Complaints Of Premature Ejaculation Research Articles

Prematür ejakülasyon tanılı hastalarda depresyon ve kaygı düzeylerinin değerlendirilmesi

OBJECTIVES: Premature ejaculation patients often present to the hospital with poor psychological conditions. The aim of this study is to evaluate the levels of depression and anxiety in patients presenting with premature ejaculation complaints. MATERIAL and METHODS: The study included only patients with lifelong premature ejaculation (PE) and acquired PE. A total of 80 patients were included in this study. After recording demographic data such as age, height, weight, body mass index (BMI), occupation, etc., patients who met the inclusion criteria were administered the Beck Depression Inventory (BDI) and Hospital Anxiety and Depression Scale (HADS) questionnaires to assess the severity of depression and anxiety. RESULTS: The premature ejaculation evaluation questionnaire scores, Beck Depression Inventory (BDI), and Hospital Anxiety and Depression Scale (HADS) scores were found to be significantly higher in individuals with premature ejaculation duration of less than 30 seconds compared to those with a duration of over 30 seconds (p<0.05). Additionally, correlation analyses showed that as the premature ejaculation questionnaire score increased, both the BDI score (r=0.775) and HADS score (r=0.882) also increased. CONCLUSION: In male patients, an increase in the severity of premature ejaculation is associated with an increase in depression and anxiety levels. Therefore, a multidisciplinary approach should be exhibited in the evaluation and treatment of patients. Keywords: premature ejaculation, depression, anxiety

Sociodemographic and Clinical Correlates of Subjects Presenting with Complaint of Premature Ejaculation

Background: Premature ejaculation (PE) is a common sexual disorder. The profile of subjects seeking treatment of PE in India has not been reported earlier. Objective: To study the sociodemographic and clinical profile of subjects presenting with the complaint of PE. Material and Methods: The subjects presenting with the complaints of PE were recruited from a specialty psychosexual OPD in the department of psychiatry of a tertiary care center in North India. The subjects were assessed on semistructured proforma, MINI-International Neuropsychiatric Interview, version 7.0, the Diagnostic and Statistical Manual of Mental Disorders, Premature Ejaculation Diagnostic Tool, Arizona Sexual Experience Scale, Hamilton Rating Scale for Depression, and Hamilton Rating Scale Anxiety, Sexual Health Inventory for Men, and Short Form-36 Health Questionnaire. Results: A total of 102 subjects were selected after screening 148 cases attending OPD with the complaints of PE after applying selection criteria. The mean age of the sample was 32.17 years (± 8.11). Most of the subjects were married (80.4%), cohabitating with partners (70.6%) and living in the rural area (53.9%). The mean age of onset was 28.29 years (± 7.83, range 17–53), and the mean duration of illness was 3.87 years (± 5.49, range 0.5–31). Prevalence of sexual, psychiatric, and medical comorbidities was 60.8%, 16.7%, and 29.5%, respectively. Emotional role functioning, energy, and general health were the most adversely affected domains of health-related quality of life. Conclusion: Most of the men in this study of PE subjects seeking treatment were married young adults. The individuals typically had moderate to severe PE. Comorbidities are prevalent, and roughly two-thirds of people have another medical, psychiatric, or sexual dysfunction.

Low frequency neuromuscular electrical stimulation applied to the bulbospongiosus muscle prolongs the ejaculation latency in a rat model.

