Comparative Evaluation Of Efficacy Research Articles

Evaluation of comparative Efficacy of Jyotishmati and Yastimadhu granules in Enhancing IQ and Memory in Children having different Prakriti –A double blind Randomized Clinical Trial

Evaluation of comparative Efficacy of Jyotishmati and Yastimadhu granules in Enhancing IQ and Memory in Children having different Prakriti –A double blind Randomized Clinical Trial

Comparative evaluation of efficacy of Trayodashang Guggul versus Rasona Pinda as an adjuvant with Katibasti in the management of Grudhrasi (Sciatica): A randomized controlled trial

Comparative evaluation of efficacy of Trayodashang Guggul versus Rasona Pinda as an adjuvant with Katibasti in the management of Grudhrasi (Sciatica): A randomized controlled trial

Evaluation of comparative efficacy of Celastrus paniculatus (Jyotishmati) capsule versus sertraline capsule in the management of Chittodvega (generalized anxiety disorder): protocol for a randomized controlled trial.

Generalized anxiety disorder (GAD) (Chittodvega) is one among many types of mental disorders explained in Ayurveda. It can be defined as a Chitta (mind) + Udvega (anxiety)= Chittodvega- Anxious status of a mind. Celastrus paniculatus also known as Jyotishmati. stimulates and improves the digestive fire and metabolism at a cellular level ( Jatharagni and Majja dhatwagni). It can be correlated to GAD. GAD is characterized by feelings of threat, restlessness, irritability, sleep disturbance, and tension, and symptoms such as palpitations, dry mouth, and sweating. It affects women more frequently than men and prevalence rates are high in midlife (prevalence in females over age 35: 10%) and older subjects. In modern medicine the first-line psychological and pharmaceutical treatments are selective serotonin reuptake inhibitors (SSRIs) like sertraline (SNRIs). To evaluate the comparative efficacy of Jyotishmati versus sertraline in the management of Chittodvega. In this randomized active controlled double blind equivalence trial a total of 70 patients will be enrolled and divided into two equal groups. Patients between 20-50 years age of either gender having symptoms of Chittodvega and a Hamilton anxiety rating (HAM-A) scale score less than 24 (i.e., mild to moderate) will be selected for the study. In Group A, sertraline capsules 25 mg for first 7 days and then dose increased to 50 mg at bedtime for next 53 days and in Group B Jyotishmati Capsules 500 mg will be given twice a day after food with water for 60 days. The patients will be assessed on the HAM-A scale, serum cortisol and WHO Quality of Life on day 0, 30, 60 and 90 and data will be analyzed using paired and unpaired t-tests for continuous variables and chi-square tests for categorical variables to evaluate whether treatments are equivalent. CTRI No. REF/2023/07/069880 Date - 15/09/2023.

Comparative Evaluation of Efficacy of Ultrasound-guided Ilioinguinal and Iliohypogasrtic Block with Conventional Technique Using PNS in Inguinal Hernia Repair

Comparative Evaluation of Efficacy of Ultrasound-guided Ilioinguinal and Iliohypogasrtic Block with Conventional Technique Using PNS in Inguinal Hernia Repair

Comparative evaluation of efficacy of Pippalyadi Agada as an adjuvant drug vs. standard drug therapy in the management of acute food poisoning: A Study Protocol

Antimicrobial resistance, a pressing challenge in modern medicine, arises from excessive antibiotic use in veterinary and human care. Underreporting and complex links between food contamination and illnesses have led to underestimating foodborne disease impacts. The World Bank’s 2019 analysis projected $15B annual treatment costs and $95.2B productivity loss in low- to middle-income countries due to foodborne diseases. “Agada” refers to symptom-relieving medications, like “Vishaghnakalpa.” Pippalyadi Agada, from Vishaghana plants, treats “Dooshivisha Chikitsa,” e.g., Kitibha, rashes, shwas. It has anti-inflammatory, antioxidant properties, aiding acute food poisoning with nausea, vomiting, fever, diarrhea. It is a carminative, curbing prolonged diarrhea, and anti-toxic. Pippalyadi Agada pacifies imbalanced Vata and Kapha, promising better relief than Agni and Pittastana interventions. As an Ayurvedic remedy, it is administered as Vati, 500mg twice daily with Anuapan Honey for 7 days. This study aims to comparatively evaluate the effectiveness of Pippalyadi Agada as an adjunct to standard drug therapy in managing acute food poisoning. Following a comprehensive drug analysis, a total of 60 eligible participants will be selected and assigned to two groups, each comprising 30 individuals. Group A will receive standard drug therapy, while Group B will receive standard drug therapy alongside Pippalyadi Agad, administered twice daily for 7 days. Assessments will occur on days 0, 3, 5, and 8, both before and after the intervention. The study anticipates that the use of Pippalyadi Agada as an adjunct to standard drug therapy will lead to improved symptom relief and faster recovery in individuals with acute food poisoning, as demonstrated by significant reductions in symptoms such as nausea, vomiting, fever, and diarrhea. The observed outcomes will contribute to a more comprehensive understanding of the potential benefits of Ayurvedic interventions in managing foodborne illnesses.

