Cellulose nanofibers reinforced biomimetic hydrogel featuring orthogonal anisotropic architecture for guiding BMSCs directional migration and osteogenic differentiation.

Magnesium phosphate mineralized Ce6 composite hydrogel with photodynamic therapy-mediated antibacterial, anti-inflammatory, and pro-angiogenic properties for application in infected wound healing.

Smart gel tectonics: 3D-printed starch-chitosan architectures with pH-responsive magnesium delivery for targeted intestinal repletion.

Bioinspired nanocellulose-based ultrathin hydrogel bioadhesives with sweat-resistant properties.

The GG/TA-Zn composite hydrogel enhances diabetic bone defect healing via inflammation regulation and vascular-bone synergistic effects.

Extracellular matrix-mimetic ink for 3D printing and minimally invasive delivery of shape-memory constructs.

Physicochemical and biological evaluation of Bioinspired Zea mays starch-derived self-healing composite hydrogels with dynamic boronate crosslinks for critical bone defects

3D-printed PRP-infused double-network hydrogels orchestrate inflammation resolution and vascular regeneration in infected wounds.

Framework nucleic acid-based hydrogel for sequential immune regulation and endogenous TGF-β1 capture in wound healing.

Self-healing injectable N-succinyl chitosan-hyaluronic dialdehyde hydrogel with chitosan-coated poly(D,l-lactide-co-glycolide) nanoparticles for kartogenin loading.

Myocardial infarction (MI), a leading cause of heart failure, involves dynamic pathological progression from acute ischemia to maladaptive fibrosis. To address this complexity, we engineered an injectable alginate composite hydrogel enabling spatiotemporal codelivery of dual therapeutics targeting distinct MI phases. The system incorporates: (i) UCL-TRO-1938, a newly identified PI3Kα activator promoting angiogenesis via PI3K/Akt signaling, released immediately during the acute injury phase; and (ii) engineered mesoporous silica nanoparticles encapsulating bone morphogenetic protein-9 (BMP-9); these nanoparticles feature an epigallocatechin gallate/zinc ion complex coating enabling pH-responsive payload release specifically within acidic infarct microenvironments. This design aims to align the release of UCL-TRO-1938 with the early demands of angiogenesis and delay BMP-9 release to coincide with the later phase of fibrosis progression. Comparative studies in murine myocardial infarction models showed that this dual-delivery platform resulted in improved outcomes compared with single-agent therapies. Intramyocardial administration significantly reduced apoptosis, enhanced angiogenesis, attenuated fibrosis, and improved cardiac function relative to controls. By synchronizing material properties with stage-specific biological responses, this temporally programmed strategy, which aligns with the pathological progression of MI, achieves enhanced functional recovery compared to conventional monotherapies, providing a clinically viable approach for myocardial repair.

3D coaxial bioprinting of RADA16-I self-assembling peptide hydrogel.

Multifunctional aloe vera composite hydrogel with photothermal antibacterial and antioxidant properties for infected wound healing

Carbon fiber-enabled superelastic hydrogel composites: Integrating high strength, efficient microwave healing and visual monitoring

Mechanisms of Hydrogel Vascularization.

RE: Xanthan gum regulates printability and antibiotic-release capacity of composite carboxymethyl cellulose hydrogels.

Electrocatalytic platinum nanomaterials are promising for tumor therapy, but their efficiency is constrained by the spatial limitations inherent in the traditional electrode/electrolyte three-phase interface mechanism. This study develops an injectable composite conductive hydrogel comprising sodium alginate, gelatin@polypyrrole, Pt nanowires, and Pt nanoparticles (SA/Gel@PPy/Pt NWs/Pt NPs) to overcome this issue. By synergizing the embedded Gel@PPy/Pt NWs with the Pt wire electrode, we create a 3D continuous electron circuit throughout the hydrogel. This overcomes the spatial limits of traditional interfaces, expanding the electrocatalytic chlorine evolution reaction from the 2D electrode surface into the 3D hydrogel volume, thus constructing a bulk-phase continuous electrode. This electrode integrates discrete catalytic sites via nanoscale electron pathways, rather than relying on the monolithic scaffold of traditional porous electrodes. The hydrogel leverages endogenous chloride ions to sustain electrocatalytic hypochlorous acid (HClO) generation, while its excellent tissue conformability enhances the therapeutic effect, enabling highly localized therapy. This potent oxidant (HClO) acts dually: it triggers proinflammatory antitumor immunity and dissolves the platinum components to release Pt ions, which synergistically induce DNA damage and enhance immunogenic cell death (ICD). Consequently, animal experiments demonstrated significant tumor suppression in a mouse model, establishing this 3D nanoelectrode network as a paradigm for efficient electrocatalytic tumor therapy.

