Common Type Of Congenital Heart Disease Research Articles

Congenital Heart Diseases in the Cleft Lip Palate Patients and its Perioperative Implications: An Observational Study In Rural Central Maharashtra, India

Introduction: Congenital heart disease (CHD) is a common birth defect that occurs in approximately 1% of live births worldwide. Cleft lip and palate (CLP), another common birth defect, affecting approximately 1 in 600- 800 live births in India. Several studies have reported an association between CHD and CLP, however, there is limited data on the prevalence and types of CHD in patients with CLP in rural areas of developing countries, including India. This study aimed to investigate the prevalence and types of CHD in patients with CLP at a rural hospital in central Maharashtra, India. Methods: This retrospective study included medical records of patients with isolated Cleft lip, isolated cleft palate and patients with cleft lip and palate, between January 2018 and December 2020. The study was conducted at a rural hospital in central Maharashtra, India. The patients’ records were examined for any heart disease. Patients who had a diagnosis of CHD were identified through medical records and echocardiography reports. The prevalence and types of CHD were compared between the two groups using descriptive statistics and chi-square tests. Results: A total of 291 patients were included in our study. 169 were males and 122 were females. Congenital heart diseases were found in 12.37% (n=36) patients.5 Cleft lip (13%), 12 Cleft lip and palate (48%), 19 Isolated cleft palate (39%) were diagnosed with Congenital heart diseases. The types of Congenital Heart Diseases reported in our study were atrial septal defect, Ventricular septal defect, Patent ductus arteriosus, Pulmonic Stenosis and Tetralogy of Fallot. Conclusion: The most common types of CHD in both groups were ASD and VSD, but the prevalence of these defects was significantly higher in the CLP group. These findings have important implications for the multidisciplinary Perioperative management of patients with CLP, as they may require close monitoring for CHD and appropriate intervention if necessary, especially in resource-limited settings.

Factors associated with preventive behaviors of COVID-19 among children with congenital heart disease: Application of protection motivation theory.

Congenital heart disease (CHD) is one of the underlying medical conditions that put children at increased risk for coronavirus. This study aimed to predict preventive behaviors of COVID-19 among children with CHD based on the protection motivation theory (PMT). This cross-sectional study was conducted from March 2021 to April 2021, on 240 children 3-7 years with CHD whose data had been registered in Persian Registry of Cardiovascular Disease/CHD (PROVE/CHD) System in Isfahan, Iran. The research variables were measured using an online researcher-made questionnaire that was based on PMT constructs. The collected data were analyzed using statistical tests (e.g., Pearson correlation coefficient and linear regression analysis). From a total of 240 participants (mean age of 4.81 ± 1.50) in the present study, 122 (50.8%) were girls. The most common types of CHD among children participating in this study were related to atrial septal defect (ASD) (29.2%, n = 70) and ventricular septal defect (VSD) (26.7%, n = 64), respectively. Protective behaviors showed a significant correlation with all constructs of PMT. The PMT constructs explained 41.0% of the variances in protective behavior, in which the perceived reward (β = 0.325) and perceived self-efficacy (β = 0.192) was the most important, respectively. The results of this study showed well the effectiveness of PMT on the preventive behaviors of COVID-19 in children with CHD. This theory can be used to teach preventive behaviors of COVID-19 to children with CHD in education programs.

Reducing radiation dose from myocardial perfusion imaging in subjects with complex congenital heart disease