Premature ejaculation (PE) is common, but its true pathophysiology is not clear, and treatments are limited. We aimed to investigate the effect of neuromuscular electrical stimulation applied in different modes and frequencies to the bulbospongiosus muscle on ejaculation parameters. In this study, 24 male Wistar albino rats were used. The rats were equally divided into three groups: control, high-frequency burst (HFB) and low-frequency (LF) (n = 8 each). Neuromuscular electrical stimulation was applied to the rats for 30 min. In the HFB group, this stimulation was applied in the burst mode at 80 Hz frequency using 200 microseconds (µs) transition time. In the LF group, manual stimulation was applied using a 2 Hz frequency and 200 µs transition time. Following the intraperitoneal administration of para-chloroamphetamine at a dose of 5 mg/kg, ejaculation time, increase in basal seminal vesicle pressure, seminal vesicle maximum pressure, number and interval time of seminal vesicle contractions and bulbospongiosus muscle electromyography activities were evaluated over 30 min. There was a significant difference between the groups in terms of ejaculation time (p = 0.002). The ejaculation times of the LF, HFB and control groups were 1344.71 ± 105.9, 908 ± 62 and 672 ± 149.7 s, respectively. The post hoc analysis revealed that the ejaculation time of the LF group was significantly longer than that of the HFB and control groups (p = 0.033 and p = 0.001, respectively). The remaining parameters did not differ significantly between the groups. The results showed that low-frequency (2 Hz) electrical stimulation applied to the male rats significantly prolonged the ejaculation time. It is thus considered that applying neuromuscular electrical stimulation before planned sexual activity can prevent the rhythmic contractions necessary for completing the ejaculatory process by maintaining subtetanic continuous contraction and prolonging the ejaculation time in patients with premature ejaculation complaints.

Evaluation of the quality of life of patients with premature ejaculation (lifelong and acquired).

SUMMARYOBJECTIVE:The aim of this study was to evaluate the quality of life of patients with lifelong and acquired premature ejaculation and to examine its relationship with depression and anxiety.METHODS:Between February 2017 and January 2018, a total of 175 patients with premature ejaculation and 132 control men who applied to the urology department of the training and research hospital with the complaint of Premature Ejaculation were included. Patients were divided into three groups according to International Society for Sexual Medicine (ISSM) criteria as follows: Group 1, lifelong premature ejaculation; Group 2, acquired premature ejaculation, and Group 3, control group without premature ejaculation. A detailed medical history of patients was obtained and physical examinations were performed. Intravaginal ejaculation latency time (IELT) was recorded and patients were administered International Erectile Function Index-5 (IIEF-5), Premature Ejaculation Diagnostic Tool (PEDT), Sexual Health Inventory for Men (SHIM), Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI)-1 and STAI-2, and Short Form-36 (SF-36).RESULTS:The mean mental component score (MCS) of the SF-36 was 51.65±6.57 in the lifelong premature ejaculation group, 49.33±8.65 in the acquired premature ejaculation group, and 61.12±11.09 in the control group (p<0.0001). The mean physical component score (PCS) was 50.99±7.43 in the lifelong premature ejaculation group, 48.32±11.58 in the acquired premature ejaculation group, and 55.17±8.10 in the control group (p<0.0001). Quality of life of premature ejaculation patients as assessed by SF-36 was lower in the subscales of physical functioning, general health perception, vitality, and role limitations due to emotional functioning, compared to the control group.CONCLUSIONS:Lifelong and acquired premature ejaculation patients deteriorate their quality of life: the deterioration in these patients’ quality of life also negatively affects their depression and anxiety states.

Correlations between Personality Traits, Patient-Reported Outcome, and Chronic Prostatitis Symptoms in Men with Different Premature Ejaculation Syndromes.

