Complex Category Research Articles

Algorithm of surgical treatment of resistant forms of pulmonary tuberculosis

Objective. To improve the effectiveness of surgical treatment of multidrug–resistant pulmonary tuberculosis and extensively drug–resistant pulmonary tuberculosis. Materials and Methods. The work is based on the analysis of the results of treatment of 316 patients. The sequence of actions to determine the optimal type and extent of surgical intervention is regulated. Results. An algorithm for the surgical treatment of multidrug–resistant pulmonary tuberculosis and extensively drug–resistant pulmonary tuberculosis was developed and implemented, based on the results of a study of this complex category of patients who underwent preoperative preparation, a sequence of actions for surgical intervention, and postoperative management technology, taking into account current specific therapy regimens. Conclusions. The application of the developed algorithm of surgical treatment allowed to reduce the incidence of pulmonary tuberculosis recurrence and postoperative complications from (14.4 ± 2.3) to (7.0 ± 1.3)% and cure 92.5% of patients.

Personal dignity: emerging threats

In connection with the growing role of the information space, the emergence of new security threats, and the transformation of the institution of human rights, it became necessary, through the prism of the traditional understanding of the category of “dignity” and “right to dignity” in the humanities, to highlight current problems of legal regulation of the right to dignity, to its protection and protection, as well as identify current trends in the legal protection of personal dignity. Dignity is a complex category in the institution of individual rights, which is a direct expression of human value, the core, source and meaning of all fundamental rights, as well as a qualitatively necessary component of their implementation and protection. A broad base of normative regulation and protection of the right to dignity makes it possible to identify system-forming norms and institutions within the framework of constitutional law, based on which it is possible, taking into account modern trends and threats to human rights in general and the right to dignity in particular, to build an adequate system for protecting personal dignity

Domestic Violence: Modern Challenges and Areas of Counteraction In Ukraine

Objective: The purpose of the article is to determine the role and significance of the interaction between the police and society as the main factor in combating crime, taking into account Ukrainian and foreign legislation, different opinions of scholars and empirical data. Theoretical Framework: The theoretical basis for this study is the scientific studies dedicated to fundamental issues of human interaction in modern conditions, the essence and general social significance of the institution of the family, as well as have thoroughly studied the problems of domestic violence. Method: The methodological basis of the research is systemic, comparative and legal analysis, formal and legal method, interpretive method, as well as methods of analysis and synthesis. Results and Discussion: A number of problematic aspects of the essence of combating domestic violence has been analyzed, which made it possible to form an understanding of this phenomenon as an extremely complex and multifaceted category that depends on a number of factors both at the individual and public levels. Contributions: It has been concluded that it is important to distinguish the areas of combating domestic violence for a more complete understanding of this process, especially in terms of large-scale armed aggression and new digital challenges. In particular, it has been emphasized on such areas as the prevention of domestic violence by servicemen and veterans, as well as the active use of digital technologies in fighting against domestic violence.

The purpose of the crime: the criminal-legal significance and correlation with the motive

The subject of the study is the norms of Russian criminal legislation containing the objectives of the crime, materials of judicial practice, as well as scientific works of scientists dealing with the issues of the criminal legal significance of the purpose of the crime and its correlation with the motive. The purpose of the study is to formulate scientifically based conclusions regarding the criminal legal significance of the purpose of the crime and its correlation with the motive. Research methods: the research is based on the dialectical method of cognition, the formal legal method, as well as methods of analysis, synthesis, induction and deduction. The object of the study is public relations in the field of criminal law regulation of the purpose of the crime. The main results of the study: the purpose of the crime is a complex category, which is revealed in three meanings. The conclusion is substantiated that the purpose of the crime is an indicator of the social danger of the crime and the identity of the perpetrator, and therefore acts as a means of differentiation and individualization of criminal responsibility. Theoretical conclusions on the correlation of motive and purpose are formulated. The correct definition of the purpose of the crime contributes to the most accurate qualification of the deed, the definition of penalties or other measures of criminal legal impact. In addition, the definition of a goal can help to establish the determinants of criminal behavior, helps to investigate the personality of the offender in the most depth and develop measures to prevent individual crimes.

