsion, SMOFlipid, on neonates receiving PN. Methods A systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted. We compared SMOFlipid to various other lipid emulsions in PN received by infants. Research findings that addressed outcomes such as mortality, sepsis, cholestasis, necrotizing enterocolitis (NEC), BPD, patent ductus arteriosus (PDA), retinopathy of prematurity (ROP), intraventricular hemorrhage (IVH), and length of hospital stay were included. Subgroup analyses were conducted based on gestational age (GA). Twenty RCTs involving 1904 neonates were included. Results Compared to other lipid emulsions, SMOFlipid significantly reduced the cholestasis risk (risk ratio (RR): 0.65, 95% confidence interval (CI): 0.48-0.87, p = 0.004, I2 = 0%). However, the incidence related to IVH, BPD, ROP, NEC, and PDA (excluding an infant subgroup with GA <28 weeks), mortality, sepsis, and duration of hospital stay did not exhibit any substantial variations. The subgroup analysis indicated a decline in PDA incidence (RR: 0.88, 95% CI: 0.79-0.99, p = 0.04, I2 = 0%) among extremely premature infants receiving SMOFlipid. Conclusion SMOFlipid offers a promising option for neonatal PN, particularly for reducing cholestasis in preterm infants and PDA in extremely premature infants. Further investigations into its comprehensive benefits and long-term effects are warranted.

Maximizing Knee OA Treatment: A Comparative Look at Physiotherapy and Injections

Background: Knee osteoarthritis (OA) is a prevalent and disabling condition often managed with physiotherapy or intra-articular injections. However, the comparative effectiveness of these treatments remains unclear. This systematic review aimed to evaluate and compare the efficacy of physiotherapy and intra-articular injections in managing knee OA. Methods: A systematic search of PubMed, Scopus, Web of Science, PEDro, and Cochrane Library was conducted. Randomized controlled trials (RCTs) comparing physiotherapy and intra-articular injections in knee OA patients were included. Key outcomes included pain (VAS), function (WOMAC, KOOS), range of motion (ROM), and quality of life. Data from five studies with a total of 552 participants were analyzed. Results: Intra-articular injections, particularly botulinum toxin and hyaluronic acid, were found to provide rapid pain relief, outperforming physiotherapy in short-term pain management. However, physiotherapy contributed significantly to long-term functional improvements, particularly in early-stage OA. Combination therapy of injections and physiotherapy yielded the best short-term pain relief and functional outcomes. Heterogeneity in study designs and follow-up periods limited the generalizability of findings. Conclusions: Intra-articular injections are effective for immediate pain control, while physiotherapy plays a crucial role in maintaining joint function, especially for long-term management. Combining both interventions may offer the most comprehensive benefits. Further research is needed to determine the long-term efficacy of these treatments.

A Novel Day-Ahead Optimization-Oriented Low-Carbon Economic Scheduling Scheme for Integrated Energy Systems

As the global energy structure undergoes transformation and the low-carbon development process continues to advance, integrated energy systems have progressively emerged as crucial technical support for achieving sustainable development. In this paper, a joint-day optimal scheduling model is put forward considering the existence of dispatchable resources in community integrated energy systems (CIES). The aim is to cut down the system operation cost and enhance energy utilization efficiency. This model is founded on the concept of energy hubs and combines the shiftable, transferable, and reducible characteristics of demand-side flexible loads. It includes gas turbine power generation systems, energy storage, as well as wind and solar renewable resources. System operation cost and carbon trading cost are comprehensively taken into account, and ultimately, the CIES low-carbon economic dispatch model with the lowest total cost as the optimization objective is established. The Yalmip toolbox and Cplex solver are employed to solve the model. The optimization results of flexible electric and thermal loads participating in dispatching under different scenarios are analyzed through simulation. The economic benefits of electric and thermal independent dispatching are compared and analyzed, and the economic benefits of electric and thermal coupled dispatching are verified. The study reveals that the rational scheduling of user-side flexible loads can notably reduce operating costs, lower the load peak-to-valley difference and carbon emissions, and boost the comprehensive economic and environmental benefits of the system.