Although the personality traits (PT), patient-reported outcome (PRO), and chronic prostatitis (CP) symptoms in premature ejaculation (PE) have been evaluated, there was no study to assess their correlations in men with different PE syndromes. The purpose of this study was to assess the correlations between the PT, PRO, and CP symptoms in men with different PE syndromes. Between January 2019 and January 2021, a cross-sectional field study was conducted in our andrology clinic. Men with the complaints of PE were divided into lifelong PE (LPE), acquired PE (APE), variable PE (VPE), and subjective PE (SPE). All subjects were required to complete a verbal questionnaire with the PRO, National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), and Temperament and Character Inventory (TCI-R). Finally, 479 men with the complaints of PE and 365 without the complaints of PE were enrolled. The incidence of PE syndromes in PE complaint group was as follows: LPE 16.70%, APE 48.85%, VPE 11.27%, and SPE 23.17%. Mean ages in PE complaint group were 42.53 ± 12.25 years. In the PE complaint group, the novelty seeking (NS) scores were strongest correlated with the personal distress and quality of life (QOL). The harm avoidance (HA) scores were strongest correlated with the severity of PE and pain syndromes. The self-transcendence (ST) scores were strongest correlated with the satisfaction with sexual intercourse and QOL. In addition, strongest association between the total scores of NIH-CPSI and the NS or ST scores was also found in the APE group. The HA scores were also strongest correlated with the total scores of NIH-CPSI in SPE. Strongest association between the total scores of NIH-CPSI and the NS/TI or ST/CI scores was also found in the APE group. The HA/TI scores were also strongest correlated with the total scores of NIH-CPSI in SPE.

The importance of inquiring the ejaculation function in men with premature ejaculation who do not actively seek treatment.

To evaluate the clinical characteristics of men presenting for other complaints whose ejaculatory function inquiry indicated premature ejaculation (PE). The data of 536 PE patients, including those who presented with the complaint of PE (group 1) and those presenting with other complaints who were diagnosed with PE (group 2) as a result of ejaculatory function inquiry using estimated intravaginal ejaculation latency time (IELT) and Premature Ejaculation Diagnostic Tool (PEDT), were retrospectively evaluated. Age, PE type, comorbidities, recommended treatments, and treatment acceptance status of all patients were recorded. These characteristics were compared for each group. Among all the patients, those who presented with PE complaints constituted 22.4%. Among the patients with both PE and ED, 98.1% applied with ED complaint and only 1.9% with PE complaint. The percentage of patients with one comorbidity was significantly higher in group 2 (p = 0.032). 90.1% of all patients and 88.5% of patients in group 2 accepted the recommended treatment for PE. The mean age and comorbidities were significantly higher in patients that refused the treatment. The most common reason for treatment refusal was the patients' lack of expectation for treatment. This study shows that men more frequently tend to seek treatment for ED than PE, and treatment acceptance rate may be higher when the patients with PE complaints who don't seek treatment are reached through ejaculatory function inquiry. The presence of comorbidities negatively affects the treatment expectation and acceptance as well as treatment seeking behavior of men with PE.

Traumatic masturbation syndrome may be an important cause of erectile dysfunction in pre-mature ejaculation patients.

We aimed to investigate of whether atypical masturbation behaviour is a pre-disposing factor in ED aetiology in pre-mature ejaculation (PE) patients. In addition to demographic data, self-estimated intravaginal ejaculatory latency time (IELT) was prospectively questioned in 2,572 patients between the ages of 18 and 60 who applied with the complaint of pre-mature ejaculation between March 2018 and May 2020. The masturbation habits of the patients were questioned with open-ended questions. After the exclusion criteria, 1,819 patients were evaluated. One thousand one hundred-fifty (63.2%) of patients were classified as lifelong PE, 369 (20.3%) were acquired PE, while 300 (16.5%) were natural-variable PE. According to the IIEF score, 714 patients (39.3%) had ED associated with PE. Eighty-eight per cent of men declared that they had masturbated in the last 4weeks. Atypical masturbatory behaviours such as 'through clothes' and 'rubbing in prone position' were significantly higher in patients with ED (13% vs. 9%, p=.04 and 11% vs. 7%, p=.02 respectively). Atypical masturbatory behaviours are also seen in a significant part of the pre-mature ejaculation population and increase the rate of erectile dysfunction accompanying PE. This situation draws attention to the necessity of questioning masturbation habits, especially in the combination of PE and ED.