IntroductionThe prevalence of defects and effective radiation dose from various myocardial perfusion imaging (MPI) strategies in congenital heart disease (CHD) is unknown. MethodsWe studied 75 subjects with complex CHD (ages 5 to 80 years) referred for MPI between 2002 and 2015. A rest and exercise or pharmacologic stress MPI was performed using 99mTechnetium sestamibi, 82rubidium or 13N-ammonia, and Sodium iodide SPECT (single-photon emission computed tomography), SPECT/CT or Cadmium zinc telluride (CZT) SPECT or PET (positron emission tomography)/CT scanners. Deidentified images were interpreted semi-quantitatively in three batches: stress only MPI, stress/rest MPI, and stress/rest MPI with taking into account a history of ventricular septal defect repair. Effective radiation dose was estimated for stress/rest MPI and predicted for 1-day stress-first (normal stress scans), and for 2-day stress/rest MPI (abnormal stress scans). ResultsThe median age was 18.6 years. The most common type of CHD was transposition of the great arteries (63%). Rest/stress MPI was abnormal in 43% of subjects and 25% of the abnormal scans demonstrated reversible defects. Of the subjects with abnormal MPI, 33% had significant underlying anatomic coronary artery obstruction. Estimated mean effective radiation dose ranged from 2.1 ± 0.6 mSv for 13N-ammonia PET/CT to 12.5 ± 0.9 mSv for SPECT/CT. Predicted effective radiation dose was significantly lower for stress-first MPI and for 2-day stress/rest protocols. ConclusionsDue to the relatively high prevalence of abnormal stress MPI, tailored protocols with a stress-first MPI as well as the use of 2-day protocols and advanced imaging technologies including CZT SPECT, novel image reconstruction software, and PET MPI could substantially reduce radiation dose in complex CHD.

Risk Factors Associated with Congenital Heart Disease in Patients Presenting to Aljalila Cardiology Clinic between January 2020- May 2020: A Case Control Study

Objective: To investigate the association of maternal diabetes, maternal smoking and syndromes with congenital heart disease (CHD) in patients attending Aljalila cardiology clinic between January 2020 and May of 2020. Methods: A case control study to assess the association of maternal diabetes, maternal smoking and syndromes with CHD. All patients that presented to the clinic between January 2020 and May of 2020 were included. An interviewer administered questionnaire was used to record the presence of maternal diabetes, maternal smoking, and the type of syndrome and type of CHD. Patients with CHD were included in the case group and patients who did not have CHD were in the control group. Age, gender, and nationality were also collected from the hospital records. Fisher exact test and logistic regression was used to analyze the results. Results: A total of 177 cases and 211 controls were recruited. All the risk factors increase the risk of CHD, with maternal diabetes (OR 6.3, 95% CI 2.7-14.6) having the strongest association, then syndromes (OR 5.1, 95% CI 2.3-11.3) and lastly maternal smoking (OR 4.0, 95% CI 1.0-16.3). The most common type of CHD is ventricular septal defect.

Phonocardiogram Signal Processing for Automatic Diagnosis of Congenital Heart Disorders through Fusion of Temporal and Cepstral Features.

Congenital heart disease (CHD) is a heart disorder associated with the devastating indications that result in increased mortality, increased morbidity, increased healthcare expenditure, and decreased quality of life. Ventricular Septal Defects (VSDs) and Arterial Septal Defects (ASDs) are the most common types of CHD. CHDs can be controlled before reaching a serious phase with an early diagnosis. The phonocardiogram (PCG) or heart sound auscultation is a simple and non-invasive technique that may reveal obvious variations of different CHDs. Diagnosis based on heart sounds is difficult and requires a high level of medical training and skills due to human hearing limitations and the non-stationary nature of PCGs. An automated computer-aided system may boost the diagnostic objectivity and consistency of PCG signals in the detection of CHDs. The objective of this research was to assess the effects of various pattern recognition modalities for the design of an automated system that effectively differentiates normal, ASD, and VSD categories using short term PCG time series. The proposed model in this study adopts three-stage processing: pre-processing, feature extraction, and classification. Empirical mode decomposition (EMD) was used to denoise the raw PCG signals acquired from subjects. One-dimensional local ternary patterns (1D-LTPs) and Mel-frequency cepstral coefficients (MFCCs) were extracted from the denoised PCG signal for precise representation of data from different classes. In the final stage, the fused feature vector of 1D-LTPs and MFCCs was fed to the support vector machine (SVM) classifier using 10-fold cross-validation. The PCG signals were acquired from the subjects admitted to local hospitals and classified by applying various experiments. The proposed methodology achieves a mean accuracy of 95.24% in classifying ASD, VSD, and normal subjects. The proposed model can be put into practice and serve as a second opinion for cardiologists by providing more objective and faster interpretations of PCG signals.