Research on Energy-Saving Transformation of Rural Residential Building Envelope Structures and Heating Modes in Northeast China

Rural areas in Northeast China present a large demand for heating energy in winter, but there are problems in such areas with poor thermal performance of building envelopes and poor indoor thermal comfort. In addition, coal-fired boilers are still widely used. China’s “Dual-Carbon Goals” and “Clean Heating” policy call for the creation of a green and comfortable living environment for rural residential buildings. This paper considers the impact of the improvement of the thermal performance of envelope structures on the initial investment of the transformation program and the rated power of the ASHP and proposes an energy-saving transformation method to replace traditional coal-fired boilers with the ASHP on the basis of the improvement of the thermal performance of envelope structures. By establishing a typical rural residential building model in Northeast China, this energy-saving method is simulated based on TRNSYS. The results show that the payback period of investment of the transformation method of “envelope structure + heating system” is not superior to that of the transformation method of only improving the thermal performance of the envelope structure, but it has advantages in the comprehensive life-cycle benefits and it has great advantages in improving the satisfaction of rural residents in the use of heating systems.

How shallow CO2 hydrate cap affects depressurization production in deeper natural gas hydrate reservoirs: An example at Site W17, South China Sea

The logging results from the Shenhu Sea show that the P-T conditions of NGH deposits are below the CO2 hydrate phase equilibrium curve. The burial depth difference between the CO2 hydrate stable zone and NGH deposits is usually above 100 m, which differs from the laboratory scale. Thus, whether CO2 hydrate caps can provide pore sealing and reinforcement of natural gas hydrate (NGH) overburden at the engineering scale is unknown. Based on this, we aimed to perfect research on the CO2 hydrate cap, including its formation process, effects on NGH exploitation, geomechanical response, and comprehensive benefit evaluation, by establishing a THMC model based on Site W17. Results indicate that (i) CO2 can form hydrates in the overburden layer with a conversion rate of about 28%, preventing the upward escape of residual liquid CO2 due to density difference. (ii) CO2 injection and CO2 hydrate cap formation can increase the decomposition driving force during depressurization to enhance production, but it fails to inhibit water invasion from the upper part of the NGH deposit due to the excessive depth difference. (iii) The CO2 hydrate cap causes strata uplift, thereby mitigating strata subsidence during depressurization production, especially for the cases of horizontal wells, where the subsidence is reduced by about 103.4%. (iv) Injecting too much CO2 may not benefit gas production, where part of the free gas will convert into NGH due to pressure rise. The optimal injection rate in this study is 40,000 m3/d. (v) Indicators like CO2 hydrate conversion rate, gas-water ratio, and maximum strata displacement show that horizontal well systems with CO2 hydrate caps are more beneficial than vertical well systems, and multi-branched well systems are more beneficial than single-direction well systems. These key findings may differ from the laboratory scale, which can provide a reference for applying CO2 hydrate caps in actual NGH exploitation.

Optimizing soil conservation through comprehensive benefit assessment in river basins

Land degradation from water erosion poses a significant threat to water security and ecosystem stability, driving global efforts in soil conservation. Quantitative assessment of soil conservation benefits—both on-site and off-site—is crucial for guiding effective conservation strategies. However, existing methodologies often fall short in quantifying the value of these combined benefits. Here, we present a comprehensive framework for quantifying soil conservation service flows in monetary terms, evaluating the effectiveness of both on-site and off-site measures. Applying this framework to the Yellow River Basin (YRB), we employ cost-avoidance algorithms related to soil fertility maintenance, dredging cost reduction, and mitigation of nonpoint source pollution. Our results reveal that while many areas contribute to both on-site and off-site benefits, over half of the YRB relies predominantly on off-site services. By strategically enhancing key regions—which constitute 30% of the basin—we demonstrate that the overall soil conservation service supply can increase by 64.2% over the multi-year average from 2001 to 2020 compared to a consideration of on-site only. These findings underscore the essential role of off-site services in fully understanding soil conservation needs, particularly in large river basins, and the identified priority areas can offer valuable insights for optimizing soil conservation efforts.

A joint optimization strategy for electric vehicles and air conditioning systems with building battery configuration

Building air conditioning systems, electric vehicles and battery energy storage systems all provide substantial flexibility for grid operations. However, the joint optimization strategy involving these three demand response resources in buildings has been infrequently studied. This research proposes a day-ahead optimization strategy to coordinate the joint operation of air conditioning systems and electric vehicles. In this framework, cooling load is predicted using an autoregressive exogenous model, while electric vehicle charging load is predicted through Monte Carlo simulations. An evaluation method is introduced to assess the comprehensive benefits of the demand response strategy, considering thermal comfort, economic efficiency, and grid friendliness. Using an office building in Tianjin, China, as a case study, the results indicate that the joint optimization strategy reduces operational costs by 3.71 % and peak electricity load by 38.62 % compared to the original strategy. Furthermore, it enhances the grid friendliness of the energy system by 42.64 %. The configuration of the battery energy storage system is also explored in conjunction with the optimization strategy to further improve grid friendliness. The impact of economic factors and thermal comfort on the configuration of the battery energy storage system is discussed. In the case study, raising the upper temperature limit by 1 °C can save at least 17.1 % in capacity, while battery energy storage system investment and operational costs can respectively be reduced by 55.04 % and 27.14 % within the thermal comfort range.

