Abstract Lung cancer is by far the leading cause of cancer death in the US, accounting for about 1 in 5 of all cancer deaths. Each year, more people die of lung cancer than of colon, breast, and prostate cancers combined. The American Cancer Society estimates that in the US, in 2024, there will be about 234,580 new cases of lung cancer (116,310 in men and 118,270 in women). It estimates there will be around 125,070 deaths from lung cancer (65,790 in men and 59,280 in women). Though these deaths can mainly be attributed to smoking, environmental factors have also had adverse effects on human health and lung cancer. We see an example of this in Florida with agricultural burning, specifically sugarcane burning. Sugarcane is one of the most important cash crops for Florida, around 10% of sugar produced in the United States comes from Florida. However, despite the economic importance of this crop, its harvesting process is controversial creating air pollution that is having adverse health effects on the surrounding communities. This review will discuss the impact of sugarcane burning on African Americans and other low-income communities, and how it’s exacerbating health issues, specifically lung cancer. As well as suggest better alternatives to sugarcane harvesting. Citation Format: Miles Jordan, Steven Erwell, Ben Mwashote, Bereket Mochona. Lung cancer disparities among African Americans and other low-income communities in South Florida [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A098.