Complex Transformation Research Articles

The interaction between a piezoelectric screw dislocation and collinear rigid lines in one-dimensional hexagonal quasicrystals

The interaction between a piezoelectric screw dislocation and collinear rigid lines in one-dimensional (1D) hexagonal quasicrystals (QCs) under anti-plane mechanical and in-plane electrical loading is analysed. Two idealized electrical assumptions, namely electrically conductive and dielectric, are considered. By using Muskhelishvilid’s complex transformation method, the explicit expressions for the field variables, the singularity of the field variables at the line tip and the force on the dislocation are obtained for a single rigid line. Based on the generalized Peach–Koehler formula, the generalized stress intensity factors and image force on dislocations in piezoelectric quasicrystal (PQC) are obtained. It is evident that the existence of phason field has an effect on image force.

Biquaternion linear canonical stockwell transform and associated uncertainty principles

The intersection of geometric methods and signal processing has led to significant advancements in various fields, including physics, engineering, and mathematics. In recent years, the biquaternion domain, a generalization of complex numbers with a geometric interpretation, has emerged as a promising tool for signal analysis. This paper introduces the Biquaternion Linear Canonical Stockwell Transform (BiQLCST), a novel fusion of advanced mathematical frameworks that offers enhanced signal analysis capabilities and unveils new uncertainty principles, bridging the gap between complex transformations and uncertainty analysis in high-dimensional spaces. First, we established the various fundamental properties, including linearity, shift, modulation, parity, orthogonality relation, reconstruction formula and Plancherel’s theorem. Heisenberg uncertainty principle associated with Biquaternion Linear Canonical Stockwell Transform (BiQLCST) is also established. Toward the end, some potential applications of the BiQLCST are presented.

A nucleobase-driven P450 peroxidase system enables regio- and stereo-specific formation of C─C and C─N bonds

P450 peroxidase activities are valued for their ability to catalyze complex chemical transformations using economical H2O2; however, they have been largely underexplored compared to their monooxygenase and peroxygenase activities. In this study, we identified an unconventional P450 enzyme, PtmB, which catalyzes the dimerization of purine nucleobases and tryptophan-containing diketopiperazines (TDKPs), yielding C3-nucleobase pyrroloindolines and nucleobase-TDKP dimers. Unlike typical TDKP P450 enzymes reliant on NAD(P)H cofactors and electron transfer systems, PtmB, and its analogs exhibit remarkable peroxidase activity in synthesizing adenine and other modified 6-aminopurine nucleobase-TDKP dimers. Structural analysis of the PtmB-substrate complex, mutation assays, and computational investigations reveal adenine's dual role as both substrate and acid-base catalyst in activating H2O2 to generate Compound I (Cpd I). This initiates a specific radical cascade reaction, facilitating the formation of precise C─C and C─N bonds. Biochemical assays and molecular dynamics simulations demonstrate that adenine's 6-NH2 hydrogen-bonding networks induce necessary conformational changes for H2O2 activation, thereby driving peroxidase activity. This study unveils an unusual catalytic mechanism for the P450 peroxidase system and underscores the pivotal role of nucleobases in enzyme-mediated reactions, which offers different prospects for developing P450 peroxidases and nucleobase-based biocatalysts.

Gustav Klucis (1895–1938): a Complex Transformation from “Soviet Artist” to “Russian Avant-Gardist”

Abstract The two main elements that render the case of Gustav Klucis unique among other Russian Avant-garde artists are: his nationality which was the cause of his tragic death during Stalin’s Great Purge but also what determined the fate of his creative legacy; and his political engagement in the development of mass (propaganda) art, which is behind the current controversial evaluation of his legacy today, and had influenced his own complicated career. Although both the circumstances of the artist’s life and the historical context are familiar to scholars, archival studies provide new materials, revealing less-known aspects of the artists’ creative biography. My paper addresses two topics. In the introduction I recall some notable facts about the “Riga Collection” of Klucis’ works, kept at the Latvian National Museum of Art, and discuss how its interpretation and interrelation to other collections of Klucis’ works were developed with an eye towards the artist’s reintegration in the context of the Russian Avant-garde. In the main part of my paper, I share some thoughts about Klucis as a theorist, related to the study of the second version of his manuscript “The Right to Experiment” and other less known materials, found in the Nikolai Khardzhiev archive.

