In this paper we study the homology of the moduli spaces of instantons associated to principal SU(n) bundles over the four-sphere. This is accomplished by exploiting an loop structure implicit in the disjoint union of all moduli spaces associated to a fixed SU(n) with arbitrary instanton number and relating these spaces to the known homology structure of the four-fold loop space on BSU(n) . Moduli spaces of instantons (self-dual connections with respect to a conformal class of metrics) associated to principal G-bundles Pk(G) = P over S4 have proven to be basic objects in modern geometry. Here G is any simple compact Lie group and k is the integer that classifies the bundle P and is referred to as the instanton number. We denote these moduli spaces by At (G). There is a natural inclusion (0. 1) ik (G): Z, (G) Qk BG induced by forgetting the self-duality condition where we have identified the moduli space of based gauge equivalence classes of all connections on P with the kth component of the four-fold loop space Q?4BG [5]. In a fundamental paper, Atiyah and Jones [5] studied the inclusion (0.1) for G = SU(2) (when S4 has its standard conformally flat metric) and posed several fundamental questions. In a series of papers Taubes (cf. [24-26]) proved several basic existence theorems, stability theorems in terms of k and provided a basis framework to describe how the topology of Ak changes as k increases. Taubes' work is much more general than we describe here in that he not only studied general Lie groups G but also replaced 54 by an arbitrary compact closed Riemannian four-manifold (with arbitrary conformal class of metric). In [7] it was observed that, over the four-sphere but with G = Sp(n), the disjoint union of .k over all k form a homotopy C4 space and that iterated loop space techniques may be profitably used to study H. (xk) for individual k. Certain computational results may be obtained immediately from these Received by the editors October 17, 1989. 1980 Mathematics Subject Classification (1985 Revision). Primary 53C55, 58E05; Secondary 53C57, 55P35.