WORKING ON COLLABORATIVE PROBLEMS IN ELEMENTARY MATH LESSONS

Problem is a complex category, which does not have a single definition accepted by everyone, but representatives of different fields have interpreted the concept of problem in different ways depending on their orientations. This article describes the characteristics of arithmetical problems, the methods and means of teaching to solve problems related to working together in primary school. Specific cases of developing students' problem-solving skills by discussing and solving any arithmetical problems are highlighted.

Rare Presentation of Anaplastic Carcinoma as a Mural Nodule in Mucinous Cystadenoma with Concurrent Benign Brenner Tumor

Abstract Introduction/Objective Mural nodules in ovarian mucinous tumors, particularly which are anaplastic carcinomas, represent an exceedingly rare and complex diagnostic category. The literature documents only a few such tumors, predominantly sarcoma-like, with favorable prognoses. In contrast, malignant mural nodules, including anaplastic carcinoma and sarcomatous or carcinosarcomatous types, are notably rare, with fewer than ten cases reported. The co-occurrence of an anaplastic carcinoma mural nodule with a benign Brenner tumor presents distinct diagnostic and treatment complexities stemming from mixed tumor pathology and associated genetic mutations like KRAS and p53, critical in the development of these unusual nodules. This report deepens our insight into rare ovarian tumors. Methods/Case Report A 60-year-old woman with persistent lower abdominal pain underwent surgery for a suspected benign ovarian cyst based on initial imaging. The removed ovary contained a 10.5 x 10 x 8 cm unilocular cyst lined with benign, mucin-containing columnar epithelium. However, a 2 cm anaplastic carcinoma mural nodule was identified within the cyst, exhibiting cellular pleomorphism, nuclear atypia, and high mitotic activity. Immunohistochemical staining confirmed the carcinoma with diffuse cytokeratin and EMA positivity. The fallopian tube was free of tumor involvement, and no capsular or lymphovascular invasion was seen. The cancer was staged as PT1a, pNx, pMx. Results (if a Case Study enter NA) NA Conclusion Anaplastic carcinoma, when present as a mural nodule within a benign-looking mucinous cystadenoma, demands an aggressive treatment strategy due to its poor prognosis and aggressive nature. Such cases require a deviation from standard benign treatment protocols to include extensive surgery, possibly, depending on disease progression, chemotherapy or radiation.

Advancing protein hydrolysis and phytosterol encapsulation: Emerging trends and innovations in protein-based microencapsulation techniques – A comprehensive review

Phytosterols represent a diverse and complex category of lipophilic bioactive compounds, exhibiting excellent pro-healthy properties. However, their consumption in daily diets is insufficient, and their application in food production is hindered by challenges such as low water solubility, high reactivity, and rapid degradation. The adoption of different protein or their structural modification as hydrolysates as wall material into microencapsulation techniques can be associated with improved solubility, enhanced bioaccessibility, increased bioavailability, and an extension of shelf life.This contribution provides an overview of advancements in modifying functional properties through various protein isolation methods and structural changes resulting from enzymatic hydrolysis. Additionally, the paper considers the state of the art in the utilization of various techniques and the composition of wall material in the encapsulation of phytosterols and other common lipophilic phytochemicals incorporated into delivery systems.Protein isolates obtained through novel methods of extraction may be characterized by an enhancement of their functional properties, which is crucial for the microencapsulation process. It entails not only recognizing their role as protective barriers for core materials against environmental conditions but also acknowledging their potential health-promoting attributes. These attributes encompass antioxidant properties and enhanced functional characteristics compared to native proteins. Moreover, the exploration of protein hydrolysates as versatile wall materials holds significant promise. These hydrolysates offer exceptional protective features for core materials, extending beyond mere environmental shielding. The envisioned impact extends beyond conventional delivery systems, offering transformative potential for the future of drug delivery and nutraceutical formulations.

Investigation of the Structural Properties and Antioxidant Potency of Pectic Polysaccharides Derived from Rohdea japonica (Thunb.) Roth.

