Introduction/Background Simulation-based medical education (SBME) has become a well-established component of contemporary curricula,1 yet we do not fully understand how trainees conceptualize their learning in this environment. Without evidence for how trainees think about their learning, some SBME instructional designs may be working against rather than supporting how trainees regulate their learning.2 Theories of self-regulated learning (SRL) suggest that a trainee’s goal orientation and the accuracy with which he self-monitors goal achievement are core learning processes.3,4 In particular, research in psychology has shown that process goals (i.e., focused on the mechanisms of performance) and outcome goals (i.e., focused on products of performance) influence learner’s conceptions and performance when learning.4,5 We studied the effects of different goal orientations (process vs. outcome) on learning outcomes and self-monitoring accuracy during suturing skills training. Methods Forty one medical students were randomly assigned to Outcome and Process goal groups. Participants completed a 25 trial acquisition session and returned two weeks later to complete a 10 trial retention session. On every third trial in both sessions, the participants self-assessed performance using a visual analogue scale. Two expert raters used the same scale to assess participants videotaped performances. We calculated inter-rater reliability and used the combined rater score in analyses of the groups’ performances. We evaluated the self-monitoring accuracy using Pearson’s correlation between expert and participant ratings. For data analysis, we used a repeated measures analysis of variance (trial by group) and t-tests to analyze performance and self-monitoring accuracy, respectively. Results While all participants improved from trial 1 to trial 25 (p<0.001), there were no significant group differences and no interaction between group and trial (all p>0.429). For the retention session, a significant group by trial interaction showed a benefit for the process goal group, only on the 10th and last trial (p=0.034). The t-test comparing the correlation coefficients reflecting participants self-monitoring accuracy showed that the process goal group was significantly better calibrated with expert evaluations during acquisition (r=0.86 vs. r=0.41, p=0.003) and was better calibrated, yet not significantly, during retention (r=0.42 vs. r=0.03, p=0.19). Conclusion We found that instructing trainees to set process or outcome goals during SRL did not lead to consistent performance differences during suturing skills training. However, trainees who set process goals during training had superior self-monitoring accuracy in both practice and retention sessions, which we suggest likely better prepares them for long-term lifelong learning. This study represents one of the first to investigate how SBME instructional design influences medical trainees conceptions both during training and over the long-term. We plan to study how to optimize self-monitoring accuracy further, while ensuring trainees maintain competence in technical skills.