Association between serum vitamin D levels and acquired premature ejaculation

Background and objective: Premature ejaculation is one of the most common and complex sexual diseases among men. Although there are four defined subtypes of premature ejaculation, the most common subtype is acquired premature ejaculation. This study investigated the association between serum vitamin D levels and acquired premature ejaculation.Material and methods: This retrospective cross-sectional study included 94 patients with a complaint of acquired premature ejaculation (the study group) and 92 patients without a complaint of premature ejaculation (the control group) between June 2018 and March 2020. Patients' demographic characteristics, laboratory results, intravaginal ejaculatory latency time, Turkish validated premature ejaculation diagnostic tool (PEDT), International Index of Erectile Function-5 (IIEF-5) and Beck Depression scores were statistically compared between groups.Results: The patients' mean age was 49.10 ± 14.85 years. There were differences between the two groups regarding serum vitamin D levels, dehydroepiandrosterone sulfate, total testosterone, and follicle-stimulating hormone levels. Upon comparing the questionnaire scores, the PEDT, intravaginal ejaculatory latency time, and Beck depression scores were clinically significant between groups. The cut-off value for serum vitamin D levels was 8.37 ng/mL, with a sensitivity of 93% and specificity of 92%. Conclusion: We revealed that serum vitamin D and follicle-stimulating hormone levels were independent risk factors according to the multivariate analysis. Measurement of serum vitamin D levels in patients with acquired premature ejaculation may be useful for treatment.

Temperament-Character Traits and Attitudes Toward Premature Ejaculation in 4 Types of Premature Ejaculation

BackgroundAlthough temperament-character traits and attitudes toward premature ejaculation (PE) are known to be associated with PE, it is of great significance to study them in PE. Moreover, few studies have evaluated these traits and attitudes in the new classification of 4 subtypes of PE. AimWe investigated the temperament-character traits and attitudes toward PE in 4 types of PE and their associations with PE. MethodsBetween December 2018 and December 2019, we conducted a survey in our hospital, and enrolled 350 men who complained of PE and 252 men without any complaint of PE. Temperament-character traits and attitudes toward PE were independently assessed by the Temperament and Character Inventory-Revised and several targeted questions, respectively. The Index of Premature Ejaculation (IPE) was used to evaluate ejaculation control, sexual life satisfaction, and distress caused by PE. OutcomesThe outcomes included differences of temperament-character traits and attitudes toward PE among 2 groups and their associations with PE. ResultsOf the 2 groups, men with PE complaints had lower novelty seeking/self-transcendence (NS/ST) scores and higher harm avoidance (HA) scores vs men without any complaints of PE. Among the 4 types of PE, men with variable PE had the highest score of HA and lowest score of NS; the lowest score of ST was recorded in men with lifelong PE. Additionally, the total and subdomain scores of IPE in men with subjective PE were higher than the other subtypes of PE. After adjusting for age, positive correlations were observed in HA score and total and subdomain scores of IPE, whereas the inverse was true corresponding to NS and ST. Clinical ImplicationsThe current study has provided a new perspective for understanding the impact of psychological factors on PE. Strengths & LimitationsThis is the first study to systematically assess the effects of personality traits and attitudes on PE, especially among the 4 types of PE. The main drawback is that the generalizability of this study may be limited by the fact that it was conducted in a single cultural/societal background. ConclusionMen who complained of PE tended to react with indifference or rejection to novelty, tended to feel unsatisfied, cannot effectively adapt to changes in the surrounding environment, and tended to avoid situations involving risk. These characteristics could lead to their becoming disheartened when faced with PE. Furthermore, the attitude of men with PE reflects the needs of the patient during treatment from one aspect.Gao P, Gao J Wang Y, et al. Temperament-Character Traits and Attitudes Toward Premature Ejaculation in 4 Types of Premature Ejaculation. J Sex Med 2021;18:72–82.

The effect of post-circumcision mucosal cuff length on premature ejaculation.