The Gains and Losses of Cultivated Land Requisition–Compensation Balance: Analysis of the Spatiotemporal Trade-Offs and Synergies in Ecosystem Services Using Hubei Province as a Case Study

The cultivated land requisition–compensation balance (CLRCB) policy is an important policy implemented by China to address the reduction in cultivated land and ensure food security. Although this policy has alleviated the loss of cultivated land quantity, it has had complex and diverse impacts on ecosystem services. Taking Hubei Province as the study area, this research explores the impact of the implementation of the CLRCB on ecosystem services and simulates the changes in ecosystem services in the study area in 2030 and the impact of CLRCB on the interactions among various services. The results show the following: (1) from 2000 to 2020, Hubei Province achieved a balance in the quantity of cultivated land through excessive compensation but failed to reach the goals of balancing cultivated land yield and productivity. (2) During the requisition–compensation process, habitat quality decreased by 501,862, and carbon storage lost 1.3 × 107 t, indicating negative ecological impacts; soil conservation services increased by 184.2 × 106 t, and water production increased by 21.29.3 × 108 m3. Within the cultivated land requisition–compensation area, habitat quality and carbon storage, as well as soil conservation and water production, exhibited synergistic relationships, while the remaining pairs of ecosystem services showed trade-off relationships. (3) The simulation of ecosystem services in 2030 indicates that soil conservation and water production are highest under the natural development scenario, while habitat quality and carbon storage are highest under the ecological protection scenario, both of which are superior to the urban development scenario. Under the natural development scenario, the trade-off and synergistic relationships among various ecosystem services in the cultivated land requisition–compensation area remain unchanged, while these relationships change significantly under the other two scenarios. This study emphasizes that future CLRCB should not only focus on maintaining the quantity of cultivated land but also consider the comprehensive benefits of ecosystem services, in order to achieve sustainable land-use management and ecological conservation.

Economic Effects Assessment of Forest City Construction: Empirical Evidence from the County-Level Areas in China

Forests are both an irreplaceable natural resource and a vital economic asset for all humankind. Based on the data of counties in mainland China from 2007 to 2020, the article explores the direct impact and spatial spillover effects of the policy implementation on the economic growth of counties with the help of the forest city pilot policy and the policy evaluation model. The results reveal that policy implementation can have a positive economic growth effect on the pilot counties, which, in turn, can significantly increase the size of the county′s GDP, the level of GDP per capita, and the total amount of nighttime lighting brightness. The implementation of forest city construction can bring about 2.74% of total GDP size, about 2.63% of per capita GDP development level, and about 7.25% of nighttime light brightness to the county on average. Cost–benefit analysis also indicates that forest city construction can bring about a comprehensive economic benefit of approximately CNY 686.453 million (approximately USD 96.82 million) to the counties. The rapid improvement in labor productivity, significant influx of high-end factors, and continuous expansion of market potential are important mechanisms through which policy implementation promotes economic growth in pilot counties. While promoting economic growth in the pilot counties, forest city construction can also have positive spatial spillover effects on neighboring areas in the pilot counties. Furthermore, when the deficits in atmospheric vapor pressure and annual evapotranspiration are used as instrumental variables for forest city construction, the empirical estimates are not significantly altered. In the process of building forest cities, county governments should be wary of issues such as the high cost of forest maintenance. This study provides a Chinese model and policy reference for other countries and regions in the world to deal with the relationship between forest city construction and county economic growth.

Analisis Kompensasi dan Lingkungan Kerja dalam Meningkatkan Loyalitas di PT. Citra Nusantara Catering

This research aims to analyze the role of compensation and work environment in increasing employee loyalty at PT. Citra Nusantara Catering. Qualitative descriptive methods with triangulation interviews and observation techniques were used to explore compensation conditions, work environment, and employee loyalty levels. The results of the research showed that the compensation provided by the company was below standard, with employee salary data indicating the need for adjustments to achieve higher compensation levels. adequate. The work environment also requires improvement, as indicated by workplace layout data. It is recommended to improve lighting, air circulation and layout arrangements to improve employee welfare and productivity. Employee attendance data is an additional factor that needs to be taken into account when analyzing loyalty levels. Research shows a correlation between compensation conditions, work environment, and employee absenteeism levels. With the results of this research, recommendations for reviewing compensation policies include salary adjustments, increasing incentives, and providing more comprehensive benefits. On the work environment side, improvements to lighting, air circulation and workplace layout are proposed to improve employee welfare and productivity. By implementing these steps, it is hoped that the company can increase employee loyalty, having a positive impact on overall company performance.