Collectively Working towards Plant-Pollinator Interactions Data Interoperability and Reuse: Lessons Learned from the WorldFAIR Project

The WorldFAIR project worked with eleven case studies to advance the implementation of the FAIR data principles (Findable, Accessible, Interoperable, and Reusable; Wilkinson et al. 2016). The Case Study on Agricultural Biodiversity (Drucker et al. 2022) addressed the challenges of advancing interoperability and mobilizing plant-pollinator interaction data for reuse. In the first phase of the project we performed a landscape analysis and found that a significant amount of data on plant-pollinator interaction was available as supplementary files of research articles, in a range of formats such as PDFs, Excel® spreadsheets, and text files. The diversity of approaches and the lack of appropriate data vocabularies led to confusion, information loss, and the need for complex data interpretation and transformation. In the second phase of the project, we performed six studies to adopt standards recommended in the first phase. Our approach for plant-pollinator data standardization was based on Darwin Core (Darwin Core Task Group 2009) and Ecological Data Language (EML, Jones et al. 2019), in conjunction with a data model and vocabulary proposed by the Brazilian Network of Plant-Pollinator Interactions (REBIPP). The studies underwent a process of “FAIRification” (i.e., transforming data into a format that adheres to the FAIR data principles) using the Global Biotic Interactions (GloBI, Poelen et al. 2014) platform. Two studies also explored the publishing model for Biotic Interactions as part of the GBIF New Data Model. The standardization strategy was successful and increased the interoperability of plant-pollinator interaction data, resulting in a process that allows tracking the provenance of the data, as well as facilitates the reuse of datasets (Drucker et al. 2024). This effort led to the development of "FAIR best practices" and guidelines for sharing plant-pollinator interaction data, as well as a FAIR assessment tool designed to help researchers and institutions evaluate adherence to the FAIR principles (Drucker et al. 2024). A tutorial to standardize plant-pollinator datasets (Gonzalez-Vaquero et al. 2024) and a cookbook with guidelines and recommendations for publishing agriculture-related plant-pollinator data (Salim et al. 2024) were developed to help different actors standardize plant-pollinator interaction data in accordance with the FAIR principles. Moving from diverse approaches and siloed initiatives to widely available FAIR plant-pollination interaction data for scientists and decision-makers will enable the development of integrative studies that enhance our understanding of species biology, behavior, ecology, phenology, and evolution.

Data-Driven Agile Leadership: The Impact of Business Intelligence Solutions on Transformation Outcomes

This article examines the integration of Business Intelligence (BI) solutions in empowering leadership teams during Agile transformations within organizations. As businesses increasingly adopt Agile methodologies to enhance adaptability and efficiency, leaders face unique challenges in monitoring and steering these complex transformations. Through a multi-case study approach, we investigate how BI tools provide real-time insights into key performance indicators such as sprint velocity and team capacity, significantly enhancing leadership's ability to make informed decisions and identify bottlenecks in the Agile process. Our findings reveal that the implementation of BI solutions fosters a culture of transparency and accountability, enabling leaders to navigate the intricacies of Agile transformation more effectively. The article contributes to the growing body of literature on Agile leadership by highlighting the symbiotic relationship between data-driven decision-making and successful organizational change. We conclude that the strategic use of BI in Agile environments not only improves visibility into transformation progress but also enhances overall organizational performance in response to dynamic market demands.