We aimed to compare the length of mucosal cuff after circumcision in patients with and without a complaint of premature ejaculation (PE). Sexually active patients without erectile dysfunction that presented to the urology polyclinic between March 2018 and June 2018 were included in this multicentered, prospective study. The circumcision age of the patients, the person who performed the procedure (surgeon, non-surgeon), penile length, and dorsal and ventral penile measurements were recorded and compared between patients with and without PE. A total of 208 patients were included in the study. The mean circumcision age of the patients was 5.7±4.2 years, and the mean dorsal and ventral mucosal sizes were 15.02±4.58 mm and 16.31±4.92 mm, respectively. PE was present in 106 of the participants. There was no statistically significant difference between the PE and non-PE groups in terms of the person who performed the procedure (surgeon, non-surgeon). However, patients with PE had statistically significantly longer dorsal and ventral mucosal measurements compared to those without PE (p<0.001). Our study showed that the dorsal and ventral lengths of mucosal tissue left behind after circumcision are a risk factor for PE. Therefore, special attention should be paid not to leave redundant dorsal and ventral mucosal tissue during this procedure.

Effectiveness and Safety of Silodosin in Treatment of Premature Ejaculation: Placebo Double Blind Control Study

Background: Premature ejaculation (PE) is a common sexual problem, many epidemiological reports have shown that approximately 20–30% of men have complaints of PE. Objective: The aim of this study was to evaluate the effectiveness of silodosin 4mg in treatment of premature ejaculation. Patients and methods: This study was conducted on 160 subjects with premature ejaculation. The patients were recruited from Dermatology and Andrology Outpatient Clinics in Al-Azhar University Hospitals . Results: According to our results, there is highly statistically significant difference (p-value < 0.001) between patient group (559.3 ± 159.9) and control group (248.4 ± 83.7) as regard intravaginal ejaculatory latency time (IVELT) post-treatment (p-value < 0.001). Also, we found highly statistically significant difference (p-value < 0.001) between premature ejaculation profile questionnaire (PEPQ) pre- and post-treatment in patients' group. As silodosin caused improvement of control over ejaculation, satisfaction with sexual intercourse, personal distress related to ejaculation and interpersonal difficulty. At the end of the study only 11 (13.75%) patients reported that they had a decreased semen volume as a side effect of silodosin, which disappeared completely after discontinuation of the drug. Conclusion: we found that, silodosin 4 mg is a promising idea in treatment of premature ejaculation, as it is effective, cheap, safe and available in Egyptian market. We recommend administration silodosin 4mg 2 hours before sexual intercourse for treatment of premature ejaculation.

Effectiveness and Safety of Silodosin in Treatment of Premature Ejaculation: Placebo Double Blind Control Study

Background: Premature ejaculation (PE) is a common sexual problem, many epidemiological reports have shown that approximately 20–30% of men have complaints of PE. Objective: The aim of this study was to evaluate the effectiveness of silodosin 4mg in treatment of premature ejaculation. Patients and methods: This study was conducted on 160 subjects with premature ejaculation. The patients were recruited from Dermatology and Andrology Outpatient Clinics in Al-Azhar University Hospitals . Results: According to our results, there is highly statistically significant difference (p-value < 0.001) between patient group (559.3 ± 159.9) and control group (248.4 ± 83.7) as regard intravaginal ejaculatory latency time (IVELT) post-treatment (p-value < 0.001). Also, we found highly statistically significant difference (p-value < 0.001) between premature ejaculation profile questionnaire (PEPQ) pre- and post-treatment in patients' group. As silodosin caused improvement of control over ejaculation, satisfaction with sexual intercourse, personal distress related to ejaculation and interpersonal difficulty. At the end of the study only 11 (13.75%) patients reported that they had a decreased semen volume as a side effect of silodosin, which disappeared completely after discontinuation of the drug. Conclusion: we found that, silodosin 4 mg is a promising idea in treatment of premature ejaculation, as it is effective, cheap, safe and available in Egyptian market. We recommend administration silodosin 4mg 2 hours before sexual intercourse for treatment of premature ejaculation.

