Community-dwelling Older Japanese Women Research Articles

One-Leg Standing Test with Eyes Open as a Screening Tool for Prefrailty in Community-Dwelling Older Japanese Women.

Background/Objectives: One-leg standing test with eyes open (OLST), a well-known balance assessment, is simple to implement and requires no special measuring equipment or space. Prefrailty has greater reversibility than frailty, and early detection of prefrailty is essential for frailty prevention in older adults, especially women. However, the association between the OLST and prefrailty remains unclear. Therefore, this study aimed to verify the relationship between the OLST and prefrailty and to validate the effectiveness of the OLST as a screening tool for prefrailty in older Japanese women. Methods: This study included 208 community-dwelling older women (mean age: 74.4 ± 5.1 years; range: 65-89) who underwent frailty assessments and OLST. Prefrailty was assessed using the Japanese version of the Cardiovascular Health Study (J-CHS) criteria. The association between prefrailty and OLST was assessed by binary logistic regression analysis, and receiver operating characteristic analyses were performed to examine the effectiveness of OLST as a screening tool for prefrailty. Results: OLST time was significantly associated with prefrailty, and those with higher OLST times were less likely to have prefrailty (ORs: 0.98; 95% CI: 0.97-0.99; p < 0.001). The area under the curve of the OLST for prefrailty was 0.713 (p < 0.001), and the optimal OLST cut-off time for discriminating prefrailty was 24 s (sensitivity: 0.56, specificity: 0.77). Conclusions: OLST could be used as a screening tool for prefrailty in older Japanese women. These findings may contribute to the early detection and prevention of frailty.

Fitness Benefits Of Nordic Walking In Community-dwelling Older Japanese Women

Fitness Benefits Of Nordic Walking In Community-dwelling Older Japanese Women

Association Between Low Kidney Function and Excess Weight Concerning Unfavourable Periodontal Health among Community-dwelling Older Japanese Women.

To investigate the association of low renal function and overweight with poor periodontal condition in community-dwelling older Japanese women. In total, 359 older women (age range: 55-74 years) participated in this study. Two periodontal parameters - the number of teeth with a probing pocket depth (PPD) or clinical attachment level (CAL) ≥ 4 mm - were used as the dependent variables. The principal independent variables were low renal function as defined by the estimated glomerular filtration rate (eGFR) and overweight as defined by the body mass index. Poisson regression analysis was used to calculate the ratio of means (RM). The RMs of the number of teeth with a PPD or CAL ≥ 4 mm in an adjusted model without an interaction term were 1.21- or 1.27-fold higher among those with an eGFR < 60, while those among the participants with an eGFR < 60 in the adjusted model with interaction terms for the number of teeth with a PPD or CAL ≥ 4 mm were 1.43- or 1.36-fold higher. In addition, increments of periodontal risk with low renal function and overweight showed a slightly smaller to negative trend. The present findings suggest a connection between unfavourable periodontal health and both renal function and being overweight among older Japanese women. A weak negative interaction was also found between poor renal condition and overweight in relation to periodontal condition.

Physical frailty predicts cognitive decline among community-dwelling older Japanese women: A prospective cohort study from the Otassha study

BackgroundPhysical frailty and cognitive decline are common issues in geriatrics within an aging society, yet the association between them remains controversial. This study aims to evaluate the association between physical frailty and cognitive decline among community-dwelling older Japanese women. MethodsA prospective cohort study was conducted in an urban area of Tokyo, Japan, involving community-dwelling older adults 65 years or older. Physical frailty was evaluated using the Japanese version of the Cardiovascular Health Study criteria, consisting of five components: shrinking, weakness, exhaustion, slowness, and low activity. Participants were classified as robust, pre-frail, or frail based on the presence of one or more criteria. Cognitive decline was defined as at least a three-point decrease in the Mini-Mental State Examination score from baseline. The association between physical frailty and cognitive decline was examined using binomial logistic regression, adjusting for potential confounders. The analysis yielded multivariable odds ratios (ORs) and 95 % confidence intervals (CIs), with robust participants using as the reference group. ResultsA total of 2,122 individuals participated in the baseline survey, with 805 included in the analysis (mean age: 72.9 ± 5.1 years). At baseline, 363 participants were classified as pre-frail, while 32 were classified as frail. During the two-year follow-up period, 68 participants experienced cognitive decline. The multivariable OR (95 % CI) for frailty, using robust as the reference, was 3.50 (1.13, 10.80). Furthermore, a linear relationship was observed between physical frailty and cognitive decline. ConclusionAmong older Japanese women, there exists a dose-response relationship between physical frailty status and cognitive decline.

