Comparative Analysis Of Clinical Efficacy Research Articles

Comparative analysis of clinical efficacy of stereotactic robot-guided puncture hematoma drainage and conventional puncture hematoma drainage in the treatment of intracerebral hemorrhage.

To compare and analyze the clinical effectiveness of conventional puncture hematoma drainage and stereotactic robot-guided puncture hematoma drainage in managing intracerebral hemorrhage. This is clinical comparative research. One hundred and twenty patients with the intracerebral hemorrhage who underwent puncture hematoma drainage in Baoding No.1 Central Hospital from March 2020 to May 2023 were included and were assigned into the control groups(n=60) and experimental groups(n=60) according to different treatment methods. The experimental group underwent stereotactic robot-guided puncture hematoma drainage, while the control group underwent conventional puncture hematoma drainage treatment. The duration and situation of surgery, levels of inflammatory factors, as well as preoperative and 1-week postoperative GCS scores and NIHSS scores were compared and analyzed between the two groups. In comparison with the control group, the experimental group exhibited considerably less surgical duration(p=0.00), higher amount of intraoperative blood drainage and hematoma clearance rate(p=0.00). The experimental group possessed a substantially more reduced incidence of complications(10%) in comparison with the control group(25%), with a statistically substantial distinction(p=0.03). After therapy, CRP, TNF-a, and IL-6 degrees were considerably more decreased (p=0.00) in the experimental group in comparison with the control group, while GCS grades were considerably more prominent and NIHSS grades were considerably more reduced (p=0.00). Stereotactic robot-guided puncture hematoma drainage is a dependable and safe operative method to treat patients who had intracerebral hemorrhage, resulting in various benefits such as short length of operation, less injury, less inflammatory reaction, high hematoma clear efficiency and satisfactory recovery of neurological function.

Comparative evaluation of the clinical performance of conventional and extended depth of focus monofocal intraocular lenses (systematic review)

A systematic review was performed in PubMed using the following keywords monofocal IOLs, monofocal IOLs with extended depth of focus (sharpness), EDOF, cataract phacoemulsification, visual acuity, and quality of life. Studies were selected in accordance with the criteria for prospective or retrospective studies. In a comparative analysis of clinical efficacy, the results of binocular IOL implantation and lens material from the same manufacturer were analyzed as the main sources. In total, 234 studies were analyzed using systematic review filters and authors knowledge of the topic. The duration of the retrospective analysis was 8 years (20172023). A total of 234 papers were analyzed over the last 8 years (20172023), further using systematic review filters and the authors knowledge of the topic.
 Data obtained indicated that traditional monofocal IOLs acted like bifocal lenses because they formed two main focal points for far and near vision, which did not provide the required level of visual acuity at an intermediate distance. The basic optical principle of EDOF (extended depth of focus) was to create a focal point for distance vision and an elongated focal point to increase the depth of field near and at intermediate distances. The results of the literature analysis indicated that the use of EDOF (compared with monofocal IOL) was associated with a higher level of visual acuity at intermediate and near distances and comparable distance visual acuity and increased depth of field, which generally provides a more natural range of vision and less use of glasses. Light phenomena, spectacle independence, and patient satisfaction were comparable among EDOF types.
 Given the above advantages, EDOF implantation can be considered a variant of an individual approach to the selection of IOLs, taking into account the possibility of using it in patients whose professional activity is associated with long-term visual work at intermediate distances (e.g., users of personal computers). In the context of the role and place of EDOF in the general system of aphakia correction following cataract phacoemulsification, further accumulation of clinical material is necessary, taking into account the IOL model and patients professional visual activity level.