This study investigated the structural composition and antioxidant properties of pectic polysaccharides extracted from Rohdea japonica (Thunb.) Roth. Pectins, which belong to a complex category of acidic polysaccharides, possess a wide range of biological effects stemming from their distinctive structural domains. The polysaccharides were extracted using water, and were subsequently purified through ion exchange and gel permeation chromatography. In order to elucidate their structural features, Fourier Transform Infrared Spectroscopy and Nuclear Magnetic Resonance techniques were applied. Two specific polysaccharides, WRJP-A2a and WRJP-A3b, with molecular weights of 42.7 kDa and 64.1 kDa, respectively, were identified to contain varying proportions of homogalacturonan, rhamnogalacturonan I, and rhamnogalacturonan II domains. Regarding antioxidant capacity, WRJP-A3b exhibited superior scavenging capabilities against DPPH, ABTS, and hydroxyl radicals, potentially attributed to its higher galacturonic acid content and abundance of homogalacturonan domains. These results enhance our comprehension of the structure-activity interplay of pectic polysaccharides sourced from Rohdea japonica (Thunb.) Roth and their potential utility in the healthcare and functional food sectors.

Network social capital as a subject of research in education

The article contains the results of a comparative analysis of the main approaches, directions and methods for studying network social capital in the social sciences and humanities in order to identify the latest and promising scientific areas in specific scientific disciplines. The article notes the growing interest of scientists from various fields – philosophers, sociologists, political scientists, economists and lawyers, teachers and psychologists in the study of the phenomenon of network social capital as a complex and multifaceted category that generates a plurality of approaches and methods for studying its genesis, types, formation mechanisms and measurement parameters. To achieve this goal, multidisciplinary and integrated approaches to research, methods of comparative analysis and classification of information, bibliographic analysis are used. On the basis of the analysis, the essential methodological foundations of the study of network social capital are revealed, the relationship of the methods used (quantitative, qualitative and mixed) with the profile of the scientific discipline that studies network social capital is shown. It is indicated that each scientific discipline brings unique ideas and methods to the study of social capital, including qualitative and quantitative, mixed methods, network analysis, experiment, etc. The author reveals the urgent need for the integration of methodological approaches and research methods of network social capital as an independent field of research based on the synthesis of ideas, concepts and principles of polydisciplinarity and interdisciplinarity.

Of Stones and Horses: Reading the Gōngsūn Lóngži in Terms of Concrete Universals

Abstract: The present article proposes a new take on the realist interpretation of the Gōngsūn Lóngzǐ, which theorizes the existence of a theory of universals in the text. Building on the “two-level ontology” hypothesis, it argues that the Gōngsūn Lóngz ǐ elaborates a complex category theory that should rather be interpreted in terms of concrete rather than abstract universals. Through the analysis of some of the most famous arguments debated in the text, such as the “white horse” and the “hard and white stone,” among others, the article delineates a distinction between what seems to be two different types of categories, “incidental qualities” and “structural qualities.” Through this analysis, the article aims to show how this interpretation can help disambiguate the meaning of certain obscure passages, and to identify an underlying line of reasoning that runs like a thread through the text, despite its complex textual history.

Efficacy and Significance of Bio Choline as Choline Source in Poultry

Choline chloride, an organic, colorless, alkaline substance that is treated as a vitamin, though not a vitamin of B complex category, due to its multifaceted functions in animal husbandry too. Specifically, in Poultry where it seems to be the prime reason for hepatic health, apart from its role in the various metabolic and physiological activities. The economic importance of Choline in Poultry has led to the stocking up of innumerable number of its Synthetic forms in the market. These are hygroscopic, corrosive, offensive, off-flavored, non eco-friendly and in being inferior quality and working wise. This has led to an effort and search for alternatives, leading to Phytogenic Herbals as ideal sources. The Bio choline from Indigenous Indian herbs like Azardarictha, Achyranthes, Andrographis, Allium sativum, Fumaria, Solanum, Silibum, and Tachyspermum, was non hygroscopic, non-corrosive, non-off flavored and ecofriendly. The Bio choline equivalence of these herbs was as Phosphotidylcholine with a capability of replacing Synthetic choline completely with good quality and excellent working.

Оценка результатов сравнительного исследования эффективности и безопасности применения комплекса «Фосфалит®» у пациентов с фосфатной формой мочекаменной болезни.