Men with subjective premature ejaculation have a similar lognormal IELT distribution as men in the general male population and differ mathematically from males with lifelong premature ejaculation after an IELT of 1.5 minutes (Part 2).

Men with Subjective premature ejaculation (PE) have complaints of PE but have normal intravaginal ejaculation latency time (IELT) durations. We found two previously published large epidemiological stopwatch-mediated IELT studies to encompass IELT details of men with Subjective PE, albeit this term was not mentioned in both studies or in reviews of them. In the current study we developed the mathematical formula of the IELT distribution of men with complaints of PE, as diagnosed by a clinician on basis of the DSM-IV-TR definition of PE, as reported in the two studies performed in the USA and Europe, respectively. The formula was calculated by investigation of the fitness of various well-known mathematical Probability Density distributions into the IELT distribution of the PE men and non-PE men of the two studies. The better the fitness the lower is the Goodnes of Fit (GOF). Another aim of the study was to investigate whether the IELT distribution of men with "complaints" of PE (Subjective PE) differs mathematically from the IELT distribution of the general male population and that of Lifelong PE. The overlap of the area under the curve (AUC) of the IELT distribution of the men with PE complaints and that of the general male population was calculated together with the cut-off point at which the AUC equals 10%. We found that the IELT distributions of the PE men in both studies were Lognormal distributions and that at the cut-off point at which the AUC is equal to 10% (p = 0.10) the IELT is 1.5 min, indicating that after 1.5 min the IELT distribution of males with complaints of PE becomes mathematically identical to that of the general male population. In conclusion, there is hard mathematical evidence that the IELT distribution of men with complaints of PE with normal IELT values (e.g., the Lognormal IELT distribution of Subjective PE) and the IELT distribution of men with Lifelong PE (e.g. the Gumbel Max IELT distribution) belong to two independent populations. According to the applied mathematical calculations Subjective PE starts after an IELT of 1.5 min and encompasses all higher IELT values. It may imply that the current IELT cut-off point in Lifelong PE should be 1.5 min instead of the approximate 1 min, as has previously been stated by ISSM and DSM 5.

AB080. Relationships between intravaginal ejaculatory latency time and National Institutes of Health-Chronic Prostatitis Symptom Index in the four types of premature ejaculation syndromes: a large observational study in China

BackgroundWe assessed the associations between intravaginal ejaculatory latency time (IELT) and National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) in men with different premature ejaculation (PE) syndromes.MethodsFrom September 2011 to September 2012, a total of 4,000 men were enrolled from the Anhui province of China. Subjects were required to complete a verbal questionnaire, including demographic information, medical and sexual history [e.g., IELT, and self-estimated scales (e.g., NIH-CPSI)].ResultsOf 3,016 of the men evaluated, 25.80% complained of PE. Distribution of the four PE syndromes among men with complaints of PE was as follows: lifelong premature ejaculation (LPE), 12.34%; acquired PE (APE), 18.77%; natural variable PE (NVPE), 44.09%; premature-like ejaculatory dysfunction (PLED), 24.81%. Men with complaints of PE reported worse NIH-CPSI scores, and lower IELT than men without complaints of PE (P<0.001 for all). Moreover, total and subdomain scores of NIH-CPSI were higher in men with APE, and IELT was higher in men with PLED. IELT was negatively associated with NIH-CPSI scores in men with complaints of PE. Negative relationships between total and subdomain scores of NIH-CPSI, and IELT were stronger in men with APE (total scores: adjusted r=−0.68, P<0.001; pain symptoms: adjusted r=−0.70, P<0.001; urinary symptoms: adjusted r=−0.67, P<0.001; quality of life impact: adjusted r=−0.64, P<0.001).ConclusionsMen with complaints of PE reported worse NIH-CPSI scores than men without complaints of PE. Relationships between IELT and NIH-CPSI scores were strongest in men with APE.