Comparative analysis of clinical efficacy and safety of omalizumab biosimilar in the treatment of patients with chronic spontaneous urticaria

BACKGROUND: Importance of optimizing strategy for treatment of chronic spontaneous urticaria is highly becoming relevance for the clinicians. Nowadays monoclonal antibodies are preferred option of treatment the refractory chronic spontaneous urticaria, main of that is omalizumab.
 AIM: to establish comparative analysis of the efficacy and safety of Genolair (JSC Generium, Russia) and Xolair (Novartis Pharma AG, Switzerland) in the treatment of patients with chronic spontaneous urticaria.
 MATERIALS AND METHODS: A 36-week, open parallel-group study was conducted. Were included 43 adult patients with chronic spontaneous urticaria who were resistant to ongoing therapy with standard and escalated doses of second-generation H1-antihistamines. All patients were divided into 2 groups: the main group (MG; n=18) ― patients who administrated Genolair; the comparison group (CG; n=25) ― patients who firstly administrated Xolair and then switching therapy to Genolair. Throughout the study period, patients completed questionnaires on the assessment of disease activity (UAS 7), urticaria control (UCT), quality of life index (DLQI). Additionally, the level of total IgE in blood serum was assessed. For statistical data processing, EXCEL 2010 and STATISTICA 7.0 software packages were used.
 RESULTS: After 4 weeks from the start of monoclonal antibody therapy, patients in both groups were responders to omalizumab. At the same time, there were no significant differences when comparing scores on the UAS 7, UCT scale between patients of the MG and the CG during the entire observation period (p 0.05). The change in treatment paradigm in CG also did not have a statistically significant effect on the indicators of urticaria activity and disease control (p 0.05). At the same time, the quality of everyday life changed more positively in the MG, which was reflected in a more pronounced change in the DLQI index at the time of the control assessment since 20 weeks of therapy (p=0.032). An increase in the level of total IgE in the blood serum of all patients with chronic spontaneous urticaria after the initiation of a course of immunobiological therapy was demonstrated, while there were no statistically significant intergroup differences in relation to changes in this laboratory parameter (p 0.05).
 CONCLUSION: During the treatment of patients with severe chronic spontaneous urticaria, resistant to ongoing therapy with standard and escalated doses of second-generation H1-antihistamines, comparable clinical efficacy and safety of the study drug Genolair and the reference drug Xolair were shown.

Comparative analysis of clinical efficacy between laparoscopic and open pancreaticoduodenectomy.

Laparoscopic pancreaticoduodenectomy (LPD) is a technically demanding procedure but is gradually gaining acceptance in clinical practice. This study was performed to compare the short-term outcomes of LPD with open pancreaticoduodenectomy (OPD). The perioperative data of the patients who underwent LPD (n = 25) and OPD (n = 40) from January 1, 2017 to December 31, 2021 at Zhangjiagang Hospital Affiliated to Soochow University were collected and retrospectively analyzed. All patients received R0 resection, and none of the patients died within the perioperative period. The preoperative data (gender, age, body mass index [BMI], and preoperative bilirubin), the intraoperative data (operative time, number of retrieved lymph nodes), and postoperative data (level 1 monitoring time, postoperative fluid diet time, postoperative fluid feeding time, and hospitalization cost) were comparable between the 2 groups (P > .05). The estimated blood loss, abdominal drainage tube removal time, postoperative hospital stay, catheter removal time, and analgesic drug use were significantly lesser in the LPD group, when compared to the OPD group (P < .05). LPD is safe and feasible. Compared to OPD, LPD has less surgical trauma, less intraoperative bleeding, and faster postoperative recovery.

Posterior Hybrid Technique for the Treatment of Traumatic Cervical Spinal Cord Injury with High Signal Intensity on T2WI.