Comparative evaluation of efficacy of infrared radiation to routine care on episiotomy wound healing among postnatal women

Comparative evaluation of efficacy of infrared radiation to routine care on episiotomy wound healing among postnatal women

Comparative evaluation of efficacy of a smartphone application for oral submucous fibrosis (OSMF) self-examination in follow-up of the patients compared to routine Outpatient Department-based follow-up: a clinical interventional study

Background: Sushruta (600 B.C.) described a condition called "Vidari" linked with progressive narrowing of mouth, depigmentation of the oral mucosa, and pain on taking food, oral submucous fibrosis (OSMF). In 1952, Schwartz called this illness, which affected five Indian women existing in Kenya, "atrophica idiopathica mucosae oris." Pindborg and Sirsat coined the term "oral submucous fibrosis" in 1966, which is still in use today. With an overall Indian prevalence rate of between 0.2–0.5%, OSMF is primarily found in India and Southeast Asia, according to global estimations. Patients with OSMF need regular follow-ups and to maintain this follow-up it is not always possible for the patient to visit a dental clinic. Hence developing a smartphone-based application for the follow-up of OSMF will be of great value to the patients. The study aims to evaluate the effectiveness of a smartphone application on OSMF self-examination in the follow-up of patients. Methods: There will be three phases of the research. The first phase will be the development of a smartphone-based application for the follow-up of patients with OSMF. The second phase will be distribution and training the patients regarding the usage of the application and the third phase will be evaluating the effectiveness of the smartphone application in maintaining the follow-up of the patients. Expected results: The follow-up of patients with OSMF is expected to be better and feasible using a smartphone application as compared to regular Outpatient Department-based follow-up. Conclusions: Designing a mobile application for the ease of users presents difficulties since it must take accessibility into account, which influences how well the application is received by users. The goal of OSMF examination awareness facilitation and intervention is to raise public knowledge. Educational activities significantly contribute to the advancement of information, convictions, and OSMF screening practice. CTRI registration: CTRI/2023/06/054514 (registration pending)

Evaluation of Comparative Efficacy of Levothyroxine versus Kshar Basti and Kanchanar Guggul in the Treatment of Hypothyroidism: A Study Protocol for Randomized Control Trial (Preprint)

Evaluation of Comparative Efficacy of Levothyroxine versus Kshar Basti and Kanchanar Guggul in the Treatment of Hypothyroidism: A Study Protocol for Randomized Control Trial (Preprint)

A Comparative Evaluation of Efficacy of Root Surface Biomodification using MTAD, MTAD+I-PRF on Adhesion of Fibrin Clot to Dentin Sem Study.

Root biomodifiers help in removing the smear layer following mechanical debridement. In this context, we evaluated and compared the in vitro efficacy of MTAD, MTAD+I-PRF, and phosphate-buffered saline-conditioned dentin surfaces by examining the distribution of the fibrin network using scanning electron microscopy. It was concluded that MTAD can serve as a potentially useful root conditioner/biomodifier. Further, the adjunct of MTAD+I-P resulted in more fibrin network linkage on the dentinal surface when compared to MTAD alone which can be of great utility in Advanced Regenerative Therapy.