Interaction Between Sarcopenic Obesity and Nonlocomotive Physical Activity on the Risk of Depressive Symptoms in Community-Dwelling Older Adult Japanese Women.

This study aimed to investigate the interaction between sarcopenic obesity and locomotive and nonlocomotive physical activity (PA) on the risk of depressive symptoms in community-dwelling older Japanese women. Participants were 143 community-dwelling older women aged 64-94years. PA was measured using a three-axis accelerometer. Participants were classified according to two levels of total, locomotive, and nonlocomotive PA. Depressive symptoms were assessed by a self-administered survey consisting of the 15-item Japanese version of the Geriatric Depression Scale (GDS-15-J). The interaction between sarcopenic obesity groups and total or locomotive PA did not affect GDS-15-J scores. However, the interaction between sarcopenic obesity groups and nonlocomotive PA significantly affected GDS-15-J scores (p < .05). Moreover, sarcopenic obesity in the low PA group had significantly higher GDS-15-J scores compared with sarcopenic obesity in the high PA group (p < .05). We concluded that sarcopenic obesity combined with low nonlocomotive PA may exacerbate depressive symptoms in older women.

Chronic Intake of a Meal Including Alaska Pollack Protein Increases Skeletal Muscle Mass and Strength in Healthy Older Women: A Double-Blind Randomized Controlled Trial

In animal studies, a meal containing Alaska pollack protein (APP) induces fast-twitch muscle hypertrophy. To our knowledge, no interventional studies have examined the benefits of APP intake on muscle mass and muscle weakness and the prevention of sarcopenia in older individuals. We evaluated the effects of APP intake on skeletal muscle mass, muscle strength, and physical performance among healthy community-dwelling older Japanese women. In this double-blind randomized controlled trial, healthy women ≥ 65 y old were allocated to an APP or whey protein control (CON) group. Participants ingested test protein meals (5.0-5.1 g protein/serving) daily for 24 wk. Between-group differences in the change of skeletal muscle mass index (SMI) as the primary outcome and muscle strength as a secondary outcome were tested using multifrequency BIA and a handheld dynamometer, respectively, at baseline, and 4, 12, and 24 wk. The mean changes in the measured primary and secondary outcome variables from baseline to 4, 12, and 24 wk were compared using unpaired t tests. There were no between-group differences in nutritional status, food intake, or total energy and protein intakes at baseline, 12 wk, or 24 wk. The change in SMI was 0.12 kg/m2 (95% CI: 0.01, 0.23 kg/m2) and 0.11 kg/m2 (95% CI: 0.03, 0.19 kg/m2) greater in the APP group than in the CON group at 12 wk and 24 wk (P ≤ 0.03) and knee extension strength was 0.07 Nm/kg BW (95% CI: 0.02, 0.12 Nm/kg BW) and 0.05 Nm/kg BW (95% CI: 0.00, 0.09 Nm/kg BW) higher in the APP group than in the CON group at these times (P ≤ 0.015), respectively. The groups did not differ at 4 wk. Daily intake of a meal containing APP compared with whey protein increases skeletal muscle mass and lower-extremity muscle strength in healthy older women, suggesting that an APP-containing meal may be useful in the prevention of sarcopenia in this group. This trial was registered at as UMIN000035718.