Institutional unlocking or technological unlocking? The logic of carbon unlocking in the new energy vehicle industry in China

As a result of unbalanced energy structure, high carbon emissions, and global climate change, carbon lock-in has gained considerable attention. To achieve carbon unlocking, technological advancements and institutional innovation are essential. This paper uses the new energy vehicle (NEV) industry as its case study, identifying the differences and evolutionary trends between institutional unlocking and technological unlocking logics, and demonstrating how these logics affect industry and enterprise development and eventually advance the process of carbon unlocking. The findings are: (1) Institutional incentives play a critical role in the development of an industry at the beginning. As the industry matures, technological innovation plays a central role in driving industry development, while institutional logic gradually loses influence and technological logic gains influence. (2) Dual logics have undergone a complex transformation of compatibility, mutual exclusivity, partial confrontation, and cooperation during the process of carbon unlocking. It is possible for the complexity of the relationship to range from low to high, with both becoming less complex as the industry matures. (3) Through ongoing gaming and adjustment, the dual logics encourage the NEV industry to realize carbon unlocking and low-carbon transformation at the same time.

Academic performance as a driver for the development of reasoning for complexity and digital transformation competencies

Academic performance as a driver for the development of reasoning for complexity and digital transformation competencies

Design of Shape Forming Elements for Architected Composites via Bayesian Optimization and Genetic Algorithms: A Concept Evaluation.

This article presents the first use of shape forming elements (SFEs) to produce architected composites from multiple materials in an extrusion process. Each SFE contains a matrix of flow channels connecting input and output ports, where materials are routed between corresponding ports. The mathematical operations of rotation and shifting are described, and design automation is explored using Bayesian optimization and genetic algorithms to select fifty or more parameters for minimizing two objective functions. The first objective aims to match a target cross-section by minimizing the pixel-by-pixel error, which is weighted with the structural similarity index (SSIM). The second objective seeks to maximize information content by minimizing the SSIM relative to a white image. Satisfactory designs are achieved with better objective function values observed in rectangular rather than square flow channels. Validation extrusion of modeling clay demonstrates that while SFEs impose complex material transformations, they do not achieve the material distributions predicted by the digital model. Using the SSIM for results comparison, initial stages yielded SSIM values near 0.8 between design and simulation, indicating a good initial match. However, the control of material processing tended to decline with successive SFE processing with the SSIM of the extruded output dropping to 0.023 relative to the design intent. Flow simulations more closely replicated the observed structures with SSIM values around 0.4 but also failed to predict the intended cross-sections. The evaluation highlights the need for advanced modeling techniques to enhance the predictive accuracy and functionality of SFEs for biomedical, energy storage, and structural applications.

Wine polyphenol oxidation mechanism and the effects on wine quality: A review.

Over the last few decades, there has been considerable interest in studying wine oxidation. This review paper provides a comprehensive overview and analysis of the molecular changes caused by oxidation in wine and how they affect wine quality. Simultaneously, the recent advancements in understanding the molecular pathways involved in wine oxidation are also discussed. The paper first explores the process of oxygen dissolution and the complex transformations that occur in polyphenols during oxidation. It then reviews the current methods of micro-oxidation (MOX) and over-oxidation (OOX). Subsequently, it introduces oxidation kinetics, and controls indexes for the degree of oxidation and the underlying principles. Additionally, it discusses the effects of oxidation on the sensory qualities of wine and analyzes the interrelationships between oxidation, functional components, and drinkability. The comprehensive review of the literature shows that OOX leads to the rapid depletion of polyphenols, reducing the overall antioxidant capacity of the wine and affecting its appearance and flavor. In contrast, MOX promotes a balanced matrix and enhances the complexity of the aroma. Polyphenols, particularly resveratrol, can interact with reactive oxygen species or activate endogenous defense mechanisms to mitigate diseases risks. However, the presence of oxygen can activate the antioxidant mechanism of resveratrol, resulting in decreased content and a diminished anti-disease effect. Despite this, a clear distinction between OOX and MOX has not been established. Future research should focus on identifying and defining precise oxidation levels using control indexes for the degree of oxidation.