Evaluation of comparative efficacy of Tinospora cardifolia and Ricinus communis via nasal administration in the management of cervical spondylosis: a randomized controlled trial protocol

Background- Cervical spondylosis is a disease that is caused by the vitiation of only one bodily humor (dosha) (Vataja nanatmaja). The vata bodily humor (dosa) becomes vitiated and settles in the cervical (manya), creating neck pain and stiffness, which ultimately led to cervical spondylosis. Cervical spondylosis can be examined primarily under the generalization of cervical spondylosis because both conditions have many of the same symptoms. A disorder known as cervical spondylosis, which affects the cervical vertebra, is a degenerative condition of the cervical spine. In addition to having negative effects on a person's health, the disease also significantly lowers the quality of life and daily activities. Ayurveda suggested a treatment for cervical spondylosis to avoid and control the condition. There are numerous therapies in Ayurveda, and Oil administration through the nostrils has been given a significant role in upper clavicular disease (Uurdhvajatrugata roga). Oil administration through nostril therapy has been specifically recommended by Acharya Charka for the treatment of cervical spondylosis. The purpose of certain ayurvedic approaches in the management of cervical spondylosis. Methods: - 60 patients will be split into two groups for this investigation. A tinospora cardifolia and a group of drugs (Mashadi oil) will be given to the group through the nostrils for seven days at a dose of eight drops. The same will be used for the other 30 patients, i.e., group B with Ricinus Communis and a group of drugs (Erandadi oil) administered through the nostrils. Expected result: The result will be assessed on the baseline of objective parameters, and data will be compared after the treatment.

Comparative evaluation of efficacy of 2% lidocaine containing adrenaline with and without hyaluronidase in inferior alveolar nerve blocks for patients requiring bilateral mandibular extractions

AbstractPurposeTo evaluate and compare the efficacy of 2% lidocaine containing adrenaline with and without hyaluronidase in inferior alveolar nerve blocks for patients requiring bilateral mandibular extractions.Patients and MethodsThis was the split‐mouth study conducted on 26 patients requiring bilateral mandibular teeth extraction. All the patients were assigned randomly to one of the two groups: (i) 2% lignocaine HCl + 1:2,00,000 adrenaline + hyaluronidase (75 IU) solution will be administered on one side which is the experimental side and (ii) 2% lignocaine HCl + 1:2,00,000 adrenaline solution on the other side is control side. In the first session, the patients randomly received the inferior alveolar nerve block with or without hyaluronidase in one side of the oral cavity. One week later, the same patient received the other technique which was not received in the first session. We also evaluated the onset, duration and need of any supplementary anaesthesia in both the groups.ResultsComparison of VAS score in the control group (2.73 ± 0.724) and experimental group (3 ± 0.693) showed statistically insignificant results (p = 0.177). Whereas the onset of local anaesthesia showed a statistically significant difference between the two groups (p < 0.001) mean of control group (2.73 ± 0.47) and experimental group (1.15 ± 0.23). Comparison of duration of anaesthesia showed a statistically significant difference (p < 0.001) with the mean duration of the experimental group being higher (106 ± 7.94) than the control group (86.27 ± 3.90). Comparison for the need for supplementary anaesthesia showed no statistically significant difference between the two groups.ConclusionWe conclude that if hyaluronidase is used, better blocks with smaller volumes are produced. LAs with hyaluronidase have been shown to improve the quality and effectiveness of anaesthetic blocks and shorten the time it takes for anaesthesia to begin, accelerate the onset of akinesia and lessen the need for additional anaesthesia. It also increases the duration of anaesthesia.

Comparative evaluation of efficacy of Trayodashang Guggul versus Rasona Pinda as an adjuvant with Katibasti in the management of Grudhrasi (Sciatica): A randomized controlled trial

Background In ayurveda, sciatica can be correlated to ‘Grudhrasi’ under Vata Nanatmaja-Vyadhi (neurological disorders caused by Vata, one of the bodily humour). In this mainly bodily humours vata and kapha are vitiating producing symptoms like piercing pain, stiffness, twitching, numbness and pain radiating from lumbosacral region to lower limb up to the foot. Therapeutic plan includes stabilizing and bringing back the vitiated vata and kapha humours to equilibrium. The prevalence of sciatica varies considerably ranging from 3.8% in the working population to 7.9% in the nonworking population. Aim Comparative evaluation of efficacy of Rasonapinda and Trayodashang guggul as an adjuvant to katibasti (oil pooling therapy) in the management of Grudhrasi (Sciatica). Objectives To assess the efficacy of Rasonapinda as an adjuvant to katibasti in subjective and objective parameters of Grudhrasi (Sciatica). To assess the efficacy of Trayodashang guggul as an adjuvant to katibasti in subjective and objective parameters of Grudhrasi (Sciatica). To compare the efficacy of Rasonapinda and Trayodashang guggul as an adjuvant to katibasti in subjective and objective parameters. Standardisation of Rasonapinda (modified formvati). Methods In this study, a total of 60 patients will be enrolled and divided equally into two groups. In group A, Trayodashang Guggul 500 mg twice a day after meal with warm water for 30 days adjuvant with katibasti for the initial 7 days will be given. In group B, Rasonapinda 500 mg twice a day after meal with warm water adjuvant with katibasti for the initial 7 days will be given for 30 days. Result The result will be assessed on baseline of subjective and objective parameters and data will be compared after treatment. Conclusions It will be based on observations and results obtained. Trial registration CTRI No. - CTRI/2022/12/048534 Dated – 27/12/2022.