940Physical frailty and the onset of depressive symptom in older Japanese women

Abstract Background The co-occurrence of physical frailty and depressive symptoms is highly prevalent in late life. However, their causal direction remains unclear. This study examined whether frailty and its components (slowness, weakness, exhaustion, low activity, and weight loss) predict the onset of depressive symptoms among older Japanese women. Methods In a two-year cohort study conducted in a metropolitan area of Tokyo, we collected baseline data in October 2017 and follow-up data in September 2019. Participants were community-dwelling older Japanese women, aged 65 to 80 years without any neurological diseases or depressive symptoms. Logistic regression analyses were applied to estimate odds ratios (OR) of the onset of depressive symptoms (15-item Geriatric Depression Scale [GDS] score ≥ 6) across the baseline frailty status or its components classified by the Japanese version of Cardiovascular Health Study criteria. Results Of the 477 women analysed (275 robust and 202 prefrail/frail). 6 (2.2%) robust and 16 (7.9%) prefrail or frail women developed depressive symptoms. After being adjusted for various covariates including baseline GDS score, the OR of the depressive symptom onset was 3.04 (95% confidence interval [CI]: 0.99, 10.47) in the prefrail or frail women. Among the five frailty components, slowness (OR: 7.55, 95%CI: 1.11, 48.98) and exhaustion (OR: 5.00, 95%CI: 1.60, 16.13) were independently associated with the onset of depressive symptoms. Conclusions Physical frailty status, particularly slowness and exhaustion, predict future depressive symptoms in older women. Key messages Early detection and intervention targeting physical frailty may help prevent depressive symptoms in later life.

Association of Protein and Magnesium Intake with Prevalence of Prefrailty and Frailty in Community-Dwelling Older Japanese Women.

We examined the association between nutrient intake and prefrailty. Data from 815 older people (63% women) who participated in a community-based health check survey (Tarumizu Study) were analyzed. Prefrailty were defined using five parameters (exhaustion, slowness, weakness, low physical activity, and weight loss). Participants with one or more components were considered to belong to the prefrailty group. Nutrition intake was estimated from a validated brief-type self-administered diet history questionnaire. Among the participants, 154 men (52%) and 278 women (54%) were found to be in a status of prefrailty. In men, there were no significant associations between nutrient intake and prefrailty. In women, carbohydrate intake was slightly higher in prefrailty group. Vitamins K, B1, B2, folic acid, pantothenic acid, phosphorus, potassium, calcium, magnesium, iron, zinc, and copper intake was significantly lower in the prefrailty group. Among the nutrients, magnesium was identified as a significant covariate of prefrailty using a stepwise regression method. In women adjusted ORs (95%CI, p value) for prefrailty in the first, second, third, and fourth quartiles of magnesium intake were 1.00 (reference), 0.52 (0.29-0.92, 0.024), 0.51 (0.28-0.95, 0.033), and 0.38 (0.19-0.74, 0.005), respectively, by multivariate logistic regression analysis (variates: age, body mass index, energy intake, supplement use, osteoporosis, magnesium, and protein intake). Protein intake did not related to prefrailty. Protein intake might be sufficient to prevent prefrailty in the present study. We propose magnesium to be an important micronutrient that prevents prefrailty in community-dwelling older Japanese women.

Urinary incontinence onset predictors in community-dwelling older women: A prospective cohort study.

We aimed to investigate whether physical function was associated with urinary incontinence (UI) onset in community-dwelling older Japanese women. This was a 4-year prospective cohort study. After excluding participants with UI and missing data in the baseline survey, we included 890 participants in the analyses. Physical function including grip strength, maximal walking speed, knee extension strength, single-leg balance, and timed up and go (TUG) were measured. The primary outcome was the onset of all UI and different types of UI (urge, stress and mixed) based on the questionnaire survey. Binary logistic regression analysis was applied to calculate the adjusted odds ratios and 95% confidence intervals for the association between physical function and the risk of all UI and different types of UI incident. Among the 890 participants, 221 (25%) developed UI during the 4-year follow-up. After adjusting for confounders, better knee extension strength, maximal walking speed and TUG were significantly associated with a lower risk of all UI and urge UI onset, and better single-leg balance and TUG were significantly associated with a lower risk of mixed UI onset (P for trend <0.05). No significant association was found between physical function and the risk of stress UI onset. This study confirmed that better lower extremity physical function is associated with lower risk of urge and mixed UI onset, indicating that exercise programs focusing on maintaining and improving lower extremity physical function may be useful for reducing such events among older women. Geriatr Gerontol Int 2021; 21: 178-184.

Relationship between oral and physical function and length of participation in long-term care prevention programs in community-dwelling older Japanese women.