Introduction. Urolithiasis is a widespread disease. The percentage of phosphate stones reaches up to 35% of all cases of all kidney stones. Patients with phosphate stones and with various urinary catheters in particular are a complex category of patients requiring the close attention of doctors. Phosphate urolithiasis clinical patterns create a constant search for various oral therapy options. The purpose of this study is to evaluate the effectiveness of the Phosphalit complex as an optional drug for metabolic disorder correction in phosphate kidney stones. Materials and methods. The prospective randomized control study included 135 patients, 131 people returned for a second visit. All the patients were divided in 4 groups: patients with phosphate urolithiasis who received Phosphalit® on a regular basis, 2 capsules 2 times a day; patients with phosphate urolithiasis who received general recommendations for lifestyle and diet changes; patients with phosphate urolithiasis against the back- ground of existing permanent urinary catheters, receiving the drug Phosphalit® on a regular basis, 2 capsules 2 times a day; patients with phosphate urolithiasis on the background of permanent urinary catheters, who received general recommendations for lifestyle and diet changes. The duration of observation and intervention was 90 days. Results. The total effectiveness of Phosphalit® in reducing the level of phosphates in the blood in both groups of patients (with and without catheters) was 90.1%, and in reducing the excretion of phosphates in urine – 93.3%. The dynamics of the degree of crystalluria and the stone size also showed positive dynamics in all the studied groups. Conclusions. Phosphalit® is an effective and safe remedy in the treatment of the phosphate urolithiasis, including patients with urinary catheters.

Energy security: new challenges and global trends

In the conditions of a permanent world energy crisis and its strengthening against the background of full-scale aggression of russia in Ukraine, questions regarding risks to national energy security come to the fore in the world. At the same time, the world is undergoing the fourth energy transition, which requires the develop­ment of a new concept of energy security by countries that are both suppliers of energy resources and their consumers. The aim of the research is to develop the conceptual principles of energy security, taking into account modern challenges caused by simultaneously growing crises in energy, economy and geopolitics. The creation of such a basis makes it possible to identify a number of solutions for neutralizing new threats that arise, in particular, in the context of the "green" transition. The research was conducted using the methods of scientific abstraction and systematization, analysis and synthesis, generalization, comparison. Concep­tual features of energy security management in conditions of radically changed context, streng­the­ning of crisis phenomena and threats of various natures are presented. The hypothesis that energy security is a complex category that expresses the ability of the fuel and energy complex of the region to supply the domestic market with the necessary volume and range of energy resources at stable and acceptable prices, to quickly mitigate unexpected fluctua­tions in demand for fuel and energy resources and to ensure uninterrupted energy supply and energy carrier parameters in real time. Based on the analysis of scientific publications and practical models of energy security, theoretical provisions, methodological principles and ener­gy security management tools that meet modern requirements have been developed. In particu­lar, the key global trends of changes in the energy markets are defined, the types and forms of modern energy threats and risks are outlined. It outlines the impact of the "green" transition that many countries have undertaken and confirmed at the UN Climate Change Confe­rence (COP28), emphasizing further energy security, taking into account both the reduction of dependence on fossil fuels and the new challenges associated with renewable energy sources. The results of the research are of prac­tical interest during the development of ener­gy policy, plans and specific actions aimed at ensuring energy security in a turbulent global environment.

A Perspective on a Two-stent Approach in Bifurcation Cases

Abstract Bifurcation lesions are the cause of 20% of all percutaneous coronary interventions, representing a complex category associated with lower procedure success rates and higher restenosis rates. However, the optimal approach to bifurcation needs further research. This paper aims to determine the optimal method for implementing a two-stent strategy in bifurcation cases. It desires to identify the characteristics that can guide our approach and the outcomes that can be expected. This paper also highlights relevant trials that support the findings. In nontrue bifurcation cases (Medina 1-1-0, 1-0-0, 0-1-0, 0-0-1), a one stent strategy, eventually with the provisional approach, is preferable. When treating a left main or non-left main bifurcation in a Medina classification of 1-1-1, 1-0-1, or 0-1-1 without meeting at least one major and two minor criteria and of DEFINITION II Classification (simple true bifurcation), the layered provisional approach is the appropriate strategy. In cases of left main or non-left main complex true bifurcation (Medina 1-1-1, 1-0-1, 0-1-1) meeting the Definition II Classification criteria, a two-stent strategy could be a suitable option in cases where the SB is more than 2.5 mm and has a lesion length of more than 16 mm.