Frequency and types of congenital heart disease in neonates: A cross-sectional study from large public sector hospital of Karachi, Pakistan

Background: Congenital heart disease (CHD) is one of the frequent congenital health issues in neonates. Early diagnosis is a key factor to combat this problem. This study aims to assess the frequency and common types of CHD among neonates presenting to a tertiary care hospital, Karachi.
 Patients and methods: This descriptive cross-sectional study was conducted in a Neonatal Intensive Care Unit (NICU) of National Institute of Child Health (NICH), Karachi from March to September 2017. All neonates of gestational age ≥37 weeks with suspected CHD (presence of blue-tinged skin, i.e. cyanosis on routine clinical examination) were included. Information regarding presence of CHD and its types were collected along with the demographic characteristics and history of the patients.
 Results: Of 134, frequency of CHD was observed in 126 (94%) patients. Out of these 126 CHD patients, Ventricular septal defect (VSD) was observed in 49 (38.9%), patent ductal arteriosus (PDA) in 29 (23%), atrial septal defect (ASD) was observed in 19 (15.1%), Transposition of great arteries (TGA) in 18 (14.3%), and tetralogy of Fallot (TOF) in 14 (11.1%) patients. A significant association of VSD was observed with neonatal age (p = <0.001), ASD with neonatal age (p = 0.037) and maternal age (p = 0.025), while TGA was found significantly associated with neonatal age (p<0.001).
 Conclusion: CHD was observed in majority of the suspected patients with VSD as commonest type of congenital heart diseases among neonates.

Spectrum of congenital heart diseases and its correlation with maternal risk factors

Objectives: The present study was sought to determine the spectrum of congenital heart diseases (CHDs) and their correlation with maternal risk factors at a tertiary care hospital situated in sub-urban area. Materials and Methods: This cross-sectional, observational study was conducted from February 2019 to February 2020. A total of 100 children suspected for CHD were screened and 67 confirmed CHD cases were enrolled into the study. Children having cardiomyopathy, rheumatic heart disease, secondary heart disease, and asymptomatic children were excluded from the study. Detailed history of presenting complaints, pregnancy, family history, consanguinity, and socioeconomic status was documented. Chest X-ray, electrocardiogram, and echocardiography were done to arrive at a definitive diagnosis. All the statistical analyses were performed using the SPSS software version 20.0 (IBM Corp, Somers, NY, USA). Results: Majority of the children presented with symptoms in the age group of 1–5 years. Most of the parents of children with CHD were educated up to secondary educational level (34%) followed by illiterate (24%). Economic status of most of the parents was upper lower class (67%). Maternal risk factors were not observed in 60% (n = 40) of the cases. 41.79% of CHD children were born to consanguineously married couple. Maternal stress was present in 40% of the cases. The most common presenting complaint was lower respiratory tract infection (LRTI in 61%). Murmur was seen in 70% (n = 47) of the cases. Majority of the cases (84%) were acyanotic and cyanosis was present in 16% of the cases. Atrial septal defect (ASD) was the most common which constituted 44.6% in acyanotic heart disease while tetralogy of Fallot (TOF) was the most common with 18.1% in cyanotic heart disease. In both cyanotic and acyanotic CHD groups, majority of the cases had no maternal risk factors (45.5% and 62.5%, respectively). Conclusion: The most common types of CHDs in acyanotic and cyanotic CHD groups are ASD and TOF, respectively. Consanguinity, stress during pregnancy, and diabetes mellitus were identified as the major risk factors for CHD. LRTI and shortness of breath were the most common clinical features in children with CHD.

Frequency and pattern of Paediatric Heart Diseases: Five years experience at The Children's Hospital, Multan.