The present study aimed to clarify the relationship between community-dwelling older women's participation period in community-based exercise programs and their oral and physical functioning. From May to September 2019, we recruited 205 older women (mean age: 77.6 ± 5.5years) who had joined weekly long-term care prevention programs such as community-based exercise programs that included oral and physical exercises, in Hiroshima Prefecture, Japan. Physical function was evaluated using a handgrip strength test, a Timed Up & Go test, a one-leg standing test, and a 30-s chair stand test. Tongue pressure, oral diadochokinesis, and Dysphagia Risk Assessment for the Community-dwelling Elderly were measured to evaluate oral functioning. After adjusting for clinical factors (i.e., age, BMI, hypertension, diabetes, stroke, heart disease, joint disease, osteoporosis, remaining teeth, denture use, oral wetness, history of dental examinations in the last year, use of interdental brush and/or dental floss), we compared the oral and physical function parameters of participants from varying program engagement periods using propensity score matching. A significant increase in mean handgrip strength was found in people who had been participating for ≥ 5years compared with those who had been participating for < 5years (p = 0.01). Furthermore, repetition of the monosyllable/ka/was significantly greater for people in the ≥ 5years group compared with those in the < 5 years group (p = 0.03). Long-term participation in an exercise program is positively associated with handgrip strength and tongue motor function in independent older women.

The additive effects of exercise and essential amino acid on muscle mass and strength in community-dwelling older Japanese women with muscle mass decline, but not weakness and slowness: a randomized controlled and placebo trial.

Exercise and essential amino acid supplementation have been separately shown to improve muscle mass in elderly people, however, the combined, added effects of both interventions have yielded inconsistent results on muscle mass, strength, and physical function improvement. To investigate the additive effects of exercise and essential amino acid supplementation on muscle mass, strength, and walking ability in older Japanese women with muscle mass decline, but not weakness and slowness. One hundred thirty women over 65years of age were defined as having muscle decline and randomly assigned into two groups; exercise and amino acid supplementation (n = 65) or exercise and placebo supplementation (n = 65). The exercise group attended a 60-min comprehensive training program once a week and were encouraged to perform a home-based exercise program. The amino acid or placebo group ingested a 3g supplement daily for 3-month. Body composition was determined by bioelectrical impedance analysis. Interview data and functional fitness measurements, such as muscle strength and walking ability were collected at baseline and after the 3-month intervention. There were no significant group × time interactions in primary outcomes such as muscle mass and strength. However, interactions were observed in the degree of low back discomfort (P = 0.014). Percent change of low back discomfort was significantly greater in exercise + amino acid group compared with exercise + placebo group. The combination of exercise and amino acid supplementation had a beneficial effect on low back discomfort. However, additional effects were not observed in primary outcomes including muscle mass and strength in this population.

Correlations between physical performance and muscle mass, strength, and quality in obese and normal-weight community-dwelling older Japanese women

Correlations between physical performance and muscle mass, strength, and quality in obese and normal-weight community-dwelling older Japanese women

Accelerometer-determined Physical Activity And Functional Fitness In Community-dwelling Older Japanese Women

PURPOSE: The proportion of elderly people in Japan’s population now exceeds 28%, identifying the country as a “super-aging society.” It is important for people to maintain health and independence as they age. Therefore, it is important for them to maintain functional fitness. The purpose of this study was to analyze the associations between accelerometer-determined physical activity and clinical measures of functional fitness. METHODS: One hundred ninety-nine community-dwelling Japanese women (age: 68.9 ± 4.8 years, BMI: 22.4 ± 2.8) wore an Active Style Pro HJA-350IT accelerometer for five weeks (Omron Healthcare Co., Ltd, Japan) on their waistline for the entire day, except when bathing, showering, swimming, or sleeping. The instrument measured the daily number of steps and accumulated time (minutes) spent in sedentary behavior (SB: < 1.5 metabolic equivalents or METs; 1 MET=3.5 ml/kg/min), light-intensity physical activity (LPA: 1.5 to 2.9 METs), and moderate- and vigorous-intensity physical activity (MVPA: ≥ 3.0 METs). Common functional fitness measures included hand grip, sit-up, sit and reach, functional reach, chair stands, 10-m walk, 10-m obstacle walk, and timed up and go. Functional fitness of participants was compared according to quartiles of steps/day and time spent in SB, LPA, and MVPA. These quartiles are denoted as Q1 (lowest activity quartile), Q2, Q3, and Q4 (highest activity quartile). RESULTS: Participants accumulated (median, [IQR]) 6,939 [5,000-8,896] steps/day, 286.1 [228.0-349.7] SB min/day, 451.1 [398.1-509.3] LPA min/day, and 68.9 [45.7-93.0] MVPA min/day. The 10-m walk, 10-m obstacle walk, and timed up and go measures differed significantly across the steps/day quartiles (Q1<Q2, p<0.05) and MVPA quartiles (Q1<Q2, Q3, Q4, p<0.05). The 10-m walk (Q1<Q2, p<0.05), timed up and go (Q1<Q2, p<0.05), and functional reach (Q2, Q3> Q4, p<0.05) measures differed significantly across SB quartiles. There were no differences observed across LPA quartiles. CONCLUSIONS: Accelerometer-determined physical activity, especially time in MVPA, was associated with a number of different functional fitness measures.