To evaluate the efficacy of the posterior hybrid technique (PHT) for the treatment of traumatic cervical spinal cord injury without vertebral fracture or dislocation with high signal intensity on T2WI (CSCIH). A comparative analysis of clinical efficacy between CSCIH patients who underwent anterior decompression and fusion (ADF) surgery and those who underwent PHT surgery was retrospectively conducted. Demographic characteristics, cervical range of motion (CRM), cross-sectional area of spinal cord (CSASC), spinal canal area residual rate (SCARR), high signal intensity ratio (HSIR), Cervical Japanese Orthopedic Association (CJOA) score, and neck disability index (NDI) were assessed. Forty-three CSCIH cases with PHT and 46 CSCIH cases with ADF were collected from January 2013 to January 2017. The CRM in patients with PHT was superior to that in patients with ADF at the final follow-up (64.21 ± 18.46° vs. 48.71 ± 19.34°, p = 0.0002). The SCARR also showed greater improvements in the PHT group than in the ADF group (final follow-up: 93.54 ± 11.09% vs. 88.13 ± 10.84%, p = 0.022). Both groups indicated significant improvements in the CSASC and HSIR (p < 0.05); however, no significant differences were observed between the two groups. All patients showed improvements in the CJOA score and the NDI after surgery (p < 0.05). At the 6-month follow-up, the ADF group had better NDI scores than the PHT group (31.17 ± 10.42 vs. 36.78 ± 9.65, p = 0.010), whereas the PHT group exhibited better improvements than the ADF group at the final follow-up (66.86 ± 9.28% vs. 57.67 ± 10.22%, p < 0.0001). The PHT was as effective as ADF in the treatment of CSCIH, whereas the PHT was superior in the improvement of patients' health-related quality of life and in CRM preservation during the long-term follow-up.

Comparative analysis of clinical efficacy between posterior percutaneous endoscopic discectomy and anterior cervical discectomy and fusion in the treatment of cervical spondylotic radiculopathy

To explore the clinical efficacy of posterior percutaneous endoscopic discectomy(PPECD) in the treatment of cervical spondylotic radiculopathy. A total of 56 patiens with single segment cervical spondylotic radiculopathy from December 2017 to October 2020, were randomly divided into observation group and control group. In observation group, there were 16 males and 11 females, including 8 cases of C4,5, 13 cases of C5,6 and 6 cases of C6,7 performed posterior percutaneous endoscopic discectomy, aged from 34 to 61 years old with an average of (51.15±6.29) years old. In control group, there were 19 males and 10 females with single segment cervical spondylotic radiculopathy including 10 cases of C4,5, 14 cases of C5,6 and 5 cases of C6,7 performed anterior cervical discectomy and fusion, aged from 40 to 65 years old with an average of (53.24±5.31) years old. The operative time, intraoperative blood loss, postoperative time of lying in bed and length of postoperative hospital stay were recorded. Visual analogue scale(VAS) and neck disability index(NDI) were used to evaluate the clinical efficacy. Cervical plain films or MRIs, CTs were taken for re-visiting patients. All patients were followed up more than 2 years. The observation group patients were followed up, the duration ranged from 24 to 42 months with an average of (30.48±4.91) months. The control group patients were followed up, the duration ranged from 25 to 47 months, with an average of (32.76±4.53) months. Compared with control group, operative time, intraoperative blood loss, postoperative time of lying in bed and length of postoperative hospital stay were decreased(P<0.05). Compared with pre-operation, VAS of neck and upper limb and NDI at the latest follow-up between two groups were significantly improved(P<0.05). Compared with control group, VAS of neck and upper limb at 1 day after operation in observation group were significantly reduced(P<0.05). There was no significant difference in VAS of neck and upper limb and NID at 1, 3 months and the latest follow-up after operation between two groups(P>0.05). In the observation group, one patient's deltoid muscle strength was weakened to grade 4 after operation, and returned to normal after 12 weeks of conservative treatment. In control group, there was 1 case of postoperative adjacent spondylosis with symptoms of spinal compression after 2 years operation, then underwent cervical artificial intervertebral disc replacement. And there was 1 case of dysphagia after operation in control group and improved after 1 year. There was no significant difference in incidence of complications between two groups. PPECD has advantages of shortening operative time, decreasing intraoperative blood loss, reducing postoperative time of lying in bed and length of postoperative hospital stay. However, applicable age range of patients and long-term clinical efficacy needs further study.

