Background: Complementary and alternative medicine (CAM) offers a different approach to conventional medicine. CAM is very popular in many countries. Objectives: To study the magnitude of use, and determinants and awareness of CAM therapy use among the population in Western region of Saudi Arabia. Method: This was a cross sectional study; a non-probability convenient sampling method was used to select 1073 subjects through online Google survey. Data were collected using interview questionnaire, which provided information on the sociodemographic characteristics of the subjects, as well as questions on the practices and awareness of CAM therapies. The GAD-7 test to assess anxiety state was also used. Results: Almost half of the study population used CAM (51.6%), particularly those who live in the villages of Makkah city. CAM therapies were used by almost half of all patients with chronic diseases particularly those with gastrointestinal disorders and anxiety. Most common CAM method were Honey, Herbs, Ruqayyah and black seeds; while Acupuncture was the least method used. CAM methods were mainly used if needed, and main source of information about its use, was from the family. Almost half of the users were satisfied with the results of using it; however, their attitude about CAM in general was neutral. Conclusion: Use of CAM is a common health practice among the Saudi population. The majority of the participants had equivocal awareness about its effects. More health education programs by specialized health care authorities on the use and benefits of CAM are needed. Doctor-patient communication regarding CAM use is important. Increasing awareness of Saudi population about instructions and restrictions when using CAM is greatly needed. Keywords: CAM, Saudi Arabia, anxiety, Jeddah city, Gastro intestinal disorders.
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