LEGAL POSITIONS OF THE CONSTITUTIONAL COURT OF UKRAINE REGARDING THE CONSTITUTIONAL DUTIES OF A PERSON AND A CITIZEN

The article analyzes the properties of the constitutional duties of a person and a citizen in the light of the legal positions of the Constitutional Court of Ukraine. After all, in order to renew the understanding of the legal nature, content orientation and social significance of the constitutional duties of a person and a citizen, it is necessary to analyze the understanding of this important category of jurisprudence through the prism of the legal positions of the Constitutional Court of Ukraine. The latter, due to their specific and meaningful content, as well as the authority of the body that formulates them, can be considered as original sources of the constitutional law of Ukraine. A careful analysis of the multifaceted practice of the Constitutional Court of Ukraine allowed to identify and analyze the basic legal positions, which in turn, supplementing and developing the achievements of the constitutional and legal doctrine of Ukraine from a practical point of view, indicate such properties of constitutional duties. First of all, all constitutional duties, regarding which the body of constitutional jurisdiction has formulated legal positions, are directly or indirectly related to ensuring the national security of Ukraine as a complex socio-legal category. Secondly, legal positions confirm the fact that constitutional duties are socially significant due to their special purpose and role in the life processes of society and the state. Thirdly, the Constitutional Court of Ukraine in its formulated legal positions emphasizes that the implementation of constitutional duties requires adequate guarantees from the state. Fourthly, in addition to the formalized guarantees, the body of constitutional jurisdiction indicated that the implementation of some constitutional duties requires public support and respect for the persons who implement them. Fifth, constitutional duties, giving rise to a wide variety of legal relations, are able to influence the relevant subjects and change, strengthen or fundamentally transform their legal status. Sixth, in some decisions, the Constitutional Court of Ukraine formulates legal positions that confirm the respective potential possibilities of constitutional obligations regarding their implementation in extraordinary situations, including those that require the introduction of a special period. And, finally, seventhly, the body of constitutional jurisdiction pointed out that the proper implementation of constitutional duties is aimed at neutralizing the factors that cause the need to introduce a special period.

MRFA-Net: Multi-Scale Receptive Feature Aggregation Network for Cloud and Shadow Detection

The effective segmentation of clouds and cloud shadows is crucial for surface feature extraction, climate monitoring, and atmospheric correction, but it remains a critical challenge in remote sensing image processing. Cloud features are intricate, with varied distributions and unclear boundaries, making accurate extraction difficult, with only a few networks addressing this challenge. To tackle these issues, we introduce a multi-scale receptive field aggregation network (MRFA-Net). The MRFA-Net comprises an MRFA-Encoder and MRFA-Decoder. Within the encoder, the net includes the asymmetric feature extractor module (AFEM) and multi-scale attention, which capture diverse local features and enhance contextual semantic understanding, respectively. The MRFA-Decoder includes the multi-path decoder module (MDM) for blending features and the global feature refinement module (GFRM) for optimizing information via learnable matrix decomposition. Experimental results demonstrate that our model excelled in generalization and segmentation performance when addressing various complex backgrounds and different category detections, exhibiting advantages in terms of parameter efficiency and computational complexity, with the MRFA-Net achieving a mean intersection over union (MIoU) of 94.12% on our custom Cloud and Shadow dataset, and 87.54% on the open-source HRC_WHU dataset, outperforming other models by at least 0.53% and 0.62%. The proposed model demonstrates applicability in practical scenarios where features are difficult to distinguish.

Mechanisms for managing investment activities in the agro-industrial complex

The relevance of the study of investment management mechanisms in the agro-industrial complex is explained by the fact that only those subjects of the agro-industrial complex that carry out active investment activities have prospects for successful functioning. However, the pace of their development is largely determined not only by the volume of investments, but also by the efficiency of their use. At the same time, the concept of «investment» reflects a complex and significant economic category. On the one hand, investments make it possible to carry out the process of agricultural production itself, and on the other, the results of the production process affect savings, that is, the possibilities of further investment. At the same time, the conducted study of the indicators of measurement and evaluation of investment projects allowed us to more fully reveal their content, objective relationships between them. At the same time, the prerequisite for calculating performance indicators was the justification of approaches that take into account objective economic laws

Should Children Be Included in Human Challenge Studies?

