The interface is a crucial element in component-based software, enabling the linkage of distinct components to facilitate interaction. Defects within the interface can significantly impact the overall trustworthiness of the system. Therefore, it is essential to assess the interface trustworthiness based on a defect-centric approach. This paper introduces a novel model for evaluating interface trustworthiness, anchored in defect analysis. First, the defect types are formalized based on interface specifications. Then, the comprehensive weight allocation method is established to characterize the importance degree of each interface defect type by combining the G1 and CRITIC methods. Subsequently, the attributes of the interface are evaluated by defect value analysis, and the trustworthiness measurement model of the interface is proposed based on these attributes. Furthermore, to evaluate the trustworthiness of the whole system, the trustworthiness measure models under different combination structure of components are established. Finally, the model’s’ applicability is demonstrated through an illustrative example. This trustworthiness evaluation from the interface view can guide interface designers to obtain high-quality interfaces and improve the trustworthiness of the entire software.