A comparative evaluation of efficacy and safety of the combination of piroxicam with tramadol versus pentazocine in post-cesarean pain management

Background: Acute pain management enhances the overall quality of life for individuals having cesarean sections. Although it is a basic human right, pain treatment following a cesarean section lacks a gold standard. Multimodal analgesia is now recommended to aid recovery and mitigate the adverse effects of strong pain-relieving medications like opioids. Multimodal analgesic therapy, with the goal of obtaining synergistic or additive analgesia with fewer side effects, is by combining lesser amounts of each drug with different mechanisms of action. Aims and Objectives: The objective of the study was to compare the efficacy and safety of the combination of piroxicam with tramadol versus pentazocine in post-cesarean pain management. Materials and Methods: Following cesarean section after skin closure, cases were randomly assigned into two groups of thirty cases each. Group A was administered tramadol 100 mg+piroxicam 20 mg and Group B received pentazocine 30 mg+piroxicam 20 mg by intramuscular injection. Diclofenac 75 mg served as the rescue pain relief medication. The main focus was pain control, evaluated using the Visual Analog Scale (VAS). Secondary outcomes included sedation levels and the duration until additional pain relief was required. The safety profile of the medications was assessed by monitoring adverse drug reactions. Statistical analysis involved methods such as student’s t-test, analysis of variance, and post hoc testing. Results: Both the groups were comparable and statistically significant in VAS, time to rescue analgesia, and mean sedation score. Conclusion: The combination of piroxicam with tramadol versus pentazocine is effective and considered as an acceptable method of pain relief after cesarean delivery.

Comparative evaluation of efficacy of diclofenac and ketoprofen administered using transdermal drug delivery route in management of post endodontic pain: A randomized controlled clinical trial.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used as a postoperative medication after endodontic treatment. The introduction of transdermal patches aided in reducing the discomfort caused by medication prescribed through the oral route. This study aims to compare the efficacy of transdermal patches of diclofenac and ketoprofen for postendodontic pain control. Thirty patients with symptomatic irreversible pulpitis in singlerooted teeth of either arch were endodontically treated by a single endodontist. Oral diclofenac for Group I and transdermal diclofenac patch for Group II and transdermal ketoprofen patch for Group III were administered as postendodontic analgesics. Visual Analog Scale chart was used to record pain intensity preoperatively and at intervals of 4, 8, and 24 h postoperatively. Paracetamol 500 mg tablets were provided as rescue medication. Repeated Measure ANOVA. There was a significant decrease in the postoperative pain intensity scores for both transdermal groups. The postoperative scores gradually decreased from day 1 to day 2. Six out of ten patients who had received diclofenac tablets complained of gastric discomfort. Both transdermal ketoprofen and diclofenac patches were effective than oral diclofenac tablet and can be used as an alternative and effective analgesic for postendodontic pain management, especially in patients with gastric discomfort.

Comparative Evaluation of Efficacy of Chlorhexidine with Centella asiatica in the Management of Stage 2 Grade B Periodontitis in Type 2 Diabetes Mellitus Patients − A Randomised Controlled Clinical Trial

