INTRODUCTION AND OBJECTIVE: Infection of inflatable penile prostheses (IPP) occurs in 1-3% of cases and is associated with significant morbidity. Immunocompromised men may be at higher risk of infection. We explored reoperation rates [removal, revision or replacement] in immune deficient men to determine if immunocompromised patients are at higher risk of device complications. METHODS: We analyzed men who underwent initial IPP insertion from 2000 to 2016 in the New York Statewide Planning and Research Cooperative System (SPARCS) database, a de-identified, comprehensive, all-payer administrative database that collects patient, physician, and hospital data in New York state. Immune deficient patients were identified using billing codes and sub-stratified into categories of chronic steroid use, organ transplant, use of immune modulating drugs, and other congenital or acquired immune deficiencies (NOS). Immunocompromised men were propensity score matched in a 1:3 fashion with immune competent men based on age, race, insurance, comorbid conditions, procedure year, hospital volume, and disease status using multivariable logistic regression. RESULTS: 234 immune deficient patients were identified who received an IPP between 2000 and 2016. 177 (76.7%) were post-transplant, 29 (12.6%) on chronic steroids, and 29 (12.6%) NOS). Patients on immune modulators were not reportable and subgroup analysis for men on chronic steroids or with immunocompromise NOS was not possible due to sample size. After propensity score matching, we analyzed 230 immunocompromised men and 690 controls. Overall, there were no differences between age, comorbidities, race, type of insurance, year of implant or hospital center volume between cases and controls. Reoperation rate was similar at 90 days (5.0% versus 6.4%, p=0.35), 1 year (8.8% versus 10.0%, p=0.35), and 3 years (11.0% versus 14%, p=0.26) between immunocompromised men and controls. Reoperation rates remained similar in our subgroup analysis of transplant patients (Table 1). CONCLUSIONS: Reoperation rates are similar between immunocompromised men and immune competent controls overall and in men with transplants. Using reoperation rate as a proxy for infection, we conclude that immune status does not place men at higher risk for post IPP infection.Source of Funding: None