In this study, we investigate a heterogeneous queueing model with intermittent server availability, server catastrophes, and a hybrid vacation policy. Our focus is on a specific scenario: server 1 is always available, while server 2 may experience breakdowns or vacations, making it intermittently accessible. Using the matrix-geometric approach (MGA), we derive matrix-based expressions for the stationary probability distribution of the number of customers in the system and various system performance measures. Additionally, we evaluate the cost function per unit of time to determine optimal values for the system’s decision variables. Furthermore, we employ an adaptive neural fuzzy inference system (ANFIS) based on soft computing technology to compare and analyze the numerical results obtained. Through this comprehensive analysis, our study contributes to the understanding and optimization of this complex queueing system, attracting the attention of researchers in the field and offering practical insights for real-world applications.