Reliability and construct validity of a novel motor-cognitive dual-task test: A Stepping Trail Making Test.

This study aimed to examine the reliability and construct validity of the Stepping Trail Making Test (S-TMT) in community-dwelling older adults. This study comprised a cross-sectional study based on a population sample. Participants comprised 1224 community-dwelling older Japanese women aged 65-81 years without functional disability, dementia, depression, Parkinson's disease, or cognitive and visual impairments. The S-TMT measured the time taken to step on a sequence of numbers (1-16) positioned on a mat (1 m2 ). Participants were instructed to step as quickly and accurately as possible. Motor functions were assessed by walking speed and knee extensor strength tests, while cognitive functions were assessed by the Symbol Digit Substitution Task (SDST) test, verbal and logical memory test, and TMT-A and -B. As a result of test-retest reliability over 6 months, the intraclass correlation coefficients of the S-TMT was 0.82 (95% confidence interval, 0.68-0.90). An adjusted multiple regression model indicated that the S-TMT was significantly associated with walking speed for motor function, and associated with the SDST, TMT-A and TMT-B for cognitive functions (P < 0.001). These results suggest that the S-TMT is a reliable dual-task test comprising mobility for motor function and a visual-dependent execution function for cognitive function in older women. Geriatr Gerontol Int 2020; 20: 291-296.

Visceral Fat Accumulation Is Associated with Mild Cognitive Impairment in Community-Dwelling Older Japanese Women.

Visceral fat accumulation is detrimental for brain health and is associated with cognitive impairment in older adults. The objectives of the present study were to examine the association between visceral fat accumulation and prevalence of mild cognitive impairment and its subtypes. a cross-sectional study. This study enrolled 6,109 community-dwelling older adults, including 3,434 women (mean age: 74.4 years) and 2,675 men (mean age: 74.3 years). Individuals with dementia, Parkinson's disease, stroke, Mini-Mental State Examination scores ≤23, and who could not perform basic activities of daily living independently were excluded. Participants underwent neurocognitive assessments to assess mild cognitive impairment (MCI) and its subtypes. Visceral fat area (VFA) was measured using abdominal bioelectrical impedance analysis. Participants were divided into quartile groups by VFA. There were 731 (21.3%) women and 562 (21.0%) men with MCI, and the median VFA values were 63.3 cm2 and 96.3 cm2, respectively. Women participants in the second (adjusted odds ratios [aOR], 0.71; 95% confidence interval [95% CI], 0.54-0.94), third (aOR, 0.66; 95% CI, 0.47-0.92), and fourth quartiles of VFA (aOR, 0.62; 95% CI, 0.41-0.93) had a significantly lower risk of MCI than those in the first quartile. Higher VFA quartiles in women were associated with lower risk of non-amnestic MCI. There were no significant differences in men between quartiles. Visceral fat accumulation was associated with MCI, especially non-amnestic MCI, in community-dwelling older Japanese women. These results suggest that visceral fat accumulation is partially protective against cognitive impairment.

Exercise Types and the Risk of Developing Cognitive Decline in Older Women: A Prospective Study.

