The aim of this study was to explore the adoption value of convolutional neural network- (CNN-) based magnetic resonance imaging (MRI) image intelligent segmentation model in the identification of nasopharyngeal carcinoma (NPC) lesions. The multisequence cross convolutional (MSCC) method was used in the complex convolutional network algorithm to establish the intelligent segmentation model two-dimensional (2D) ResUNet for the MRI image of the NPC lesion. Moreover, a multisequence multidimensional fusion segmentation model (MSCC-MDF) was further established. With 45 patients with NPC as the research objects, the Dice coefficient, Hausdorff distance (HD), and percentage of area difference (PAD) were calculated to evaluate the segmentation effect of MRI lesions. The results showed that the 2D-ResUNet model processed by MSCC had the largest Dice coefficient of 0.792 ± 0.045 for segmenting the tumor lesions of NPC, and it also had the smallest HD and PAD, which were 5.94 ± 0.41 mm and 15.96 ± 1.232%, respectively. When batch size = 5, the convergence curve was relatively gentle, and the convergence speed was the best. The largest Dice coefficient of MSCC-MDF model segmenting NPC tumor lesions was 0.896 ± 0.09, and its HD and PAD were the smallest, which were 5.07 ± 0.54 mm and 14.41 ± 1.33%, respectively. Its Dice coefficient was lower than other algorithms (P < 0.05), but HD and PAD were significantly higher than other algorithms (P < 0.05). To sum up, the MSCC-MDF model significantly improved the segmentation performance of MRI lesions in NPC patients, which provided a reference for the diagnosis of NPC.
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