Introduction: Chemical plaque control agents are used as an adjunct to non-surgical periodontal therapy. Adjunctives can assist in proper oral hygiene maintenance. Type 2 diabetes mellitus is a metabolic disease that can reflect in the periodontium. Periodontal disease prevention and management in Type 2 diabetes patients need routine dental care. Over counter mouthwashes used by patients can result in side effects; this has popularised the use of herbal mouthrinses that have minimal side effects. Aim: The present study aimed at evaluating the efficacy of chlorhexidine (CHX) with Centella asiatica in the management of Stage 2 Grade B periodontitis in type 2 diabetes mellitus patients. Materials and method: Seventy Type 2 diabetes mellitus patients with periodontitis were recruited for this study. In Group A, 35 subjects received scaling and root planing (SRP) and 10% C. asiatica mouthwash. In Group B, 35 subjects received SRP and 0.2% CHX mouthwash (Colgate-plax, Colgate-Palmolive). Clinical periodontal outcomes measured were plaque index (PI), gingival index (GI), bleeding on probing (BOP) and probing depth (PD) at baseline, 1 month and 3 months post therapy. Salivary total antioxidant capacity (TAOC) and Interleukin 1β levels were also measured at baseline and 3 months. Results: Clinical parameters PI, GI, BOP and PD were reduced significantly in groups A and B, post-treatment, 3-month follow-up. However, the intergroup comparison didnot show any significant difference. Salivary TAOC levels were significantly increased in both groups after 3 months therapy. The intergroup comparison of salivary TAOC levels between groups didnot show any significant difference. Salivary interleukin 1β levels were significantly reduced in both groups post-treatment. Conclusion: This study suggests the anti-inflammatory and antioxidant potential of C. asiatica mouthwash and a safe alternative to CHX mouthwash as an adjunct in the management of Stage 2 Grade B periodontitis in type 2 diabetes mellitus patients.

Comparative evaluation of efficacy of topical amlexanox 5% oral paste and triamcinolone acetonide 0.1% oromucosal paste in the treatment of oral lichen planus: A randomized control trial

Comparative evaluation of efficacy of topical amlexanox 5% oral paste and triamcinolone acetonide 0.1% oromucosal paste in the treatment of oral lichen planus: A randomized control trial

A Short-term Comparative Evaluation of Efficacy of Hydroalcoholic Herbal Phytonutrient Mouthrinse as an Adjunct with Scaling & Root Planning in Old Age Home Inmates with Chronic Periodontitis: a Randomized Control Clinical Trial

AIM: The aim of this study is to compare & evaluate clinical efficacy of a herbal phytonutrients mouthrinse with Hedychium coronarium, Echinacea, Calendula-officinalis and Ocimum sanctum extracts in patients with gingivitis & chronic periodontitis in adjunct with scaling & root planning. MATERIAL & METHODS: 30 subjects diagnosed with chronic periodontitis based on periodontal examination and microbiological evaluation, were selected from an Old Age Home. The study population was randomly divided into 3 groups of 10 subjects each: Group I - Phytonutrient herbal mouthrinse, Group II - 0.2% chlorhexidine gluconate and Group III – Distilled water. RESULTS: ANOVA test showed significant difference in the mean values of FMPI, FMBI and PPD variables– PHT: (FMBI-P value- .005); (FMPI- P value- .002); (PPD- P value- <0.001), CHX: (FMBI-P value- .003); (FMPI- P value- .441); (PPD- P value- 0.049), DW: (FMBI-P value- .089); (FMPI- P value-.081); (PPD- P value- 0.104). There was statistically significant difference in the efficacy of PHT when compared with CHX and DW mouthrinse on plaque accumulation, gingival health and oral hygiene status. CONCLUSION: Herbal phytonutrient rich-mouthrinse can prove to be effective alternatives to CHX with minimal side effects.

Evaluation of comparative efficacy of Celastrus paniculatus (Jyotishmati) capsule versus sertraline capsule in the management of Chittodvega (generalized anxiety disorder): protocol for a randomized controlled trial

Background Generalized anxiety disorder (GAD) (Chittodvega) is one among many types of mental disorders explained in Ayurveda. It can be defined as a Chitta (mind) + Udvega (anxiety)= Chittodvega- Anxious status of a mind. Celastrus paniculatus is one of the most important medicinal plants of the Celatraceae family commonly known as Jyotishmati. It stimulates and improves the digestive fire and metabolism at a cellular level (Jatharagni and Majja dhatwagni). It can be correlated to GAD. GAD is characterized by feelings of threat, restlessness, irritability, sleep disturbance, and tension, and symptoms such as palpitations, dry mouth, and sweating. It affects women more frequently than men and prevalence rates are high in midlife (prevalence in females over age 35: 10%) and older subjects. In modern medicine the first-line psychological and pharmaceutical treatments are selective serotonin reuptake inhibitors (SSRIs) like sertraline (SNRIs). Aim and objectives To evaluate the comparative efficacy of Jyotishmati versus sertraline in the management of Chittodvega. Methods In this randomized clinical equivalence trial a total of 70 patients will be enrolled and divided into two equal groups. Patients between 20–50 years age of either gender having symptoms of Chittodvega and a Hamilton anxiety rating (HAM-A) scale score less than 24 (i.e., mild to moderate) will be selected for the study. In Group A, sertraline capsules 25 mg for first 7 days and then dose increased to 50 mg at bedtime for next 53 days and in Group B Jyotishmati Capsules 500 mg will be given twice a day after food with water for 60 days. Result and observation The patients will be assessed on the HAM-A scale, serum cortisol and WHO Quality of Life on day 0, 30, 60 and 90 and data collected will be analysed by using statistical tests. Trial registration CTRI No. REF/2023/07/069880 Date – 15/09/2023