Participation in exercise may be useful for dementia prevention; however, the specific exercise types which may best to reduce the risk of developing cognitive decline have remained unidentified in the literature. To examine the relationships of specific exercise types with the risk of developing cognitive decline in older women. This 1- to 2-year population-based cohort study included 687 community-dwelling older Japanese women without disability, neurological disease, dementia, or cognitive impairment assessed as <24 points on the Mini-Mental State Examination (MMSE) at the baseline survey. Developing cognitive decline was defined as a decrease of ≥3 points in the participant's MMSE score during the follow-up. We classified individuals into participation (≥3 months) and non-participation (<3 months) groups for 17 different exercise types. Log-binominal regression analyses were applied to compare risk ratios and confidence intervals of developing cognitive decline between the two groups. Thirty-nine participants (5.7%) developed cognitive decline during the follow-up period. After adjusting for confounders (age, MMSE score, depressive symptoms, body mass index, heart disease, hypertension, diabetes, smoking, low educational level, and the follow-up period in the baseline survey), those who participated in calisthenics demonstrated a significantly lower risk of developing cognitive decline than those who did not participate in calisthenics. No significant relationships between other exercise types and the risk of developing cognitive decline were found. Participation in calisthenics significantly reduced the risk of cognitive decline in community-dwelling older Japanese women, indicating that calisthenics may be a useful type of exercise for promoting dementia prevention.

Association between non-locomotive light-intensity physical activity and depressive symptoms in Japanese older women: A cross-sectional study

AimThis study aimed to examine associations between accelerometer-based intensity and type of physical activity (PA) and depressive symptoms in older Japanese women. MethodsIn this cross-sectional study, data were obtained from 143 community-dwelling older Japanese women aged 65–86 years, and depressive symptoms were assessed based on self-reported scores of the Geriatric Depression Scale-15-J. PA was measured objectively using an accelerometer worn continuously for ≥10 h/day for 4 days, and average daily durations of light-intensity PA (LPA) and moderate-to-vigorous intensity PA (MVPA), as well as type of PA (locomotive vs. non-locomotive), were examined. ResultsDepressive symptoms were present in 23 participants (19.1%). One-way analysis of covariance revealed participants without depressive symptoms had a significantly higher non-locomotive LPA compared to those with depressive symptoms (357 ± 82 vs 298 ± 66 min/day, F = 9.69, p < 0.01). However, no significant differences in the duration of locomotive LPA (48 ± 20 vs 43 ± 16 min/day; F = 0.80, p = 0.373), locomotive MVPA (23 ± 16 vs 26 ± 18 min/day; F = 0.34, p = 0.559), and non-locomotive MVPA (37 ± 25 vs 23 ± 16 min/day; F = 3.07, p = 0.082) between participants with and without depressive symptoms. ConclusionsOur results suggest that individuals with lower LPA have a higher risk of depressive symptoms compared to those undertaking higher durations of LPA. In particular, non-locomotive LPA may be one of the important factors contributing to the prevention of depressive symptoms in Japanese older women.

The Effects of Mold-Fermented Cheese on Brain-Derived Neurotrophic Factor in Community-Dwelling Older Japanese Women With Mild Cognitive Impairment: A Randomized, Controlled, Crossover Trial

ObjectivesTo investigate the effects of mold-fermented cheese (MFC) on brain-derived neurotrophic factor (BDNF) in community-dwelling older Japanese women with mild cognitive impairment (MCI). DesignRandomized controlled crossover trial. InterventionParticipants were randomly assigned to 2 groups. The MFC group was provided with 33.4 g MFC (camembert cheese) daily for 3 months, and the non-MFC group was provided with the same amount of non-MFC (processed cheese made from mozzarella cheese and cream cheese) for 3 months. After the post-intervention analysis (primary analysis), there was a 3-month washout period, followed by a crossover period (secondary analysis). Setting and ParticipantsUrban community in Tokyo, Japan. A total of 71 older women aged ≥70 years with MCI based on selected criteria in 689 community-dwelling women. MeasuresFace-to-face interviews were conducted to administer the Geriatric Depression Scale (GDS) and Mini-Mental State Examination (MMSE) and collect data on medical history. Physical function measures included grip strength, knee extension strength, and usual walking speed. Blood samples were obtained to determine the levels of albumin, vitamin D, high-sensitivity C-reactive protein, and BDNF. ResultsSignificant interactions were observed in BDNF after intervention of MFC intake in the secondary (F = 5.368, P = .024) and combined analyses (F = 4.354, P = .039) but not the primary analysis. There were no significant changes in the 3 categories of MMSE score (normal, MCI, moderate or severe cognitive impairment), GDS score, physical function, and blood indicators. Conclusions and ImplicationsThree months of MFC ingestion had beneficial effects on BDNF levels in community-dwelling older women with MCI; however, the BDNF increases did not translate into MMSE scores. Further study into the effects of interventions on cognitive function and depression in older people with MCI is necessary.

