A 3D Eulerian-Lagrangian CFD model is set up to simulate the turbulent flow and mixing of coarse dense particles in a standard batch vessel, mechanically agitated by a down-pumping pitched-blade turbine. Flow is investigated in the just-suspended regime and regimes much above. All simulations are fully and successfully validated by experimental Lagrangian measurements provided by positron emission particle tracking. Predicted distributions of the local 3D phase-velocity components, local particle slip velocities and local particle concentration show very good agreement with experiment. Lagrangian particle trajectories are exploited to infer detailed accurate information on particle circulation time and local residence time. The predicted two-phase flow number is in excellent agreement with experimental values under all flow regimes. Being accurate and robust, the numerical model can be extended to study even more complex particle-liquid suspensions of industrial relevance, and to provide much needed Lagrangian data to other data-driven modelling techniques.