EVALUATION OF THE EMPIRICAL APPROACH IN THE SELECTION OF PATHOGENETIC AGENTS IN THE TREATMENT OF PULMONARY TUBERCULOSIS (by the example of the drugs Glutoxime and Tubosan)

Clinical, radiological, and laboratory data of 62 patients with respiratory tuberculosis were studied with the purpose of comparative analysis of clinical efficacy of Glutoxime and Tubosan and evaluation of efficiency of the empirical approach in drug selection. Three groups of patients were formed: the 1st group - 20 patients who received Glutoxim along with anti-tuberculosis drugs. Group 2 - 23 patients (Tubosan), Group 3 – control, 19 patients (only anti-tuberculosis drugs). Empirical approach to the choice of pathogenetic drugs has a limited positive effect on the efficacy and tolerability of etiotropic therapy. In the conditions of forced polypragmasy, the prescription of drugs should be justified by modern highly informative criteria, not being limited only by clinical indications.

Comparative Analysis of Clinical Efficacy of Negative Pressure Wound Therapy Plus Lavage System in the Treatment of Wagner Grade 3-5 Diabetic Foot Ulcers Combined with Infection

To compare and analyze the clinical efficacy of negative pressure wound therapy (NPWT) combined with lavage system in the treatment of Wagner grade 3-5 diabetic foot ulcers combined with infections. The clinical data of 100 patients with Wagner grade 3-5 diabetic foot ulcers combined with infections admitted to our department between January 2016 and January 2020 were retrospectively analyzed. According to the methods of surgical wound management, they were divided into two groups, a combination treatment group treated by NPWT plus a lavage system and a single treatment group receiving NPWT only. Patients were studied for the types of bacterial infection found in the wounds, the amount of time it took for the wound bacterial culture to turn negative, and the status of blood inflammatory indicators, including white blood cell count and C-reactive protein (CRP). Data concerning hospitalization were collected, including the waiting time before the first operation, the number of operations, length of hospital stay, NPWT usage time, and wound closure time. In addition, data concerning patient condition after discharge were also collected, including the duration of out-of-hospital antibiotic use, the final wound healing rate, the final wound healing time, and long-term wound complications, which include wound dehiscence, new ulcer, infection recurrence, readmission, reoperation, and amputation. There were no statistically significant differences in age, sex, course of disease, lesion side, lesion size and combined diseases between the two groups. Likewise, there was no significant difference in the species and genus, or the composition of bacteria found in the wounds ( P>0.05). However, the combination treatment group showed better results than the single treatment group did in the amount of time it took for wound bacterial culture to turn negative ( P<0.05). As for the blood inflammatory indicators, there was no significant difference between the two groups except that the CRP of the combination group decreased more significantly than that of the single treatment group did at one week postop. The number of surgeries, length of hospital stay, NPWT use time, and wound closure time were lower in the combination treatment group than those in the single treatment group ( P<0.05). However, there was no significant difference in long-term wound complications between the two groups. When applying NPWT plus lavage system in the treatment of Wagner grade 3-5 diabetic foot ulcers combined with infection, wound infection can be controlled effectively at an early stage and the amount of time needed for wound bacterial culture to turn negative can also be reduced. In addition, the combination treatment stimulates granulation growth of the wounds to effectively cover the wound at an early stage.

Comparative Analysis of Clinical Efficacy between Laparoscopic Assisted Radical Gastrectomy and Open Surgery in the Treatment of Advanced Gastric Cancer

Comparative Analysis of Clinical Efficacy between Laparoscopic Assisted Radical Gastrectomy and Open Surgery in the Treatment of Advanced Gastric Cancer

Comparative analysis of clinical efficacy and safety of Plavix and aspirin in the treatment of coronary heart disease.

Comparative analysis of clinical efficacy and safety of Plavix and aspirin in the treatment of coronary heart disease.