Exercise and/or Dietary Varieties and Incidence of Frailty in Community-Dwelling Older Women: A 2-Year Cohort Study.

Exercise and dietary habits rich in variety may reduce the risk of frailty incident, but such association remains unexamined. This study aimed to examine the longitudinal associations between exercise and/or dietary varieties and incidence of frailty in older women. A 2-year population-based prospective cohort study. Six hundred and four community-dwelling older Japanese women aged ≥75 years with non-frailty at baseline survey. Frailty was assessed using Fried's frailty criteria composed of shrinking, weakness, slowness, low activity, and exhaustion at both baseline and follow-up surveys. Frailty incident was defined as the presence of ≥3 components at the follow-up survey. At baseline, information about exercise and dietary habits were obtained from all participants through a face-to-face interview. Participants were grouped into two categories, high (≥2) and low (<2) exercise varieties, assessed by the number of participations in 17 exercise types. By dietary variety, assessed using Dietary Variety Score (range, 0 to 10), participants were grouped into two, high (≥4 points) and low (<4 points) dietary varieties. Binary logistic regression analyses were applied to obtain adjusted odds ratios (ORs) and 95% confident intervals (CIs) of the incidence of frailty in the 4 groups (low-exercise and low-dietary varieties [low EV + low DV] as reference; low-exercise and high-dietary varieties [low EV + high DV]; high-exercise and low-dietary varieties [high EV + low DV]; and high-exercise and high-dietary varieties [high EV + high DV]). Frailty incidence rate was 9.3% over the 2-year follow-up period. Incidence rates of frailty in the 4 groups were as follows: 23.7%, 10.1%, 6.5%, and 7.7% in the low EV + low DV, low EV + high DV, high EV + low DV, and high EV + high DV groups, respectively. After adjustment for covariates, only the high EV + high DV group was associated with a significantly lower OR (0.38; 95% CI 0.15-0.92) of frailty incidence compared with the low EV + low DV group. Higher variety of exercise and diet was significantly associated with lower incidence of frailty. Thus, the combination of variety-rich exercise and dietary program may be useful in preventing the incidence of frailty in older women.

Exercise type and activities of daily living disability in older women: An 8-year population-based cohort study.

Exercise may reduce the risk of disability for activities of daily living (ADL), but the degree of associations between specific exercise types and such a risk remains unclear. This study aimed to examine the longitudinal associations between exercise types and the incidence of ADL disability in older women. This 8-year population-based prospective cohort study enrolled 1003 community-dwelling older Japanese women without ADL disability in the baseline surveys. In the baseline surveys, all participants were asked whether or not they participated in any of 16 exercise types through a face-to-face interview. ADL were assessed using a modified form of the Katz index that comprised five ADL tasks. ADL disability was defined as dependence in at least one ADL task during the 8-year follow-up period. Binary logistic regression analyses were applied to obtain adjusted odds ratios (ORs) and 95% confident intervals (CIs) for the incidence of ADL disability based on participation or non-participation in each exercise type. Activities of daily living disability was noted in 130 participants (13.0%) over the 8-year follow-up period. After adjustment for confounders and other exercise types, participation in dancing, compared to non-participation, was associated with a significantly lower OR (0.27; 95% CI: 0.09-0.75) for incident ADL disability. There were no significant associations between other exercise types and incident ADL disability. Dancing was significantly and independently associated with a lower incidence of ADL disability. Thus, dancing may solely contribute to a reduced risk of ADL disability in older women.