Background & Objectives:Heart diseases in paediatric population are considered to be significant contributors to mortality and morbidity. Congenital heart disease (CHD) as well as acquired heart disease (AHD) are frequent causes of hospital admission among children. This study was aimed at finding out frequency and pattern of heart diseases in admitted patients at The Children’s Hospital, Multan.Methods:This study is a retrospective chart review of five years at Paediatric Cardiology Department of The Children’s Hospital and The Institute of Child Health, Multan, Pakistan, from January 2015 to December 2019. Children aged one month to 15 years, admitted as a diagnosed case of heart disease on the basis of echocardiography were included.Results:Out of a total of 4115 confirmed cases of heart disease admitted during the study period, 3250 (79.0%) were CHD while 865 (21.0%) were AHD. Overall, 2861 (69.5%) patients were aged less than one year. VSD followed by ASD were the commonest acyanotic heart lesion seen among 927 (28.5%) and 644 (19.8%) cases while TOF was the commonest cyanotic type heart lesion found in 396 (12.2%). Rheumatic heart disease (RHD) was the commonest type of AHD, seen in 330 (38.2%) cases followed by acute myocarditis found in 230 (26.6%) cases.Conclusion:Burden of heart diseases is rising in our region. VSD, ASD and TOF were the most common types of CHDs while RHD and acute myocarditis were the most frequent types of AHDs.

Congenital Heart Disease Characteristics in Low Birth Weight Infants at Dr. Hasan Sadikin General Hospital in 2010–2014

Background : Congenital heart disease (CHD) is a multifactorial disease defined as an anomaly in the macroscopic structure of the heart that may cause functional disorders. The incidence of CHD is reported higher in infants with low birth weight (LBW) than the entire population of neonates. This study aimed to describe the characteristics of CHD in infants born with LBW. Methods : This was a retrospective descriptive study with a cross-sectional design, performed in October–November 2015. Data were obtained from medical records of inpatients infants at Dr. Hasan Sadikin General Hospital, Bandung in the period of 2010–2014. The data presented were the characteristics of CHD in LBW infants. Results : Of 364 LBW infants treated in the hospital within 5 years period, 21 infants (14 girls and 7 boys) were diagnosed as CHD, with birth weight group predominantly (n18; 85.7%) in the range of 1,500–2,499 gr. Non-cyanosis CHD was prevalent in 95.2% (n20),and patent ductus arteriosus (PDA)was found in 76.1% (n16). Comorbid conditions mostly found in this study were preterm birth (n17), sepsis (n10), and neonatal hyperbilirubinemia (n9). Conclusions : The most common type of CHD in low birth weight infants in Dr. Hasan Sadikin General Hospital is Patent Ductus Arteriosus. The presence of congenital heart disease should be considered in low birth weight infants, thus it is essential to perform screening for early recognition.

Profile of Children with Congenital Heart Disease and Upper Respiratory Tract Infection in Dr. Soetomo General Hospital Surabaya Period March 2018

Introduction: Congenital Heart Disease (CHD) is the leading cause of death in the first year of life. One of the manifestations of CHD is upper respiratory infection (URI). In Indonesia, 90% of the acute respiratory infection is URI and it becomes the most common reason for children to go to emergency center. The aim of this study is to describe the profile of children with congenital heart disease and upper respiratory tract infection (URTI) in Dr. Soetomo General Hospital, Surabaya, based on sex, age, immunization status, social-economic status, and type of CHD. Methods: This descriptive study was done by collecting data using medical records and questionnaires from March 1st to 31st 2018. Results: Total number of the sample was 46 patients; 18 (39.1%) of them were male and 28 (60.9%) were female, with male to female ratio was 1:1.6. The most common age group (69.6%) was toddler (0-5 years old). The most common type of CHD was acyanotic (89.1%). Conclusion: Female patients had more (80%) severe URI than male patients. Patients with severe URI only occur in toddlers. Interestingly, 60% of patients with severe URI had complete immunization. Patients with severe URI had parents with moderate (60%) and low income (40%). There were 100% of patients with severe URI who had acyanotic CHD.