Immunological indicators of the risk of the transition from chronic gastritis to gastric ulcer in adolescents

As is known, gastric ulcer (GCC) and duodenal ulcer (duodenal ulcer) are chronic, complex-etiology diseases, the mechanism of which is based on complex transformations of nervous, hypothalamic-pituitary, hypothalamic-pituitary-adrenal and local gastroduodenal processes that lead to a change in trophism in the mucous membrane of the stomach and duodenum. In turn, the incipient ulcerative defect is a source of irritation of the enteric receptors, supporting disorders of neurohormonal regulation. Thus, the resulting “vicious circle” causes the chronic course of peptic ulcer disease. During the study of chronic diseases of gastroduodenal localization, including peptic ulcer disease, many doctrines of its occurrence have been proposed. However, the issue of the origin of peptic ulcer disease still remains insufficiently studied; approaches and tactics for managing patients with erosive and ulcerative lesions of the upper gastrointestinal tract are being developed. The aim of the study was to evaluate immunological indicators that determine the risk of chronic gastritis turning into gastric ulcer. The study included 120 children aged 14-17 years, permanently residing in the Bukhara region of the Republic of Uzbekistan. Taking into account the importance of H. Pylori in the development of HCG, patients were distributed depending on the association of HCG with H. Pylori. To study cytokines, blood tests of patients were performed to determine the titer of antibodies (IgG and IdM) to H. Pylori, immunoglobulins A, M, G in blood serum, secretory IgA in oral fluid, IL-1β, IL-10, TNFα, VEGF in the serum of patients. At the same time, blood sampling was carried out in the periods before and 3 weeks (21 days) after treatment. Thus, the study of the value of immunological blood parameters in the progression of HCG to gastric ulcer disease dictates the need to develop immunological indicators for predicting the progression of HCG to gastric ulcer in adolescents. An increase in TNFα levels indicates a high risk of developing gastric ulcer as a result of vascular damage and impaired local circulation. In the study, an established increase in the level of IL-1β indicates activation of the synthesis of proinflammatory cytokines in HCG, especially in HCG associated with H. Pylori. The use of these recommendations contributes to the monitoring of HCG, improving the effectiveness of diagnosis and the correct choice of treatment for patients with HCG, reducing mortality and disability at the same time.

White matter functional networks in the developing brain.

Functional magnetic resonance imaging (fMRI) is widely used to depict neural activity and understand human brain function. Studies show that functional networks in gray matter undergo complex transformations from neonatal age to childhood, supporting rapid cognitive development. However, white matter functional networks, given the much weaker fMRI signal, have not been characterized until recently, and changes in white matter functional networks in the developing brain remain unclear. Aims to examine and compare white matter functional networks in neonates and 8-year-old children. We acquired resting-state fMRI data on 69 full-term healthy neonates and 38 healthy 8-year-old children using a same imaging protocol and studied their brain white matter functional networks using a similar pipeline. First, we utilized the ICA method to extract white matter functional networks. Next, we analyzed the characteristics of the white matter functional networks from both time-domain and frequency-domain perspectives, specifically, intra-network functional connectivity (intra-network FC), inter-network functional connectivity (inter-network FC), and fractional amplitude of low-frequency fluctuation (fALFF). Finally, the differences in the above functional networks' characteristics between the two groups were evaluated. As a supplemental measure and to confirm with literature findings on gray matter functional network changes in the developing brain, we also studied and reported functional networks in gray matter. White matter functional networks in the developing brain can be depicted for both the neonates and the 8-year-old children. White matter intra-network FC within the optic radiations, corticospinal tract, and anterior corona radiata was lower in 8-year-old children compared to neonates (p < 0.05). Inter-network FC between cerebral peduncle (CP) and anterior corona radiation (ACR) was higher in 8-year-olds (p < 0.05). Additionally, 8-year-olds showed a greater distribution of brain activity energy in the high-frequency range of 0.01-0.15 Hz. Significant developmental differences in brain white matter functional networks exist between the two group, characterized by increased inter-network FC, decreased intra-network FC, and higher high-frequency energy distribution. Similar findings were also observed in gray matter functional networks. White matter functional networks can be reliably measured in the developing brain, and the differences in these networks reflect functional differentiation and integration in brain development.