Evaluation of dapoxetine treatment success in lifelong premature ejaculation patients with penile sympathetic skin response.

Hyperactivity of the sympathetic nervous system may play an important role in primary premature ejaculation (PPE), and dapoxetine, a selective serotonin reuptake inhibitor, plays a role in its treatment. We evaluated the success of dapoxetine treatment in PPE patients with a penile sympathetic skin response (PSSR). Of 63 patients who were admitted to our outpatient clinic between March 2017 and December 2017 with a complaint of premature ejaculation and diagnosed with PPE, 56 completed treatment (minimum 12 tablets) with on-demand use 30mg of dapoxetine and returned for a follow-up appointment. Before and after treatment, the International Index of Erectile Function (IIEF-5) and Arabic index PE (AIPE) scores, intravaginal ejaculation latency time (IELT), testosterone values and PSSR values were compared. The IELT and AIPE values increased significantly in the 56 patients who were re-evaluated after dapoxetine treatment. No significant changes were observed in testosterone levels and IIEF-5. In the PSSR measurement, while the amplitude decreased, the latency was prolonged significantly. PSSR may be an important determinant in the measurement of dapoxetine treatment success for PPE patients, but additional studies are needed.

A comparative study of guided vs. pure self-treatment for premature ejaculation

ABSTRACTSelf-treatments have previously shown some efficacy in treating premature ejaculation (PE). It has been hypothesized that adding professional support to cognitive-behaviour bibliotherapy could improve self-treatment outcomes. Therefore, the aim of this study was to compare treatment outcomes for participants with PE who used bibliotherapy alone (pure self-treatment) versus those who used the bibliotherapy with brief support from a health professional (guided self-treatment). Health professionals were not experienced sex therapists, but had attended a short training session in order to equip them to support the self-help process. In total, 135 men reporting difficulties with PE were recruited between February and June 2013. Seventy-one (52.59%) completed the protocol: 37 in the pure self-treatment condition, 34 in the guided self-treatment condition. Thirty-five participants (50%) met criteria for ISSM definition of lifelong PE, 14 (20%) for acquired PE, and 22 (30%) presented other forms of PE complaints. At 4–8 months post-treatment, improvements were found in both groups and in each subtype of PE on self-reported measures of sexual functioning and sexual cognitions. Univariate analyses indicated slightly greater treatment effects in the guided self-treatment group, but multivariate tests failed to identify a significant effect of therapist support. These mixed findings raise questions regarding the amount and quality of therapist input used in this study, and also about a possible ceiling effect of cognitive-behaviour therapy for PE.

Assessment of hormonal activity in patients with premature ejaculation.

ABSTRACTPurposePremature ejaculation is considered the most common type of male sexual dysfunction. Hormonal controls of ejaculation have not been exactly elucidated. The aim of our study is to investigate the role of hormonal factors in patients with premature ejaculation.Materials and MethodsSixty-three participants who consulted our outpatient clinics with complaints of premature ejaculation and 39 healthy men as a control group selected from volunteers were included in the study. A total of 102 sexual active men aged between 21 and 76 years were included. Premature ejaculation diagnostic tool questionnaires were used to assessment of premature ejaculation. Serum levels of follicle stimulating hormone, luteinizing hormone, prolactin, total and free testosterone, thyroid-stimulating hormone, free triiodothyronine and thyroxine were measured.ResultsThyroid-stimulating hormone, luteinizing hormone, and prolactin levels were significantly lower in men with premature ejaculation according to premature ejaculation diagnostic tool (p=0.017, 0.007 and 0.007, respectively). Luteinizing hormone level (OR, 1.293; p=0.014) was found to be an independent risk factor for premature ejaculation.ConclusionsLuteinizing hormone, prolactin, and thyroid-stimulating hormone levels are associated with premature ejaculation which was diagnosed by premature ejaculation diagnostic tool questionnaires. The relationship between these findings have to be determined by more extensive studies.