Estimating Sediment Trap Efficiency of Flood Events During Flood Season in the Three Gorges Reservoir

AbstractSediment trapping significantly influences the comprehensive benefits of reservoirs and hinders the connection between sediment and nutrients in the upstream and downstream of rivers. Quantifying the role of sediment trapping by dams is important because this operation controls fluvial geomorphology, aquatic ecology, and water quality, particularly for flood processes with highly variable inflows. This study developed a new model to calculate the sediment trap efficiency (TE) of flood events during the flood season in the Three Gorges Reservoir (TGR) using a generalized theoretical approach. The TE of 55 flood events that occurred since the impoundment of the TGR were calculated and ranged from 16.0% to 99.8%, with a mean of 77.8%. Contrary to the previous understanding that large reservoirs have consistently large TE values based on long‐term data, our results show that large reservoirs can have a wide range of TE values during short‐term flood events. The proposed model estimates TE using three variables: inflow discharge, outflow discharge, and reservoir water level. Furthermore, the additional sedimentation risk to the TGR by optimized scheduling during the flood season is discussed. The results provide a reference for sedimentation management and optimal operation in the TGR.

Comprehensive Benefits of Sodium-Glucose Cotransporter 2 Inhibitors in Heart Failure With Reduced Ejection Fraction: A Literature Review.

Sodium-glucose cotransporter 2 (SGLT2) inhibitors, initially developed for type 2 diabetes, have emerged as a promising treatment for heart failure with reduced ejection fraction (HFrEF). They show significant cardiovascular benefits, including reduced cardiovascular mortality and heart failure hospitalizations. This review consolidates knowledge on the efficacy of SGLT2 inhibitors in HFrEF, focusing on their mechanisms of action, clinical benefits, and patient outcomes. To consolidate existing knowledge on the efficacy of SGLT2 inhibitors in reducing cardiovascular mortality in HFrEF, with an emphasis on pathophysiology, clinical benefits, and patient outcomes, major medical databases such as PubMed, Scopus, and Web of Science were reviewed, prioritizing research published from 2020 to 2024. Key studies and clinical trials, including DAPA-HF and EMPEROR-Reduced, were analyzed to understand the impacts of SGLT2 inhibitors on HFrEF management. The review highlights the multifaceted mechanisms by which SGLT2 inhibitors exert their cardiovascular benefits, including osmotic diuresis, natriuresis, improved myocardial energetics, and anti-inflammatory and antifibrotic effects. Clinical trials have consistently demonstrated significant reductions in cardiovascular mortality and hospitalizations among HFrEF patients treated with SGLT2 inhibitors. These benefits are observed across diverse demographic and clinical subgroups, indicating their broad applicability in clinical practice. SGLT2 inhibitors significantly advance HFrEF management, reducing cardiovascular mortality and hospitalizations. However, gaps remain in long-term outcomes, early diagnostic indicators, and mechanisms of action. Future research should address these gaps and explore personalized medicine to optimize treatment. Integrating SGLT2 inhibitors into standard HFrEF management guidelines, supported by updated policies and educational initiatives for healthcare providers, will be crucial to maximize their therapeutic potential and improve patient outcomes.

Stochastic optimal allocation of grid-side independent energy storage considering energy storage participating in multi-market trading operation

The integration of large-scale intermittent renewable energy generation into the power grid imposes challenges to the secure and economic operation of the system, and energy storage (ES) can effectively mitigate this problem as a flexible resource. However, the conventional ES allocation is mostly planned to meet the regulation demands of individual entities, which is likely to result in low utilization of ES and difficult to recover the investment cost. Therefore, a two-stage stochastic optimal allocation model for grid-side independent ES (IES) considering ES participating in the operation of multi-market trading, such as peak-valley arbitrage, frequency regulation, and leasing, is proposed in this paper to improve the comprehensive benefits and utilization rate of ES. The first stage aims to allocate IES and develop a systematic scheduling plan based on the forecast of wind power output and load demand, while the second stage responds to the uncertainty of wind power output by re-dispatching generating units and invoking ES power leased by wind farms. Then, a two-layer loop iterative solution algorithm based on the Benders decomposition is formed to effectively solve the proposed model. Finally, the approach developed in this paper is applied to a modified IEEE RTS-79 test system, and the results verify that it is both feasible and effective.