Comparative Evaluation of Efficacy of Platelet Rich Plasma (PRP) and Platelet Rich Fibrin (PRF) in Bone Regeneration after Surgical Removal of Impacted Bilateral Mandibular Third Molars - A Comparative Study.

Aims and Objectives: To compare the efficacy of platelet rich plasma (PRP) and platelet rich fibrin (PRF) in bone regeneration after removal of impacted bilateral third molars. Materials and Methods: The study was carried out as an open clinical trial on 20 patients chosen from the ones referred to the department of Oral & Maxillofacial Surgery for surgical removal of bilateral mandibular third molar. Patients were prepared for surgical procedure, Inferior alveolar nerve block given using 2% lignocaine hydrochloride with 1:2,00,000 adrenaline. Third molar were removed by flap reflection and bone drilling. Finally, PRF in lower left mandibular third molar region and PRP in lower right mandibular third molar region was inserted and wound closure was done. Cone bean computer tomography (CBCT) was made on 1st postoperative day and 4 months after surgery to evaluate alveolar bone height and density. Result: Alveolar bone height and bone density at post-operative 1st day and 4 months were compared between PRP and PRF group. The bone density and bone volume were analyzed, and there was no significant difference between bone density in PRP and PRF at day 1 and 4th month. Conclusion: As per our study and evaluation, in our postoperative follow up there was no statistically significant differences in bone regeneration by placement of PRP and PRF in extracted socket of third molar. Thus, with this study we can conclude that PRF, would be a good option to Oral and Maxillofacial Surgeons in the near future due to ease of extraction.

Evaluation of comparative efficacy of cow milk treated Sida Cordifolia oil nasal administration (Ksheerbala Taila Nasya) versus Convolvulus pluricaulis oil nasal administration (Shankapushpi Taila Nasya) in the management of primary insomnia (Anidra)- a trial protocol

Background: Ayurveda, formerly known as the "Science of Life," is a distinct science and philosophy that aims to achieve comprehensive wellbeing by balancing the psychological, emotional, spiritual, and physical facets of life. The three basic principles listed by Ayurveda to maintain good health are Food (Ahara), sleep (Nindra), and Celibacy (Bramhacharya). According to Ayurveda, it is a strong rigid support of life. Many people today depend on sleeping pills and have developed a dependence on them. Potentially harmful side effects of sleeping drugs include drowsiness during the day, constipation, dizziness, and problems maintaining equilibrium. It is said that a vitiated Vata Dosha sets off the effects of insomnia, hence balancing Vata Dosha can provide relief in the event of Insomnia. Convolvulus Pluricaulis (Shankhpushpi) herb is a memory enhancer that can also be used as a brain tonic to stimulate brain and brain function. According to Ayurveda, the entrance to the brain is through the nose. Nasal administration refers to the practice of administering medication nasally. It is the most important therapy to treat upper clavicular disease. Objective: To study the evaluation of comparative efficacy of cow milk treated sida cordifolia oil nasal administration (Ksheerbala Taila Nasya) versus Convolvulus Pluricaulis Oil Nasal Administration (Shankapushpi Taila Nasya) in the Management of Primary Insomnia (Anidra)-RCT Protocol: In this study, a total of 128 patients will be divided into two groups. In group, A (64 patient) cow milk treated with Sida Cordifoila Oil Nasal Administration will be administered eight drops in each nostril for 15 days. The same will be used for the other 64 patients i.e., group B with Convolvulus Pluricaulis Oil Nasal Administration. Expected result: The result will be assessed on the objective parameter and data will be compared after the treatment.