The side effects of many drug classes cover a wide range of skin reactions. One of the most commonly diagnosed diseases nowadays is depression also, antidepressants are widely used in other indications. Therefore, paying attention to the possible undesirable effects of this group of drugs is worth. In the practice of an occupational medicine physician, unfavorable manifestations of the drugs used in the area of the skin should be skillfully differentiated from occupational skin diseases. The aim of this article was to review the types of skin, hair and nail complications in patients treated with antidepressants. For this purpose, online databases were reviewed and case reports, research and review reports were analyzed. The characteristics of severe skin complications generated with antidepressants were presented, as well as case studies of their occurrence after starting the treatment. Complications of a lower severity were also reviewed. Examples of actions in the area of hair and nails were indicated. In the literature on the subject, there are