Clinical Characteristic and Outcome of Acute Lower Respiratory Tract Infection in Children with Congenital Heart Disease

Background : Acute Lower Respiratory Tract Infection (ALRTI) is the leading cause of deaths in children under 5 years of age worldwide, and has high morbidity and mortality in children with Congenital Heart Disease (CHD). The objective of this study was to obtain the incidence, clinical characteristic, and outcome of ALRTI children with CHD. Methods : A retrospective hospital-based study was conducted from January 2007–December 2011 to medical record of child patients with ALRTI and CHD in the Department of Child Health of Dr. Hasan Sadikin General Hospital, Bandung. The diagnosis of CHD was determined by echocardiography. The collected data was analyzed and presented in percentage shown in tables. Results : From 3,897 children who had ALRTI, there were 149 children with CHD (3.8%), with 11.4% of whom founded with recurrent episodes. This happened often in girls than boys with quite similar ratio of 1.37: 1.The majority of children (80%) was under 1 year old of age, 72.5% with malnutrition, and 24.8% with severe malnutrition. Clinical symptoms mostly found were difficulty of breathing (98%), fever (85.2%), cough (75.2%), and runny nose (63.1%). The most common types of CHD were Patent Ductus Arteriosus (47.6%), followed by Ventricular Septal Defect (47%). Bronchopneumonia (86.6%) was the common type of ALRTI. The length of stay was mostly less than 10 days (70.5%). From all the children 43.7% had complications, and 6.7% died. Conclusions : The ALRTI in children with CHD is not common and has good outcome. The majority for CHD lesions are Patent Ductus Arteriosus and Ventricular Septal Defect while for ALRTI is Bronchopneumonia. DOI : 10.15850/amj.v2n3.483

PS-030 Congenital Heart Disease And Microcephaly At Birth: A Danish Population-based Cohort Study Of Children With Down Syndrome

Background and aims Neurodevelopmental disorders are common in children with congenital heart disease (CHD) and largely ascribed to prenatal factors such as impaired cerebral growth. It remains to be established whether this is due to impaired intrauterine cerebral blood flow or genuine genetic causes. Down syndrome (DS) is a known cause of CHD, neurodevelopmental disorders and microcephaly. Hence, studies on DS may provide insight into the causes of impaired cerebral growth in CHD. We aimed to assess the risk of microcephaly in children with DS and CHD compared to children with DS and no CHD. Methods Children with DS (n = 389) and specific birth characteristics were identified in national registries. Head circumference and the risk of microcephaly (head circumference Results There was no difference in head circumference between the groups, 0.0 cm (95% CI -0.4–0.4). Adjustment did not significantly alter the results. The risk of microcephaly was slightly higher in newborns with CHD, OR 1.4 (95% CI 0.8–2.6). Adjustment did not significantly alter the results. Conclusions We did not find indications of impaired head growth in children with DS and concomitant CHD. There might be a slight increase in the risk of microcephaly. We suggest that the most common types of CHD in DS i.e. atrioventricular septal defects, ventricular septal defects and atrial septal defects do not impair prenatal cerebral growth in children with DS.

Major adverse cardiovascular events in adult congenital heart disease: a population-based follow-up study from Taiwan

BackgroundThe aim of the present study was to identify the long-term major adverse cardiovascular events (MACE) in adult congenital heart disease (ConHD) patients in Taiwan.MethodsFrom the National Health Insurance Research Database (1997-2010), adult patients (≥18 years) with ConHD were identified and compared to non-ConHD control patients. The primary end point was the incidence of MACE. Cox proportional hazards models were used to compute hazard ratios as estimates for multivariate adjusted relative risks with or without adjusting for age and sex.ResultsA total of 3,267 adult patients with ConHD were identified between 2000 and 2003 with a median follow-up of 11 years till December 31, 2010. The five most common types of ConHD were atrial septal defects, ventricular septal defects, patent ductus arteriosus, tetralogy of Fallot, and pulmonary stenosis. Overall, the incidence of MACE was 4.0-fold higher in the ConHD group compared with the controls. After adjustment for age and gender, the patients with ConHD had an increased risk of heart failure, malignant dysrhythmia, acute coronary syndrome, and stroke. The adult ConHD patients had a decreased life-long risk of MACE if they received surgical correction, especially in the patients with atrial septal defects.ConclusionsAfter a median of 11 years of follow-up, the Taiwanese patients with ConHD were at an increased risk of life-long cardiovascular MACE, including heart failure, stroke, acute coronary syndrome, and malignant dysrhythmia. Surgical correction may help to decrease long-term MACE in ConHD patients, especially those with ASD.