Recent Advances (2018–2023) and Research Opportunities in the Study of Groundwater in Cold Regions

ABSTRACTIncreasing greenhouse gas levels drive extensive changes in Arctic and cold‐dominated environments, leading to a warmer, more humid, and variable climate. Associated permafrost thaw creates new groundwater flow paths in cold regions that are causing unprecedented environmental changes. This review of recent advances in groundwater research in cold environments has revealed that a new paradigm is emerging where groundwater is at the center of these changes. Groundwater flow and associated heat and solute transport are now used as a basis to understand hydrological changes, permafrost dynamics, water quality, integrity of infrastructure along with ecological impacts. Although major advances have been achieved in cold regions' cryohydrogeological research, the remaining knowledge gaps are numerous. For example, groundwater as a drinking water source is poorly documented despite its social importance. Lateral transport processes for carbon and contaminants are still inadequately understood. Numerical models are improving, but the highly complex physical‐ecological changes occurring in the arctic involve coupled thermal, hydrological, hydrogeological, mechanical, and geochemical processes that are difficult to represent and hamper quantitative analysis and limit predictive capacity. Systematic long‐term observatories where measurements involving groundwater are considered central are needed to help resolve these research gaps. Innovative transdisciplinary research will be critical to comprehend and predict these complex transformations.

The arylbipyridine platinum (II) complex increases the level of ROS and induces lipid peroxidation in glioblastoma cells.

Here we present the biological properties of the arylbipyridine platinum (II) complex (arylbipy-Pt) and describe the potential mechanism of its antitumor action which differs from that of the well-known cisplatin. Leading to the oxidative stress and lipid peroxidation, the arylbipyridine platinum (II) complex showcases the significant cytotoxicity against the glioblastoma cells as shown by the MTT test. Using the 5-ethyl-2-deoxyuridine we study the proliferative activity of glioblastoma cells to affirm that arylbipyridine platinum (II) complex does not impede cell division or DNA replication. Staining by the MitoCLox dye and 2',7'-dichlorodihydrofluorescein diacetate demonstrates that the glioblastoma cells treated with arylbipy-Pt exhibit a strong increase of the lipid peroxidation and the stimulation of the reactive oxygen species formation. The hypothesis that arylbipy-Pt promotes oxidative death of tumor cells is confirmed by control experiments using N-acetyl-L-cysteine as an antioxidant. Further evidence for the oxidative mechanism of action is provided by real-time PCR, which shows high expression levels for genes associated with the heat shock proteins HSP27 and HSP70, which can be used as markers of tumor cell ferroptosis. To elucidate the chemical nature of the arylbipy-Pt complex activity, we perform 195Pt NMR spectroscopy and cyclic voltammetry measurements under biologically relevant conditions. The results obtained clearly indicate the structural transformation of the arylbipy-Pt complex in the DMSO-saline mixture, which is crucial for its further antitumor activity via the oxidative pathway. The found correlation between the molecular structure of arylbipy-Pt and its effect on the tumor cell cycle paves the way for the rational design of Pt complexes possessing the alternative mechanism of antitumor activity as compared to DNA intercalation, providing possible solutions to the major problems such as toxicity and drug resistance.

Changes in spectra of cultivated and gathered plants in the Bronze Age

The Bronze Age (BA) in Central Europe witnessed significant transformations in various aspects of human activities. This study focuses on changes in subsistence strategies during the BA, represented by the assortment of edible plants. We examined charred macroremains from 39 archaeological sites in the Czech Republic. Our aims include providing an overview of crop records, determining the dating of new crop introductions, and identifying spatial patterns of the assortment changes. The results indicate a complex agricultural transformation. Emmer and einkorn dominated in the Early Bronze Age (EBA), while the broomcorn millet was widespread in the Middle Bronze Age (MBA). The Late Bronze Age (LBA) saw increased cereal and pulse diversity, whereas the Final Bronze Age (FBA), characterised by coexisting cereals, represented a terminal stage of the process of gradually evolving subsistence strategies. The study highlights the sudden introduction of broomcorn millet in the MBA and expanding the range of crops, which allowed more flexible responses to local conditions and a better distribution of field work throughout the year.