A Methacrylated Gelatin-Based Composite Hydrogel Integrated with Chitin, Hyaluronic Acid, and Czo Nanoparticles for ROS Modulation and Adhesive Wound Healing

Industrial effluents containing dyes such as crystal violet (CV) have adverse environmental effects due to their chemical inertness, toxicity and nonbiodegradability. Conventional separation techniques used to remove these pollutants are often inefficient; however, photocatalytic degradation using hydrogel photocatalysts is an effective and sustainable approach for wastewater treatment. CuO and ZnO nanoparticles (NPs) were successfully synthesized via a common co-precipitation method. The prepared metal oxide NPs were then incorporated into the hydrogel matrix to form hydrogel nanocomposites. For hydrogel preparation, polyvinyl alcohol (PVA) was used as a polymer, acrylic amide (Am) and butyl acrylate (BA) were used as monomers, and ammonium persulphate (APS) was used as an initiator. The successful fabrication of the hydrogel nanocomposite was verified using FTIR spectroscopy, XRD, SEM, and Brunauer–Emmett–Teller (BET) analysis. From FTIR spectroscopy data, the interaction and cross-linking of monomers and the polymer matrix were confirmed. The average crystallite size and uniform incorporation of metal oxide NPs into the hydrogel network were studied using XRD parameters. SEM images showed that after the integration of spherical-shaped metal oxide NPs into the hydrogel network, the surface of the hydrogel nanocomposite became rough and stratified, and the BET results indicated that the specific surface areas of ZnO- and CuO-doped hydrogel composites were 4.0835 cm2 g−1 and 4.9142 cm2 g−1, respectively. The photocatalytic activity of the synthesized hydrogel nanocomposites was investigated using an initial crystal violet (CV) concentration of 5 ppm to evaluate their degradation efficiency under visible light irradiation. The results showed that within an irradiation time of 110 min, the photocatalytic removal efficiency of CV reached 92.86% for the ZnO-doped hydrogel nanocomposite and 94.21% for the CuO-doped hydrogel nanocomposite at pH 9 using 0.01 g of the photocatalyst under visible light irradiation. The photocatalytic activity followed pseudo-first-order kinetics with rate constants of 0.0154 min−1 and 0.0148 min−1 for CuO- and ZnO-doped hydrogel nanocomposites, respectively. Furthermore, scavenging experiments showed that ˙OH radicals were the prominent species responsible for the degradation of CV. In this study, metal oxide-doped hydrogel nanocomposites were explored as sustainable and efficient photocatalysts for environmental remediation. The synthesized materials exhibited promising efficacy for the treatment of dye-contaminated wastewater.

Water contamination by heavy metals remains a major global challenge, requiring efficient, sustainable, and low-cost remediation materials. Chitosan and cellulose are recognized as effective biosorbents due to their high affinity toward metal ions, biodegradability, and availability. However, their individual limitations motivate the design of composite with enhanced properties. In this study, chitosan/cellulose composite hydrogel beads crosslinked with glutaraldehyde (CHB-CF-GLA) were synthesized and evaluated for Cu(II) removal under batch and dynamic conditions. The composite was characterized by FESEM-EDS, ATR-FTIR, XRD, swelling analysis, and determination of pHpzc to elucidate its structural and physicochemical features. Batch experiments optimized pH, initial Cu(II) concentration, and adsorption capacity, while non-linear kinetic and isotherm models described the adsorption mechanism. The adsorbent exhibited good stability and reusability over multiple cycles. Fixed-bed column studies demonstrated that increasing bed height prolonged breakthrough and exhaustion times, while higher influent concentrations and flow rates led to earlier column saturation. The experimental breakthrough curves were well described by the Thomas and Yoon–Nelson models, whereas the Adams–Bohart model showed limited applicability. COMSOL Multiphysics 3.5 simulations validated the experimental data and predicted column performance. Overall, CHB-CF-GLA is an efficient and functional adsorbent with strong potential for continuous Cu(II) removal in water treatment applications.