Human challenge studies, in which human research subjects are intentionally exposed to pathogens to contribute to scientific knowledge, raise many ethical complexities. One controversial question is whether it is ethically permissible to include children as participants. Commentary of the past decades endorses the exclusion of children, while new guidance suggests that pediatric human challenge studies can be ethically permissible. This paper argues that neither children's exclusion nor their inclusion are well justified. I examine and reject three arguments for exclusion, but suggest that these arguments establish pediatric human challenge studies as a complex ethical category of research that requires caution. I then argue for a strong presumption against children's inclusion, by drawing on an analogy to children's inclusion in phase I trials, emphasizing a requirement of necessity, and suggesting that accommodating children's vulnerability promotes an age de-escalation approach for pediatric human challenge studies research. In the final section, I suggest a procedure for ethics review.

Instrumental Tracheal Rupture

Abstract Tracheal rupture is an urgent life-threatening complication that relates to complex and poorly understood areas of trauma surgery. The article presents a review of modern world and domestic literature on instrumental tracheal ruptures, the Relevance of early diagnosis and various treatment methods. Based on an analysis of modern literature data, the article describes the issues of conservative and surgical treatment methods, as well as an assessment of their results. The problem of the diagnostic algorithm and the choice of conservative, surgical treatment has not been solved and remains relevant. The issues of treating patients with a defect in the membranous wall of the trachea in intensive care and in need of artificial ventilation in clinical practice remain unresolved. All of the above indicates the Relevance of the study.Aim of the study To present data from domestic and foreign literature on the diagnosis and treatment of instrumental tracheal ruptures.Material and methods A review of the literature was carried out for the period from 1993 to 2024 in Russian and English, available on the databases Pubmed, Medline, UpTodate, Scopus, E-library, on topics such as post-intubation tracheal rupture, iatrogenic tracheal rupture, diagnosis and treatment of instrumental tracheal ruptures, closed tracheal injury.Results The concept of the classification system, risk factors, etiopathogenesis is outlined. Information is provided on the diagnostic significance of computed tomography and tracheobronchoscopy. Close attention is paid to the methods and choice of treatment tactics, the principles of intraoperative tactics, and the strategy of conservative treatment. A comparative assessment of treatment Results and their complications with a conservative or surgical treatment approach is given.Conclusion Thus, an analysis of domestic and foreign literature indicates that the issues of diagnosis and treatment of iatrogenic tracheal injuries remain largely unresolved. There is no generally accepted algorithm for instrumental diagnosis of tracheal ruptures. There are no uniform approaches to determining indications and contraindications for conservative and surgical treatment of tracheal injuries. There are diametrically opposed opinions regarding the choice of treatment tactics. These contradictions create significant difficulties in assessing the Results of treatment of this complex category of patients.

Synthesis, Characterization, and Bioactivity Studies of the Schiff Base Ligand and its Zinc(II) Complex

One of the largest concerns to global health in recent decades has been identified as the growth of bacteria resistance to antibiotics. The Schiff base (SBs) and the zinc(II) SBs complex compounds category have attracted a lot of interest because of their function in chemical syntheses and their potential for bioactive and pharmacological effects. The present study includes the synthesis of various SBs with different substituents. Equimolar mixtures of benzaldehyde derivatives (1, 2) and aniline derivatives (3, 4) are used to carry out a series of condensation reactions to get compounds (5-7). By stoichiometrically combining Zn (II) acetate and ZnCl2 separately with the SBs ligand (7) in ethanol, it has been possible to prepare the SBs zinc(II) complex (8). The structure of the ligand and its metal complex are analyzed using (Fourier transform infrared spectroscopy, 1H-NMR, 13C-NMR) spectroscopy, scanning electron microscopy, and liquid chromatography–mass spectrometry. Moreover, the synthesized compounds are verified in vitro against Escherichia coli Gram negative, Staphylococcus aureus Gram positive, and fungi (Candida albicans). Compounds (5, 7, and 8) indicated significant growth inhibition against E. coli Gram negative and fungi (C. albicans) with different inhibition zones starting from 7 to 17.5 mm.