Innovative approache for the nonlinear atangana conformable Klein-Gordon equation unveiling traveling wave patterns

The aim of current work is to establish novel traveling wave solutions of the nonlinear Atangana conformable Klein - Gordon equation using a new extended direct algebraic technique. The Klein - Gordon equation is the relativistic state of the Schrödinger equation with a second - order time derivative and zero spin. Complex wave variable transformation is used to convert Atangana conformable nonlinear differential equation into an ordinary differential equation. Using the proposed technique based on Maple software structure, various types of solutions, such as, generalized trigonometric, generalized hyperbolic, and exponential functions, are established. When special parameteric values are considered for this method, solitary wave solutions can be obtained through other methods, such as the (G′G)-expansion method, the modified Kudryashov method, the sub-equation method, and so forth. A physical explanation is provided for the solutions under consideration to enhance comprehension of the physical phenomena resulting from the obtained solutions, provided that the physical parameters are set appropriately using 3D, 2D, and contour simulations. The results demonstrated that the new extended direct algebraic method provides a more potent mathematical tool for solving numerous more nonlinear partial differential equations with the aid of symbolic computation.

Social-Ecological Urbanism as a Research Perspective to Analyse Transportation Inequalities in the Region of Łódź, Poland

The systems perspective enables the understanding of complex transformations which take place in urban regions. Social-ecological urbanism is an analytical methodology that integrates the systems perspective and unpacks relationships between the social-ecological and socio-technical subsystems of urban regions. In this article, we look for the most suitable approach to analysing the transformations of a tramway system and its impacts on public transportation inequalities in the metropolitan region of Łódź, Poland. As a departure point, we use the classic methods of communicative planning theory. The presented method uses a detailed case study analysis that carefully follows all the activities, stakeholders, and processes. We complement this approach by looking at the ongoing transformations of transportation equity through the lens of socio-ecological urbanism and by analysing the stakeholders’ roles and attitudes within the process. Our analysis indicates the role of public participation in the process, which affected and strengthened the transformations. This approach is greatly enhanced by the application of the social-ecological urbanism framework, with its analysis of services performed by various system components. Understanding their specific roles helps in planning future redevelopment. Our key finding is the necessity of combining communicative planning methods with strategic planning of the systems transformation process.

ISOTOPE COMPOSITION OF Pb AND Nd OF THE LATE NEOPROTEROZOIC–EARLY PALEOZOIC GRANITOIDS IN EASTERN TUVA (Case study of the Kaa-Khem batholith)

We present the results of Nd and Pb isotope studies of late Neoproterozoic–early Paleozoic granitoids of the Kaa-Khem batholith, which formed in different geodynamic settings within the early Caledonian structures of Eastern Tuva (Altai–Sayan sialic area). Based on the obtained isotope data, we assess the role of different source materials in the formation of melts for these granitoids and compare these rocks with coeval granitoids from the Lake Zone of Mongolia. The plagiogranitoid associations of the island arc stage of the Kaa-Khem batholith formation (572–562 Ma) are characterized by mantle Nd isotope values. In contrast, the Pb isotope characteristics of these intrusive associations correspond to an upper-crust source formed predominantly by terrigenous sediments. The granitoid associations of the accretion–collision stage of the Kaa-Khem batholith formation (512–450 Ma) have a less radiogenic primary Pb isotope composition as compared with the island arc granitoids. Evidently, during the magma formation at this stage, the relative role of terrigenous material decreased, while the role of depleted mantle material increased. At the same time, the decrease in ɛNd values in the granitoids as compared with the depleted mantle indicates that, along with the upper-mantle component, the role of the lower-crust component increased. These Nd and Pb isotope characteristics of the accretionary granitoids of the Kaa-Khem batholith indicate a significant contribution of the lower-crust source to their formation. This source is the crystalline basement of the Tuva–Mongolian microcontinent. The Pb isotope characteristics of the accretion–collision granitoids of the Kaa-Khem batholith are shifted to the upper-crust compositions relative to those of the Lake Zone granitoids. The reason is that the latter formed predominantly through the transformation of early Caledonian island arc complexes, which were generated with a higher portion of mantle component.