45-Year-Old Woman With Fever and Malaise

45-Year-Old Woman With Fever and Malaise

Применение урапидила для коррекции артериальной гипертензии при хирургии катаракты

Purpose. Comparative analysis of clinical efficacy of urapidil and droperidol for relief of arterial hypertension (AH) during cataract surgery. Material and methods. The study included 30 patients who underwent relief of intraoperative hypertension with urapidil or droperidol in combination with sedation. According to method of treatment of hypertension, 3 groups of patients were distinguished: 1st group – 10 patients whom were injected only with urapidil, 2nd group – 10 patients whom were injected urapidil against the background of sedation; 3rd group – 10 patients whom received droperidol against the background of sedation. Results. We relieved intraoperative rise in blood pressure and avoided complications associated with it, in all 3 groups. Using of urapidil did not cause side effects from cardiovascular, respiratory and nervous systems. The dose of urapidil was reduced when used in conjunction with sedatives. Droperidol has been shown to be effective in patients with cognitive impairment with signs of arousal. Conclusion. The applied methods of relief of intraoperative AH were effective in all patients. Urapidil for correction of AH in outpatients is justified due to its effectiveness and safety. Droperidol for treatment of AH is preferable for patients with unstable psychoemotional status, agitation. Such patients should be monitored in hospital. Key words: urapidil, ebrantil, droperidol, intraoperative arterial hypertension, ophthalmosurgery.

Выбор оптимального анестетика и метода общей анестезии при лазерной хирургии ретинопатии недоношенных

Purpose. Comparative analysis of clinical efficacy and safety of inhalational general anesthesia (GA) with halothane and sevoflurane in premature infants with retinopathy of prematurity (ROP) during laser coagulation (LC) of the avascular retina. Material and methods. The clinical material included 284 children who underwent laser surgery of ROP in the period from 2008 to 2017 (method of continuous sampling). Introduction to anesthesia and maintenance of anesthesia was performed by inhalation of anesthetic (halothane or sevoflurane) with O2 using face mask and Mapleson breathing circuit. Two groups were formed: in the 1st group (167 people) halothane was used at anesthetic at oxygen concentration of 0.3 vol%, in the 2nd group (117 people) – sevoflurane at concentration of 1–1.5 vol%. Results. In case of GA with halothane in children of the 1st group, in 68 children (40.7%) developed negative reactions during anesthesia in the form of of respiratory depression, in several cases – up to pronounced bradypnea, bradycardia, prolonged awakening after surgery. In the 2nd group with GA with sevoflurane, negative reactions in the form of moderate bradycardia and bradypnea were observed only in 14 children (11.9%). All complications and reactions were promptly eliminated in all cases. Conclusion. Based on the obtained results, the optimal inhalation anesthetic for LC of retina in premature infants is sevoflurane in low concentrations (at the sedation level) using the Mapleson breathing circuit and face mask. With this method of anesthesia, the frequency of side effects of sevoflurane, negative reactions during anesthesia and the degree of their severity are extremely low. Key words: premature infants, retinopathy of premature, sevoflurane, general anesthesia, laser coagulation of the retina.

Эффективность комплексного лечения изолированных васкулитов диска зрительного нерва

Purpose. To study effectiveness combination of topical corticosteroid therapy and sulodexide in complex treatment of patients with isolated optic disk vasculitis (IODV). Material and methods. The study included 17 patients with IODV (middle age was 26.7±6.2 years on average). Depending on different of additions to topical corticosteroid therapy, the patients were divided into two groups: the main group (8 people), treatment regimen of which additionally included sulodexide during and after the end of inpatient treatment, and the control group (9 people), which at inpatient treatment sulodexide was not prescribed, and then picamilon was prescribed. The results of treatment were assessed according to the measured of best corrected visual acuity (BCVA), static perimetry with determination total number of scotomas (TNS) in the central visual field, and the central retinal thickness (CRT) was examined. Morphometric indicators of intact eyes were taken as variant of the norm. Based on the data of ophthalmoscopy and biomicroscopy, the total clinical index of inflammation (TCII) was calculated. All studies were performed upon admission of patients to inpatient treatment and after its completion, and then after 1, 3 and 6 months. Results. As result of study, an increased efficacy of pharmacotherapy in patients with IODV was established when sulodexide is included in the complex treatment. We noted: reduction times of disappearance of TCII by 1.6 times; increase of BCVA by 3 times after 6 months; disappearance of TNS in the central visual field is 2 times faster; restoration of CRT to normal values by 3 times faster. Conclusion. Comparative analysis of clinical efficacy of complex treatment of IODV, including topical corticosteroid therapy and sulodexide, allows us to recommend it for use in clinical practice. Key words: isolated optic disk vasculitis, corticosteroid therapy, sulodexide.