Outcomes of Spinal Fusion in Children With Congenital Heart Disease

The children with congenital heart disease (CHD) have an increased risk of developing scoliosis. Many children with CHD may benefit from surgical intervention for scoliosis. However, there is uncertainty about the safety of spinal fusion in children with heart disease. The purpose of this study is to assess whether spinal fusion is safe and effective for children who have CHD. We reviewed all the cases of children with CHD undergoing first-time spinal fusion for spinal deformity at Mayo Clinic between August 1976 and June 2008. Data were abstracted regarding cardiac history, major Cobb angle, type of spinal fusion (anterior, posterior, or both), intraoperative and postoperative complications, mortality, and follow-up. Sixty-four children under the age of 18 (64% female patients; mean age=11.5 y) were included in the study. The most common types of CHD were pulmonary atresia with ventricular septal defect and tetralogy of Fallot. Sixty-three percent of all patients had had prior cardiac surgery; 22% were cyanotic at the time of spinal fusion. Nine patients had single-ventricle physiology; 5 of whom had had Fontan palliation. Nine patients had pulmonary hypertension. Posterior fusion alone was carried out for 69% of the patients. Spinal instrumentation was used in 70% of cases. Average anesthesia time was 7.3 hours. Mean hospital stay was 9 days. Eighteen children (30%) required prolonged intubation of 1 day or longer. Prolonged intubation was more common in patients with a larger Cobb angle and in patients with pulmonary hypertension. Postoperative complications occurred in 27% of all patients and were more common in the patients with pulmonary hypertension. One child died postoperatively from a hemorrhage because of an arterial-esophageal fistula unrelated to her spinal fusion. Spinal fusion in children with CHD is generally safe and effective. Children with pulmonary hypertension are at higher risk for complications from spinal fusion. Level IV--Case Series.

Congenital heart disease in live-born children: incidence, distribution, and yearly changes in the Campania Region

Congenital heart disease (CHD), the most common cardiac malformation in the fetal and neonatal period, represents a heterogeneous group of defects with little known cause. The aim of this study was to investigate the incidence rate (IR) of CHD without spontaneous resolution in the first year of life, the age at diagnosis, the most common type of CHD, and the IR changes in severe and nonsevere CHD during the study period. From January 1997 to December 2002, 4559 live births with CHD (diagnosed until December 2004) were enrolled in the Campania Region. Number of live-born children by month was derived from national registries. About 70% of CHD patients were diagnosed within the first year of life. The overall mean regional IR of CHD was 11.1 (confidence interval 10.8-11.4) patients per 1000 live-born children. The overall mean IR of CHD was significantly different in the five provinces of the Campania Region, but the annual IR remained stable in each of them throughout the study period. The relative risk in live-born children and residents in the areas with an elevated IR of CHD was higher for nonsevere CHD, but of low significance for severe CHD. At least one-third of CHD patients had atrial septal defects. We described the highest IR of CHD from one of the largest samples used up to now for this purpose (410 181 live-born children), but we think that this value could be higher (poor surveillance in some areas). Moreover, this study increases the awareness that CHD patients with a few symptoms are frequently underdiagnosed in areas with inadequate health services and that by an improved availability of pediatric echocardiographic assesments seem warranted. Eight years of surveillance and an increasing attention of both pediatricians and cardiologists to mild CHD in some provinces allowed us to demonstrate that, despite previous reports, the most common CHD in our region was atrial septal defect.