The Nexus between Polyphenols and Gut Microbiota and Their Interplay in Human Health: A Brief Review

Polyphenols are a broad class of naturally occurring substances in plants and have drawn extensive attention as they may possess promising health-promoting benefits. Recently, gut microbiota and polyphenol interactions have been directly linked to the well-being of humans. The classification, sources, and interactions of polyphenols with the gut microbiota are presented in this review, highlighting their key health benefits in humans. Polyphenols undergo complex transformations within the gastrointestinal tract and interact with the gut microbiota, a varied collection of bacteria living in the digestive system. The interactions substantially influence the composition, functioning, metabolic activity, and gut microbiota diversity. Research indicates that polyphenols may possess prebiotic-like properties, favouring Lactobacilli and Bifidobacteria growth, among other beneficial bacteria. The fermentation of polyphenols is aided by these bacteria, which produce bioactive metabolites that may improve human health and well-being in various ways. Moreover, the alteration of gut microbiology caused by polyphenols has been linked to improvements in several health outcomes, including enhanced metabolic health, fortified immunological function, and a decreased susceptibility to chronic conditions like heart disease and certain forms of cancer. In summary, the intriguing relationship between polyphenols and gut microbiota has significant health implications for humans. Understanding these relationships can open the door to tailored dietary treatments and the development of functional foods to support a balanced gut microbiota and general well-being.

A-198 ESG Opportunities Harnessed During Pathology Transformation

Abstract Background Synnovis (a SYNLAB business) is in the process of delivering one of the largest Pathology transformation programmes in the UK, moving to a seven-site hub and spoke model from 89 laboratories over a dispersed geography. This remit also presented an opportunity for SYNLAB to deliver on its Environmental Social Governance (ESG) ambitions, by embedding ESG principles into programme delivery. There are several examples within each ESG pillar that demonstrate the benefits to be leveraged during transformation. Methods SYNLAB’s vision is to deliver sustainable diagnostic services. The integration of ESG into both the decision-making process and transformation structure ties these ambitions into programme benefits realisation. As well as setting performance level targets, the delivery of ESG benefits provide measures of success throughout the transformation journey, motivating stakeholders and building confidence along the way. Results Environment: The efficient use of space and LEAN principle design has consolidated the fragmented laboratory services spanning 15,000m2 into a bespoke, cutting-edge Pathology Hub with 6 spokes (hospital based services). The new hub building was designed to achieve BREEAM Excellent standards which measure performance against criteria such as energy management and efficiency, sustainable design and materials. The hub’s energy is from renewable-backed sources, and we will achieve a 47% reduction in CO2 equivalent (CO2e) emissions by unifying a significant proportion of its legacy footprint in this way. Further energy savings will be achieved through the associated analytical equipment consolidation, including a decrease from 50 to 14 microtomes, a decrease of 29 to 15 ventilated benches and a reduction of over 200 fridges and freezers across the service. In addition, substantial CO2e emissions savings are also being delivered by moving to a greener logistics provider, utilising electric vehicles and bikes. 2023 saw such emissions fall by 60% across Synnovis, helping to keep London’s air cleaner. Social: The transformation programme enables the hand back of over 6,000m2 of real estate to Synnovis’ NHS partners to use for critical hospital services (the equivalent of over 150 operating theatres). Governance Both internally and externally, ESG is integrated within the Synnovis organisational culture. For example, internally it applies mandatory sustainability metrics to its solution selection processes. These influenced the selection of Abbott’s Indexor solution to support the transformation of Blood Sciences, delivering a saving of over 2.8 million plastic sample bags every year. Externally, SYNLAB works with its partners to manage this substantial and complex transformation programme. Risk management is assured through transparency, securing confidence in the good use of public funds, ensuring responsiveness to customer and partner feedback, and ensuring accountability for and the delivery of targeted healthcare outcomes. Conclusions The integration of SYNLAB’s ESG strategy within the transformation programme is delivering tangible benefits across all ESG pillars. It has highlighted that in addition to the core outcome of services transformation, there are many more opportunities that can be realised as a result of making ESG an integral part of the pathology transformation programme.