CLINICAL EFFICACY AND SAFETY OF OUTPATIENT TREATMENT OF PATIENTS WITH DEEP VEIN THROMBOSIS OF THE LOWER EXTREMITIES.

Summary. We studied the results of stationary and ambulatory surgical treatment of patients with deep vein thrombosis (DVT) of the lower extremities. A comparative analysis of clinical efficacy and safety of ambulatory and stationary modes of anticoagulant therapy of DVT. Based on this, marked indications for ambulatory surgical treatment of patients with DVT.

The comparative analysis of clinical efficacy of laparoscopic Roux-en-Y gastric bypass vs. laparoscopic sleeve gastrectomy in treatment of obesity combined with type 2 diabetes mellitus

Objective To comparatively analyze the feasibility, safety and clinical efficacy of laparoscopic Roux-en-Y gastric bypass (LRYGB) vs. laparoscopic sleeve gastrectomy (LSG) in treatment of obesity combined with type 2 diabetes mellitus (T2DM). Methods The retrospetive cross-sectional study was conducted. The clinical data of 48 patients who underwent surgical treatment in our hospital between January 2014 and June 2017 were collected. Twenty patients were given LRYGB and 28 patients LSG. All the patients were followed up for 1 year. The surgical and postoperative recovery situations, the effect of weight reduction and hypoglycemic effect were compared between the two groups. Results The operations were performed successfully on 48 patients, without conversion to open surgery. There were no postoperative complications (anastomotic leak, bleeding and stenosis, etc) and perioperative deaths. As compared with LRYGB group, operation time, time of postoperative gastrointestinal function recovery, time of out of bed and duration of hospital stay were significantly shortened, and volume of intraoperative blood loss was significantly reduced in LSG group (P 0.05 for all). The remission rate of T2DM at 12th month postoperatively was 90% in LRYGB group and 92.86% in LSG group, with an effective rate of 100.0%. Moreover, there was no statistically significant difference between the two groups (P>0.05). Conclusion Both LRYGB and LSG are safe and effective in the treatment of obesity combined with T2DM, with a good short-term outcome and similar clinical effect. The LSG can be considered as a priority operation for its simple procedure and quick postoperative recovery. Key words: Obesity; Type 2 diabetes mellitus; Roux-en-Y gastric bypass; Sleeve gastrectomy; Clinical efficacy; Laparoscope

Comparative analysis of clinical efficacy between stereotactic ablative radiotherapy and surgery for early-stage non-small cell lung cancer

Objective To compare the clinical efficacy and safety between stereotactic ablative radiotherapy (SABR) and surgery in the treatment of early-stage non-small cell lung cancer (NSCLC). Methods A total of 227 patients who were initially diagnosed with early-stage NSCLC and with complete clinical data admitted to Henan Cancer Hospital between June 2012 and December 2016 were recruited and assigned into the SABR (n=73) and surgery groups (n=154). Kaplan-Meier method was used to calculate survival rate and survival comparison was performed using the log-rank test. Chi-square test was adopted to compare the baseline data between two groups. Results All patients completed corresponding treatment. The samples of SABR group and operation group were 74 and 155 cases respectively. The 1-year and 3-year overall survival (OS) rates in the SABR and surgery groups were 97.2%, 81.9% and 96.5%, 78.2%(P=0.603), respectively. The 1-year and 3-year progression-free survival (PFS) rates in the SABR and surgery groups were 90.1%, 66.9% and 89.2%, 66.9%(P=0.565), respectively. The 1-year and 3-year locoregional recurrence-free survival rates in the SABR and surgery groups were 92.8%, 84.0% and 96.5%, 90.8%(P=0.133), respectively. The 1-year and 3-year distant metastasis-free survival rates in the SABR and surgery groups were 97.2%, 75.4% and 89.2%, 69.8%(P=0.095), respectively. Conclusions SABR and surgery yield similar OS, PFS, locoregional recurrence-free and distant metastasis-free survival rates in the treatment of early-stage NSCLC. Therefore, SABR is an alternative treatment for patients with early-stage NSCLC. Key words: Carcinoma, non-small cell lung/radiotherapy; Radiotherapy, stereotactic ablative; Prognosis

Literature Review: Biotin and Hair Loss: Valuable or Just “In Vogue”?