AB226. The relationship between self-estimated intravaginal ejaculatory latency time and International Prostate Symptom Score in middle-aged men complaining of ejaculating prematurely in China

ObjectiveWe performed this study to evaluate the association between International Prostate Symptom Score (IPSS) and intravaginal ejaculatory latency time (IELT) in men with the four premature ejaculation (PE) syndromes.MethodsFrom June 2012 to January 2014, a total of 690 men aged 40–59 years complaining of ejaculating prematurely and another 452 male healthy subjects of the same age without these complaints were included in this study. Men with the complaints of ejaculating prematurely were classified as one of the four PE syndromes: lifelong PE, acquired PE (APE), variable PE, and subjective PE. Each of them completed a detailed questionnaire including information on demographics, medical and sexual history (e.g., self-estimated IELT), IPSS, and International Index of Erectile Function-5.ResultsMen complaining of ejaculating prematurely reported higher IPSS (11.2±6.0 vs. 5.5±3.3) and shorter self-estimated IELT (2.1±1.6 vs. 4.8±3.3 min) than men without complaints (P<0.001 for each). By unilabiate analysis, self-estimated IELT in men with the four PE syndromes showed significant correlations with IPSS (P<0.001 for all). After adjusting for age, self-estimated IELT was negatively associated with IPSS in men with PE complaints (adjusted r=−0.378, P<0.001). Also, the association was stronger in men with APE (adjusted r=−0.502, P<0.001).ConclusionsMen complaining of ejaculating prematurely reported worse IPSS than men without these complaints. Self-estimated IELT was negatively associated with IPSS in men complaining of ejaculating prematurely, and the correlation was the strongest in men with APE.

Prematür Ejakülasyon Şikâyeti ile Başvuran Hastalarda Erektil Disfonksiyon Görülme Sıklığı

Prematür Ejakülasyon Şikâyeti ile Başvuran Hastalarda Erektil Disfonksiyon Görülme Sıklığı

The relationship between self-estimated intravaginal ejaculatory latency time and International Prostate Symptom Score in middle-aged men complaining of ejaculating prematurely in China.

Some factors associated with the four premature ejaculation (PE) syndromes have been studied, but the association between International Prostate Symptom Score (IPSS) and the four PE syndromes has not been investigated. We performed this study to evaluate the association between IPSS and intravaginal ejaculatory latency time (IELT) in men with the four PE syndromes. From June 2012 to January 2014, a total of 690 men aged 40-59 years complaining of ejaculating prematurely and another 452 male healthy subjects of the same age without these complaints were included in this study. Men with the complaints of ejaculating prematurely were classified as one of the four PE syndromes: lifelong PE, acquired PE (APE), variable PE, and subjective PE. Each of them completed a detailed questionnaire including information on demographics, medical and sexual history (e.g., self-estimated IELT), IPSS, and International Index of Erectile Function-5. Associations between IPSS and self-estimated IELT in middle-aged men with the four PE syndromes. Men complaining of ejaculating prematurely reported higher IPSS (11.2 ± 6.0 vs. 5.5 ± 3.3 ) and shorter self-estimated IELT (2.1 ± 1.6 minutes vs. 4.8 ± 3.3) than men without complaints (P < 0.001 for each). By unilabiate analysis, self-estimated IELT in men with the four PE syndromes showed significant correlations with IPSS (P < 0.001 for all). After adjusting for age, self-estimated IELT was negatively associated with IPSS in men with PE complaints (adjusted r = -0.378, P < 0.001). Also, the association was stronger in men with APE (adjusted r = -0.502, P < 0.001). Men complaining of ejaculating prematurely reported worse IPSS than men without these complaints. Self-estimated IELT was negatively associated with IPSS in men complaining of ejaculating prematurely, and the correlation was the strongest in men with APE.