1. Jeff Donovan, MD, PhD, FISHRS (donovan.jeffrey{at}gmail.com) 1. Toronto, Ontario, Canada ![Figure][1]</img> Soleymani, T., et al. The infatuation with biotin supplementation: is there truth behind its rising popularity? A comparative analysis of clinical efficacy versus social popularity

Analysis of Results of Kyphotic Deformity Reduction Using Puncture Vertebroplasty and Stenoplasty in Patients with Traumatic Compression Fractures of Thoraco-Lumbar Localization

Correction of posttraumatic deformity and stabilization of injured segment play an important role in treatment and complication prevention after traumatic compression vertebral body fractures. Possibilities of deformity reduction using vertebroplasty and a combination of distractive titanium cage with insertion of bone cement into vertebral body (stenoplasty) are not well studied. Retrospective comparative analysis of clinical efficacy and degree of kyphotic deformity reduction using puncture vertebroplasty (1 st group, n=15) and stenoplasty (2 nd group, n=15) in patients with traumatic A1 compression fractures of thoraco-lumbar vertebral bodies was performed. Severity of pain syndrome (VAS) and degree of injured segment deformity (kyphotic angle and wedge-shaping index) were assessed. In both groups surgical intervention resulted in marked pain reduction but in long-term period it was less significant for 2 nd group (p=0.0035). Postoperatively kyphotic angle median and wedge-shaping index changed statistically significant in 2 nd group from 12.60 (10.50; 13.40) to 2.50 (1.90; 3.20) (p=0.0015) and from 25.3% (22.8; 26.7) to 9.3% (8.9; 11.4) (p=0.0022), respectively and not significantly in 1 st group from 13.10 (11.40; 14.30) to 12.90 (11.20; 14.00) (p= 0.93) and from 26.5% (24.0; 28.8) to 25.9% (23.8; 28.4) (p=0.86), respectively. Progression of posttraumatic kyphosis in late postoperative period was noted in 1 st group (P M Ü=0.042) but not in 2nd group (P =0.58). In traumatic A1 compression fractures stenoplasty enabled to perform kyphotic deformity correction in the early period of spinal injury, to achieve significantly greater reduction of kyphotic angle and to preserve the result in remote postoperative period as compared to puncture vertebroplasty

Comparative analysis of clinical efficacy and cost between University of Wisconsin solution and histidine-tryptophan-ketoglutarate

To compare University of Wisconsin solution (Viaspan), the universal standard for organ preservation, with histidine-tryptophan-ketoglutarate solution. An analysis of each solution, in reference to clinical trials with specific organs, is presented and assessed to find the efficacy of each in a clinical environment. Also to view each solution from an economical standpoint, and in the end develop an overall understanding of the key similarities and differences between each solution in order to assess appropriate use of each in a clinical setting. A literature search was conducted by using PubMed, MEDLINE, BIOSIS, Embase, and other online data bases to find the most recent studies of University of Wisconsin and histidine-tryptophan-ketoglutarate solutions. Search terms included University of Wisconsin solution, histidine-tryptophan-ketoglutarate, preservation solution, cost analysis, biliary complication, and other related subjects. Previous research was selected from the literature search to provide basic information on the 2 solutions and also to provide clinical examples of each solution and the efficacy of each with specific organs. Information and published articles on the 2 solutions were gathered for descriptive and comparative purposes. The 2 solutions appear equally effective in organ preservation. Each solution has its own organ-specific qualities, and each has different complications. The studies reviewed here indicate that the differences are minor and thus suggest that the 2 solutions are equally acceptable for clinical use. Of the 2 solutions, histidine-tryptophan-ketoglutarate costs less than University of Wisconsin solution.